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Aliases for FAM49A Gene

Aliases for FAM49A Gene

  • Family With Sequence Similarity 49 Member A 2 3 5
  • Family With Sequence Similarity 49, Member A 2

External Ids for FAM49A Gene

Previous GeneCards Identifiers for FAM49A Gene

  • GC02M016653
  • GC02M016505

Summaries for FAM49A Gene

GeneCards Summary for FAM49A Gene

FAM49A (Family With Sequence Similarity 49 Member A) is a Protein Coding gene. An important paralog of this gene is FAM49B.

Gene Wiki entry for FAM49A Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM49A Gene

Genomics for FAM49A Gene

Regulatory Elements for FAM49A Gene

Promoters for FAM49A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM49A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM49A Gene

Chromosome:
2
Start:
16,549,459 bp from pter
End:
16,666,331 bp from pter
Size:
116,873 bases
Orientation:
Minus strand

Genomic View for FAM49A Gene

Genes around FAM49A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM49A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM49A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM49A Gene

Proteins for FAM49A Gene

  • Protein details for FAM49A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0Q0-FA49A_HUMAN
    Recommended name:
    Protein FAM49A
    Protein Accession:
    Q9H0Q0
    Secondary Accessions:
    • B3KNZ1
    • Q53QW2

    Protein attributes for FAM49A Gene

    Size:
    323 amino acids
    Molecular mass:
    37313 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM49A Gene

Proteomics data for FAM49A Gene at MOPED

Post-translational modifications for FAM49A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM49A Gene

No data available for DME Specific Peptides for FAM49A Gene

Domains & Families for FAM49A Gene

Protein Domains for FAM49A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM49A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0Q0

UniProtKB/Swiss-Prot:

FA49A_HUMAN :
  • Belongs to the FAM49 family.
Family:
  • Belongs to the FAM49 family.
genes like me logo Genes that share domains with FAM49A: view

No data available for Gene Families for FAM49A Gene

Function for FAM49A Gene

genes like me logo Genes that share phenotypes with FAM49A: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM49A Gene

Localization for FAM49A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM49A Gene COMPARTMENTS Subcellular localization image for FAM49A gene
Compartment Confidence
cytosol 2
cytoskeleton 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM49A Gene

Pathways & Interactions for FAM49A Gene

SuperPathways for FAM49A Gene

No Data Available

Interacting Proteins for FAM49A Gene

Gene Ontology (GO) - Biological Process for FAM49A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM49A Gene

Drugs & Compounds for FAM49A Gene

No Compound Related Data Available

Transcripts for FAM49A Gene

Unigene Clusters for FAM49A Gene

Family with sequence similarity 49, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM49A Gene

No ASD Table

Relevant External Links for FAM49A Gene

GeneLoc Exon Structure for
FAM49A
ECgene alternative splicing isoforms for
FAM49A

Expression for FAM49A Gene

mRNA expression in normal human tissues for FAM49A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM49A Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.6), Brain - Anterior cingulate cortex (BA24) (x4.3), and Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for FAM49A Gene

This gene is overexpressed in Bone (43.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for FAM49A Gene



SOURCE GeneReport for Unigene cluster for FAM49A Gene Hs.467769

genes like me logo Genes that share expression patterns with FAM49A: view

Protein tissue co-expression partners for FAM49A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FAM49A Gene

Orthologs for FAM49A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM49A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM49A 36
  • 100 (a)
OneToOne
FAM49A 35
  • 100 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia FAM49A 35
  • 92.16 (n)
  • 100 (a)
FAM49A 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM49A 36
  • 100 (a)
OneToOne
FAM49A 35
  • 93.7 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Fam49a 16
Fam49a 36
  • 100 (a)
OneToOne
Fam49a 35
  • 90.3 (n)
  • 99.69 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM49A 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM49A 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam49a 35
  • 91.02 (n)
  • 99.69 (a)
chicken
(Gallus gallus)
Aves FAM49A 35
  • 83.08 (n)
  • 96.59 (a)
FAM49A 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM49A 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam49a 35
  • 81.42 (n)
  • 95.36 (a)
Str.9897 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12282 35
zebrafish
(Danio rerio)
Actinopterygii znf395 36
  • 84 (a)
OneToMany
znf395 36
  • 86 (a)
OneToMany
sbcb866 35
znf395 35
  • 77.71 (n)
  • 86.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32066 36
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R07G3.8 35
  • 47.57 (n)
  • 38.41 (a)
R07G3.8 36
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
OneToMany
Species with no ortholog for FAM49A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM49A Gene

ENSEMBL:
Gene Tree for FAM49A (if available)
TreeFam:
Gene Tree for FAM49A (if available)

Paralogs for FAM49A Gene

Paralogs for FAM49A Gene

(4) SIMAP similar genes for FAM49A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FAM49A: view

Variants for FAM49A Gene

Sequence variations from dbSNP and Humsavar for FAM49A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs15653 -- 16,550,242(+) CACCC(A/G)TAAGT utr-variant-3-prime
rs719433 -- 16,612,700(+) AGCTG(A/C)GTGAG intron-variant
rs888574 -- 16,639,541(-) GCCCC(A/C)CACTG intron-variant
rs888575 -- 16,615,328(-) TAAAA(C/T)GACCA intron-variant
rs811308 -- 16,642,599(-) cgtgt(A/T)ctagc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM49A Gene

Variant ID Type Subtype PubMed ID
esv34115 CNV Loss 18971310
nsv506999 CNV Insertion 20534489
nsv2622 CNV Insertion 18451855
esv23923 CNV Loss 19812545

Variation tolerance for FAM49A Gene

Residual Variation Intolerance Score: 25.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM49A Gene

HapMap Linkage Disequilibrium report
FAM49A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM49A Gene

Disorders for FAM49A Gene

Relevant External Links for FAM49A

Genetic Association Database (GAD)
FAM49A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM49A

No disorders were found for FAM49A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM49A Gene

Publications for FAM49A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384. (PMID: 24554482) Leger P.D. … Haas D.W. (J. Neurovirol. 2014) 3
  4. CBFI^ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. (PMID: 23333304) Kim D.Y. … Gross J.D. (Mol. Cell 2013) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for FAM49A Gene

Sources for FAM49A Gene

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