FAM46C Gene
protein-coding GIFtS : 46
GCID: GC01 P118148
family with sequence similarity 46, member C
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Aliasesfor FAM46C gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Family With Sequence Similarity 46, Member C 1 2 FLJ202021 Protein FAM46C2
Export aliases for FAM46C gene to outside databases Previous GC identifers: GC01P117860 GC01P117950 GC01P116005
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Summariesfor FAM46C gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: FA46C_HUMAN, Q5VWP2 Function : Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon
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Genomic Viewsfor FAM46C gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_032977.9 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FAM46C gene promoter: USF1 AML1a Nkx2-5 E4BP4 Nkx5-1 Tal-1beta Evi-1 E47 USF-1 TGIF Other transcription factors Search SABiosciences Chromatin IP Primers for FAM46C Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat FAM46C
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1p12 Ensembl cytogenetic band: 1p12 HGNC cytogenetic band: 1p12 FAM46C Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P118148: view genomic region
(about GC identifiers )
Start:
118,148,556 bp from pter
End:
118,171,011 bp from pter
Size:
22,456 bases
Orientation:
plus strand
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Proteinsfor FAM46C gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: FA46C_HUMAN, Q5VWP2 (See
protein sequence )Recommended Name: Protein FAM46C Size : 391 amino acids; 44944 Da
Secondary accessions : A3KMG2 Q8NE25 Q9NXK0Explore the universe of human proteins at neXtProt for FAM46C: NX_Q5VWP2 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q5VWP2 FAM46C Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_060179.2 ENSEMBL proteins: ENSP00000358458 Human Recombinant Protein Products: FAM46C Antibody Products: Assay Products for FAM46C:
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Protein
Domains / Familiesfor FAM46C gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
FAM46C for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q5VWP2 ProtoNet protein and cluster: Q5VWP2
1 Blocks protein family : IPB012937 Protein of unknown function DUF1693 UniProtKB/Swiss-Prot: FA46C_HUMAN, Q5VWP2 Similarity : Belongs to the FAM46 family
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Functionfor FAM46C gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: FA46C_HUMAN, Q5VWP2 Function : Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferonInduction : By type I interferons
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM46C (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM46COriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: FAM46C (NM_017709 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM46C Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM46C
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM46C
3 GenomeRNAi human phenotypes for FAM46C :
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Pathways & Interactionsfor FAM46C gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM46C STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)5/11 Interacting proteins for FAM46C (Q5VWP2 2 , 3 ENSP00000358458 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 11 )About this table
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Drugs & Compoundsfor FAM46C gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for FAM46C Search CenterWatch for drugs/clinical trials and news about FAM46C / FA46C
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Transcriptsfor FAM46C gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for FAM46C gene: NM_017709.3 Unigene Cluster for FAM46C:
Family with sequence similarity 46, member C Hs.356216 [show with all ESTs ] Unigene Representative Sequence: NM_017709 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000369448 (uc001ehe.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM46C (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM46COriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: FAM46C (NM_017709 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM46C Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM46C
Additional cDNA sequence: AK000209.1 AK091327.1 BC036516.2 BC131726.1
7 DOTS entries : DT.100749760 DT.114680
DT.121463791 DT.100738160 DT.121463775 DT.121463738 DT.121463826 24/108 AceView cDNA sequences (see all 108 ):
H63792 AI207563 AK091327 AW407254 AA342944 AW514641 N76797 AW503624 AL046016 AL046017 AA620782 BM727587 AI214292 BM729327 AI634701 AI828223 AA933047 NM_017709 AI624555 BM972348 AI114522 BM973277 BI460186 AW440742 GeneLoc Exon Structure
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Expression for FAM46C gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section FAM46C expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TCTGCAGCCT
About this image FAM46C expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See FAM46C Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for FAM46C SOURCE GeneReport for Unigene cluster: Hs.356216 SABiosciences Custom PCR Arrays for FAM46C Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FAM46CBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat FAM46C QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FAM46C QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FAM46C In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM46C
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Orthologsfor FAM46C gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for FAM46C gene from 4/19 species (see all 19 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
FAM46C1
family with sequence similarity 46, member C
78.8(n) 89.49(a)
 
426544 NM_001007972.1 NP_001007973.1
zebrafish (Danio rerio)
Actinopterygii
zgc661972
hypothetical protein MGC66197
73.9(n)
 
393479 BC048046.1
fruit fly (Drosophila melanogaster)
Insecta
CG304971
CG30497
62.91(n) 63.5(a)
 
246653 NM_136477.3 NP_610321.2
worm (Caenorhabditis elegans)
Secernentea
pqn-441
Protein PQN-44
52.3(n) 48.28(a)
 
172187 NM_059179.1 NP_491580.1
ENSEMBL Gene Tree for FAM46C (if available)TreeFam Gene Tree for FAM46C (if available)
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Paralogsfor FAM46C gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for FAM46C gene FAM46B 2 FAM46D 2 FAM46A 2 4 SIMAP similar genes for FAM46C using alignment to 1 protein entry: FA46C_HUMAN :FAM46A XTP11 FAM46D FAM46B
FAM46C for paralogs About GeneDecksing
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Genomic Variantsfor FAM46C gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for FAM46C (118148556 - 118171011 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for FAM46C 1 CNV : 58328
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FAM46C
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Disorders
/ Diseasesfor FAM46C gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
FAM46C for disorders About GeneDecksing
OMIM gene information: 613952
OMIM disorders : --4 diseases for FAM46C : About MalaCards venezuelan equine encephalitis yellow fever chikungunya encephalitis Export disorders for FAM46C gene to outside databases
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Publicationsfor FAM46C gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for FAM46C gene integrated from 9 sources : (articles sorted by number of sources associating them with FAM46C) Utopia : connect your pdf to the dynamic world of online information
A diverse range of gene products are effectors of the type I interferon antiviral response. (PubMed id 21478870) 1 , 2 Schoggins J.W.... Rice C.M. (2011) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 1 , 2 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) Mapping of chromosome 1p deletions in myeloma identifi es FAM46C at 1p12 and CDKN2C at 1p32.3 as being genes in regions associated with adverse survival. (PubMed id 21994415) 1 Boyd K.D....Morgan G.J. (2011) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201) 1 Abdelmohsen K....Gorospe M. (2009) Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514) 1 Rual J.F....Vidal M. (2005)
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External Searches for FAM46C gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing FAM46C gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing FAM46C gene
(According to HUGE )
About This Section --
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Specialized Databases showing FAM46C gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for FAM46C Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for FAM46C gene: Search GeneIP for patents involving FAM46C GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor FAM46C gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for FAM46C OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for FAM46C OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FAM46C OriGene Protein Over-expression Lysate for FAM46C Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for FAM46C OriGene 3'-UTR Clone for FAM46C OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM46C OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM46C Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for FAM46C OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for FAM46C OriGene Custom Protein Services for FAM46C OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM46C QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FAM46C QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat FAM46C QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat FAM46C QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FAM46C QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FAM46C
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FAM46C Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM46C
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM46C
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