FAM47C Gene
protein-coding GIFtS: 35
GCID: GC0XP037026
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Family With Sequence Similarity 47, Member C
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Aliases
for FAM47C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
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| Aliases |
|---|
| Family With Sequence Similarity 47, Member C1 2 | | Putative Protein FAM47C2 |
Export aliases for FAM47C gene to outside databasesPrevious GC identifer: GC0XP036936 |
Summaries
for FAM47C gene(According to Entrez Gene,
GeneCards,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
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Entrez Gene summary for FAM47C Gene:
This gene encodes a product belonging to a family of proteins with unknown function. The coding sequence of this
family member includes several tandemly repeated regions. (provided by RefSeq, Sep 2011)
GeneCards Summary for FAM47C Gene:
FAM47C (family with sequence similarity 47, member C) is a protein-coding gene. An important paralog of this gene is FAM47A.
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Genomic Views
for FAM47C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 75),
Regulatory elements and Epigenetics data according to
QIAGEN, and/or
SwitchGear Genomics)
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TryGeneCards Plus | RefSeq DNA sequence:- NC_000023.11 NC_018934.2 NT_167197.2
Regulatory elements:
 Regulatory transcription factor binding sites in the FAM47C gene promoter:
POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 Evi-1 POU2F1 FOXO4 POU2F1b POU2F1a POU2F1c
Other transcription factors
Search Chromatin IP Primers for FAM47C
Epigenetics:
| | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM47C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp21.1 Ensembl cytogenetic band: Xp21.1 HGNC cytogenetic band: Xp21.1FAM47C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP037026: view genomic region
(about GC identifiers)
Start:
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37,026,432 bp from pter |
End:
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37,029,739 bp from pter |
Size:
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3,308 bases |
Orientation:
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plus strand |
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Proteins
for FAM47C gene
(According to
1UniProtKB,
HORDE,
2neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Antibodies by
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FA47C_HUMAN, Q5HY64 (See
protein sequence)Recommended Name: Putative protein FAM47C Size: 1035 amino acids; 115338 Da
Sequence caution: Sequence=BAC86381.1; Type=Erroneous initiation;
Secondary accessions: Q6ZU46Explore the universe of human proteins at neXtProt for FAM47C: NX_Q5HY64
Explore proteomics data for FAM47C at MOPED
Post-translational modifications:  Modification sites at neXtProt Modification sites at PhosphoSitePlus
See FAM47C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB
REFSEQ proteins: NP_001013758.1
ENSEMBL proteins: ENSP00000367913
FAM47C Human Recombinant
Protein Products:FAM47C Antibody
Products:FAM47C Assay Products: |
Domains /
Families
for FAM47C gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
TryGeneCards Plus | 1 InterPro protein domain:Graphical View of Domain Structure for InterPro Entry Q5HY64 ProtoNet protein and cluster: Q5HY64 UniProtKB/Swiss-Prot: FA47C_HUMAN, Q5HY64Similarity: Belongs to the FAM47 family
FAM47C for domains About GeneDecksing
|
Function
for FAM47C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
transcription factor targeting from QIAGEN
and/or HOMER,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
SwitchGear Genomics,
Gene Editing from DNA2.0,
Clones from OriGene,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
ESI BIO,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Animal Models:
Inhib. RNA
Products: |  | OriGene RNAi products in human, mouse, rat for FAM47C
| | | Predesigned siRNA for gene silencing in human, mouse, rat FAM47C |
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for FAM47C | |  | Browse ESI BIO Cell Lines and PureStem Progenitors for FAM47C  | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM47C |
Localization
for FAM47C gene
(According to UniProtKB, COMPARTMENTS Subcellular localization database,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Subcellular locations from COMPARTMENTS:
| Compartment | Confidence |
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| nucleus | 3 | | cytosol | 2 |
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Pathways & Interactions
for FAM47C gene
(SuperPaths according to PathCards,
Pathways according to
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
QIAGEN,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene).
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Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM47C
Interactions:
Search GeneGlobe Interaction Network for FAM47C
|
Drugs & Compounds
for FAM47C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience,
ApexBio,
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB)
About This Section
TryGeneCards Plus |  Browse compounds at ApexBio
 Browse Tocris compounds for FAM47C (FA47C)
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Transcripts
for FAM47C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
SwitchGear Genomics,
Tagged/untagged cDNA clones from
OriGene,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene, and/or
QIAGEN
)
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REFSEQ mRNAs for FAM47C gene: NM_001013736.2 Unigene Cluster for FAM47C: Family with sequence similarity 47, member C Hs.535216 [show with all ESTs]Unigene Representative Sequence: NM_0010137361 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000358047(uc004ddl.2)
Inhib. RNA
Products: | | OriGene RNAi products in human, mouse, rat for FAM47C
| |
| | Predesigned siRNA for gene silencing in human, mouse, rat FAM47C |
Primer
Products: | | Browse OriGene qPCR
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FAM47C | | | QuantiTect SYBR Green Assays in human, mouse, rat FAM47C | | | QuantiFast Probe-based Assays in human, mouse, rat FAM47C |
Additional mRNA sequence: AK125992.1 1 DOTS entry: DT.40283264 6 AceView cDNA sequences: AW016180 AK125992 AI125523 T19457 AW172301 AI867768
GeneLoc Exon Structure
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Expression
for FAM47C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MaxQB,
plus additional links to
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
QIAGEN,
Primers from
OriGene, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
TryGeneCards Plus | FAM47C expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
About this image FAM47C Protein expression data from MOPED1, PaxDb2 and
MaxQB3: About this image
SOURCE GeneReport for Unigene cluster: Hs.535216
Custom PCR Arrays for FAM47C
Primer
Products: | | Browse OriGene qPCR
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FAM47C | | | QuantiTect SYBR Green Assays in human, mouse, rat FAM47C | | | QuantiFast Probe-based Assays in human, mouse, rat FAM47C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM47C |
Orthologs
for FAM47C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
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This gene was present in the common ancestor of chordates.
Orthologs for FAM47C gene from Selected species (see all 8) About this table
Species with no ortholog for FAM47C
ENSEMBL Gene Tree for FAM47C (if available)
TreeFam Gene Tree for FAM47C (if available) |
Paralogs
for FAM47C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
TryGeneCards Plus | Paralogs for FAM47C gene
- FAM47A2 FAM47E2 FAM47B2
1 SIMAP similar gene for FAM47C using alignment to 1 protein entry: FA47C_HUMAN:FAM47A
FAM47C for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for FAM47C
PGOHUM00000246831 PGOHUM00000256836
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Genomic Variants
for FAM47C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD), the Human Cytochrome P450 Allele
Nomenclature Database, and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM47C (37026432 - 37029739 bp)
Structural Variations
Database of Genomic Variants (DGV) variations for FAM47C: --
Locus Specific Mutation Databases (LSDB): FAM47C
| | Site Specific Mutation Identification with PCR Assays |
| | SeqTarget long-range PCR primers for resequencing FAM47C |
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Disorders
/ Diseases
for FAM47C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
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TryGeneCards Plus | -- |
Publications
for FAM47C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for FAM47C gene integrated from 10 sources:
(articles sorted by number of sources associating them with FAM47C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (Nature 2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
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External Searches for FAM47C gene (in PubMed,
OMIM, and NCBI Bookshelf)
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|
Genome Databases showing FAM47C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
Other Databases showing FAM47C gene
(According to HUGE)
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Specialized Databases showing FAM47C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for FAM47C | Pharmacogenomics, SNPs, Pathways |
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| | |
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TryGeneCards Plus | Patent Information for FAM47C gene:
Search GeneIP for patents involving FAM47C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for FAM47C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or
ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
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|  | Block miRNA regulation of human, mouse, rat FAM47C using miScript Target Protectors | | SeqTarget long-range PCR primers for resequencing FAM47C | | | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM47C | | Predesigned siRNA for gene silencing in human, mouse, rat FAM47C | | | QuantiFast Probe-based Assays in human, mouse, rat FAM47C | | QuantiTect SYBR Green Assays in human, mouse, rat FAM47C | | | Custom PCR Arrays for FAM47C | | Search Chromatin IP Primers for FAM47C | | | Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FAM47C | | Search GeneGlobe Interaction Network for FAM47C | | | Regulatory tfbs in FAM47C promoter |
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 |  | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM47C |
| |  |  |  |  | | | Search ThermoFisher Antibodies for FAM47C |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM47C |
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