Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM46B Gene

Aliases for FAM46B Gene

  • Family With Sequence Similarity 46 Member B 2 3 5
  • Family With Sequence Similarity 46, Member B 2

External Ids for FAM46B Gene

Previous GeneCards Identifiers for FAM46B Gene

  • GC01M027204
  • GC01M027331
  • GC01M025584

Summaries for FAM46B Gene

GeneCards Summary for FAM46B Gene

FAM46B (Family With Sequence Similarity 46 Member B) is a Protein Coding gene. An important paralog of this gene is FAM46A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM46B Gene

Genomics for FAM46B Gene

Regulatory Elements for FAM46B Gene

Enhancers for FAM46B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F027044 1.3 Ensembl ENCODE 12.5 -32.5 -32548 2.5 HDGF PKNOX1 ARNT ZNF48 ZNF2 ETS1 GLIS2 ZNF143 FOS DEK FAM46B ZDHHC18 UBXN11 GC01P027050 LOC101928391
GH01F027057 1.3 FANTOM5 Ensembl ENCODE 11.8 -45.8 -45758 3.0 ZNF146 KLF1 PKNOX1 SP3 NRF1 CEBPB BCL11B SP1 HIC1 SMARCA4 FAM46B ENSG00000243659 ACTG1P20 RNU6-48P TMEM222 LOC105376890 WDTC1 ZDHHC18 NUDC GPR3
GH01F026958 1.3 FANTOM5 ENCODE 11.4 +52.0 52000 3.9 MLX ARID4B SIN3A DMAP1 ZNF48 ETS1 ZNF121 GLIS2 FOS ZNF263 NUDC PIGV NR0B2 FAM46B GPATCH3 ENSG00000226698 SFN LOC105376890 WDTC1 RNU6-48P
GH01F027032 1 Ensembl ENCODE 12.5 -20.8 -20798 1.5 KLF1 PKNOX1 ZBTB8A TBX21 SP1 ZFHX2 SCRT2 IKZF1 ZNF143 NBN FAM46B ZDHHC18 LOC101928391 GC01P027050
GH01F026971 1 Ensembl ENCODE 11.5 +40.6 40550 1.0 BCOR SMARCA5 SAP130 CHD4 ZMYM3 CEBPB ZKSCAN1 ZNF592 ZNF7 CBX1 FAM46B PIGV GPATCH3 NUDC KDF1 GC01P026975 GC01P026960
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM46B on UCSC Golden Path with GeneCards custom track

Promoters for FAM46B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001518598 542 2601 HDGF PKNOX1 CREB3L1 SIN3A FOS KLF13 SP3 SP5 NFYC REST

Genomic Location for FAM46B Gene

Chromosome:
1
Start:
27,005,020 bp from pter
End:
27,012,842 bp from pter
Size:
7,823 bases
Orientation:
Minus strand

Genomic View for FAM46B Gene

Genes around FAM46B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM46B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM46B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM46B Gene

Proteins for FAM46B Gene

  • Protein details for FAM46B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A09-FA46B_HUMAN
    Recommended name:
    Protein FAM46B
    Protein Accession:
    Q96A09

    Protein attributes for FAM46B Gene

    Size:
    425 amino acids
    Molecular mass:
    46688 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH12790.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH14160.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI13555.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FAM46B Gene

Post-translational modifications for FAM46B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM46B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM46B Gene

Domains & Families for FAM46B Gene

Protein Domains for FAM46B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM46B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96A09

UniProtKB/Swiss-Prot:

FA46B_HUMAN :
  • Belongs to the FAM46 family.
Family:
  • Belongs to the FAM46 family.
genes like me logo Genes that share domains with FAM46B: view

No data available for Gene Families for FAM46B Gene

Function for FAM46B Gene

Gene Ontology (GO) - Molecular Function for FAM46B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19060904
genes like me logo Genes that share ontologies with FAM46B: view
genes like me logo Genes that share phenotypes with FAM46B: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM46B Gene

Localization for FAM46B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM46B gene
Compartment Confidence
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM46B Gene

Pathways & Interactions for FAM46B Gene

SuperPathways for FAM46B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM46B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM46B Gene

Transcripts for FAM46B Gene

mRNA/cDNA for FAM46B Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(51) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM46B Gene

Family with sequence similarity 46, member B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM46B Gene

No ASD Table

Relevant External Links for FAM46B Gene

GeneLoc Exon Structure for
FAM46B
ECgene alternative splicing isoforms for
FAM46B

Expression for FAM46B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM46B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM46B Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x5.2), Esophagus - Mucosa (x4.8), Esophagus - Muscularis (x4.5), Skin - Not Sun Exposed (Suprapubic) (x4.5), and Esophagus - Gastroesophageal Junction (x4.1).

Protein differential expression in normal tissues from HIPED for FAM46B Gene

This gene is overexpressed in Urine (62.9) and Heart (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM46B Gene



Protein tissue co-expression partners for FAM46B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM46B Gene:

FAM46B

SOURCE GeneReport for Unigene cluster for FAM46B Gene:

Hs.632378
genes like me logo Genes that share expression patterns with FAM46B: view

No data available for mRNA Expression by UniProt/SwissProt for FAM46B Gene

Orthologs for FAM46B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM46B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM46B 34 35
  • 99.45 (n)
cow
(Bos Taurus)
Mammalia FAM46B 34 35
  • 89.57 (n)
dog
(Canis familiaris)
Mammalia FAM46B 34 35
  • 89.25 (n)
mouse
(Mus musculus)
Mammalia Fam46b 34 16 35
  • 87.22 (n)
rat
(Rattus norvegicus)
Mammalia Fam46b 34
  • 86.51 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM46B 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM46B 35
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM46B 35
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fam46ba 35
  • 67 (a)
OneToMany
fam46bb 35
  • 65 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3131 34
fruit fly
(Drosophila melanogaster)
Insecta CG30497 35
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pqn-44 35
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 45 (a)
OneToMany
Species where no ortholog for FAM46B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FAM46B Gene

ENSEMBL:
Gene Tree for FAM46B (if available)
TreeFam:
Gene Tree for FAM46B (if available)

Paralogs for FAM46B Gene

Paralogs for FAM46B Gene

(4) SIMAP similar genes for FAM46B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM46B: view

Variants for FAM46B Gene

Sequence variations from dbSNP and Humsavar for FAM46B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs111358590 -- 27,005,588(+) ACCCT(C/T)TTAGA utr-variant-3-prime
rs111816845 -- 27,005,529(+) GTGGG(C/T)TGCAG utr-variant-3-prime
rs112273605 -- 27,007,034(+) TATCA(C/T)GGTAA intron-variant
rs112565021 -- 27,004,619(+) GTCCA(A/G)ATTCA downstream-variant-500B
rs112576634 -- 27,008,613(+) AGGTG(-/T)CTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM46B Gene

Variant ID Type Subtype PubMed ID
nsv834535 CNV gain+loss 17160897
nsv1000012 CNV gain 25217958
esv3585551 CNV gain 21293372

Variation tolerance for FAM46B Gene

Residual Variation Intolerance Score: 25.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.57; 82.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM46B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM46B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM46B Gene

Disorders for FAM46B Gene

Relevant External Links for FAM46B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM46B

No disorders were found for FAM46B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM46B Gene

Publications for FAM46B Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for FAM46B Gene

Sources for FAM46B Gene

Content
Loading form....