FAM3D Gene
protein-coding GIFtS : 49
GCID: GC03 M058619
family with sequence similarity 3, member D
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Aliasesfor FAM3D gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Family With Sequence Similarity 3, Member D 1 2 EF71 2 OIT11 2 Cytokine-Like Protein EF-72 Protein FAM3D2
Export aliases for FAM3D gene to outside databases Previous GC identifers: GC03M057483 GC03M057988 GC03M058474 GC03M058577 GC03M058594
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Summariesfor FAM3D gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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Genomic Viewsfor FAM3D gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000003.11 NC_018914.1 NT_022517.18 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FAM3D gene promoter: POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) STAT5A POU3F2 LCR-F1 c-Rel HOXA5 MRF-2 Pax-4a Other transcription factors Search SABiosciences Chromatin IP Primers for FAM3D Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM3D
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 3p14.2 Ensembl cytogenetic band: 3p14.2 HGNC cytogenetic band: 3p21.1 FAM3D Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03M058619: view genomic region
(about GC identifiers )
Start:
58,619,670 bp from pter
End:
58,652,575 bp from pter
Size:
32,906 bases
Orientation:
minus strand
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Proteinsfor FAM3D gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: FAM3D_HUMAN, Q96BQ1 (See
protein sequence )Recommended Name: Protein FAM3D precursor Size : 224 amino acids; 24963 Da
Subcellular location : Secreted (Potential)
Secondary accessions : Q547G2Explore the universe of human proteins at neXtProt for FAM3D: NX_Q96BQ1 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q96BQ1 FAM3D Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_620160.1 ENSEMBL proteins: ENSP00000351632 ENSP00000417099 ENSP00000417453 ENSP00000418414 ENSP00000418982 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
FAM3D for ontologies About GeneDecksing FAM3D Antibody Products: Assay Products for FAM3D:
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Protein
Domains / Familiesfor FAM3D gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
FAM3D for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q96BQ1 ProtoNet protein and cluster: Q96BQ1
UniProtKB/Swiss-Prot: FAM3D_HUMAN, Q96BQ1 Similarity : Belongs to the FAM3 family
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Functionfor FAM3D gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM3D (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM3DOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: FAM3D (NM_138805 ) Sino Biological Human cDNA Clone for FAM3D DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM3D Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM3D
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM3D
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
FAM3D for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for FAM3D :Animal Models: Mouse knock-out Oit1 tm1Lex for FAM3D 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Oit1) :
FAM3D for phenotypes About GeneDecksing
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Pathways & Interactionsfor FAM3D gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM3D Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0046676 negative regulation of insulin secretion
IDA 12160727
FAM3D for ontologies About GeneDecksing
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Drugs & Compoundsfor FAM3D gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for FAM3D Search CenterWatch for drugs/clinical trials and news about FAM3D
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Transcriptsfor FAM3D gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for FAM3D gene: NM_138805.2 Unigene Cluster for FAM3D:
Family with sequence similarity 3, member D Hs.61265 [show with all ESTs ] Unigene Representative Sequence: AY358677 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000358781 (uc003dkq.3 ) ENST00000483787 ENST00000489857 ENST00000482623 ENST00000498347 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM3D (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM3DOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: FAM3D (NM_138805 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM3D Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM3D
Additional cDNA sequence: AF494381.1 AK127546.1 AY358677.1 BC015359.1
7 DOTS entries : DT.99988086 DT.412932
DT.97846649 DT.120887453 DT.100737621 DT.95368904 DT.91690432 24/109 AceView cDNA sequences (see all 109 ):
AI732367 AA563933 AY358677 BM848881 AA025434 BM987269 AI673534 CB145558 BM850007 AF494381 CK823244 AA514424 AA297176 BC015359 BM851081 NM_138805 BM848852 AA297147 AA470683 BM851193 BM851303 BM848978 BM848962 BM848979 GeneLoc Exon Structure
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Expression for FAM3D gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section FAM3D expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CCCCCGAAGC
About this image FAM3D expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Kidney Renal Collecting Duct System Kidney Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See FAM3D Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for FAM3D SOURCE GeneReport for Unigene cluster: Hs.61265 UniProtKB/Swiss-Prot: FAM3D_HUMAN, Q96BQ1 Tissue specificity : Abundantly expressed in placenta and weakly expressed in small intestine SABiosciences Custom PCR Arrays for FAM3D Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FAM3DBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat FAM3D QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FAM3D QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FAM3D In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM3D
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Orthologsfor FAM3D gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for FAM3D gene from 6/15 species (see all 15 ) About this table
ENSEMBL Gene Tree for FAM3D (if available)TreeFam Gene Tree for FAM3D (if available)
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Paralogsfor FAM3D gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for FAM3D gene FAM3C 2 FAM3A 2 FAM3B 2 3 SIMAP similar genes for FAM3D using alignment to 5 protein entries: FAM3D_HUMAN (see all proteins ):FAM3A FAM3C FAM3B
FAM3D for paralogs About GeneDecksing
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Genomic Variantsfor FAM3D gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 3 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for FAM3D (58619670 - 58652575 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for FAM3D 1 CNV : 68382
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FAM3D
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Disorders
/ Diseasesfor FAM3D gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
FAM3D for disorders About GeneDecksing
OMIM gene information: 608619
OMIM disorders : --4 diseases for FAM3D : About MalaCards muscle-eye-brain disease hearing loss brain disease schizophrenia 1 disease from the University of Copenhagen DISEASES database for FAM3D :Sleep disorder Human Genome Epidemiology (HuGE) Navigator: FAM3D (1 document)Export disorders for FAM3D gene to outside databases
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Publicationsfor FAM3D gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for FAM3D gene, integrated from 9 sources (see all 11 ): (articles sorted by number of sources associating them with FAM3D) Utopia : connect your pdf to the dynamic world of online information
Cloning, expression, and initial characterization of a novel cytokine-like gene family. (PubMed id 12160727) 1 , 2 , 3, 9 Zhu Y.... Young P.R. (2002) Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002) 1 , 2 Ramachandran P....Loo J.A. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 1 , 2 Clark H.F.... Gray A.M. (2003) Exome sequencing supports a de novo mutational paradi gm for schizophrenia. (PubMed id 21822266) 1 Xu B....Karayiorgou M. (2011) An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014) 1 Shimada M....Tokunaga K. (2010) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548) 1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for FAM3D gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing FAM3D gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing FAM3D gene
(According to HUGE )
About This Section --
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Specialized Databases showing FAM3D gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for FAM3D Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for FAM3D gene: Search GeneIP for patents involving FAM3D GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor FAM3D gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for FAM3D OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for FAM3D OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FAM3D Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for FAM3D Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM3D OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM3D Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for FAM3D OriGene Custom Protein Services for FAM3D OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM3D QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FAM3D QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM3D QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat FAM3D QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FAM3D QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FAM3D
Search Tocris compounds for FAM3D
FAM3D Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM3D
Search ThermoFisher Antibodies for FAM3D
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM3D
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Aliases for FAM3D
Databases for FAM3D
Disorders / Diseases for FAM3D
Domains / Families for FAM3D
Drugs / Compounds for FAM3D
Expression for FAM3D
Function for FAM3D
Genomic Views for FAM3D
Intellectual Property for FAM3D
Orthologs for FAM3D
Paralogs for FAM3D
Pathways / Interactions for FAM3D
Products for FAM3D
Proteins for FAM3D
Publications for FAM3D
Search Box for FAM3D
Summaries for FAM3D
Transcripts for FAM3D
Variants for FAM3D
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