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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FAM46A Gene

protein-coding GIFtS: 48
GCID: GC06M082201

family with sequence similarity 46, member A

(Previous name: chromosome 6 open reading frame 37 )
(Previous symbol: C6orf37)

Explore 5 diseases affiliated with
FAM46A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Family With Sequence Similarity 46, Member A¹ ²		FLJ20037¹
C6orf37¹ ² ³		Chromosome 6 Open Reading Frame 37¹
XTP11² ³		Protein FAM46A²
HBV X-Transactivated Gene 11 Protein² ³		Retinal Expressed Gene C6orf37²
HBV XAg-Transactivated Protein 11² ³

External Ids:	HGNC: 18345¹	Entrez Gene: 55603²	Ensembl: ENSG00000112773⁷	OMIM: 611357⁵	UniProtKB: Q96IP4³

Export aliases for FAM46A gene to outside databases

Previous GC identifers: GC06M082512 GC06M079672

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for FAM46A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007299.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FAM46A gene promoter:
AREB6 LHX3b/Lhx3b POU2F1 POU2F1a LHX3a/Lhx3a Nkx2-5 Pax-4a C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FAM46A promoter sequence

Search SABiosciences Chromatin IP Primers for FAM46A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM46A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14 Ensembl cytogenetic band: 6q14.1 HGNC cytogenetic band: 6q14

FAM46A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM46A gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M082201: view genomic region (about GC identifiers)

Start:	82,201,156 bp from pter	End:	82,462,491 bp from pter
Size:	261,336 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FA46A_HUMAN, Q96IP4 (See protein sequence)

Recommended Name: Protein FAM46A

Size: 442 amino acids; 49666 Da

Sequence caution: Sequence=AAH00683.1; Type=Erroneous initiation;

Secondary accessions: A8K7U4 Q5TF86 Q8NFZ9 Q9BW32 Q9NXV5

Alternative splicing: 2 isoforms: Q96IP4-1 Q96IP4-2

Explore the universe of human proteins at neXtProt for FAM46A: NX_Q96IP4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96IP4

FAM46A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_060103.2

ENSEMBL proteins:

ENSP00000401884 ENSP00000358769 ENSP00000318298 ENSP00000358771 ENSP00000404872

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals FAM46A Protein Novus Biologicals FAM46A Lysate
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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for FAM46A

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	Novus Biologicals FAM46A Antibodies
	Search for Antibodies for FAM46A at Abcam
	Uscn Antibodies for FAM46A
	ThermoFisher Antibodies for FAM46A

Assay Products for FAM46A:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for FAM46A
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FAM46A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FAM46A for domains About GeneDecksing

1 InterPro domain/family:

IPR012937 DUF1693

Graphical View of Domain Structure for InterPro Entry Q96IP4

ProtoNet protein and cluster: Q96IP4

1 Blocks protein family: IPB012937 Protein of unknown function DUF1693

UniProtKB/Swiss-Prot: FA46A_HUMAN, Q96IP4

Similarity: Belongs to the FAM46 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

miRNA Products:		OriGene 3'-UTR Clone: FAM46A Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FAM46A
		8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate FAM46A (see all 52):
		hsa-miR-140-5p hsa-miR-3607-3p hsa-miR-642a hsa-miR-607 hsa-miR-4328 hsa-miR-300 hsa-miR-548k hsa-miR-30d

		SwitchGear 3'UTR luciferase reporter plasmid: FAM46A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM46A (see all 4) OriGene shRNA RFP: FAM46A OriGene siRNA: FAM46A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM46A

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for FAM46A

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM46A (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM46A OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FAM46A (NM_017633)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM46A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM46A

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FAM46A
		Search LifeMap BioReagents cell lines for FAM46A

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM46A

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FAM46A

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/20 Interacting proteins for FAM46A (Q96IP4³ ENSP00000318298⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATXN1	P54253³, ENSP00000244769⁴	I2D: score=2 STRING: ENSP00000244769
EGLN2	Q96KS0³	I2D: score=2
RAB4B-EGLN2	Q96KS0³	I2D: score=2
BAG6	P46379³, ENSP00000365131⁴	I2D: score=2 STRING: ENSP00000365131
ZFYVE9	O95405³, ENSP00000287727⁴	I2D: score=2 STRING: ENSP00000287727

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAM46A
Search CenterWatch for drugs/clinical trials and news about FAM46A / FA46A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FAM46A gene:

NM_017633.2

Unigene Cluster for FAM46A:

Family with sequence similarity 46, member A

Hs.10784 [show with all ESTs]

Unigene Representative Sequence: NM_017633

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000412306 ENST00000369754(uc003pjf.3) ENST00000320172(uc003pjg.3)

ENST00000369756(uc003pjh.1) ENST00000423467

miRNA Products:		OriGene 3'-UTR Clone: FAM46A Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FAM46A
		8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate FAM46A (see all 52):
		hsa-miR-140-5p hsa-miR-3607-3p hsa-miR-642a hsa-miR-607 hsa-miR-4328 hsa-miR-300 hsa-miR-548k hsa-miR-30d

		SwitchGear 3'UTR luciferase reporter plasmid: FAM46A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM46A (see all 4) OriGene shRNA RFP: FAM46A OriGene siRNA: FAM46A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM46A

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM46A (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM46A OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FAM46A (NM_017633)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM46A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM46A

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM46A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FAM46A
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM46A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM46A

Additional cDNA sequence:

AF350451.1 AJ420583.1 AJ420591.1 AJ420592.1 AK000044.1 AK056057.1 AK096704.1 AK292109.1

AY740520.1 BC000683.2 BC007351.2 BX648876.1 FJ211061.1

14 DOTS entries:

DT.445041 DT.92428345 DT.70102080 DT.91645287 DT.121357853 DT.121357896 DT.121357898 DT.95210334

DT.97768233 DT.100029007 DT.92428347 DT.95166364 DT.121357848 DT.95166119

24/270 AceView cDNA sequences (see all 270):

W24768 BM756429 CA443100 BQ631697 BM755531 AA447800 CD514367 BE349007

BX502345 CA771043 BQ437950 BE253590 AA021540 AA490635 R78251 BG055014

AA456648 CA308095 AW188795 BM915335 AA757798 AJ346644 AI291802 AI274450

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for FAM46A About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4
SP1:			-		-
SP2:					-
SP3:
SP4:

ECgene alternative splicing isoforms for FAM46A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM46A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTGAATCAG

About this image

FAM46A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Mature Horizontal Cells

Horizontal, Retina

Bone

Thoracic Rib

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

Midbrain dopaminergic-like neurons (Generation of midbra...)

Primitive gut tube-like cells (A scalable, suspensi...)

See FAM46A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM46A

SOURCE GeneReport for Unigene cluster: Hs.10784

UniProtKB/Swiss-Prot: FA46A_HUMAN, Q96IP4

Tissue specificity: Widely expressed, with preferential expression observed in the retina compared to other ocular

tissues

SABiosciences Custom PCR Arrays for FAM46A

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM46A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FAM46A
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM46A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM46A

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM46A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FAM46A gene from 6/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FAM46A¹	family with sequence similarity 46, member A	84.95(n) 93.88(a)		421845 NM_001031085.1 NP_001026256.1
lizard (Anolis carolinensis)	Reptilia	FAM46A⁶	--	87(a)	1 ↔ 1	1(198460110-198464764)
African clawed frog (Xenopus laevis)	Amphibia	Xl.13086²	Xenopus laevis transcribed sequence with strong similarity more	83.12(n)		48047239
zebrafish (Danio rerio)	Actinopterygii	LOC100330676¹	protein FAM46A-like	77.48(n) 87.07(a)		100330676 XM_002664776.1 XP_002664822.1
fruit fly (Drosophila melanogaster)	Insecta	CG30497⁶	--	25(a)	1 → many	2R(3624524-3670142)
worm (Caenorhabditis elegans)	Secernentea	pqn-44⁶	Prion-like-(Q/N-rich)-domain-bearing protein famil...	34(a)	1 → many	I(5372854-5384511)

ENSEMBL Gene Tree for FAM46A (if available)
TreeFam Gene Tree for FAM46A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FAM46A gene

FAM46B² FAM46D² FAM46C²

4 SIMAP similar genes for FAM46A using alignment to 5 protein entries: FA46A_HUMAN (see all proteins):

XTP11 FAM46C FAM46D FAM46B

FAM46A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150196714^1,2		--	82455039(+)	`CACTAC/TAGAGC`	1	--	int¹		0	--	--	--	--
rs117509199^1,2	F,	--	82455041(+)	`CTATAG/AAGCCT`	1	--	int¹		1		NA	120
rs7745467^1,2	C,F,H,	--	82455072(+)	`ACTGAT/CGAAAT`	1	--	int¹		26		NA NS EA WA	2912
rs185205352^1,2		--	82455249(+)	`AGCTAA/GATGCT`	1	--	int¹		0	--	--	--	--
rs145693445^1,2		--	82455251(+)	`CTAGAA/TGCTTT`	1	--	int¹		0	--	--	--	--
rs116490781^1,2	F,	--	82455266(+)	`GCTAAC/TTGAGC`	1	--	int¹		1		WA	118
rs191106390^1,2		--	82455296(+)	`TGACAA/GCTGGA`	1	--	int¹		0	--	--	--	--
rs140613611^1,2		--	82455467(+)	`AACTTC/TTTTAT`	1	--	ut3¹		0	--	--	--	--
rs181807865^1,2		--	82455615(+)	`ATATTC/TCAAAA`	1	--	ut3¹		0	--	--	--	--
rs35764369^1,2	C,	--	82455662(+)	`CTCAAA/GGCAGG`	1	--	ut3¹		2		NA	122

HapMap Linkage Disequilibrium report for FAM46A (82201156 - 82451156 bp, first 250kb of FAM46A)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM46A: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM46A

DNA2.0 Custom Variant and Variant Library Synthesis for FAM46A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FAM46A for disorders           About GeneDecksing

OMIM gene information: 611357    OMIM disorders: --

5 diseases for FAM46A:    About MalaCards

retinitis retinitis pigmentosa retinal disease colorectal cancer

ataxia

Human Genome Epidemiology (HuGE) Navigator: FAM46A (4 documents)

Export disorders for FAM46A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FAM46A gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with FAM46A)

Utopia: connect your pdf to the dynamic
world of online information

Identification and characterization of C6orf37, a novel candidate human retinal disease gene on chromosome 6q14. (PubMed id 12054608)^{1, 2, 3} Lagali P.S.... Ayyagari R. (2002)
Genetic analysis of FAM46A in Spanish families with a utosomal recessive retinitis pigmentosa: characterisation of novel VNTRs. (PubMed id 17803723)^{1, 3} BarragA!n I....AntiA+olo G. (2008)
Identification of a novel VNTR polymorphism in C6orf37 and its association with colorectal cancer risk in Chinese population. (PubMed id 16545789)^{1, 2} Cui J....Yao C. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)¹ Lee K.A....Doedens J.R. (2011)
A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)¹ He C....Hunter D.J. (2010)
Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)¹ Lango Allen H....Hirschhorn J.N. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55603	HGNC: 18345	AceView: FAM46A	Ensembl:ENSG00000112773	euGenes: HUgn55603
ECgene: FAM46A	H-InvDB: FAM46A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FAM46A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FAM46A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FAM46A gene:
Search GeneIP for patents involving FAM46A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	Browse OriGene Antibodies		OriGene shRNA RFP for FAM46A
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM46A		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM46A
	OriGene Protein Over-expression Lysate for FAM46A		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for FAM46A		OriGene 3'-UTR Clone for FAM46A
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM46A		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM46A
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for FAM46A		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for FAM46A		OriGene Custom Protein Services for FAM46A
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM46A
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM46A
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM46A
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM46A
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM46A
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM46A

	GenScript Custom Purified and Recombinant Proteins Services for FAM46A		GenScript cDNA clones with any tag delivered in your preferred vector for FAM46A
	GenScript Custom Assay Services for FAM46A		GenScript Custom Superior Antibodies Services for FAM46A
	GenScript Custom overexpressing Cell Line Services for FAM46A		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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	Regulatory tfbs in FAM46A promoter
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	Search for Antibodies for FAM46A at Abcam
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FAM46A Proteins, Antibodies, CLIAs, and ELISAs

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM46A

	SwitchGear 3'UTR luciferase reporter plasmids for FAM46A
	SwitchGear Promoter luciferase reporter plasmids for FAM46A

ThermoFisher Antibodies for FAM46A

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM46A

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes FAM46A gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

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Export list of displayed genes

FAM46A Gene

family with sequence similarity 46, member A

Aliases
for FAM46A gene

Summaries
for FAM46A gene

Genomic Views
for FAM46A gene

Proteins
for FAM46A gene

Protein Domains /
Families
for FAM46A gene

Function
for FAM46A gene

Pathways & Interactions
for FAM46A gene

Drugs & Compounds
for FAM46A gene

Transcripts
for FAM46A gene

Expression
for FAM46A gene

Orthologs
for FAM46A gene

Paralogs
for FAM46A gene

Genomic Variants
for FAM46A gene

Disorders / Diseases
for FAM46A gene

Publications
for FAM46A gene

External Searches for FAM46A gene

Genome Databases showing FAM46A gene

Other Databases showing FAM46A gene

Specialized Databases showing FAM46A gene

Intellectual Property
for FAM46A gene

Products
for FAM46A gene

View Random Gene

Advanced Search

Export list of displayed genes

FAM46A Gene

family with sequence similarity 46, member A

Aliasesfor FAM46A gene

Summariesfor FAM46A gene

Genomic Viewsfor FAM46A gene

Proteinsfor FAM46A gene

Protein Domains /Familiesfor FAM46A gene

Functionfor FAM46A gene

Pathways & Interactionsfor FAM46A gene

Drugs & Compoundsfor FAM46A gene

Transcriptsfor FAM46A gene

Expression for FAM46A gene

Orthologsfor FAM46A gene

Paralogsfor FAM46A gene

Genomic Variantsfor FAM46A gene

Disorders / Diseasesfor FAM46A gene

Publicationsfor FAM46A gene

External Searches for FAM46A gene

Genome Databases showing FAM46A gene

Other Databases showing FAM46A gene

Specialized Databases showing FAM46A gene

Intellectual Propertyfor FAM46A gene

Productsfor FAM46A gene

View Random Gene

Aliases
for FAM46A gene

Summaries
for FAM46A gene

Genomic Views
for FAM46A gene

Proteins
for FAM46A gene

Protein Domains /
Families
for FAM46A gene

Function
for FAM46A gene

Pathways & Interactions
for FAM46A gene

Drugs & Compounds
for FAM46A gene

Transcripts
for FAM46A gene

Expression
for FAM46A gene

Orthologs
for FAM46A gene

Paralogs
for FAM46A gene

Genomic Variants
for FAM46A gene

Disorders / Diseases
for FAM46A gene

Publications
for FAM46A gene

Intellectual Property
for FAM46A gene

Products
for FAM46A gene