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Aliases for FAM46C Gene

Aliases for FAM46C Gene

  • Family With Sequence Similarity 46, Member C 2 3

External Ids for FAM46C Gene

Previous GeneCards Identifiers for FAM46C Gene

  • GC01P117860
  • GC01P117950
  • GC01P118148
  • GC01P116005

Summaries for FAM46C Gene

GeneCards Summary for FAM46C Gene

FAM46C (Family With Sequence Similarity 46, Member C) is a Protein Coding gene. Diseases associated with FAM46C include chromosome 1p deletion and yellow fever. An important paralog of this gene is FAM46A.

UniProtKB/Swiss-Prot for FAM46C Gene

  • Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM46C Gene

Genomics for FAM46C Gene

Regulatory Elements for FAM46C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM46C Gene

Start:
117,605,934 bp from pter
End:
117,628,389 bp from pter
Size:
22,456 bases
Orientation:
Plus strand

Genomic View for FAM46C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM46C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM46C Gene

Proteins for FAM46C Gene

  • Protein details for FAM46C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VWP2-FA46C_HUMAN
    Recommended name:
    Protein FAM46C
    Protein Accession:
    Q5VWP2
    Secondary Accessions:
    • A3KMG2
    • Q8NE25
    • Q9NXK0

    Protein attributes for FAM46C Gene

    Size:
    391 amino acids
    Molecular mass:
    44944 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM46C Gene

Proteomics data for FAM46C Gene at MOPED

Post-translational modifications for FAM46C Gene

  • Ubiquitination at Lys65, Lys234, Lys246, and Lys264
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM46C Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FAM46C Gene

Domains for FAM46C Gene

Protein Domains for FAM46C Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM46C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VWP2

UniProtKB/Swiss-Prot:

FA46C_HUMAN :
  • Q5VWP2
Family:
  • Belongs to the FAM46 family.
genes like me logo Genes that share domains with FAM46C: view

No data available for Gene Families for FAM46C Gene

Function for FAM46C Gene

Molecular function for FAM46C Gene

UniProtKB/Swiss-Prot Function:
Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon.
UniProtKB/Swiss-Prot Induction:
By type I interferons.

Gene Ontology (GO) - Molecular Function for FAM46C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM46C: view
genes like me logo Genes that share phenotypes with FAM46C: view

Animal Model Products

CRISPR Products

miRNA for FAM46C Gene

miRTarBase miRNAs that target FAM46C

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM46C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM46C Gene

Localization for FAM46C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM46C Gene COMPARTMENTS Subcellular localization image for FAM46C gene
Compartment Confidence
cytoskeleton 2
cytosol 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM46C Gene

Pathways for FAM46C Gene

SuperPathways for FAM46C Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM46C Gene

None

No data available for Pathways by source for FAM46C Gene

Transcripts for FAM46C Gene

mRNA/cDNA for FAM46C Gene

(108) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM46C Gene

Family with sequence similarity 46, member C:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM46C

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM46C Gene

No ASD Table

Relevant External Links for FAM46C Gene

GeneLoc Exon Structure for
FAM46C
ECgene alternative splicing isoforms for
FAM46C

Expression for FAM46C Gene

mRNA expression in normal human tissues for FAM46C Gene

mRNA differential expression in normal tissues according to GTEx for FAM46C Gene

This gene is overexpressed in Testis (7.6), Whole Blood (7.6), and Pancreas (6.2).

Protein differential expression in normal tissues for FAM46C Gene

This gene is overexpressed in Frontal cortex (25.0), Monocytes (20.9), and Liver (10.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FAM46C Gene

SOURCE GeneReport for Unigene cluster for FAM46C Gene Hs.356216

genes like me logo Genes that share expressions with FAM46C: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for FAM46C Gene

Orthologs for FAM46C Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM46C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM46C 35
  • 85.39 (n)
  • 93.96 (a)
FAM46C 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM46C 35
  • 88.83 (n)
  • 96.68 (a)
FAM46C 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam46c 35
  • 89.94 (n)
  • 95.91 (a)
Fam46c 16
Fam46c 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM46C 35
  • 98.89 (n)
  • 99.49 (a)
FAM46C 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam46c 35
  • 90.28 (n)
  • 96.16 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM46C 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM46C 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM46C 35
  • 78.8 (n)
  • 89.49 (a)
FAM46C 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam46c 35
  • 77.58 (n)
  • 83.38 (a)
zebrafish
(Danio rerio)
Actinopterygii fam46c 35
  • 71.85 (n)
  • 75.91 (a)
zgc66197 35
fam46c 36
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005088 35
  • 64.32 (n)
  • 63.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30497 35
  • 62.91 (n)
  • 63.5 (a)
CG30497 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pqn-44 35
  • 52.3 (n)
  • 48.28 (a)
pqn-44 36
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToMany
Species with no ortholog for FAM46C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM46C Gene

ENSEMBL:
Gene Tree for FAM46C (if available)
TreeFam:
Gene Tree for FAM46C (if available)

Paralogs for FAM46C Gene

Paralogs for FAM46C Gene

Selected SIMAP similar genes for FAM46C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM46C: view

Variants for FAM46C Gene

Sequence variations from dbSNP and Humsavar for FAM46C Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs826402 -- 117,624,727(-) TTTTT(C/T)CCCCT utr-variant-3-prime
rs826403 -- 117,624,577(-) AGCAA(C/T)TTAGT utr-variant-3-prime
rs826404 -- 117,622,100(-) CAAAA(A/G)GTTAG intron-variant
rs826405 -- 117,621,202(-) ATGAG(C/T)GCTCT intron-variant
rs826411 -- 117,613,900(+) AGAAT(A/G)TGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM46C Gene

Variant ID Type Subtype PubMed ID
nsv831170 CNV Gain 17160897
nsv819506 CNV Gain 19587683

Relevant External Links for FAM46C Gene

HapMap Linkage Disequilibrium report
FAM46C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM46C Gene

Disorders for FAM46C Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for FAM46C Gene in MalaCards »

(2) Diseases for FAM46C Gene including...

Relevant External Links for FAM46C

Genetic Association Database (GAD)
FAM46C
genes like me logo Genes that share disorders with FAM46C: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for FAM46C Gene

Publications for FAM46C Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A diverse range of gene products are effectors of the type I interferon antiviral response. (PMID: 21478870) Schoggins J.W. … Rice C.M. (Nature 2011) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for FAM46C Gene

Sources for FAM46C Gene

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