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Aliases for FAM3D Gene

Aliases for FAM3D Gene

  • Family With Sequence Similarity 3 Member D 2 3 5
  • Oncoprotein-Induced Transcript 1 2 3
  • Family With Sequence Similarity 3, Member D 2
  • Cytokine-Like Protein EF-7 3
  • Protein FAM3D 3
  • OIT1 3
  • EF7 3

External Ids for FAM3D Gene

Previous GeneCards Identifiers for FAM3D Gene

  • GC03M057483
  • GC03M057988
  • GC03M058474
  • GC03M058577
  • GC03M058594
  • GC03M058619

Summaries for FAM3D Gene

GeneCards Summary for FAM3D Gene

FAM3D (Family With Sequence Similarity 3 Member D) is a Protein Coding gene. Diseases associated with FAM3D include Narcolepsy. GO annotations related to this gene include cytokine activity. An important paralog of this gene is FAM3A.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM3D Gene

Genomics for FAM3D Gene

Regulatory Elements for FAM3D Gene

Enhancers for FAM3D Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G058560 1 Ensembl ENCODE 9.6 +105.2 105186 2.1 SOX5 SOX13 CTCF TEAD1 JUN BHLHE40 TEAD4 ZNF384 RBBP5 RAD21 ACOX2 FAM3D-AS1 FAM107A RPP14 HTD2 FAM3D ENSG00000243384
GH03G058693 0.8 ENCODE dbSUPER 11.7 -27.3 -27322 0.6 BHLHE40 NR2F1 IKZF1 DPF2 SPI1 FAM3D C3orf67-AS1 FAM107A PXK
GH03G058641 0.7 dbSUPER 12.5 +24.1 24115 1.8 CTCF FOXA2 PKNOX1 MAX SIN3A RAD21 ZNF7 FOXA1 NR2F2 JUND FAM3D FAM3D-AS1 ENSG00000243384 C3orf67-AS1 FAM107A GC03M058625
GH03G058666 1.1 Ensembl ENCODE dbSUPER 7.4 -0.9 -944 3.1 NRF1 SALL2 YBX1 MNT ZFHX2 ZNF366 ZNF24 FOS EGR2 ZBTB17 KCTD6 FAM3D C3orf67-AS1
GH03G058640 0.7 Ensembl 10.8 +26.0 25969 0.6 CTCF RB1 RAD21 PATZ1 ZNF143 SMC3 KLF8 CREM ZBTB20 ZNF263 FAM3D-AS1 FAM3D ENSG00000243384 C3orf67-AS1 GC03M058625 FAM107A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM3D on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM3D Gene

Chromosome:
3
Start:
58,633,943 bp from pter
End:
58,666,848 bp from pter
Size:
32,906 bases
Orientation:
Minus strand

Genomic View for FAM3D Gene

Genes around FAM3D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM3D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM3D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM3D Gene

Proteins for FAM3D Gene

  • Protein details for FAM3D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BQ1-FAM3D_HUMAN
    Recommended name:
    Protein FAM3D
    Protein Accession:
    Q96BQ1
    Secondary Accessions:
    • Q547G2

    Protein attributes for FAM3D Gene

    Size:
    224 amino acids
    Molecular mass:
    24963 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM3D Gene

Post-translational modifications for FAM3D Gene

  • Glycosylation at isoforms=107
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM3D Gene

Domains & Families for FAM3D Gene

Protein Domains for FAM3D Gene

ProtoNet:

Suggested Antigen Peptide Sequences for FAM3D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96BQ1

UniProtKB/Swiss-Prot:

FAM3D_HUMAN :
  • Belongs to the FAM3 family.
Family:
  • Belongs to the FAM3 family.
genes like me logo Genes that share domains with FAM3D: view

No data available for Gene Families for FAM3D Gene

Function for FAM3D Gene

Gene Ontology (GO) - Molecular Function for FAM3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity NAS 12160727
genes like me logo Genes that share ontologies with FAM3D: view
genes like me logo Genes that share phenotypes with FAM3D: view

Animal Models for FAM3D Gene

MGI Knock Outs for FAM3D:

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM3D

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM3D Gene

Localization for FAM3D Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM3D Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM3D gene
Compartment Confidence
extracellular 5
cytosol 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FAM3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 12160727
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM3D: view

Pathways & Interactions for FAM3D Gene

SuperPathways for FAM3D Gene

No Data Available

Interacting Proteins for FAM3D Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000351632%0d%0a9606.ENSP00000237596%0d%0a
Selected Interacting proteins: Q96BQ1-FAM3D_HUMAN ENSP00000351632 for FAM3D Gene via IID STRING

Gene Ontology (GO) - Biological Process for FAM3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046676 negative regulation of insulin secretion IDA 12160727
genes like me logo Genes that share ontologies with FAM3D: view

No data available for Pathways by source and SIGNOR curated interactions for FAM3D Gene

Drugs & Compounds for FAM3D Gene

No Compound Related Data Available

Transcripts for FAM3D Gene

Unigene Clusters for FAM3D Gene

Family with sequence similarity 3, member D:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM3D Gene

No ASD Table

Relevant External Links for FAM3D Gene

GeneLoc Exon Structure for
FAM3D
ECgene alternative splicing isoforms for
FAM3D

Expression for FAM3D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM3D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM3D Gene

This gene is overexpressed in Colon - Transverse (x18.2), Esophagus - Mucosa (x13.1), and Minor Salivary Gland (x9.6).

Protein differential expression in normal tissues from HIPED for FAM3D Gene

This gene is overexpressed in Nasal epithelium (47.3) and Lavage (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM3D Gene



NURSA nuclear receptor signaling pathways regulating expression of FAM3D Gene:

FAM3D

SOURCE GeneReport for Unigene cluster for FAM3D Gene:

Hs.61265

mRNA Expression by UniProt/SwissProt for FAM3D Gene:

Q96BQ1-FAM3D_HUMAN
Tissue specificity: Abundantly expressed in placenta and weakly expressed in small intestine.

Evidence on tissue expression from TISSUES for FAM3D Gene

  • Intestine(4.7)
  • Saliva(4)
  • Stomach(2.4)
genes like me logo Genes that share expression patterns with FAM3D: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM3D Gene

Orthologs for FAM3D Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM3D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM3D 34 35
  • 99.4 (n)
dog
(Canis familiaris)
Mammalia FAM3D 34 35
  • 83.63 (n)
cow
(Bos Taurus)
Mammalia FAM3D 34 35
  • 81.68 (n)
mouse
(Mus musculus)
Mammalia Oit1 35 16 34
  • 77.98 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam3d 34
  • 77.26 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM3D 35
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM3D 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM3D 34 35
  • 63.76 (n)
lizard
(Anolis carolinensis)
Reptilia FAM3D 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam3d 34
  • 60.96 (n)
Str.10335 34
zebrafish
(Danio rerio)
Actinopterygii zgc:101783 35
  • 36 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea M70.4 35
  • 8 (a)
ManyToMany
Y73B3A.3 35
  • 8 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.67 35
  • 32 (a)
OneToMany
Species where no ortholog for FAM3D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM3D Gene

ENSEMBL:
Gene Tree for FAM3D (if available)
TreeFam:
Gene Tree for FAM3D (if available)

Paralogs for FAM3D Gene

Paralogs for FAM3D Gene

(3) SIMAP similar genes for FAM3D Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM3D: view

Variants for FAM3D Gene

Sequence variations from dbSNP and Humsavar for FAM3D Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000031450 -- 58,651,023(+) GTCAC(G/T)CTTAT intron-variant
rs1000034674 -- 58,642,601(+) CTGAC(A/C)CTGTA intron-variant
rs1000097837 -- 58,634,774(+) AGTGT(A/G)CACTG intron-variant, downstream-variant-500B
rs1000284070 -- 58,656,886(+) GGGCT(A/G)AACCA intron-variant
rs1000343914 -- 58,663,077(+) TATTT(G/T)TAGTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM3D Gene

Variant ID Type Subtype PubMed ID
dgv4749n100 CNV gain 25217958
esv28465 CNV gain 19812545
esv3449945 CNV duplication 20981092
esv3596253 CNV gain 21293372
esv3893702 CNV loss 25118596
nsv460560 CNV loss 19166990
nsv590379 CNV loss 21841781

Variation tolerance for FAM3D Gene

Residual Variation Intolerance Score: 45.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM3D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM3D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM3D Gene

Disorders for FAM3D Gene

MalaCards: The human disease database

(1) MalaCards diseases for FAM3D Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
narcolepsy
  • narcolepsy, without cataplexy
- elite association - COSMIC cancer census association via MalaCards
Search FAM3D in MalaCards View complete list of genes associated with diseases

Relevant External Links for FAM3D

Genetic Association Database (GAD)
FAM3D
Human Genome Epidemiology (HuGE) Navigator
FAM3D
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM3D
genes like me logo Genes that share disorders with FAM3D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM3D Gene

Publications for FAM3D Gene

  1. Cloning, expression, and initial characterization of a novel cytokine-like gene family. (PMID: 12160727) Zhu Y. … Young P.R. (Genomics 2002) 2 3 4 22 64
  2. Identification of FAM3D as a new endogenous chemotaxis agonist for the formyl peptide receptors. (PMID: 26966188) Peng X. … Wang Y. (J. Cell. Sci. 2016) 2 3 64
  3. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 46 64
  4. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PMID: 16740002) Ramachandran P. … Loo J.A. (J. Proteome Res. 2006) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for FAM3D Gene

Sources for FAM3D Gene

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