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Aliases for FAM46B Gene

Aliases for FAM46B Gene

  • Family With Sequence Similarity 46 Member B 2 3 5
  • Family With Sequence Similarity 46, Member B 2

External Ids for FAM46B Gene

Previous GeneCards Identifiers for FAM46B Gene

  • GC01M027204
  • GC01M027331
  • GC01M025584

Summaries for FAM46B Gene

GeneCards Summary for FAM46B Gene

FAM46B (Family With Sequence Similarity 46 Member B) is a Protein Coding gene. An important paralog of this gene is FAM46A.

Additional gene information for FAM46B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM46B Gene

Genomics for FAM46B Gene

Regulatory Elements for FAM46B Gene

Enhancers for FAM46B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H027516 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -511.0 -510972 13 HDGF PKNOX1 FOXA2 ARNT ZFP64 SIN3A ARID4B DMAP1 ZNF2 YY1 ACTG1P20 ARID1A MAP3K6 FAM76A PHACTR4 NPM1P39 WASF2 GPN2 ENSG00000231344 EYA3
GH01H027614 2 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -613.0 -612996 23 HDGF PKNOX1 FOXA2 YBX1 ZNF121 GATA2 ZNF143 ZNF207 ATF7 RUNX3 ACTG1P20 FGR FAM76A TRNAU1AP NPM1P39 ARID1A THEMIS2 PTAFR SNHG12 GPN2
GH01H027605 2 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -595.6 -595608 5 HDGF PKNOX1 MLX ARNT ARID4B DMAP1 ZNF2 ZNF766 CBX5 ZNF143 ARID1A TRNAU1AP ACTG1P20 FAM76A NPM1P39 SNHG12 PHACTR4 MAP3K6 WASF2 AHDC1
GH01H027871 1.7 FANTOM5 ENCODE dbSUPER 11.3 -861.8 -861782 5 HDGF PKNOX1 ATF1 SIN3A FEZF1 GTF3C2 ZNF143 ZNF207 FOS ATF7 FGR THEMIS2 EYA3 RPA2 XKR8 YTHDF2 GMEB1 PHACTR4 PTAFR SNHG12
GH01H027045 1.5 Ensembl ENCODE dbSUPER 12.5 -33.4 -33359 0 ATF1 ARNT ZNF2 GLIS2 ZNF143 FOS RUNX3 DEK YY2 REST FAM46B ZNF593 ZDHHC18 GC01P027050 LOC101928391
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM46B on UCSC Golden Path with GeneCards custom track

Promoters for FAM46B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000003652 42 1600 HDGF PKNOX1 MLX ARNT SIN3A YY1 ZNF143 FOS SP3 SP5

Genomic Location for FAM46B Gene

Chromosome:
1
Start:
27,005,020 bp from pter
End:
27,012,842 bp from pter
Size:
7,823 bases
Orientation:
Minus strand

Genomic View for FAM46B Gene

Genes around FAM46B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM46B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM46B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM46B Gene

Proteins for FAM46B Gene

  • Protein details for FAM46B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A09-FA46B_HUMAN
    Recommended name:
    Protein FAM46B
    Protein Accession:
    Q96A09

    Protein attributes for FAM46B Gene

    Size:
    425 amino acids
    Molecular mass:
    46688 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH12790.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH14160.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI13555.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FAM46B Gene

Post-translational modifications for FAM46B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM46B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM46B Gene

Domains & Families for FAM46B Gene

Gene Families for FAM46B Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for FAM46B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM46B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96A09

UniProtKB/Swiss-Prot:

FA46B_HUMAN :
  • Belongs to the FAM46 family.
Family:
  • Belongs to the FAM46 family.
genes like me logo Genes that share domains with FAM46B: view

Function for FAM46B Gene

Phenotypes From GWAS Catalog for FAM46B Gene

Gene Ontology (GO) - Molecular Function for FAM46B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with FAM46B: view
genes like me logo Genes that share phenotypes with FAM46B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM46B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM46B Gene

Localization for FAM46B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM46B gene
Compartment Confidence
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM46B Gene

Pathways & Interactions for FAM46B Gene

SuperPathways for FAM46B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM46B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM46B Gene

Drugs & Compounds for FAM46B Gene

No Compound Related Data Available

Transcripts for FAM46B Gene

mRNA/cDNA for FAM46B Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(51) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM46B Gene

Family with sequence similarity 46, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM46B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FAM46B Gene

No ASD Table

Relevant External Links for FAM46B Gene

GeneLoc Exon Structure for
FAM46B
ECgene alternative splicing isoforms for
FAM46B

Expression for FAM46B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM46B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM46B Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x5.2), Esophagus - Mucosa (x4.8), Esophagus - Muscularis (x4.5), Skin - Not Sun Exposed (Suprapubic) (x4.5), and Esophagus - Gastroesophageal Junction (x4.1).

Protein differential expression in normal tissues from HIPED for FAM46B Gene

This gene is overexpressed in Urine (62.9) and Heart (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM46B Gene



Protein tissue co-expression partners for FAM46B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM46B Gene:

FAM46B

SOURCE GeneReport for Unigene cluster for FAM46B Gene:

Hs.632378
genes like me logo Genes that share expression patterns with FAM46B: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM46B Gene

Orthologs for FAM46B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM46B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM46B 33 34
  • 99.45 (n)
cow
(Bos Taurus)
Mammalia FAM46B 33 34
  • 89.57 (n)
dog
(Canis familiaris)
Mammalia FAM46B 33 34
  • 89.25 (n)
mouse
(Mus musculus)
Mammalia Fam46b 33 16 34
  • 87.22 (n)
rat
(Rattus norvegicus)
Mammalia Fam46b 33
  • 86.51 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM46B 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM46B 34
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM46B 34
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fam46ba 34
  • 67 (a)
OneToMany
fam46bb 34
  • 65 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3131 33
fruit fly
(Drosophila melanogaster)
Insecta CG30497 34
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pqn-44 34
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 45 (a)
OneToMany
Species where no ortholog for FAM46B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FAM46B Gene

ENSEMBL:
Gene Tree for FAM46B (if available)
TreeFam:
Gene Tree for FAM46B (if available)

Paralogs for FAM46B Gene

Paralogs for FAM46B Gene

(4) SIMAP similar genes for FAM46B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM46B: view

Variants for FAM46B Gene

Sequence variations from dbSNP and Humsavar for FAM46B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000029318 -- 27,005,050(+) AGGTG(G/T)TAAGA utr-variant-3-prime
rs1000072607 -- 27,009,632(+) TTGGT(C/G)CAAGG intron-variant
rs1001668955 -- 27,005,703(+) CCGGC(A/G)TGCTG utr-variant-3-prime
rs1001747447 -- 27,008,189(+) CTGGG(A/G)GTTGG intron-variant
rs1001763769 -- 27,005,467(+) GTAGT(A/G)GCCCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM46B Gene

Variant ID Type Subtype PubMed ID
esv3585551 CNV gain 21293372
nsv1000012 CNV gain 25217958
nsv834535 CNV gain+loss 17160897

Variation tolerance for FAM46B Gene

Residual Variation Intolerance Score: 25.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.57; 82.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM46B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM46B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM46B Gene

Disorders for FAM46B Gene

Relevant External Links for FAM46B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM46B

No disorders were found for FAM46B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM46B Gene

Publications for FAM46B Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 60
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60

Products for FAM46B Gene

Sources for FAM46B Gene

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