FAM3C Gene
protein-coding GIFtS: 54
GCID: GC07M120988
|
|
family with sequence similarity 3, member C
| |
Aliases
for FAM3C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 3, Member C1 2 | | ILEI1 2 3 | | Interleukin-Like EMT Inducer2 3 | | GS38761 | | Predicted Osteoblast Protein2 | | Protein FAM3C2 |
Export aliases for FAM3C gene to outside databasesPrevious GC identifers: GC07M119466 GC07M120529 GC07M120543 GC07M120582 GC07M120776 GC07M115352 |
Summaries
for FAM3C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FAM3C:
This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GGdomain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. (provided by RefSeq,Mar 2010)
UniProtKB/Swiss-Prot: FAM3C_HUMAN, Q92520Function: May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition
Gene Wiki entry for FAM3C
|
Genomic Views
for FAM3C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM3C gene promoter:
NF-YA NF-YC HNF-3beta CBF-C CBF-A CBF-B CP1A CP1C NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM3C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM3C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q31 Ensembl cytogenetic band: 7q31.31 HGNC cytogenetic band: 7q22.1-q31.1FAM3C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M120988: view genomic region
(about GC identifiers)
Start:
|
120,988,905 bp from pter |
End:
|
121,036,422 bp from pter |
Size:
|
47,518 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 120,383,656-120,431,153 |
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Proteins
for FAM3C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FAM3C_HUMAN, Q92520 (See
protein sequence)Recommended Name: Protein FAM3C precursor Size: 227 amino acids; 24680 Da
Subcellular location: Secreted (By similarity). Cytoplasmic vesicle. Note=Cytoplasmic in some cancer cells
Miscellaneous: Up-regulation and/or mislocalization in breast cancer and liver carcinoma cells is strongly correlatedwith metastasis formation and survival
Secondary accessions: A6NDN2 A8K3R7Explore the universe of human proteins at neXtProt for FAM3C: NX_Q92520
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92520
FAM3C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001035109.1 NP_055703.1
ENSEMBL proteins: ENSP00000353025 ENSP00000408636 ENSP00000414940 ENSP00000397174
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
FAM3C for ontologies About GeneDecksing
FAM3C Antibody Products:
Assay Products for FAM3C: |
Protein
Domains /
Families
for FAM3C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM3C for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q92520ProtoNet protein and cluster: Q92520 UniProtKB/Swiss-Prot: FAM3C_HUMAN, Q92520Similarity: Belongs to the FAM3 family |
Function
for FAM3C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FAM3C_HUMAN, Q92520Function: May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM3C (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM3C (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM3C |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
FAM3C for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for FAM3C:
|
Pathways & Interactions
for FAM3C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM3C
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
3 Interacting proteins for FAM3C (Q925203 ENSP000003530254) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0008150 | biological_process |
ND | -- |
FAM3C for ontologies About GeneDecksing
|
Drugs & Compounds
for FAM3C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM3C
Search CenterWatch for drugs/clinical trials and news about FAM3C
|
Transcripts
for FAM3C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM3C gene (2 alternative transcripts): NM_001040020.1 NM_014888.2 Unigene Cluster for FAM3C: Family with sequence similarity 3, member C Hs.434053 [show with all ESTs]Unigene Representative Sequence: BC0242006 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000359943(uc003vjx.3 uc010lkm.3) ENST00000474082 ENST00000412653
ENST00000426156 ENST00000497622 ENST00000455828
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM3C (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM3C (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FAM3C (NM_014888) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM3C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM3C |
Additional cDNA sequence: AK290682.1 AK292731.1 BC024200.1 BC046932.1 BC068526.1 D87120.1 DQ786255.1 15 DOTS entries: DT.100657632 DT.100819551 DT.92452902 DT.121116457 DT.121324334 DT.92452900 DT.447318 DT.436968 DT.100819552 DT.121116450 DT.121116420 DT.99964047 DT.121116442 DT.92452891 DT.95160120 24/279 AceView cDNA sequences (see all 279): CA405456 N26151 F09697 AI097279 AA782534 AV711782 N45649 AA078382 Z38281 AA459098 BM670664 AA878725 F10792 BG168116 AU135611 BM678977 BQ002696 N26357 AW953034 CB132714 AA730211 AI218317 D87120 AW263955
GeneLoc Exon Structure
|
Expression
for FAM3C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM3C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTATTTTGA
About this image
See FAM3C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM3C
SOURCE GeneReport for Unigene cluster: Hs.434053
UniProtKB/Swiss-Prot: FAM3C_HUMAN, Q92520Tissue specificity: Present in most secretory epithelia (at protein level)
SABiosciences Custom PCR Arrays for FAM3C
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM3C
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM3C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM3C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM3C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM3C |
Orthologs
for FAM3C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FAM3C gene from 5/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FAM3C1 |
family with sequence similarity 3, member C |
84.43(n)
92.07(a) |
|
417758 NM_001097646.1 NP_001091115.1 |
lizard
(Anolis carolinensis) |
Reptilia |
FAM3C6 |
-- |
88(a) |
1 ↔ 1 |
5(68796535-68810998) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.294832 |
Xenopus laevis transcribed sequence with moderate similarity to protein spQ92520 (H.sapiens) G786_HUMAN Protein GS3786 less |
79.89(n) |
|
BU900741.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.43432 |
Danio rerio mRNA similar to DNA segment, Chr 6, Wayne State University 176, expressed (cDNA clone MGC55444 IMAGE2639669), complete cds less |
74.97(n) |
|
BC044170.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
M70.46Y73B3A.36 |
Protein Y73B3A.3 |
7(a)7(a) |
many ↔ manymany ↔ many |
IV(2253004-2263662) X(84043-93664) |
ENSEMBL Gene Tree for FAM3C (if available)
TreeFam Gene Tree for FAM3C (if available) |
Paralogs
for FAM3C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM3C gene
- FAM3D2 FAM3A2 FAM3B2
3 SIMAP similar genes for FAM3C using alignment to 4 protein entries: FAM3C_HUMAN (see all proteins):FAM3A FAM3D FAM3B
FAM3C for paralogs About GeneDecksing
|
Genomic Variants
for FAM3C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM3C (120988905 - 121036422 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FAM3C
1 CNV: 2710 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM3C |
|
Disorders
/ Diseases
for FAM3C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAM3C for disorders About GeneDecksing
OMIM gene information: 608618
OMIM disorders: --
12  diseases for FAM3C: About MalaCardsmuscle-eye-brain disease pancreatic cancer fuchs' endothelial dystrophy pancreatitis
temporal lobe epilepsy intestinal atresia osteopoikilosis hearing loss
brain disease breast cancer retinitis carcinoma
3 diseases from the University of Copenhagen DISEASES database for FAM3C:Coffin-Siris syndrome Osteopoikilosis Intestinal atresia Human Genome Epidemiology (HuGE) Navigator: FAM3C (2 documents)
Export disorders for FAM3C gene to outside databases
|
Publications
for FAM3C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM3C gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with FAM3C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning, expression, and initial characterization of a novel cytokine-like gene family. (PubMed id 12160727)1, 2, 3, 9 Zhu Y.... Young P.R. (2002)
- ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells. (PubMed id 16959614)1, 2 Waerner T....Beug H. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach. (PubMed id 16215274)1, 9 Gronborg M....Pandey A. (2006)
- GG: a domain involved in phage LTF apparatus and implicated in human MEB and non-syndromic hearing loss diseases. (PubMed id 16406369)1, 9 Guo J....Yu L. (2006)
- A follow-up association study of two genetic variants for bone mineral density variation in Caucasians. (PubMed id 22159821)1 Zhang L.S....Deng H.W. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus. (PubMed id 22792070)1 Medina-Gomez C....Rivadeneira F. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
|
External Searches for FAM3C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM3C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM3C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM3C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM3C | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM3C gene:
Search GeneIP for patents involving FAM3C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM3C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM3C | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM3C | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM3C | | | OriGene Protein Over-expression Lysate for FAM3C | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM3C | | OriGene 3'-UTR Clone for FAM3C | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM3C | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM3C | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FAM3C | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM3C | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM3C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM3C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM3C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM3C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM3C |
| |
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|
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM3C |
|  |  |  | | | | ThermoFisher Antibody for FAM3C |
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