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Aliases for FAM46D Gene

Aliases for FAM46D Gene

  • Family With Sequence Similarity 46 Member D 2 3 5
  • Cancer/Testis Antigen 112 2 3
  • Family With Sequence Similarity 46, Member D 2
  • CT1.26 3
  • CT112 3

External Ids for FAM46D Gene

Previous GeneCards Identifiers for FAM46D Gene

  • GC0XP079397
  • GC0XP079562
  • GC0XP079675
  • GC0XP073172

Summaries for FAM46D Gene

Entrez Gene Summary for FAM46D Gene

  • Antibodies against the protein encoded by this gene were found only in plasma from cancer patients. While it may be a target for immunotherapy, the function of this gene is unknown. [provided by RefSeq, Dec 2009]

GeneCards Summary for FAM46D Gene

FAM46D (Family With Sequence Similarity 46 Member D) is a Protein Coding gene. An important paralog of this gene is FAM46A.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM46D Gene

Genomics for FAM46D Gene

Regulatory Elements for FAM46D Gene

Enhancers for FAM46D Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM46D on UCSC Golden Path with GeneCards custom track

Promoters for FAM46D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM46D on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM46D Gene

Chromosome:
X
Start:
80,335,504 bp from pter
End:
80,446,885 bp from pter
Size:
111,382 bases
Orientation:
Plus strand

Genomic View for FAM46D Gene

Genes around FAM46D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM46D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM46D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM46D Gene

Proteins for FAM46D Gene

  • Protein details for FAM46D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEK8-FA46D_HUMAN
    Recommended name:
    Protein FAM46D
    Protein Accession:
    Q8NEK8
    Secondary Accessions:
    • B2R9Q6
    • Q7Z3F6
    • Q8NHU1

    Protein attributes for FAM46D Gene

    Size:
    389 amino acids
    Molecular mass:
    44500 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM46D Gene

Proteomics data for FAM46D Gene at MOPED

Post-translational modifications for FAM46D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM46D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM46D Gene

Domains & Families for FAM46D Gene

Protein Domains for FAM46D Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM46D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NEK8

UniProtKB/Swiss-Prot:

FA46D_HUMAN :
  • Belongs to the FAM46 family.
Family:
  • Belongs to the FAM46 family.
genes like me logo Genes that share domains with FAM46D: view

No data available for Gene Families for FAM46D Gene

Function for FAM46D Gene

Phenotypes for FAM46D Gene

genes like me logo Genes that share phenotypes with FAM46D: view

Animal Model Products

miRNA for FAM46D Gene

miRTarBase miRNAs that target FAM46D

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM46D Gene

Localization for FAM46D Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM46D Gene COMPARTMENTS Subcellular localization image for FAM46D gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM46D Gene

Pathways & Interactions for FAM46D Gene

SuperPathways for FAM46D Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM46D Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM46D Gene

Drugs & Compounds for FAM46D Gene

No Compound Related Data Available

Transcripts for FAM46D Gene

mRNA/cDNA for FAM46D Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM46D Gene

Family with sequence similarity 46, member D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM46D Gene

No ASD Table

Relevant External Links for FAM46D Gene

GeneLoc Exon Structure for
FAM46D
ECgene alternative splicing isoforms for
FAM46D

Expression for FAM46D Gene

mRNA expression in normal human tissues for FAM46D Gene

mRNA differential expression in normal tissues according to GTEx for FAM46D Gene

This gene is overexpressed in Testis (x47.6).

SOURCE GeneReport for Unigene cluster for FAM46D Gene Hs.367959

genes like me logo Genes that share expression patterns with FAM46D: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FAM46D Gene

Orthologs for FAM46D Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM46D Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM46D 35
  • 86.68 (n)
  • 80.93 (a)
FAM46D 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM46D 35
  • 87.54 (n)
  • 82.47 (a)
FAM46D 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam46d 35
  • 82.47 (n)
  • 77.32 (a)
Fam46d 16
Fam46d 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM46D 35
  • 98.8 (n)
  • 97.69 (a)
FAM46D 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam46d 35
  • 83.16 (n)
  • 77.84 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM46D 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM46D 35
  • 70.67 (n)
  • 69.19 (a)
FAM46D 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM46D 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam46d 35
  • 69.02 (n)
  • 69.71 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100149701 35
  • 64.74 (n)
  • 66.4 (a)
FAM46D 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG30497 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pqn-44 36
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for FAM46D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM46D Gene

ENSEMBL:
Gene Tree for FAM46D (if available)
TreeFam:
Gene Tree for FAM46D (if available)

Paralogs for FAM46D Gene

Paralogs for FAM46D Gene

(4) SIMAP similar genes for FAM46D Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM46D: view

Variants for FAM46D Gene

Sequence variations from dbSNP and Humsavar for FAM46D Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1113265 - 80,443,094(+) TTAGA(C/G)TTCTA reference, missense
rs747692172 -- 80,354,289(+) GATAC(G/T)TTTTC intron-variant
rs747727898 -- 80,351,095(+) TCAAC(A/C)TTGGA intron-variant
rs747746030 -- 80,439,055(+) AAAAT(A/G)TTAGC intron-variant
rs747765287 -- 80,418,994(+) ACTCT(G/T)TTCAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM46D Gene

Variant ID Type Subtype PubMed ID
nsv6972 CNV Insertion 18451855
esv1341044 CNV Insertion 17803354

Variation tolerance for FAM46D Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.17% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FAM46D Gene

Disorders for FAM46D Gene

Relevant External Links for FAM46D

Genetic Association Database (GAD)
FAM46D
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM46D

No disorders were found for FAM46D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM46D Gene

Publications for FAM46D Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. (PMID: 19377476) Tarpey P.S. … Stratton M.R. (Nat. Genet. 2009) 3
  5. Identification of FAM46D as a novel cancer/testis antigen using EST data and serological analysis. (PMID: 19540335) Bettoni F. … Camargo A.A. (Genomics 2009) 3

Products for FAM46D Gene

Sources for FAM46D Gene

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