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Aliases for FAM43A Gene

Aliases for FAM43A Gene

  • Family With Sequence Similarity 43, Member A 2 3

External Ids for FAM43A Gene

Previous GeneCards Identifiers for FAM43A Gene

  • GC03P195887
  • GC03P194406
  • GC03P191784

Summaries for FAM43A Gene

GeneCards Summary for FAM43A Gene

FAM43A (Family With Sequence Similarity 43, Member A) is a Protein Coding gene. An important paralog of this gene is FAM43B.

Gene Wiki entry for FAM43A Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM43A Gene

Genomics for FAM43A Gene

Regulatory Elements for FAM43A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM43A Gene

194,685,893 bp from pter
194,689,037 bp from pter
3,145 bases
Plus strand

Genomic View for FAM43A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for FAM43A Gene

Proteins for FAM43A Gene

  • Protein details for FAM43A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM43A
    Protein Accession:
    Secondary Accessions:
    • A3KME2
    • Q8IXP4
    • Q8WZ07

    Protein attributes for FAM43A Gene

    423 amino acids
    Molecular mass:
    45776 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAL55769.1; Type=Frameshift; Positions=246; Evidence={ECO:0000305};

neXtProt entry for FAM43A Gene

Proteomics data for FAM43A Gene at MOPED

Post-translational modifications for FAM43A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM43A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM43A Gene

Domains & Families for FAM43A Gene

Protein Domains for FAM43A Gene


Suggested Antigen Peptide Sequences for FAM43A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM43 family.
  • Belongs to the FAM43 family.
genes like me logo Genes that share domains with FAM43A: view

No data available for Gene Families for FAM43A Gene

Function for FAM43A Gene

Gene Ontology (GO) - Molecular Function for FAM43A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FAM43A: view

Phenotypes for FAM43A Gene

GenomeRNAi human phenotypes for FAM43A:
genes like me logo Genes that share phenotypes with FAM43A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM43A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM43A Gene

Localization for FAM43A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for FAM43A Gene

Pathways & Interactions for FAM43A Gene

SuperPathways for FAM43A Gene

No Data Available

Interacting Proteins for FAM43A Gene

Gene Ontology (GO) - Biological Process for FAM43A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM43A Gene

Drugs & Compounds for FAM43A Gene

No Compound Related Data Available

Transcripts for FAM43A Gene

mRNA/cDNA for FAM43A Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(78) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM43A Gene

Family with sequence similarity 43, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM43A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM43A Gene

No ASD Table

Relevant External Links for FAM43A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM43A Gene

mRNA expression in normal human tissues for FAM43A Gene

mRNA differential expression in normal tissues according to GTEx for FAM43A Gene

This gene is overexpressed in Spleen (x5.4).

Protein differential expression in normal tissues from HIPED for FAM43A Gene

This gene is overexpressed in Neutrophil (44.5) and Spinal cord (24.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM43A Gene

SOURCE GeneReport for Unigene cluster for FAM43A Gene Hs.435080

genes like me logo Genes that share expression patterns with FAM43A: view

Protein tissue co-expression partners for FAM43A Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FAM43A Gene

Orthologs for FAM43A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM43A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM43A 35
  • 91.1 (n)
  • 93.38 (a)
FAM43A 36
  • 93 (a)
(Canis familiaris)
Mammalia FAM43A 35
  • 83.96 (n)
  • 80.95 (a)
FAM43A 36
  • 78 (a)
(Mus musculus)
Mammalia Fam43a 35
  • 85.34 (n)
  • 88.18 (a)
Fam43a 16
Fam43a 36
  • 88 (a)
(Pan troglodytes)
Mammalia FAM43A 35
  • 99.13 (n)
  • 98.82 (a)
FAM43A 36
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC100909474 35
  • 85.55 (n)
  • 89.57 (a)
(Monodelphis domestica)
Mammalia FAM43A 36
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia FAM43A 36
  • 67 (a)
(Gallus gallus)
Aves FAM43A 35
  • 77.99 (n)
  • 74.59 (a)
FAM43A 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam43a 35
  • 72.69 (n)
  • 75.8 (a)
(Danio rerio)
Actinopterygii Dr.27125 35
fam43a 35
  • 72.49 (n)
  • 76.33 (a)
fam43a 36
  • 73 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8312 36
  • 14 (a)
(Caenorhabditis elegans)
Secernentea F52D10.2 36
  • 27 (a)
Species with no ortholog for FAM43A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM43A Gene

Gene Tree for FAM43A (if available)
Gene Tree for FAM43A (if available)

Paralogs for FAM43A Gene

Paralogs for FAM43A Gene

(1) SIMAP similar genes for FAM43A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM43A: view

Variants for FAM43A Gene

Sequence variations from dbSNP and Humsavar for FAM43A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs789858 -- 194,685,237(-) ACCCC(A/G)GCAAG upstream-variant-2KB
rs789859 -- 194,685,159(-) TGTGT(A/C)GTTAG upstream-variant-2KB
rs789860 -- 194,684,901(-) CTGCT(A/T)GCCTC upstream-variant-2KB
rs789861 -- 194,684,517(-) GTGCC(A/C)GGCCC upstream-variant-2KB
rs810965 -- 194,685,702(-) AATCC(G/T)CCAAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM43A Gene

Variant ID Type Subtype PubMed ID
nsv519476 CNV Gain 19592680
nsv526568 CNV Gain 19592680

Variation tolerance for FAM43A Gene

Gene Damage Index Score: 2.56; 44.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM43A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM43A Gene

Disorders for FAM43A Gene

Relevant External Links for FAM43A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FAM43A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM43A Gene

Publications for FAM43A Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder. (PMID: 18937294) Lasky-Su J. … Faraone S.V. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 67
  4. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S. … Cupples L.A. (BMC Med. Genet. 2007) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for FAM43A Gene

Sources for FAM43A Gene

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