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Aliases for FAM46D Gene

Aliases for FAM46D Gene

  • Family With Sequence Similarity 46, Member D 2 3
  • Cancer/Testis Antigen 112 2 3
  • Protein FAM46D 3
  • CT1.26 3
  • CT112 3

External Ids for FAM46D Gene

Previous GeneCards Identifiers for FAM46D Gene

  • GC0XP079397
  • GC0XP079562
  • GC0XP079675
  • GC0XP073172

Summaries for FAM46D Gene

Entrez Gene Summary for FAM46D Gene

  • Antibodies against the protein encoded by this gene were found only in plasma from cancer patients. While it may be a target for immunotherapy, the function of this gene is unknown. [provided by RefSeq, Dec 2009]

GeneCards Summary for FAM46D Gene

FAM46D (Family With Sequence Similarity 46, Member D) is a Protein Coding gene. Diseases associated with FAM46D include recurrent corneal erosion. An important paralog of this gene is FAM46A.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM46D Gene

Genomics for FAM46D Gene

Regulatory Elements for FAM46D Gene

Genomic Location for FAM46D Gene

80,335,504 bp from pter
80,445,311 bp from pter
109,808 bases
Plus strand

Genomic View for FAM46D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM46D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM46D Gene

Proteins for FAM46D Gene

  • Protein details for FAM46D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM46D
    Protein Accession:
    Secondary Accessions:
    • B2R9Q6
    • Q7Z3F6
    • Q8NHU1

    Protein attributes for FAM46D Gene

    389 amino acids
    Molecular mass:
    44500 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM46D Gene

Proteomics data for FAM46D Gene at MOPED

Post-translational modifications for FAM46D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM46D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM46D Gene

Domains for FAM46D Gene

Protein Domains for FAM46D Gene


Suggested Antigen Peptide Sequences for FAM46D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM46 family.
  • Belongs to the FAM46 family.
genes like me logo Genes that share domains with FAM46D: view

No data available for Gene Families for FAM46D Gene

Function for FAM46D Gene

Gene Ontology (GO) - Molecular Function for FAM46D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM46D: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FAM46D Gene

Localization for FAM46D Gene

Subcellular locations from

Jensen Localization Image for FAM46D Gene COMPARTMENTS Subcellular localization image for FAM46D gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM46D Gene

Pathways for FAM46D Gene

SuperPathways for FAM46D Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM46D Gene


No data available for Pathways by source for FAM46D Gene

Transcripts for FAM46D Gene

mRNA/cDNA for FAM46D Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM46D Gene

Family with sequence similarity 46, member D:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM46D

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM46D Gene

No ASD Table

Relevant External Links for FAM46D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM46D Gene

mRNA expression in normal human tissues for FAM46D Gene

mRNA differential expression in normal tissues according to GTEx for FAM46D Gene

This gene is overexpressed in Testis (47.6).

SOURCE GeneReport for Unigene cluster for FAM46D Gene Hs.367959

genes like me logo Genes that share expressions with FAM46D: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for FAM46D Gene

Orthologs for FAM46D Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM46D Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM46D 35
  • 86.68 (n)
  • 80.93 (a)
FAM46D 36
  • 81 (a)
(Canis familiaris)
Mammalia FAM46D 35
  • 87.54 (n)
  • 82.47 (a)
FAM46D 36
  • 82 (a)
(Mus musculus)
Mammalia Fam46d 35
  • 82.47 (n)
  • 77.32 (a)
Fam46d 16
Fam46d 36
  • 77 (a)
(Pan troglodytes)
Mammalia FAM46D 35
  • 98.8 (n)
  • 97.69 (a)
FAM46D 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Fam46d 35
  • 83.16 (n)
  • 77.84 (a)
(Monodelphis domestica)
Mammalia FAM46D 36
  • 65 (a)
(Gallus gallus)
Aves FAM46D 35
  • 70.67 (n)
  • 69.19 (a)
FAM46D 36
  • 67 (a)
(Anolis carolinensis)
Reptilia FAM46D 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam46d 35
  • 69.02 (n)
  • 69.71 (a)
(Danio rerio)
Actinopterygii LOC100149701 35
  • 64.74 (n)
  • 66.4 (a)
FAM46D 36
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30497 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea pqn-44 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
Species with no ortholog for FAM46D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM46D Gene

Gene Tree for FAM46D (if available)
Gene Tree for FAM46D (if available)

Paralogs for FAM46D Gene

Paralogs for FAM46D Gene

(4) SIMAP similar genes for FAM46D Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM46D: view

Variants for FAM46D Gene

Sequence variations from dbSNP and Humsavar for FAM46D Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs966011 -- 80,435,531(-) AGTAC(A/T)TTACA intron-variant
rs966012 -- 80,435,425(-) AAAAC(G/T)GTTTT intron-variant
rs1113265 - 80,443,094(+) TTAGA(C/G)TTCTA reference, missense
rs1494481 -- 80,417,398(-) agatg(A/T)ctgat intron-variant
rs1494482 -- 80,403,208(-) GAGTG(C/T)ATTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM46D Gene

Variant ID Type Subtype PubMed ID
nsv6972 CNV Insertion 18451855
esv1341044 CNV Insertion 17803354

Relevant External Links for FAM46D Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM46D Gene

Disorders for FAM46D Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for FAM46D Gene in MalaCards »

(1) Disease for FAM46D Gene

(2) University of Copenhagen DISEASES for FAM46D Gene

Relevant External Links for FAM46D

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with FAM46D: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for FAM46D Gene

Publications for FAM46D Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  5. A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. (PMID: 19377476) Tarpey P.S. … Stratton M.R. (Nat. Genet. 2009) 3

Products for FAM46D Gene

Sources for FAM46D Gene

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