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Aliases for FAM46D Gene

Aliases for FAM46D Gene

  • Family With Sequence Similarity 46 Member D 2 3 5
  • Cancer/Testis Antigen 112 2 3
  • Family With Sequence Similarity 46, Member D 2
  • Putative Nucleotidyltransferase FAM46D 3
  • Protein FAM46D 3
  • EC 2.7.7.- 4
  • CT1.26 3
  • CT112 3

External Ids for FAM46D Gene

Previous GeneCards Identifiers for FAM46D Gene

  • GC0XP079397
  • GC0XP079562
  • GC0XP079675
  • GC0XP073172

Summaries for FAM46D Gene

Entrez Gene Summary for FAM46D Gene

  • Antibodies against the protein encoded by this gene were found only in plasma from cancer patients. While it may be a target for immunotherapy, the function of this gene is unknown. [provided by RefSeq, Dec 2009]

GeneCards Summary for FAM46D Gene

FAM46D (Family With Sequence Similarity 46 Member D) is a Protein Coding gene. An important paralog of this gene is FAM46A.

UniProtKB/Swiss-Prot for FAM46D Gene

  • Probable nucleotidyltransferase that may act as a non-canonical poly(A) RNA polymerase.

Additional gene information for FAM46D Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM46D Gene

Genomics for FAM46D Gene

GeneHancer (GH) Regulatory Elements for FAM46D Gene

Promoters and enhancers for FAM46D Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI080334 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 550.8 -0.2 -203 1 CTCF POLR2A NRF1 ZBTB33 YY1 CHAMP1 FAM46D CHMP1B2P PIR60465
GH0XI080420 Promoter 0.7 EPDnew 550.2 +85.0 84958 0.1 ATF4 RFX1 FAM46D PIR61302 GC0XP080337
GH0XI080423 Enhancer 0.8 ENCODE 0.2 +88.3 88293 0.2 HDAC1 ARNT NCOA2 CHAMP1 TCF12 GATA2 PHF21A ZBTB2 CEBPB ZEB2 PIR61302 FAM46D GC0XP080337
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM46D on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM46D gene promoter:

Genomic Locations for FAM46D Gene

Genomic Locations for FAM46D Gene
111,382 bases
Plus strand

Genomic View for FAM46D Gene

Genes around FAM46D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM46D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM46D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM46D Gene

Proteins for FAM46D Gene

  • Protein details for FAM46D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative nucleotidyltransferase FAM46D
    Protein Accession:
    Secondary Accessions:
    • B2R9Q6
    • Q7Z3F6
    • Q8NHU1

    Protein attributes for FAM46D Gene

    389 amino acids
    Molecular mass:
    44500 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM46D Gene

Post-translational modifications for FAM46D Gene

No Post-translational modifications

Other Protein References for FAM46D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM46D Gene

Domains & Families for FAM46D Gene

Gene Families for FAM46D Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM46D Gene

Suggested Antigen Peptide Sequences for FAM46D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM46 family.
  • Belongs to the FAM46 family.
genes like me logo Genes that share domains with FAM46D: view

Function for FAM46D Gene

Molecular function for FAM46D Gene

UniProtKB/Swiss-Prot Function:
Probable nucleotidyltransferase that may act as a non-canonical poly(A) RNA polymerase.

Enzyme Numbers (IUBMB) for FAM46D Gene

Gene Ontology (GO) - Molecular Function for FAM46D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016740 transferase activity IEA --
GO:0016779 nucleotidyltransferase activity IEA --
genes like me logo Genes that share ontologies with FAM46D: view
genes like me logo Genes that share phenotypes with FAM46D: view

Animal Model Products

miRNA for FAM46D Gene

miRTarBase miRNAs that target FAM46D

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM46D Gene

Localization for FAM46D Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM46D gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
cytoskeleton 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM46D Gene

Pathways & Interactions for FAM46D Gene

SuperPathways for FAM46D Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM46D Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM46D Gene

Drugs & Compounds for FAM46D Gene

No Compound Related Data Available

Transcripts for FAM46D Gene

mRNA/cDNA for FAM46D Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM46D Gene

Family with sequence similarity 46, member D:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM46D Gene

No ASD Table

Relevant External Links for FAM46D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM46D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM46D Gene

mRNA differential expression in normal tissues according to GTEx for FAM46D Gene

This gene is overexpressed in Testis (x47.6).

NURSA nuclear receptor signaling pathways regulating expression of FAM46D Gene:


SOURCE GeneReport for Unigene cluster for FAM46D Gene:


mRNA Expression by UniProt/SwissProt for FAM46D Gene:

Tissue specificity: restricted to testis.

Evidence on tissue expression from TISSUES for FAM46D Gene

  • Eye(2.1)
genes like me logo Genes that share expression patterns with FAM46D: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM46D Gene

Orthologs for FAM46D Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM46D Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM46D 33 34
  • 98.8 (n)
(Canis familiaris)
Mammalia FAM46D 33 34
  • 87.54 (n)
(Bos Taurus)
Mammalia FAM46D 33 34
  • 86.68 (n)
(Rattus norvegicus)
Mammalia Fam46d 33
  • 83.16 (n)
(Mus musculus)
Mammalia Fam46d 33 16 34
  • 82.47 (n)
(Monodelphis domestica)
Mammalia FAM46D 34
  • 65 (a)
(Gallus gallus)
Aves FAM46D 33 34
  • 70.67 (n)
(Anolis carolinensis)
Reptilia FAM46D 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam46d 33
  • 69.02 (n)
(Danio rerio)
Actinopterygii LOC100149701 33
  • 64.74 (n)
FAM46D 34
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30497 34
  • 23 (a)
(Caenorhabditis elegans)
Secernentea pqn-44 34
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 45 (a)
Species where no ortholog for FAM46D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM46D Gene

Gene Tree for FAM46D (if available)
Gene Tree for FAM46D (if available)

Paralogs for FAM46D Gene

Paralogs for FAM46D Gene

(4) SIMAP similar genes for FAM46D Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM46D: view

Variants for FAM46D Gene

Sequence variations from dbSNP and Humsavar for FAM46D Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000074159 -- 80,404,872(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000086672 -- 80,395,774(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000109106 -- 80,345,542(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000150752 -- 80,369,150(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000228614 -- 80,340,529(+) C/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM46D Gene

Variant ID Type Subtype PubMed ID
esv1341044 CNV insertion 17803354
nsv1115875 CNV duplication 24896259
nsv6972 CNV insertion 18451855

Variation tolerance for FAM46D Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM46D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM46D Gene

Disorders for FAM46D Gene

Additional Disease Information for FAM46D

No disorders were found for FAM46D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM46D Gene

Publications for FAM46D Gene

  1. Identification of FAM46D as a novel cancer/testis antigen using EST data and serological analysis. (PMID: 19540335) Bettoni F … Camargo AA (Genomics 2009) 3 4 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. FAM46 proteins are novel eukaryotic non-canonical poly(A) polymerases. (PMID: 27060136) Kuchta K … Ginalski K (Nucleic acids research 2016) 4 58

Products for FAM46D Gene

Sources for FAM46D Gene

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