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Aliases for FAM46A Gene

Aliases for FAM46A Gene

  • Family With Sequence Similarity 46, Member A 2 3
  • HBV X-Transactivated Gene 11 Protein 3 4
  • HBV XAg-Transactivated Protein 11 3 4
  • C6orf37 3 4
  • XTP11 3 4
  • Chromosome 6 Open Reading Frame 37 2
  • Retinal Expressed Gene C6orf37 3
  • Protein FAM46A 3

External Ids for FAM46A Gene

Previous HGNC Symbols for FAM46A Gene

  • C6orf37

Previous GeneCards Identifiers for FAM46A Gene

  • GC06M082512
  • GC06M082201
  • GC06M079672

Summaries for FAM46A Gene

GeneCards Summary for FAM46A Gene

FAM46A (Family With Sequence Similarity 46, Member A) is a Protein Coding gene. An important paralog of this gene is FAM46C.

Gene Wiki entry for FAM46A Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM46A Gene

Genomics for FAM46A Gene

Regulatory Elements for FAM46A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM46A Gene

Start:
81,491,439 bp from pter
End:
81,752,774 bp from pter
Size:
261,336 bases
Orientation:
Minus strand

Genomic View for FAM46A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM46A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM46A Gene

Proteins for FAM46A Gene

  • Protein details for FAM46A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IP4-FA46A_HUMAN
    Recommended name:
    Protein FAM46A
    Protein Accession:
    Q96IP4
    Secondary Accessions:
    • A8K7U4
    • Q5TF86
    • Q8NFZ9
    • Q9BW32
    • Q9NXV5

    Protein attributes for FAM46A Gene

    Size:
    442 amino acids
    Molecular mass:
    49666 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH00683.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM46A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM46A Gene

Proteomics data for FAM46A Gene at MOPED

Post-translational modifications for FAM46A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM46A Gene

No data available for DME Specific Peptides for FAM46A Gene

Domains for FAM46A Gene

Protein Domains for FAM46A Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96IP4

UniProtKB/Swiss-Prot:

FA46A_HUMAN :
  • Q96IP4
Family:
  • Belongs to the FAM46 family.
genes like me logo Genes that share domains with FAM46A: view

No data available for Gene Families for FAM46A Gene

Function for FAM46A Gene

Gene Ontology (GO) - Molecular Function for FAM46A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with FAM46A: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM46A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM46A Gene

Localization for FAM46A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM46A Gene COMPARTMENTS Subcellular localization image for FAM46A gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM46A Gene

Pathways for FAM46A Gene

SuperPathways for FAM46A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM46A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010468 regulation of gene expression IMP 21810271
GO:0030193 regulation of blood coagulation IMP 21810271
genes like me logo Genes that share ontologies with FAM46A: view

No data available for Pathways by source for FAM46A Gene

Transcripts for FAM46A Gene

Unigene Clusters for FAM46A Gene

Family with sequence similarity 46, member A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM46A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM46A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4
SP1: - -
SP2: -
SP3:
SP4:

Relevant External Links for FAM46A Gene

GeneLoc Exon Structure for
FAM46A
ECgene alternative splicing isoforms for
FAM46A

Expression for FAM46A Gene

mRNA expression in normal human tissues for FAM46A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM46A Gene

SOURCE GeneReport for Unigene cluster for FAM46A Gene Hs.10784

mRNA Expression by UniProt/SwissProt for FAM46A Gene

Q96IP4-FA46A_HUMAN
Tissue specificity: Widely expressed, with preferential expression observed in the retina compared to other ocular tissues.
genes like me logo Genes that share expressions with FAM46A: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for FAM46A Gene

Orthologs for FAM46A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM46A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM46A 35
  • 99.55 (n)
  • 100 (a)
FAM46A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM46A 35
  • 94.24 (n)
  • 97 (a)
FAM46A 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM46A 35
  • 94.9 (n)
  • 97.22 (a)
FAM46A 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam46a 35
  • 91.36 (n)
  • 96.26 (a)
Fam46a 16
Fam46a 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM46A 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM46A 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam46a 35
  • 91.02 (n)
  • 96.02 (a)
chicken
(Gallus gallus)
Aves FAM46A 35
  • 85.54 (n)
  • 94.29 (a)
FAM46A 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM46A 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13086 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fam46a 35
  • 83.38 (n)
  • 92.03 (a)
Str.1648 35
zebrafish
(Danio rerio)
Actinopterygii fam46a 36
  • 83 (a)
OneToMany
FAM46A (1 of 2) 36
  • 83 (a)
OneToMany
LOC100330676 35
  • 76.71 (n)
  • 85.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30497 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pqn-44 36
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToMany
Species with no ortholog for FAM46A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM46A Gene

ENSEMBL:
Gene Tree for FAM46A (if available)
TreeFam:
Gene Tree for FAM46A (if available)

Paralogs for FAM46A Gene

Paralogs for FAM46A Gene

Selected SIMAP similar genes for FAM46A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM46A: view

Variants for FAM46A Gene

Sequence variations from dbSNP and Humsavar for FAM46A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs11040 -- 81,752,132(+) TTCAC(A/C)CTCCG reference, missense
rs194607 -- 81,747,430(+) TGCAG(C/G)GGCTG utr-variant-3-prime
rs742961 -- 81,753,798(-) AGGCA(A/G)CGAGC upstream-variant-2KB
rs915124 -- 81,753,019(+) ATCAA(A/C)ACCAG upstream-variant-2KB
rs915125 -- 81,753,659(+) CGAGA(C/T)GTAAA upstream-variant-2KB

Relevant External Links for FAM46A Gene

HapMap Linkage Disequilibrium report
FAM46A
Human Gene Mutation Database (HGMD)
FAM46A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM46A Gene

Disorders for FAM46A Gene

Relevant External Links for FAM46A

Genetic Association Database (GAD)
FAM46A
Human Genome Epidemiology (HuGE) Navigator
FAM46A
genes like me logo Genes that share disorders with FAM46A: view

No data available for UniProtKB/Swiss-Prot for FAM46A Gene

Publications for FAM46A Gene

  1. Identification and characterization of C6orf37, a novel candidate human retinal disease gene on chromosome 6q14. (PMID: 12054608) Lagali P.S. … Ayyagari R. (Biochem. Biophys. Res. Commun. 2002) 2 3 4
  2. Identification of a novel VNTR polymorphism in C6orf37 and its association with colorectal cancer risk in Chinese population. (PMID: 16545789) Cui J. … Yao C. (Clin. Chim. Acta 2006) 3 4 48
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for FAM46A Gene

Sources for FAM46A Gene

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