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Aliases for FAM3D Gene

Aliases for FAM3D Gene

  • Family With Sequence Similarity 3, Member D 2 3
  • Cytokine-Like Protein EF-7 3
  • Protein FAM3D 3
  • OIT1 3
  • EF7 3

External Ids for FAM3D Gene

Previous GeneCards Identifiers for FAM3D Gene

  • GC03M057483
  • GC03M057988
  • GC03M058474
  • GC03M058577
  • GC03M058594
  • GC03M058619

Summaries for FAM3D Gene

GeneCards Summary for FAM3D Gene

FAM3D (Family With Sequence Similarity 3, Member D) is a Protein Coding gene. GO annotations related to this gene include cytokine activity. An important paralog of this gene is FAM3B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM3D Gene

Genomics for FAM3D Gene

Regulatory Elements for FAM3D Gene

Genomic Location for FAM3D Gene

Start:
58,633,943 bp from pter
End:
58,666,848 bp from pter
Size:
32,906 bases
Orientation:
Minus strand

Genomic View for FAM3D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM3D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM3D Gene

Proteins for FAM3D Gene

  • Protein details for FAM3D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BQ1-FAM3D_HUMAN
    Recommended name:
    Protein FAM3D
    Protein Accession:
    Q96BQ1
    Secondary Accessions:
    • Q547G2

    Protein attributes for FAM3D Gene

    Size:
    224 amino acids
    Molecular mass:
    24963 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM3D Gene

Proteomics data for FAM3D Gene at MOPED

Post-translational modifications for FAM3D Gene

  • Glycosylation at Asn107
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM3D Gene

No data available for DME Specific Peptides for FAM3D Gene

Domains for FAM3D Gene

Protein Domains for FAM3D Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM3D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96BQ1

UniProtKB/Swiss-Prot:

FAM3D_HUMAN :
  • Q96BQ1
Family:
  • Belongs to the FAM3 family.
genes like me logo Genes that share domains with FAM3D: view

No data available for Gene Families for FAM3D Gene

Function for FAM3D Gene

Gene Ontology (GO) - Molecular Function for FAM3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity NAS 12160727
genes like me logo Genes that share ontologies with FAM3D: view

Phenotypes for FAM3D Gene

MGI mutant phenotypes for FAM3D:
inferred from 1 alleles
GenomeRNAi human phenotypes for FAM3D:
genes like me logo Genes that share phenotypes with FAM3D: view

Animal Models for FAM3D Gene

MGI Knock Outs for FAM3D:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM3D

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for FAM3D Gene

Localization for FAM3D Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM3D Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM3D Gene COMPARTMENTS Subcellular localization image for FAM3D gene
Compartment Confidence
extracellular 5
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FAM3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 12160727
genes like me logo Genes that share ontologies with FAM3D: view

Pathways for FAM3D Gene

SuperPathways for FAM3D Gene

No Data Available

Interacting Proteins for FAM3D Gene

Gene Ontology (GO) - Biological Process for FAM3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046676 negative regulation of insulin secretion IDA 12160727
genes like me logo Genes that share ontologies with FAM3D: view

No data available for Pathways by source for FAM3D Gene

Transcripts for FAM3D Gene

Unigene Clusters for FAM3D Gene

Family with sequence similarity 3, member D:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM3D

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM3D Gene

No ASD Table

Relevant External Links for FAM3D Gene

GeneLoc Exon Structure for
FAM3D
ECgene alternative splicing isoforms for
FAM3D

Expression for FAM3D Gene

mRNA expression in normal human tissues for FAM3D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM3D Gene

This gene is overexpressed in Colon - Transverse (18.2), Esophagus - Mucosa (13.1), and Minor Salivary Gland (9.6).

Protein differential expression in normal tissues for FAM3D Gene

This gene is overexpressed in Nasal epithelium (47.3) and Lavage (8.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FAM3D Gene

SOURCE GeneReport for Unigene cluster for FAM3D Gene Hs.61265

mRNA Expression by UniProt/SwissProt for FAM3D Gene

Q96BQ1-FAM3D_HUMAN
Tissue specificity: Abundantly expressed in placenta and weakly expressed in small intestine.
genes like me logo Genes that share expressions with FAM3D: view

In Situ Assay Products

No data available for Expression partners for FAM3D Gene

Orthologs for FAM3D Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM3D Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM3D 35
  • 81.68 (n)
  • 73.42 (a)
FAM3D 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM3D 35
  • 83.63 (n)
  • 80.36 (a)
FAM3D 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Oit1 35
  • 77.98 (n)
  • 72.4 (a)
Oit1 16
Oit1 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM3D 35
  • 99.4 (n)
  • 100 (a)
FAM3D 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam3d 35
  • 77.26 (n)
  • 72.43 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM3D 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM3D 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM3D 35
  • 63.76 (n)
  • 59.17 (a)
FAM3D 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM3D 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam3d 35
  • 60.96 (n)
  • 55.41 (a)
Str.10335 35
zebrafish
(Danio rerio)
Actinopterygii zgc:101783 36
  • 36 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea M70.4 36
  • 8 (a)
ManyToMany
Y73B3A.3 36
  • 8 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.67 36
  • 32 (a)
OneToMany
Species with no ortholog for FAM3D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM3D Gene

ENSEMBL:
Gene Tree for FAM3D (if available)
TreeFam:
Gene Tree for FAM3D (if available)

Paralogs for FAM3D Gene

Paralogs for FAM3D Gene

Selected SIMAP similar genes for FAM3D Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM3D: view

Variants for FAM3D Gene

Sequence variations from dbSNP and Humsavar for FAM3D Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs731608 -- 58,639,043(+) TCACA(A/G)TGCTT intron-variant
rs900873 -- 58,638,913(-) AGACC(A/G)TAATA intron-variant
rs900874 -- 58,637,531(-) CAAGG(A/G)CCCTT intron-variant
rs900877 -- 58,668,711(-) CATGG(A/G)TTCTT upstream-variant-2KB
rs900878 -- 58,668,538(-) agagc(A/G)aacgc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM3D Gene

Variant ID Type Subtype PubMed ID
nsv460560 CNV Loss 19166990
nsv876833 CNV Gain 21882294
esv28465 CNV Gain 19812545

Relevant External Links for FAM3D Gene

HapMap Linkage Disequilibrium report
FAM3D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM3D Gene

Disorders for FAM3D Gene

(1) University of Copenhagen DISEASES for FAM3D Gene

Relevant External Links for FAM3D

Genetic Association Database (GAD)
FAM3D
Human Genome Epidemiology (HuGE) Navigator
FAM3D
genes like me logo Genes that share disorders with FAM3D: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for FAM3D Gene

Publications for FAM3D Gene

  1. Cloning, expression, and initial characterization of a novel cytokine-like gene family. (PMID: 12160727) Zhu Y. … Young P.R. (Genomics 2002) 2 3 4 23
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PMID: 16740002) Ramachandran P. … Loo J.A. (J. Proteome Res. 2006) 3 4
  5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 48

Products for FAM3D Gene

Sources for FAM3D Gene

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