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Aliases for FAM49B Gene

Aliases for FAM49B Gene

  • Family With Sequence Similarity 49, Member B 2 3
  • L1 3 4
  • BM-009 3

External Ids for FAM49B Gene

Previous GeneCards Identifiers for FAM49B Gene

  • GC08M130922
  • GC08M126172
  • GC08M130853

Summaries for FAM49B Gene

GeneCards Summary for FAM49B Gene

FAM49B (Family With Sequence Similarity 49, Member B) is a Protein Coding gene. An important paralog of this gene is FAM49A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM49B Gene

Genomics for FAM49B Gene

Regulatory Elements for FAM49B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM49B Gene

Chromosome:
8
Start:
129,839,593 bp from pter
End:
130,017,129 bp from pter
Size:
177,537 bases
Orientation:
Minus strand

Genomic View for FAM49B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM49B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM49B Gene

Proteins for FAM49B Gene

  • Protein details for FAM49B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUQ9-FA49B_HUMAN
    Recommended name:
    Protein FAM49B
    Protein Accession:
    Q9NUQ9
    Secondary Accessions:
    • Q96AZ5
    • Q9NW21
    • Q9NZE7

    Protein attributes for FAM49B Gene

    Size:
    324 amino acids
    Molecular mass:
    36748 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF64265.1; Type=Frameshift; Positions=65, 90, 126, 169, 172, 252, 292; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM49B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM49B Gene

Proteomics data for FAM49B Gene at MOPED

Post-translational modifications for FAM49B Gene

  • Ubiquitination at Lys 199, Lys 207, Lys 213, and Lys 317
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM49B Gene

Domains & Families for FAM49B Gene

Protein Domains for FAM49B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM49B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NUQ9

UniProtKB/Swiss-Prot:

FA49B_HUMAN :
  • Belongs to the FAM49 family.
Family:
  • Belongs to the FAM49 family.
genes like me logo Genes that share domains with FAM49B: view

No data available for Gene Families for FAM49B Gene

Function for FAM49B Gene

Gene Ontology (GO) - Molecular Function for FAM49B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM49B: view

Phenotypes for FAM49B Gene

genes like me logo Genes that share phenotypes with FAM49B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM49B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM49B Gene

Localization for FAM49B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM49B Gene COMPARTMENTS Subcellular localization image for FAM49B gene
Compartment Confidence
extracellular 5
cytosol 2

Gene Ontology (GO) - Cellular Components for FAM49B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005929 cilium IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with FAM49B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM49B Gene

Pathways & Interactions for FAM49B Gene

SuperPathways for FAM49B Gene

No Data Available

Interacting Proteins for FAM49B Gene

Gene Ontology (GO) - Biological Process for FAM49B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM49B Gene

Drugs & Compounds for FAM49B Gene

No Compound Related Data Available

Transcripts for FAM49B Gene

Unigene Clusters for FAM49B Gene

Family with sequence similarity 49, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM49B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM49B Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b
SP1: - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - -
SP7: - - - - -
SP8: - - - - - -
SP9: - - - - - - - -
SP10: - - -
SP11: - - - - - -
SP12: - - - -
SP13:

Relevant External Links for FAM49B Gene

GeneLoc Exon Structure for
FAM49B
ECgene alternative splicing isoforms for
FAM49B

Expression for FAM49B Gene

mRNA expression in normal human tissues for FAM49B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM49B Gene

This gene is overexpressed in Whole Blood (x11.0).

Protein differential expression in normal tissues from HIPED for FAM49B Gene

This gene is overexpressed in Lymph node (7.8) and NK cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM49B Gene



SOURCE GeneReport for Unigene cluster for FAM49B Gene Hs.126941

genes like me logo Genes that share expression patterns with FAM49B: view

Protein tissue co-expression partners for FAM49B Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FAM49B Gene

Orthologs for FAM49B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM49B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM49B 35
  • 95.47 (n)
  • 100 (a)
FAM49B 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM49B 35
  • 92.59 (n)
  • 96.6 (a)
FAM49B 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam49b 35
  • 94.75 (n)
  • 99.69 (a)
Fam49b 16
Fam49b 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM49B 35
  • 99.9 (n)
  • 100 (a)
FAM49B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam49b 35
  • 95.06 (n)
  • 99.69 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM49B 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM49B 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM49B 35
  • 86.63 (n)
  • 95.99 (a)
FAM49B 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM49B 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam49b 35
  • 82.61 (n)
  • 97.22 (a)
African clawed frog
(Xenopus laevis)
Amphibia cg32066-prov 35
zebrafish
(Danio rerio)
Actinopterygii fam49bb 35
  • 77.06 (n)
  • 88.27 (a)
wufj85c11 35
fam49bb 36
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG32066 36
  • 54 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R07G3.8 36
  • 33 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3933 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 59 (a)
OneToMany
Species with no ortholog for FAM49B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM49B Gene

ENSEMBL:
Gene Tree for FAM49B (if available)
TreeFam:
Gene Tree for FAM49B (if available)

Paralogs for FAM49B Gene

Paralogs for FAM49B Gene

Pseudogenes.org Pseudogenes for FAM49B Gene

genes like me logo Genes that share paralogs with FAM49B: view

Variants for FAM49B Gene

Sequence variations from dbSNP and Humsavar for FAM49B Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs10050 -- 129,841,473(+) ACTTA(G/T)AAAAA utr-variant-3-prime, nc-transcript-variant
rs167238 -- 129,925,965(-) TGGAA(A/G)TTGGA intron-variant
rs167239 -- 129,862,545(+) ggctc(A/T)ctaca intron-variant
rs169881 -- 129,918,219(-) TATTA(A/G)AAACA intron-variant
rs177113 -- 129,934,965(-) agctt(A/C)tatgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM49B Gene

Variant ID Type Subtype PubMed ID
nsv524349 CNV Gain 19592680
esv268928 CNV Insertion 20981092
esv1565412 CNV Insertion 17803354
nsv398375 CNV Insertion 16902084
nsv6396 CNV Insertion 18451855
nsv521998 CNV Loss 19592680

Variation tolerance for FAM49B Gene

Residual Variation Intolerance Score: 37.94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM49B Gene

HapMap Linkage Disequilibrium report
FAM49B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM49B Gene

Disorders for FAM49B Gene

Relevant External Links for FAM49B

Genetic Association Database (GAD)
FAM49B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM49B
genes like me logo Genes that share disorders with FAM49B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM49B Gene

Publications for FAM49B Gene

  1. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  4. Urine, peritoneal fluid and omental fat proteomes of reproductive age women: Endometriosis-related changes and associations with endocrine disrupting chemicals. (PMID: 25284053) Williams K.E. … Fisher S.J. (J Proteomics 2015) 67
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67

Products for FAM49B Gene

Sources for FAM49B Gene

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