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Aliases for FAM47B Gene

Aliases for FAM47B Gene

  • Family With Sequence Similarity 47 Member B 2 3 5
  • Family With Sequence Similarity 47, Member B 2

External Ids for FAM47B Gene

Previous GeneCards Identifiers for FAM47B Gene

  • GC0XP034720
  • GC0XP032702

Summaries for FAM47B Gene

GeneCards Summary for FAM47B Gene

FAM47B (Family With Sequence Similarity 47 Member B) is a Protein Coding gene. An important paralog of this gene is FAM47C.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM47B Gene

Genomics for FAM47B Gene

Regulatory Elements for FAM47B Gene

Enhancers for FAM47B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG034884 0.6 ENCODE 0.2 -57.8 -57828 1.6 SMARCC1 JUN CEBPB EP300 JUND ATF3 STAT3 FOS NFE2L2 FAM47B ENSG00000273704
GH0XG034778 0.5 ENCODE 0.1 -163.6 -163617 1.9 JUND JUN FOS MAFK TMEM47 ENSG00000273704 FAM47B
GH0XG034880 0.2 ENCODE 0.2 -61.9 -61868 1.2 FAM47B ENSG00000273704
GH0XG034876 0.2 ENCODE 0.2 -65.1 -65051 1.5 FAM47B ENSG00000273704
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM47B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM47B Gene

34,942,796 bp from pter
34,944,917 bp from pter
2,122 bases
Plus strand

Genomic View for FAM47B Gene

Genes around FAM47B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM47B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM47B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM47B Gene

Proteins for FAM47B Gene

  • Protein details for FAM47B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM47B
    Protein Accession:
    Secondary Accessions:
    • Q5JQN5
    • Q6PIG3

    Protein attributes for FAM47B Gene

    645 amino acids
    Molecular mass:
    73945 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM47B Gene

Post-translational modifications for FAM47B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM47B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM47B Gene

Domains & Families for FAM47B Gene

Protein Domains for FAM47B Gene


Suggested Antigen Peptide Sequences for FAM47B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM47 family.
  • Belongs to the FAM47 family.
genes like me logo Genes that share domains with FAM47B: view

No data available for Gene Families for FAM47B Gene

Function for FAM47B Gene

genes like me logo Genes that share phenotypes with FAM47B: view

Animal Model Products

CRISPR Products

miRNA for FAM47B Gene

miRTarBase miRNAs that target FAM47B

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM47B Gene

Localization for FAM47B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM47B gene
Compartment Confidence
nucleus 3
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM47B Gene

Pathways & Interactions for FAM47B Gene

SuperPathways for FAM47B Gene

No Data Available

Interacting Proteins for FAM47B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000328307 Q8NA70-FA47B_HUMAN for FAM47B Gene via STRING IID

Gene Ontology (GO) - Biological Process for FAM47B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM47B Gene

Drugs & Compounds for FAM47B Gene

No Compound Related Data Available

Transcripts for FAM47B Gene

mRNA/cDNA for FAM47B Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM47B Gene

Family with sequence similarity 47, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM47B Gene

No ASD Table

Relevant External Links for FAM47B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM47B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM47B Gene

mRNA differential expression in normal tissues according to GTEx for FAM47B Gene

This gene is overexpressed in Testis (x52.6).

NURSA nuclear receptor signaling pathways regulating expression of FAM47B Gene:


SOURCE GeneReport for Unigene cluster for FAM47B Gene:

genes like me logo Genes that share expression patterns with FAM47B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM47B Gene

Orthologs for FAM47B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM47B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM47B 35
  • 95 (a)
LOC473866 34
  • 84.92 (n)
(Canis familiaris)
Mammalia -- 35
  • 45 (a)
(Mus musculus)
Mammalia Fam47c 35
  • 37 (a)
4930480E11Rik 35
  • 25 (a)
4930402K13Rik 35
  • 21 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 27 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 26 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 24 (a)
-- 35
  • 21 (a)
(Danio rerio)
Actinopterygii zgc:158260 35 35
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4199 35
  • 20 (a)
Species where no ortholog for FAM47B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM47B Gene

Gene Tree for FAM47B (if available)
Gene Tree for FAM47B (if available)

Paralogs for FAM47B Gene

Paralogs for FAM47B Gene

(1) SIMAP similar genes for FAM47B Gene using alignment to 1 proteins: Pseudogenes for FAM47B Gene

genes like me logo Genes that share paralogs with FAM47B: view

Variants for FAM47B Gene

Sequence variations from dbSNP and Humsavar for FAM47B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1001444390 -- 34,942,036(+) TTATT(A/G)TAAAG upstream-variant-2KB
rs1001474972 -- 34,941,304(+) CTCAA(C/T)ATTTA upstream-variant-2KB
rs1002557863 -- 34,942,990(+) ACGGA(A/G)GGCAT reference, synonymous-codon
rs1003154042 -- 34,943,415(+) GACTC(C/T)GGTGT reference, missense
rs1004735324 -- 34,941,197(+) AGATG(A/G)CATTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM47B Gene

Variant ID Type Subtype PubMed ID
esv2664433 CNV deletion 23128226
esv3573850 CNV loss 25503493
nsv519107 CNV gain 19592680
nsv527976 CNV gain 19592680

Variation tolerance for FAM47B Gene

Residual Variation Intolerance Score: 96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.27; 40.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM47B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM47B Gene

Disorders for FAM47B Gene

Relevant External Links for FAM47B

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM47B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM47B Gene

Publications for FAM47B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 64
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  5. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PMID: 17903301) Vasan R.S. … Benjamin E.J. (BMC Med. Genet. 2007) 46 64

Products for FAM47B Gene

Sources for FAM47B Gene

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