Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM3C Gene

Aliases for FAM3C Gene

  • Family With Sequence Similarity 3 Member C 2 3 5
  • Interleukin-Like EMT Inducer 2 3 4
  • Interleukin-Like Epithelial-Mesenchymal Transition Inducer 2 3
  • Family With Sequence Similarity 3, Member C 2 3
  • Predicted Osteoblast Protein 2 3
  • ILEI 3 4
  • GS3786 3

External Ids for FAM3C Gene

Previous GeneCards Identifiers for FAM3C Gene

  • GC07M119466
  • GC07M120529
  • GC07M120543
  • GC07M120582
  • GC07M120776
  • GC07M120988
  • GC07M115352

Summaries for FAM3C Gene

Entrez Gene Summary for FAM3C Gene

  • This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. [provided by RefSeq, Mar 2010]

GeneCards Summary for FAM3C Gene

FAM3C (Family With Sequence Similarity 3 Member C) is a Protein Coding gene. Diseases associated with FAM3C include buschke-ollendorff syndrome and coffin-siris syndrome. Among its related pathways are Platelet activation, signaling and aggregation. GO annotations related to this gene include cytokine activity. An important paralog of this gene is FAM3B.

UniProtKB/Swiss-Prot for FAM3C Gene

  • May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.

Gene Wiki entry for FAM3C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM3C Gene

Genomics for FAM3C Gene

Regulatory Elements for FAM3C Gene

Promoters for FAM3C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM3C on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM3C Gene

Chromosome:
7
Start:
121,348,245 bp from pter
End:
121,396,369 bp from pter
Size:
48,125 bases
Orientation:
Minus strand

Genomic View for FAM3C Gene

Genes around FAM3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM3C Gene

Proteins for FAM3C Gene

  • Protein details for FAM3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92520-FAM3C_HUMAN
    Recommended name:
    Protein FAM3C
    Protein Accession:
    Q92520
    Secondary Accessions:
    • A6NDN2
    • A8K3R7

    Protein attributes for FAM3C Gene

    Size:
    227 amino acids
    Molecular mass:
    24680 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Up-regulation and/or mislocalization in breast cancer and liver carcinoma cells is strongly correlated with metastasis formation and survival.

neXtProt entry for FAM3C Gene

Proteomics data for FAM3C Gene at MOPED

Post-translational modifications for FAM3C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM3C Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for FAM3C

No data available for DME Specific Peptides for FAM3C Gene

Domains & Families for FAM3C Gene

Protein Domains for FAM3C Gene

ProtoNet:

Suggested Antigen Peptide Sequences for FAM3C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92520

UniProtKB/Swiss-Prot:

FAM3C_HUMAN :
  • Belongs to the FAM3 family.
Family:
  • Belongs to the FAM3 family.
genes like me logo Genes that share domains with FAM3C: view

No data available for Gene Families for FAM3C Gene

Function for FAM3C Gene

Molecular function for FAM3C Gene

UniProtKB/Swiss-Prot Function:
May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.

Gene Ontology (GO) - Molecular Function for FAM3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM3C: view
genes like me logo Genes that share phenotypes with FAM3C: view

Animal Models for FAM3C Gene

MGI Knock Outs for FAM3C:

Animal Model Products

CRISPR Products

miRNA for FAM3C Gene

miRTarBase miRNAs that target FAM3C

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM3C Gene

Localization for FAM3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM3C Gene

Secreted. Cytoplasmic vesicle. Note=Cytoplasmic in some cancer cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM3C Gene COMPARTMENTS Subcellular localization image for FAM3C gene
Compartment Confidence
extracellular 5
golgi apparatus 5

Gene Ontology (GO) - Cellular Components for FAM3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031089 platelet dense granule lumen TAS --
genes like me logo Genes that share ontologies with FAM3C: view

Pathways & Interactions for FAM3C Gene

genes like me logo Genes that share pathways with FAM3C: view

Interacting Proteins for FAM3C Gene

Gene Ontology (GO) - Biological Process for FAM3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
genes like me logo Genes that share ontologies with FAM3C: view

No data available for SIGNOR curated interactions for FAM3C Gene

Drugs & Compounds for FAM3C Gene

No Compound Related Data Available

Transcripts for FAM3C Gene

Unigene Clusters for FAM3C Gene

Family with sequence similarity 3, member C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM3C Gene

No ASD Table

Relevant External Links for FAM3C Gene

GeneLoc Exon Structure for
FAM3C
ECgene alternative splicing isoforms for
FAM3C

Expression for FAM3C Gene

mRNA expression in normal human tissues for FAM3C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM3C Gene

This gene is overexpressed in Bone (38.8) and Cerebrospinal fluid (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM3C Gene



SOURCE GeneReport for Unigene cluster for FAM3C Gene Hs.434053

mRNA Expression by UniProt/SwissProt for FAM3C Gene

Q92520-FAM3C_HUMAN
Tissue specificity: Present in most secretory epithelia (at protein level).
genes like me logo Genes that share expression patterns with FAM3C: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for FAM3C Gene

Orthologs for FAM3C Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM3C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM3C 35
  • 99.71 (n)
  • 99.56 (a)
FAM3C 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM3C 36
  • 95 (a)
OneToOne
FAM3C 35
  • 93.83 (n)
  • 95.15 (a)
dog
(Canis familiaris)
Mammalia FAM3C 35
  • 94.27 (n)
  • 98.68 (a)
FAM3C 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam3c 36
  • 94 (a)
OneToOne
Fam3c 16
Fam3c 35
  • 88.25 (n)
  • 94.27 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM3C 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM3C 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam3c 35
  • 86.64 (n)
  • 94.27 (a)
chicken
(Gallus gallus)
Aves FAM3C 36
  • 87 (a)
OneToOne
FAM3C 35
  • 84.43 (n)
  • 92.07 (a)
lizard
(Anolis carolinensis)
Reptilia FAM3C 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.29483 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fam3c 35
  • 78.67 (n)
  • 80.44 (a)
Str.17429 35
zebrafish
(Danio rerio)
Actinopterygii fam3c 36
  • 66 (a)
OneToOne
Dr.4343 35
fam3c 35
  • 65.56 (n)
  • 66.82 (a)
worm
(Caenorhabditis elegans)
Secernentea M70.4 36
  • 8 (a)
ManyToMany
Y73B3A.3 36
  • 8 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.67 36
  • 32 (a)
OneToMany
Species with no ortholog for FAM3C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM3C Gene

ENSEMBL:
Gene Tree for FAM3C (if available)
TreeFam:
Gene Tree for FAM3C (if available)

Paralogs for FAM3C Gene

Paralogs for FAM3C Gene

(3) SIMAP similar genes for FAM3C Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FAM3C: view

Variants for FAM3C Gene

Sequence variations from dbSNP and Humsavar for FAM3C Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1017114 -- 121,382,365(-) TTTTT(C/G)CTCAG intron-variant
rs917727 -- 121,378,525(-) GTCAC(A/G)GTAAT intron-variant
rs2536153 -- 121,374,759(-) TTAGA(C/T)ATTAT intron-variant
rs2536154 -- 121,373,198(-) CCTGA(C/T)TTTAA intron-variant
rs2536155 -- 121,371,561(-) GGGAA(A/C)AAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM3C Gene

Variant ID Type Subtype PubMed ID
nsv7405 OTHER Inversion 18451855
dgv2132e1 CNV Complex 17122850

Variation tolerance for FAM3C Gene

Residual Variation Intolerance Score: 33.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 5.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM3C Gene

HapMap Linkage Disequilibrium report
FAM3C
Human Gene Mutation Database (HGMD)
FAM3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM3C Gene

Disorders for FAM3C Gene

MalaCards: The human disease database

(2) MalaCards diseases for FAM3C Gene - From: DISEASES

Disorder Aliases PubMed IDs
buschke-ollendorff syndrome
  • osteopoikilosis
coffin-siris syndrome
  • dwarfism-onychodysplasia
- elite association - COSMIC cancer census association via MalaCards
Search FAM3C in MalaCards View complete list of genes associated with diseases

Relevant External Links for FAM3C

Genetic Association Database (GAD)
FAM3C
Human Genome Epidemiology (HuGE) Navigator
FAM3C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM3C
genes like me logo Genes that share disorders with FAM3C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM3C Gene

Publications for FAM3C Gene

  1. Cloning, expression, and initial characterization of a novel cytokine-like gene family. (PMID: 12160727) Zhu Y. … Young P.R. (Genomics 2002) 2 3 4 23 67
  2. Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach. (PMID: 16215274) GrA … Pandey A. (Mol. Cell Proteomics 2006) 3 23
  3. GG: a domain involved in phage LTF apparatus and implicated in human MEB and non-syndromic hearing loss diseases. (PMID: 16406369) Guo J. … Yu L. (FEBS Lett. 2006) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. ILEI: a novel marker for epithelial-mesenchymal transition and poor prognosis in colorectal cancer. (PMID: 24738665) Gao Z.H. … Xu H.M. (Histopathology 2014) 3

Products for FAM3C Gene

Sources for FAM3C Gene

Back to Top

Content