Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM46C Gene

Aliases for FAM46C Gene

  • Family With Sequence Similarity 46 Member C 2 3 5
  • Family With Sequence Similarity 46, Member C 2
  • EC 2.7.7.- 4

External Ids for FAM46C Gene

Previous GeneCards Identifiers for FAM46C Gene

  • GC01P117860
  • GC01P117950
  • GC01P118148
  • GC01P116005

Summaries for FAM46C Gene

GeneCards Summary for FAM46C Gene

FAM46C (Family With Sequence Similarity 46 Member C) is a Protein Coding gene. An important paralog of this gene is FAM46A.

UniProtKB/Swiss-Prot for FAM46C Gene

  • Probable nucleotidyltransferase that may act as a non-canonical poly(A) RNA polymerase.

  • (Microbial infection) Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon.

Additional gene information for FAM46C Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM46C Gene

Genomics for FAM46C Gene

GeneHancer (GH) Regulatory Elements for FAM46C Gene

Promoters and enhancers for FAM46C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I117604 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 557.6 +1.1 1051 4.4 PKNOX1 CLOCK SIN3A ZNF2 YY1 POLR2B ZNF213 FOS KLF13 SP3 LOC100996263 FAM46C PIR50715 GDAP2 ENSG00000271427 ENSG00000212266 WDR3
GH01I117662 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 19.4 +58.7 58663 4.1 PKNOX1 ATF1 SMAD1 IRF4 ZNF766 ATF7 RUNX3 JUNB ZNF592 ATF4 FAM46C ENSG00000212266 LOC100996263 MAN1A2 GC01P117648 GC01M117689
GH01I117635 Enhancer 0.8 dbSUPER 18.1 +31.5 31531 3.9 HDAC1 HDGF RAD21 TCF12 GATA2 RUNX3 CEBPB ZEB2 SMARCA4 IKZF1 FAM46C LOC100996263 ENSG00000212266 VDAC2P3 PIR50715
GH01I117651 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 8.3 +48.7 48665 6 HDGF PKNOX1 ARNT SIN3A IRF4 ZNF766 FOS JUNB ZNF592 SREBF1 WDR3 FAM46C MAN1A2 GDAP2 GC01P117648 ENSG00000212266 GC01M117689
GH01I117646 Enhancer 0.8 ENCODE dbSUPER 16.5 +40.6 40615 0.9 RFX1 CAVIN1 HLF CEBPG ZNF316 NFIC ATF4 HDAC2 MGA FAM46C ENSG00000212266 LOC100996263 GC01P117648 VDAC2P3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM46C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM46C gene promoter:

Genomic Locations for FAM46C Gene

Genomic Locations for FAM46C Gene
22,456 bases
Plus strand

Genomic View for FAM46C Gene

Genes around FAM46C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM46C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM46C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM46C Gene

Proteins for FAM46C Gene

  • Protein details for FAM46C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative nucleotidyltransferase FAM46C
    Protein Accession:
    Secondary Accessions:
    • A3KMG2
    • Q8NE25
    • Q9NXK0

    Protein attributes for FAM46C Gene

    391 amino acids
    Molecular mass:
    44944 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM46C Gene

Post-translational modifications for FAM46C Gene

  • Ubiquitination at posLast=6565, Lys234, posLast=246246, and Lys264

Other Protein References for FAM46C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM46C Gene

Domains & Families for FAM46C Gene

Gene Families for FAM46C Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for FAM46C Gene

Suggested Antigen Peptide Sequences for FAM46C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM46 family.
  • Belongs to the FAM46 family.
genes like me logo Genes that share domains with FAM46C: view

Function for FAM46C Gene

Molecular function for FAM46C Gene

UniProtKB/Swiss-Prot Function:
Probable nucleotidyltransferase that may act as a non-canonical poly(A) RNA polymerase.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon.
UniProtKB/Swiss-Prot Induction:
By type I interferons.

Enzyme Numbers (IUBMB) for FAM46C Gene

Phenotypes From GWAS Catalog for FAM46C Gene

Gene Ontology (GO) - Molecular Function for FAM46C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016740 transferase activity IEA --
GO:0016779 nucleotidyltransferase activity IEA --
genes like me logo Genes that share ontologies with FAM46C: view
genes like me logo Genes that share phenotypes with FAM46C: view

Animal Models for FAM46C Gene

MGI Knock Outs for FAM46C:

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM46C Gene

Localization for FAM46C Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM46C gene
Compartment Confidence
cytoskeleton 2
nucleus 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM46C Gene

Pathways & Interactions for FAM46C Gene

SuperPathways for FAM46C Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM46C Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM46C Gene

Drugs & Compounds for FAM46C Gene

No Compound Related Data Available

Transcripts for FAM46C Gene

mRNA/cDNA for FAM46C Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(108) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM46C Gene

Family with sequence similarity 46, member C:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM46C Gene

No ASD Table

Relevant External Links for FAM46C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM46C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM46C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM46C Gene

This gene is overexpressed in Testis (x7.6), Whole Blood (x7.6), and Pancreas (x6.2).

Protein differential expression in normal tissues from HIPED for FAM46C Gene

This gene is overexpressed in Frontal cortex (25.0), Monocytes (20.9), and Liver (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM46C Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM46C Gene:


SOURCE GeneReport for Unigene cluster for FAM46C Gene:


Evidence on tissue expression from TISSUES for FAM46C Gene

  • Intestine(4.2)
genes like me logo Genes that share expression patterns with FAM46C: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM46C Gene

Orthologs for FAM46C Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM46C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM46C 33 34
  • 98.89 (n)
(Monodelphis domestica)
Mammalia FAM46C 34
  • 93 (a)
(Rattus norvegicus)
Mammalia Fam46c 33
  • 90.28 (n)
(Mus musculus)
Mammalia Fam46c 33 16 34
  • 89.94 (n)
(Canis familiaris)
Mammalia FAM46C 33 34
  • 88.83 (n)
(Bos Taurus)
Mammalia FAM46C 33 34
  • 85.39 (n)
(Ornithorhynchus anatinus)
Mammalia FAM46C 34
  • 65 (a)
(Gallus gallus)
Aves FAM46C 33 34
  • 78.8 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam46c 33
  • 77.58 (n)
(Danio rerio)
Actinopterygii fam46c 33 34
  • 71.85 (n)
zgc66197 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005088 33
  • 64.32 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG30497 33 34
  • 62.91 (n)
(Caenorhabditis elegans)
Secernentea pqn-44 33 34
  • 52.3 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
Species where no ortholog for FAM46C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM46C Gene

Gene Tree for FAM46C (if available)
Gene Tree for FAM46C (if available)

Paralogs for FAM46C Gene

Paralogs for FAM46C Gene

(4) SIMAP similar genes for FAM46C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM46C: view

Variants for FAM46C Gene

Sequence variations from dbSNP and Humsavar for FAM46C Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs145471785 not-provided, not specified 117,623,763(+) G/A coding_sequence_variant, missense_variant
rs149654076 not-provided, not specified 117,623,757(+) G/A/C coding_sequence_variant, missense_variant
rs1630312 not-provided, not specified 117,623,069(+) C/G/T coding_sequence_variant, missense_variant, synonymous_variant
rs34495780 not-provided, not specified 117,622,914(+) G/A coding_sequence_variant, missense_variant
rs587778306 not-provided, not specified 117,623,641(+) C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM46C Gene

Variant ID Type Subtype PubMed ID
nsv1007736 CNV gain 25217958
nsv819506 CNV gain 19587683
nsv831170 CNV gain 17160897

Variation tolerance for FAM46C Gene

Residual Variation Intolerance Score: 45.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.39; 27.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM46C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM46C Gene

Disorders for FAM46C Gene

Additional Disease Information for FAM46C

No disorders were found for FAM46C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM46C Gene

Publications for FAM46C Gene

  1. A diverse range of gene products are effectors of the type I interferon antiviral response. (PMID: 21478870) Schoggins JW … Rice CM (Nature 2011) 3 4 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58

Products for FAM46C Gene

Sources for FAM46C Gene

Loading form....