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Aliases for FAM46A Gene

Aliases for FAM46A Gene

  • Family With Sequence Similarity 46, Member A 2 3
  • HBV X-Transactivated Gene 11 Protein 3 4
  • HBV XAg-Transactivated Protein 11 3 4
  • C6orf37 3 4
  • XTP11 3 4
  • Chromosome 6 Open Reading Frame 37 2
  • Retinal Expressed Gene C6orf37 3
  • Protein FAM46A 3

External Ids for FAM46A Gene

Previous Symbols for FAM46A Gene

  • C6orf37

Summaries for FAM46A Gene

GeneCards Summary for FAM46A Gene

FAM46A (Family With Sequence Similarity 46, Member A) is a Protein Coding gene. An important paralog of this gene is FAM46C.

Gene Wiki entry for FAM46A Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM46A Gene

Genomics for FAM46A Gene

Genomic Location for FAM46A Gene

81,491,439 bp from pter
81,752,774 bp from pter
261,336 bases
Minus strand

Genomic View for FAM46A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM46A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM46A Gene

Regulatory Elements for FAM46A Gene

Proteins for FAM46A Gene

  • Protein details for FAM46A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM46A
    Protein Accession:
    Secondary Accessions:
    • A8K7U4
    • Q5TF86
    • Q8NFZ9
    • Q9BW32
    • Q9NXV5

    Protein attributes for FAM46A Gene

    442 amino acids
    Molecular mass:
    49666 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH00683.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM46A Gene


neXtProt entry for FAM46A Gene

Proteomics data for FAM46A Gene at MOPED

Post-translational modifications for FAM46A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM46A Gene

No data available for DME Specific Peptides for FAM46A Gene

Domains for FAM46A Gene

Protein Domains for FAM46A Gene



  • Belongs to the FAM46 family.:
    • Q96IP4
genes like me logo Genes that share domains with FAM46A: view

No data available for Gene Families for FAM46A Gene

Function for FAM46A Gene

Gene Ontology (GO) - Molecular Function for FAM46A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with FAM46A: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM46A Gene

Localization for FAM46A Gene

Subcellular locations from

Jensen Localization Image for FAM46A Gene COMPARTMENTS Subcellular localization image for FAM46A gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for FAM46A Gene

Pathways for FAM46A Gene

SuperPathways for FAM46A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM46A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010468 regulation of gene expression IMP 21810271
GO:0030193 regulation of blood coagulation IMP 21810271
genes like me logo Genes that share ontologies with FAM46A: view

No data available for Pathways by source for FAM46A Gene

Transcripts for FAM46A Gene

Unigene Clusters for FAM46A Gene

Family with sequence similarity 46, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM46A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4
SP1: - -
SP2: -

Relevant External Links for FAM46A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM46A Gene

mRNA expression in normal human tissues for FAM46A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM46A Gene

SOURCE GeneReport for Unigene cluster for FAM46A Gene Hs.10784

mRNA Expression by UniProt/SwissProt for FAM46A Gene

Tissue specificity: Widely expressed, with preferential expression observed in the retina compared to other ocular tissues.
genes like me logo Genes that share expressions with FAM46A: view

Orthologs for FAM46A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM46A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM46A 36
  • 99.55 (n)
  • 100 (a)
FAM46A 37
  • 100 (a)
(Bos Taurus)
Mammalia FAM46A 36
  • 94.24 (n)
  • 97 (a)
FAM46A 37
  • 97 (a)
(Canis familiaris)
Mammalia FAM46A 36
  • 94.9 (n)
  • 97.22 (a)
FAM46A 37
  • 93 (a)
(Mus musculus)
Mammalia Fam46a 36
  • 91.36 (n)
  • 96.26 (a)
Fam46a 16
Fam46a 37
  • 93 (a)
(Monodelphis domestica)
Mammalia FAM46A 37
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia FAM46A 37
  • 96 (a)
(Rattus norvegicus)
Mammalia Fam46a 36
  • 91.02 (n)
  • 96.02 (a)
(Gallus gallus)
Aves FAM46A 36
  • 85.54 (n)
  • 94.29 (a)
FAM46A 37
  • 87 (a)
(Anolis carolinensis)
Reptilia FAM46A 37
  • 82 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13086 36
tropical clawed frog
(Silurana tropicalis)
Amphibia fam46a 36
  • 83.38 (n)
  • 92.03 (a)
Str.1648 36
(Danio rerio)
Actinopterygii fam46a 37
  • 83 (a)
FAM46A (1 of 2) 37
  • 83 (a)
LOC100330676 36
  • 76.71 (n)
  • 85.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30497 37
  • 26 (a)
(Caenorhabditis elegans)
Secernentea pqn-44 37
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 50 (a)
Species with no ortholog for FAM46A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM46A Gene

Gene Tree for FAM46A (if available)
Gene Tree for FAM46A (if available)

Paralogs for FAM46A Gene

Paralogs for FAM46A Gene

Selected SIMAP similar genes for FAM46A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM46A: view

Variants for FAM46A Gene

Sequence variations from dbSNP and Humsavar for FAM46A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs11040 -- 81,752,132(+) TTCAC(A/C)CTCCG reference, missense
rs194607 -- 81,747,430(+) TGCAG(C/G)GGCTG utr-variant-3-prime
rs742961 -- 81,753,798(-) AGGCA(A/G)CGAGC upstream-variant-2KB
rs915124 -- 81,753,019(+) ATCAA(A/C)ACCAG upstream-variant-2KB
rs915125 -- 81,753,659(+) CGAGA(C/T)GTAAA upstream-variant-2KB

Relevant External Links for FAM46A Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Structural Variations from Database of Genomic Variants (DGV) for FAM46A Gene

Disorders for FAM46A Gene

Relevant External Links for FAM46A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with FAM46A: view

No data available for UniProtKB/Swiss-Prot for FAM46A Gene

Publications for FAM46A Gene

  1. Identification and characterization of C6orf37, a novel candidate human retinal disease gene on chromosome 6q14. (PMID: 12054608) Lagali P.S. … Ayyagari R. (Biochem. Biophys. Res. Commun. 2002) 2 3 4
  2. Identification of a novel VNTR polymorphism in C6orf37 and its association with colorectal cancer risk in Chinese population. (PMID: 16545789) Cui J. … Yao C. (Clin. Chim. Acta 2006) 3 4 49
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for FAM46A Gene

Sources for FAM46A Gene

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