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Aliases for FAM46B Gene

Aliases for FAM46B Gene

  • Family With Sequence Similarity 46, Member B 2 3

External Ids for FAM46B Gene

Summaries for FAM46B Gene

GeneCards Summary for FAM46B Gene

FAM46B (Family With Sequence Similarity 46, Member B) is a Protein Coding gene. An important paralog of this gene is FAM46A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM46B Gene

Genomics for FAM46B Gene

Genomic Location for FAM46B Gene

Start:
27,005,020 bp from pter
End:
27,012,842 bp from pter
Size:
7,823 bases
Orientation:
Minus strand

Genomic View for FAM46B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM46B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM46B Gene

Regulatory Elements for FAM46B Gene

Proteins for FAM46B Gene

  • Protein details for FAM46B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A09-FA46B_HUMAN
    Recommended name:
    Protein FAM46B
    Protein Accession:
    Q96A09
    Secondary Accessions:

    Protein attributes for FAM46B Gene

    Size:
    425 amino acids
    Molecular mass:
    46688 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH12790.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH14160.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI13555.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FAM46B Gene

Proteomics data for FAM46B Gene at MOPED

Post-translational modifications for FAM46B Gene

No Post-translational modifications

Other Protein References for FAM46B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM46B Gene

Domains for FAM46B Gene

Protein Domains for FAM46B Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

FA46B_HUMAN
Family:
  • Belongs to the FAM46 family.:
    • Q96A09
genes like me logo Genes that share domains with FAM46B: view

No data available for Gene Families for FAM46B Gene

Function for FAM46B Gene

Gene Ontology (GO) - Molecular Function for FAM46B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM46B: view

Phenotypes for FAM46B Gene

GenomeRNAi human phenotypes for FAM46B:
genes like me logo Genes that share phenotypes with FAM46B: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FAM46B Gene

Localization for FAM46B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM46B Gene COMPARTMENTS Subcellular localization image for FAM46B gene
Compartment Confidence
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for FAM46B Gene

Pathways for FAM46B Gene

SuperPathways for FAM46B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM46B Gene

None

No data available for Pathways by source for FAM46B Gene

Transcripts for FAM46B Gene

mRNA/cDNA for FAM46B Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(51) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM46B Gene

Family with sequence similarity 46, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM46B Gene

No ASD Table

Relevant External Links for FAM46B Gene

GeneLoc Exon Structure for
FAM46B
ECgene alternative splicing isoforms for
FAM46B

Expression for FAM46B Gene

mRNA expression in normal human tissues for FAM46B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM46B Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (5.2), Esophagus - Mucosa (4.8), Esophagus - Muscularis (4.5), Skin - Not Sun Exposed (Suprapubic) (4.5), and Esophagus - Gastroesophageal Junction (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FAM46B Gene

SOURCE GeneReport for Unigene cluster for FAM46B Gene Hs.632378

genes like me logo Genes that share expressions with FAM46B: view

Orthologs for FAM46B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM46B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM46B 36
  • 99.45 (n)
  • 99.53 (a)
FAM46B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM46B 36
  • 89.57 (n)
  • 92.71 (a)
FAM46B 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM46B 36
  • 89.25 (n)
  • 92.47 (a)
FAM46B 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam46b 36
  • 87.22 (n)
  • 91.76 (a)
Fam46b 16
Fam46b 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM46B 37
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam46b 36
  • 86.51 (n)
  • 91.53 (a)
chicken
(Gallus gallus)
Aves FAM46B 37
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM46B 37
  • 63 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3131 36
zebrafish
(Danio rerio)
Actinopterygii fam46ba 37
  • 67 (a)
OneToMany
fam46bb 37
  • 65 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG30497 37
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pqn-44 37
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 45 (a)
OneToMany
Species with no ortholog for FAM46B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FAM46B Gene

ENSEMBL:
Gene Tree for FAM46B (if available)
TreeFam:
Gene Tree for FAM46B (if available)

Paralogs for FAM46B Gene

Paralogs for FAM46B Gene

Selected SIMAP similar genes for FAM46B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM46B: view

Variants for FAM46B Gene

Sequence variations from dbSNP and Humsavar for FAM46B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs11520 -- 27,005,302(+) CTCCT(G/T)TATAC utr-variant-3-prime
rs4970471 -- 27,012,612(+) CAGCC(G/T)TCCCC missense, reference
rs12408364 -- 27,007,110(+) ATTGG(G/T)TGGGG intron-variant
rs12725625 -- 27,013,891(+) ttttt(G/T)tgttt upstream-variant-2KB
rs12730425 -- 27,012,129(+) GCCCT(C/T)GACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM46B Gene

Variant ID Type Subtype PubMed ID
nsv870497 CNV Loss 21882294
nsv834535 CNV Gain+Loss 17160897

Relevant External Links for FAM46B Gene

HapMap Linkage Disequilibrium report
FAM46B

Disorders for FAM46B Gene

No disorders were found for FAM46B Gene.

No data available for UniProtKB/Swiss-Prot for FAM46B Gene

Publications for FAM46B Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J. … Zoghbi H.Y. (Cell 2006) 3
  5. An empirical framework for binary interactome mapping. (PMID: 19060904) Venkatesan K. … Vidal M. (Nat. Methods 2009) 3

Products for FAM46B Gene

Sources for FAM46B Gene

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