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Aliases for FAM46B Gene

Aliases for FAM46B Gene

  • Family With Sequence Similarity 46 Member B 2 3 5
  • Family With Sequence Similarity 46, Member B 2

External Ids for FAM46B Gene

Previous GeneCards Identifiers for FAM46B Gene

  • GC01M027204
  • GC01M027331
  • GC01M025584

Summaries for FAM46B Gene

GeneCards Summary for FAM46B Gene

FAM46B (Family With Sequence Similarity 46 Member B) is a Protein Coding gene. An important paralog of this gene is FAM46A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM46B Gene

Genomics for FAM46B Gene

Regulatory Elements for FAM46B Gene

Enhancers for FAM46B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM46B on UCSC Golden Path with GeneCards custom track

Promoters for FAM46B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM46B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM46B Gene

27,005,020 bp from pter
27,012,842 bp from pter
7,823 bases
Minus strand

Genomic View for FAM46B Gene

Genes around FAM46B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM46B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM46B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM46B Gene

Proteins for FAM46B Gene

  • Protein details for FAM46B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM46B
    Protein Accession:

    Protein attributes for FAM46B Gene

    425 amino acids
    Molecular mass:
    46688 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH12790.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH14160.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI13555.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FAM46B Gene

Proteomics data for FAM46B Gene at MOPED

Post-translational modifications for FAM46B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM46B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM46B Gene

Domains & Families for FAM46B Gene

Protein Domains for FAM46B Gene


Suggested Antigen Peptide Sequences for FAM46B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM46 family.
  • Belongs to the FAM46 family.
genes like me logo Genes that share domains with FAM46B: view

No data available for Gene Families for FAM46B Gene

Function for FAM46B Gene

genes like me logo Genes that share phenotypes with FAM46B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM46B Gene

Localization for FAM46B Gene

Subcellular locations from

Jensen Localization Image for FAM46B Gene COMPARTMENTS Subcellular localization image for FAM46B gene
Compartment Confidence
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM46B Gene

Pathways & Interactions for FAM46B Gene

SuperPathways for FAM46B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM46B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM46B Gene

Drugs & Compounds for FAM46B Gene

No Compound Related Data Available

Transcripts for FAM46B Gene

mRNA/cDNA for FAM46B Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(51) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM46B Gene

Family with sequence similarity 46, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM46B Gene

No ASD Table

Relevant External Links for FAM46B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM46B Gene

mRNA expression in normal human tissues for FAM46B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM46B Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x5.2), Esophagus - Mucosa (x4.8), Esophagus - Muscularis (x4.5), Skin - Not Sun Exposed (Suprapubic) (x4.5), and Esophagus - Gastroesophageal Junction (x4.1).

Protein differential expression in normal tissues from HIPED for FAM46B Gene

This gene is overexpressed in Urine (62.9) and Heart (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM46B Gene

SOURCE GeneReport for Unigene cluster for FAM46B Gene Hs.632378

genes like me logo Genes that share expression patterns with FAM46B: view

Protein tissue co-expression partners for FAM46B Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for FAM46B Gene

Orthologs for FAM46B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM46B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM46B 35
  • 89.57 (n)
  • 92.71 (a)
FAM46B 36
  • 92 (a)
(Canis familiaris)
Mammalia FAM46B 35
  • 89.25 (n)
  • 92.47 (a)
FAM46B 36
  • 92 (a)
(Mus musculus)
Mammalia Fam46b 35
  • 87.22 (n)
  • 91.76 (a)
Fam46b 16
Fam46b 36
  • 91 (a)
(Pan troglodytes)
Mammalia FAM46B 35
  • 99.45 (n)
  • 99.53 (a)
FAM46B 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fam46b 35
  • 86.51 (n)
  • 91.53 (a)
(Monodelphis domestica)
Mammalia FAM46B 36
  • 65 (a)
(Gallus gallus)
Aves FAM46B 36
  • 68 (a)
(Anolis carolinensis)
Reptilia FAM46B 36
  • 63 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3131 35
(Danio rerio)
Actinopterygii fam46ba 36
  • 67 (a)
fam46bb 36
  • 65 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30497 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea pqn-44 36
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
Species with no ortholog for FAM46B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FAM46B Gene

Gene Tree for FAM46B (if available)
Gene Tree for FAM46B (if available)

Paralogs for FAM46B Gene

Paralogs for FAM46B Gene

(4) SIMAP similar genes for FAM46B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM46B: view

Variants for FAM46B Gene

Sequence variations from dbSNP and Humsavar for FAM46B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs11520 -- 27,005,302(+) CTCCT(G/T)TATAC utr-variant-3-prime
rs4970471 -- 27,012,612(+) CAGCC(G/T)TCCCC reference, missense
rs12408364 -- 27,007,110(+) ATTGG(G/T)TGGGG intron-variant
rs12725625 -- 27,013,891(+) ttttt(G/T)tgttt upstream-variant-2KB
rs12730425 -- 27,012,129(+) GCCCT(C/T)GACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM46B Gene

Variant ID Type Subtype PubMed ID
nsv870497 CNV Loss 21882294
nsv834535 CNV Gain+Loss 17160897

Variation tolerance for FAM46B Gene

Residual Variation Intolerance Score: 25.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.57; 82.49% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FAM46B Gene

Disorders for FAM46B Gene

Relevant External Links for FAM46B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM46B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM46B Gene

Publications for FAM46B Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Development and application of a DNA microarray-based yeast two-hybrid system. (PMID: 23275563) Suter B. … Wanker E.E. (Nucleic Acids Res. 2013) 3

Products for FAM46B Gene

Sources for FAM46B Gene