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FAM47C Gene(Protein Coding)

Family With Sequence Similarity 47 Member C

GCID:
GC0XP037026
GIFtS:
32
Genes Participants
UDN Logo

Aliases for FAM47C Gene

Aliases for FAM47C Gene

  • Family With Sequence Similarity 47 Member C 2 3 5
  • Family With Sequence Similarity 47, Member C 2

External Ids for FAM47C Gene

Previous GeneCards Identifiers for FAM47C Gene

  • GC0XP036936

Summaries for FAM47C Gene

Entrez Gene Summary for FAM47C Gene

  • This gene encodes a product belonging to a family of proteins with unknown function. The coding sequence of this family member includes several tandemly repeated regions. [provided by RefSeq, Sep 2011]

GeneCards Summary for FAM47C Gene

FAM47C (Family With Sequence Similarity 47 Member C) is a Protein Coding gene. An important paralog of this gene is FAM47A.

Additional gene information for FAM47C Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM47C Gene

Genomics for FAM47C Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for FAM47C Gene

Promoters and enhancers for FAM47C Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH0XI037008 Promoter 0.5 EPDnew 550.8 0.0 -19 0.1 FAM47C LOC100422408
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM47C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM47C gene promoter:

Genomic Locations for FAM47C Gene

Genomic Locations for FAM47C Gene
chrX:37,008,359-37,011,666
(GRCh38/hg38)
Size:
3,308 bases
Orientation:
Plus strand
chrX:37,026,432-37,029,739
(GRCh37/hg19)

Genomic View for FAM47C Gene

Genes around FAM47C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM47C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM47C Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FAM47C Gene

Proteins for FAM47C Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FAM47C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5HY64-FA47C_HUMAN
    Recommended name:
    Putative protein FAM47C
    Protein Accession:
    Q5HY64
    Secondary Accessions:
    • Q6ZU46

    Protein attributes for FAM47C Gene

    Size:
    1035 amino acids
    Molecular mass:
    115338 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC86381.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FAM47C Gene

Protein Expression for FAM47C Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FAM47C Gene

No Post-translational modifications

Other Protein References for FAM47C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM47C Gene

Domains & Families for FAM47C Gene

Gene Families for FAM47C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM47C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM47C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5HY64

UniProtKB/Swiss-Prot:

FA47C_HUMAN :
  • Belongs to the FAM47 family.
Family:
  • Belongs to the FAM47 family.
genes like me logo Genes that share domains with FAM47C: view

Function for FAM47C Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
genes like me logo Genes that share phenotypes with FAM47C: view

Animal Model Products

CRISPR Products

miRNA for FAM47C Gene

miRTarBase miRNAs that target FAM47C

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM47C Gene

Localization for FAM47C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM47C gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM47C Gene

Pathways & Interactions for FAM47C Gene

SuperPathways for FAM47C Gene

PathCards logo More details on SuperPathways for FAM47C
No Data Available

Interacting Proteins for FAM47C Gene

Gene Ontology (GO) - Biological Process for FAM47C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM47C Gene

Drugs & Compounds for FAM47C Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for FAM47C Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for FAM47C Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM47C Gene

Family with sequence similarity 47, member C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM47C Gene

No ASD Table

Relevant External Links for FAM47C Gene

GeneLoc Exon Structure for
FAM47C
ECgene alternative splicing isoforms for
FAM47C

Expression for FAM47C Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM47C Gene

mRNA expression in normal human tissues for FAM47C Gene
mRNA expression by GTEx for FAM47C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM47C Gene

This gene is overexpressed in Testis (x41.4).

Protein differential expression in normal tissues from HIPED for FAM47C Gene

This gene is overexpressed in Colon muscle (37.8) and Esophagus (31.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM47C Gene



Protein tissue co-expression partners for FAM47C Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM47C Gene:

FAM47C

SOURCE GeneReport for Unigene cluster for FAM47C Gene:

Hs.535216
genes like me logo Genes that share expression patterns with FAM47C: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM47C Gene

Orthologs for FAM47C Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM47C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FAM47C 34
  • 92 (a)
 OneToOne
LOC473867 33
  • 88.01 (n)
dog
(Canis familiaris)
 Mammalia -- 34
  • 46 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Fam47c 34
  • 37 (a)
 ManyToMany
4930480E11Rik 34
  • 25 (a)
 ManyToMany
4930402K13Rik 34
  • 20 (a)
 ManyToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 34
  • 28 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 25 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 34
  • 26 (a)
 ManyToMany
-- 34
  • 22 (a)
 ManyToMany
zebrafish
(Danio rerio)
 Actinopterygii zgc:158260 34 34
  • 23 (a)
 ManyToMany
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.4199 34
  • 20 (a)
 OneToMany
Species where no ortholog for FAM47C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM47C Gene

ENSEMBL:
Gene Tree for FAM47C (if available)
TreeFam:
Gene Tree for FAM47C (if available)

Paralogs for FAM47C Gene

Paralogs for FAM47C Gene

(1) SIMAP similar genes for FAM47C Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for FAM47C Gene

genes like me logo Genes that share paralogs with FAM47C: view

Variants for FAM47C Gene

Sequence variations from dbSNP and Humsavar for FAM47C Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs112924019 -- 37,008,275(+) G/A/C upstream_transcript_variant
rs113171765 -- 37,012,123(+) G/A downstream_transcript_variant
rs113759376 -- 37,009,155(+) G/A/C coding_sequence_variant, missense_variant
rs138169403 -- 37,009,941(+) C/T coding_sequence_variant, missense_variant
rs138293293 -- 37,010,575(+) G/A/T coding_sequence_variant, missense_variant

Variation tolerance for FAM47C Gene

Residual Variation Intolerance Score: 99.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.57; 72.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM47C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM47C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM47C Gene

Disorders for FAM47C Gene

Additional Disease Information for FAM47C

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FAM47C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM47C Gene

Publications for FAM47C Gene

  1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58

Products for FAM47C Gene

Sources for FAM47C Gene

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