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Aliases for FAM3D Gene

Aliases for FAM3D Gene

  • Family With Sequence Similarity 3 Member D 2 3 5
  • Family With Sequence Similarity 3, Member D 2 3
  • Cytokine-Like Protein EF-7 3
  • OIT1 3
  • EF7 3

External Ids for FAM3D Gene

Previous GeneCards Identifiers for FAM3D Gene

  • GC03M057483
  • GC03M057988
  • GC03M058474
  • GC03M058577
  • GC03M058594
  • GC03M058619

Summaries for FAM3D Gene

GeneCards Summary for FAM3D Gene

FAM3D (Family With Sequence Similarity 3 Member D) is a Protein Coding gene. Diseases associated with FAM3D include Narcolepsy. GO annotations related to this gene include cytokine activity. An important paralog of this gene is FAM3B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM3D Gene

Genomics for FAM3D Gene

Regulatory Elements for FAM3D Gene

Enhancers for FAM3D Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM3D on UCSC Golden Path with GeneCards custom track

Promoters for FAM3D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM3D on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM3D Gene

58,633,943 bp from pter
58,666,848 bp from pter
32,906 bases
Minus strand

Genomic View for FAM3D Gene

Genes around FAM3D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM3D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM3D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM3D Gene

Proteins for FAM3D Gene

  • Protein details for FAM3D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM3D
    Protein Accession:
    Secondary Accessions:
    • Q547G2

    Protein attributes for FAM3D Gene

    224 amino acids
    Molecular mass:
    24963 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM3D Gene

Proteomics data for FAM3D Gene at MOPED

Post-translational modifications for FAM3D Gene

  • Glycosylation at Asn 107
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM3D Gene

No data available for DME Specific Peptides for FAM3D Gene

Domains & Families for FAM3D Gene

Protein Domains for FAM3D Gene


Suggested Antigen Peptide Sequences for FAM3D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM3 family.
  • Belongs to the FAM3 family.
genes like me logo Genes that share domains with FAM3D: view

No data available for Gene Families for FAM3D Gene

Function for FAM3D Gene

genes like me logo Genes that share phenotypes with FAM3D: view

Animal Models for FAM3D Gene

MGI Knock Outs for FAM3D:

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM3D

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM3D Gene

Localization for FAM3D Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM3D Gene


Subcellular locations from

Jensen Localization Image for FAM3D Gene COMPARTMENTS Subcellular localization image for FAM3D gene
Compartment Confidence
extracellular 5
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FAM3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM3D: view

Pathways & Interactions for FAM3D Gene

SuperPathways for FAM3D Gene

No Data Available

Interacting Proteins for FAM3D Gene

Gene Ontology (GO) - Biological Process for FAM3D Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM3D Gene

Drugs & Compounds for FAM3D Gene

No Compound Related Data Available

Transcripts for FAM3D Gene

Unigene Clusters for FAM3D Gene

Family with sequence similarity 3, member D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM3D Gene

No ASD Table

Relevant External Links for FAM3D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM3D Gene

mRNA expression in normal human tissues for FAM3D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM3D Gene

This gene is overexpressed in Colon - Transverse (x18.2), Esophagus - Mucosa (x13.1), and Minor Salivary Gland (x9.6).

Protein differential expression in normal tissues from HIPED for FAM3D Gene

This gene is overexpressed in Nasal epithelium (47.3) and Lavage (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM3D Gene

SOURCE GeneReport for Unigene cluster for FAM3D Gene Hs.61265

mRNA Expression by UniProt/SwissProt for FAM3D Gene

Tissue specificity: Abundantly expressed in placenta and weakly expressed in small intestine.
genes like me logo Genes that share expression patterns with FAM3D: view

Primer Products

No data available for Protein tissue co-expression partners for FAM3D Gene

Orthologs for FAM3D Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM3D Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM3D 35
  • 81.68 (n)
  • 73.42 (a)
FAM3D 36
  • 74 (a)
(Canis familiaris)
Mammalia FAM3D 35
  • 83.63 (n)
  • 80.36 (a)
FAM3D 36
  • 78 (a)
(Mus musculus)
Mammalia Oit1 35
  • 77.98 (n)
  • 72.4 (a)
Oit1 16
Oit1 36
  • 71 (a)
(Pan troglodytes)
Mammalia FAM3D 35
  • 99.4 (n)
  • 100 (a)
FAM3D 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fam3d 35
  • 77.26 (n)
  • 72.43 (a)
(Monodelphis domestica)
Mammalia FAM3D 36
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia FAM3D 36
  • 68 (a)
(Gallus gallus)
Aves FAM3D 35
  • 63.76 (n)
  • 59.17 (a)
FAM3D 36
  • 57 (a)
(Anolis carolinensis)
Reptilia FAM3D 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam3d 35
  • 60.96 (n)
  • 55.41 (a)
Str.10335 35
(Danio rerio)
Actinopterygii zgc:101783 36
  • 36 (a)
(Caenorhabditis elegans)
Secernentea M70.4 36
  • 8 (a)
Y73B3A.3 36
  • 8 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.67 36
  • 32 (a)
Species with no ortholog for FAM3D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM3D Gene

Gene Tree for FAM3D (if available)
Gene Tree for FAM3D (if available)

Paralogs for FAM3D Gene

Paralogs for FAM3D Gene

(3) SIMAP similar genes for FAM3D Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM3D: view

Variants for FAM3D Gene

Sequence variations from dbSNP and Humsavar for FAM3D Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs17059569 - 58,645,594(+) GCAGG(A/G)CTTGA reference, missense
rs33966924 - 58,640,148(+) AAATG(A/C/T)CTTCT reference, missense
rs731608 -- 58,639,043(+) TCACA(A/G)TGCTT intron-variant
rs1026951 -- 58,659,229(+) CTGCT(C/G)CCTCT intron-variant, upstream-variant-2KB
rs1026952 -- 58,659,868(+) CTAGG(A/G)CCTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM3D Gene

Variant ID Type Subtype PubMed ID
nsv460560 CNV Loss 19166990
nsv876833 CNV Gain 21882294
esv28465 CNV Gain 19812545

Variation tolerance for FAM3D Gene

Residual Variation Intolerance Score: 45.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.29% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FAM3D Gene

Disorders for FAM3D Gene

MalaCards: The human disease database

(1) MalaCards diseases for FAM3D Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • narcolepsy, without cataplexy
- elite association - COSMIC cancer census association via MalaCards
Search FAM3D in MalaCards View complete list of genes associated with diseases

Relevant External Links for FAM3D

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FAM3D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM3D Gene

Publications for FAM3D Gene

  1. Cloning, expression, and initial characterization of a novel cytokine-like gene family. (PMID: 12160727) Zhu Y. … Young P.R. (Genomics 2002) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Oit1/Fam3D, a gut-secreted protein displaying nutritional status-dependent regulation. (PMID: 22226334) de Wit N.J. … van der Meer R. (J. Nutr. Biochem. 2012) 3
  4. Exome sequencing supports a de novo mutational paradigm for schizophrenia. (PMID: 21822266) Xu B. … Karayiorgou M. (Nat. Genet. 2011) 3
  5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3

Products for FAM3D Gene

Sources for FAM3D Gene