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FAM46A Gene

protein-coding   GIFtS: 51
GCID: GC06M082201

Family With Sequence Similarity 46, Member A

(Previous name: chromosome 6 open reading frame 37)
(Previous symbol: C6orf37)
  Search for FAM46A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 46, Member A1 2     HBV XAg-Transactivated Protein 112 3
C6orf371 2 3     Chromosome 6 Open Reading Frame 371
XTP112 3     Protein FAM46A2
HBV X-Transactivated Gene 11 Protein2 3     Retinal Expressed Gene C6orf372

External Ids:    HGNC: 183451   Entrez Gene: 556032   Ensembl: ENSG000001127737   OMIM: 6113575   UniProtKB: Q96IP43   

Export aliases for FAM46A gene to outside databases

Previous GC identifers: GC06M082512 GC06M079672


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM46A Gene:
FAM46A (family with sequence similarity 46, member A) is a protein-coding gene. An important paralog of this gene is FAM46B.

Gene Wiki entry for FAM46A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM46A gene promoter:
         AREB6   LHX3b/Lhx3b   POU2F1   POU2F1a   LHX3a/Lhx3a   Nkx2-5   Pax-4a   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM46A promoter sequence
   Search Chromatin IP Primers for FAM46A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM46A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14   Ensembl cytogenetic band:  6q14.1   HGNC cytogenetic band: 6q14

FAM46A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM46A gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M082201:  view genomic region     (about GC identifiers)

Start:
82,201,156 bp from pter      End:
82,462,491 bp from pter
Size:
261,336 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FA46A_HUMAN, Q96IP4 (See protein sequence)
Recommended Name: Protein FAM46A  
Size: 442 amino acids; 49666 Da
Sequence caution: Sequence=AAH00683.1; Type=Erroneous initiation;
Secondary accessions: A8K7U4 Q5TF86 Q8NFZ9 Q9BW32 Q9NXV5
Alternative splicing: 2 isoforms:  Q96IP4-1   Q96IP4-2   

Explore the universe of human proteins at neXtProt for FAM46A: NX_Q96IP4

Explore proteomics data for FAM46A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM46A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060103.2  
    ENSEMBL proteins: 
     ENSP00000401884   ENSP00000358769   ENSP00000318298   ENSP00000358771   ENSP00000404872  

    FAM46A Human Recombinant Protein Products:

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    Novus Biologicals FAM46A Protein
    Novus Biologicals FAM46A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FAM46A

     
    Search eBioscience for Proteins for FAM46A 

    FAM46A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals FAM46A Antibodies
    Abcam antibodies for FAM46A
    Cloud-Clone Corp. Antibodies for FAM46A
    ThermoFisher Antibodies for FAM46A
    LSBio Antibodies in human, mouse, rat for FAM46A

    FAM46A Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FAM46A
    Cloud-Clone Corp. CLIAs for FAM46A
    Search eBioscience for ELISAs for FAM46A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR012937 DUF1693

    Graphical View of Domain Structure for InterPro Entry Q96IP4

    ProtoNet protein and cluster: Q96IP4

    1 Blocks protein domain: IPB012937 Protein of unknown function DUF1693

    UniProtKB/Swiss-Prot: FA46A_HUMAN, Q96IP4
    Similarity: Belongs to the FAM46 family


    Find genes that share domains with FAM46A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with FAM46A           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM46A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FAM46A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM46A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM46A

    miRNA
    Products:
        
    miRTarBase miRNAs that target FAM46A:
    hsa-mir-21-5p (MIRT030931), hsa-mir-34a-5p (MIRT047395), hsa-mir-19b-3p (MIRT031187), hsa-mir-346 (MIRT042717), hsa-mir-484 (MIRT041668), hsa-mir-9-5p (MIRT021473)

    Block miRNA regulation of human, mouse, rat FAM46A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAM46A (see all 52):
    hsa-miR-140-5p hsa-miR-3607-3p hsa-miR-642a hsa-miR-607 hsa-miR-4328 hsa-miR-300 hsa-miR-548k hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidFAM46A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FAM46A
    Predesigned siRNA for gene silencing in human, mouse, rat FAM46A

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for FAM46A

    Clone
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    OriGene clones in human, mouse for FAM46A (see all 8)
    OriGene ORF clones in mouse, rat for FAM46A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FAM46A (NM_017633)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM46A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM46A

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for FAM46A
    Browse ESI BIO Cell Lines and PureStem Progenitors for FAM46A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM46A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    cytoskeleton1
    extracellular1
    mitochondrion1
    peroxisome1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM46A
    Interactions:

        Search GeneGlobe Interaction Network for FAM46A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for FAM46A (Q96IP43 ENSP000003182984) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAG6P463793, ENSP000003651314I2D: score=2 STRING: ENSP00000365131
    ENSG00000096155P463793I2D: score=2 
    ENSG00000227761P463793I2D: score=2 
    ENSG00000228760P463793I2D: score=2 
    ENSG00000229524P463793I2D: score=2 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM46A (FA46A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM46A gene: 
    NM_017633.2  

    Unigene Cluster for FAM46A:

    Family with sequence similarity 46, member A
    Hs.10784  [show with all ESTs]
    Unigene Representative Sequence: NM_017633
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000412306 ENST00000369754(uc003pjf.3) ENST00000320172(uc003pjg.3)
    ENST00000369756(uc003pjh.1) ENST00000423467
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FAM46A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAM46A (see all 52):
    hsa-miR-140-5p hsa-miR-3607-3p hsa-miR-642a hsa-miR-607 hsa-miR-4328 hsa-miR-300 hsa-miR-548k hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidFAM46A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FAM46A
    Predesigned siRNA for gene silencing in human, mouse, rat FAM46A
    Clone
    Products:
         
    OriGene clones in human, mouse for FAM46A (see all 8)
    OriGene ORF clones in mouse, rat for FAM46A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FAM46A (NM_017633)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM46A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM46A
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FAM46A
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM46A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM46A
      QuantiTect SYBR Green Assays in human, mouse, rat FAM46A
      QuantiFast Probe-based Assays in human, mouse, rat FAM46A

    Additional mRNA sequence: 

    AF350451.1 AJ420583.1 AJ420591.1 AJ420592.1 AK000044.1 AK056057.1 AK096704.1 AK292109.1 
    AY740520.1 BC000683.2 BC007351.2 BX648876.1 FJ211061.1 

    14 DOTS entries:

    DT.445041  DT.92428345  DT.70102080  DT.91645287  DT.121357853  DT.121357896  DT.121357898  DT.95210334 
    DT.97768233  DT.100029007  DT.92428347  DT.95166364  DT.121357848  DT.95166119 

    Selected AceView cDNA sequences (see all 270):

    CD106889 AI274450 AA564797 BP375237 BQ217344 R78251 BU165686 AI022319 
    BF589953 AA021540 BP376234 BM854524 AW467406 BX486271 AW188795 AW965039 
    CB068845 BM719250 AK096704 CD513146 BE349007 BU741620 BQ272503 AI291802 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FAM46A    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4
    SP1:        -     -                     
    SP2:              -                     
    SP3:                                    
    SP4:                                    


    ECgene alternative splicing isoforms for FAM46A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM46A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGAATCAG
    FAM46A Expression
    About this image


    FAM46A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem SK11, NCr-fac & Meso-prx Progenitor
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone Marrow
     
     Placenta (Extraembryonic Tissues)
             Syncytiotrophoblast-like cells
     
     Kidney (Urinary System)
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
     
     Mesoderm (Gastrulation Derivatives)
             PureStem 7SMOO32, NCr-fac & Meso Progenitor
    FAM46A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM46A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.10784

    UniProtKB/Swiss-Prot: FA46A_HUMAN, Q96IP4
    Tissue specificity: Widely expressed, with preferential expression observed in the retina compared to other ocular
    tissues

        Custom PCR Arrays for FAM46A
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    QuantiTect SYBR Green Assays in human, mouse, rat FAM46A
    QuantiFast Probe-based Assays in human, mouse, rat FAM46A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM46A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FAM46A gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam46a1 , 5 family with sequence similarity 46, member A1, 5 91.36(n)1
    96.26(a)1
      9 (46.04 cM)5
    2129431  NM_001160378.11  NP_001153850.11 
     853204395 
    chicken
    (Gallus gallus)
    Aves FAM46A1 family with sequence similarity 46, member A 85.54(n)
    94.29(a)
      421845  NM_001031085.1  NP_001026256.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAM46A6
    family with sequence similarity 46, member A
    82(a)
    1 ↔ 1
    1(198454415-198469227)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.130862 Xenopus laevis transcribed sequence with strong similarity more 83.12(n)    48047239 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003306761 protein FAM46A-like 76.71(n)
    85.71(a)
      100330676  XM_005157860.1  XP_005157917.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG304976
    --
    26(a)
    1 → many
    2R(3624524-3670142)
    worm
    (Caenorhabditis elegans)
    Secernentea pqn-446
    Protein PQN-44, isoform c
    35(a)
    1 → many
    I(5372851-5384508) WBGene00004131


    ENSEMBL Gene Tree for FAM46A (if available)
    TreeFam Gene Tree for FAM46A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM46A gene
    FAM46B2  FAM46D2  FAM46C2  
    4 SIMAP similar genes for FAM46A using alignment to 5 protein entries:     FA46A_HUMAN (see all proteins):
    XTP11    FAM46C    FAM46D    FAM46B

    Find genes that share paralogs with FAM46A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM46A (see all 207)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1501967141,2
    --82455039(+) CACTAC/TAGAGC 1 -- int10--------
    rs1175091991,2
    C,F--82455041(+) CTATAG/AAGCCT 1 -- int11Minor allele frequency- A:0.02NA 120
    rs1124001861,2
    C--82455047(+) AGCCTC/AGAACA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs77454671,2
    C,F,H--82455072(+) ACTGAT/CGAAAT 1 -- int126Minor allele frequency- C:0.20NA NS EA WA 2912
    rs1852053521,2
    --82455249(+) AGCTAA/GATGCT 1 -- int10--------
    rs1456934451,2
    --82455251(+) CTAGAA/TGCTTT 1 -- int10--------
    rs1164907811,2
    F--82455266(+) GCTAAC/TTGAGC 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1911063901,2
    --82455296(+) TGACAA/GCTGGA 1 -- int10--------
    rs1406136111,2
    --82455467(+) AACTTC/TTTTAT 1 -- ut310--------
    rs1126270131,2
    C--82455553(+) TCAGTT/ATTTTA 1 -- ut311Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for FAM46A (82201156 - 82451156 bp, first 250kb of FAM46A)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FAM46A: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM46A
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM46A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611357    OMIM disorders: --


    Find genes that share disorders with FAM46A           About GenesLikeMe

    Genetic Association Database (GAD): FAM46A
    Human Genome Epidemiology (HuGE) Navigator: FAM46A (4 documents)

    Export disorders for FAM46A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM46A gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with FAM46A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel VNTR polymorphism in C6orf37 and its association with colorectal cancer risk in Chinese population. (PubMed id 16545789)1, 2, 4 Cui J....Yao C. (Clin. Chim. Acta 2006)
    2. Identification and characterization of C6orf37, a novel candidate human retinal disease gene on chromosome 6q14. (PubMed id 12054608)1, 2, 3 Lagali P.S.... Ayyagari R. (Biochem. Biophys. Res. Commun. 2002)
    3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    4. Genetic analysis of FAM46A in Spanish families with autosomal recessive retinitis pigmentosa: characterisation of novel VNTRs. (PubMed id 17803723)1, 3 BarragA!n I....AntiA+olo G. (Ann. Hum. Genet. 2008)
    5. [VNTR polymorphism of C6orf37 in Chinese population]. (PubMed id 16924696)1, 4 Cui J....Lai M.D. (Zhejiang Da Xue Xue Bao Yi Xue Ban 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    9. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. (PubMed id 23563607)1 Berndt S.I....Ingelsson E. (Nat. Genet. 2013)
    10. Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations. (PubMed id 23972371)1 Franceschini N....Zhu X. (Am. J. Hum. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55603 HGNC: 18345 AceView: FAM46A Ensembl:ENSG00000112773 euGenes: HUgn55603
    ECgene: FAM46A H-InvDB: FAM46A

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM46A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM46A gene:
    Search GeneIP for patents involving FAM46A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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