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Aliases for FAM3C Gene

Aliases for FAM3C Gene

  • Family With Sequence Similarity 3 Member C 2 3 5
  • Interleukin-Like EMT Inducer 2 3 4
  • Interleukin-Like Epithelial-Mesenchymal Transition Inducer 2 3
  • Predicted Osteoblast Protein 2 3
  • ILEI 3 4
  • Family With Sequence Similarity 3, Member C 2
  • Protein FAM3C 3
  • GS3786 3

External Ids for FAM3C Gene

Previous GeneCards Identifiers for FAM3C Gene

  • GC07M119466
  • GC07M120529
  • GC07M120543
  • GC07M120582
  • GC07M120776
  • GC07M120988
  • GC07M115352

Summaries for FAM3C Gene

Entrez Gene Summary for FAM3C Gene

  • This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. [provided by RefSeq, Mar 2010]

GeneCards Summary for FAM3C Gene

FAM3C (Family With Sequence Similarity 3 Member C) is a Protein Coding gene. Diseases associated with FAM3C include Deafness, Autosomal Recessive 17 and Coffin-Siris Syndrome 1. Among its related pathways are Response to elevated platelet cytosolic Ca2+. GO annotations related to this gene include cytokine activity. An important paralog of this gene is FAM3D.

UniProtKB/Swiss-Prot for FAM3C Gene

  • May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.

Gene Wiki entry for FAM3C Gene

Additional gene information for FAM3C Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM3C Gene

Genomics for FAM3C Gene

Regulatory Elements for FAM3C Gene

Enhancers for FAM3C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H121371 1 ENCODE dbSUPER 23.1 +23.5 23537 2 CTCF PKNOX1 TBL1XR1 RBBP5 BMI1 EBF1 BATF POLR2A ATF7 ETV6 FAM3C CYCSP19 WNT16
GH07H121381 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.2 +11.6 11579 5 PKNOX1 SIN3A EBF1 CEBPG BATF RELA POLR2A EED ATF7 RUNX3 FAM3C ING3 WNT16
GH07H121543 1.2 Ensembl ENCODE 11.6 -149.1 -149136 4 ATF1 BATF RAD21 RFX5 ZNF143 ATF7 RCOR1 FOS ETV6 RUNX3 FAM3C CYCSP19 WNT16 LOC105375478 ENSG00000227743
GH07H121417 0.7 ENCODE 18.5 -23.5 -23549 4 SMARCE1 ZEB2 DPF2 FOXA1 ZNF217 CTBP1 JUND GATA3 FOSL2 FOS FAM3C CYCSP19 LOC100130618 ENSG00000227371 RPL18P4
GH07H121350 0.5 dbSUPER 22.5 +42.5 42496 6 CTCF IKZF1 SCRT2 KLF4 BATF FAM3C WNT16 CYCSP19
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM3C on UCSC Golden Path with GeneCards custom track

Promoters for FAM3C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000217424 369 2000 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF766 CBX5 ZNF143

Genomic Location for FAM3C Gene

Chromosome:
7
Start:
121,348,245 bp from pter
End:
121,396,369 bp from pter
Size:
48,125 bases
Orientation:
Minus strand

Genomic View for FAM3C Gene

Genes around FAM3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM3C Gene

Proteins for FAM3C Gene

  • Protein details for FAM3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92520-FAM3C_HUMAN
    Recommended name:
    Protein FAM3C
    Protein Accession:
    Q92520
    Secondary Accessions:
    • A6NDN2
    • A8K3R7

    Protein attributes for FAM3C Gene

    Size:
    227 amino acids
    Molecular mass:
    24680 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Up-regulation and/or mislocalization in breast cancer and liver carcinoma cells is strongly correlated with metastasis formation and survival.

neXtProt entry for FAM3C Gene

Post-translational modifications for FAM3C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM3C Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for FAM3C
  • Santa Cruz Biotechnology (SCBT) Antibodies for FAM3C

No data available for DME Specific Peptides for FAM3C Gene

Domains & Families for FAM3C Gene

Gene Families for FAM3C Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for FAM3C Gene

ProtoNet:

Suggested Antigen Peptide Sequences for FAM3C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92520

UniProtKB/Swiss-Prot:

FAM3C_HUMAN :
  • Belongs to the FAM3 family.
Family:
  • Belongs to the FAM3 family.
genes like me logo Genes that share domains with FAM3C: view

Function for FAM3C Gene

Molecular function for FAM3C Gene

UniProtKB/Swiss-Prot Function:
May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.

Phenotypes From GWAS Catalog for FAM3C Gene

Gene Ontology (GO) - Molecular Function for FAM3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity NAS 12160727
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM3C: view
genes like me logo Genes that share phenotypes with FAM3C: view

Animal Models for FAM3C Gene

MGI Knock Outs for FAM3C:

Animal Model Products

CRISPR Products

miRNA for FAM3C Gene

miRTarBase miRNAs that target FAM3C

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM3C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM3C Gene

Localization for FAM3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM3C Gene

Secreted. Cytoplasmic vesicle. Note=Cytoplasmic in some cancer cells.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM3C gene
Compartment Confidence
extracellular 5
golgi apparatus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0031089 platelet dense granule lumen TAS --
GO:0031410 cytoplasmic vesicle IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FAM3C: view

Pathways & Interactions for FAM3C Gene

genes like me logo Genes that share pathways with FAM3C: view

Gene Ontology (GO) - Biological Process for FAM3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0007275 multicellular organism development IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with FAM3C: view

No data available for SIGNOR curated interactions for FAM3C Gene

Drugs & Compounds for FAM3C Gene

No Compound Related Data Available

Transcripts for FAM3C Gene

Unigene Clusters for FAM3C Gene

Family with sequence similarity 3, member C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM3C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FAM3C Gene

No ASD Table

Relevant External Links for FAM3C Gene

GeneLoc Exon Structure for
FAM3C
ECgene alternative splicing isoforms for
FAM3C

Expression for FAM3C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM3C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM3C Gene

This gene is overexpressed in Bone (38.8) and Cerebrospinal fluid (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM3C Gene



NURSA nuclear receptor signaling pathways regulating expression of FAM3C Gene:

FAM3C

SOURCE GeneReport for Unigene cluster for FAM3C Gene:

Hs.434053

mRNA Expression by UniProt/SwissProt for FAM3C Gene:

Q92520-FAM3C_HUMAN
Tissue specificity: Present in most secretory epithelia (at protein level).

Evidence on tissue expression from TISSUES for FAM3C Gene

  • Nervous system(4.6)
  • Intestine(4.5)
  • Liver(4.4)
  • Muscle(4.3)
  • Bone(4.2)
  • Skin(2.4)
genes like me logo Genes that share expression patterns with FAM3C: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM3C Gene

Orthologs for FAM3C Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM3C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM3C 33 34
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia FAM3C 33 34
  • 94.27 (n)
cow
(Bos Taurus)
Mammalia FAM3C 33 34
  • 93.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM3C 34
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam3c 33 16 34
  • 88.25 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM3C 34
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam3c 33
  • 86.64 (n)
chicken
(Gallus gallus)
Aves FAM3C 33 34
  • 84.43 (n)
lizard
(Anolis carolinensis)
Reptilia FAM3C 34
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam3c 33
  • 78.67 (n)
Str.17429 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.29483 33
zebrafish
(Danio rerio)
Actinopterygii fam3c 33 34
  • 65.56 (n)
Dr.4343 33
worm
(Caenorhabditis elegans)
Secernentea M70.4 34
  • 8 (a)
ManyToMany
Y73B3A.3 34
  • 8 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.67 34
  • 32 (a)
OneToMany
Species where no ortholog for FAM3C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM3C Gene

ENSEMBL:
Gene Tree for FAM3C (if available)
TreeFam:
Gene Tree for FAM3C (if available)

Paralogs for FAM3C Gene

Paralogs for FAM3C Gene

(3) SIMAP similar genes for FAM3C Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FAM3C: view

Variants for FAM3C Gene

Sequence variations from dbSNP and Humsavar for FAM3C Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000024291 -- 121,372,684(+) TGTAG(C/T)AGTTC intron-variant
rs1000115553 -- 121,376,670(+) ATTTT(A/G)AATTT intron-variant
rs1000142013 -- 121,359,618(+) ACTAT(A/G)TATTA intron-variant
rs1000244679 -- 121,388,208(+) AGGTA(C/T)ACTCT intron-variant
rs1000271839 -- 121,369,890(+) TCTGA(A/G)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM3C Gene

Variant ID Type Subtype PubMed ID
esv2759558 CNV loss 17122850
nsv1034353 CNV loss 25217958
nsv7405 OTHER inversion 18451855

Variation tolerance for FAM3C Gene

Residual Variation Intolerance Score: 33.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 5.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM3C Gene

Human Gene Mutation Database (HGMD)
FAM3C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM3C Gene

Disorders for FAM3C Gene

MalaCards: The human disease database

(2) MalaCards diseases for FAM3C Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
deafness, autosomal recessive 17
  • autosomal recessive nonsyndromic deafness 17
coffin-siris syndrome 1
  • coffin-siris syndrome
- elite association - COSMIC cancer census association via MalaCards
Search FAM3C in MalaCards View complete list of genes associated with diseases

Relevant External Links for FAM3C

Genetic Association Database (GAD)
FAM3C
Human Genome Epidemiology (HuGE) Navigator
FAM3C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM3C
genes like me logo Genes that share disorders with FAM3C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM3C Gene

Publications for FAM3C Gene

  1. Cloning, expression, and initial characterization of a novel cytokine-like gene family. (PMID: 12160727) Zhu Y … Young PR (Genomics 2002) 2 3 4 22 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. (PMID: 19396169) Cho YS … Kim HL (Nature genetics 2009) 3 45 60
  4. ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells. (PMID: 16959614) Waerner T … Beug H (Cancer cell 2006) 3 4 60
  5. GG: a domain involved in phage LTF apparatus and implicated in human MEB and non-syndromic hearing loss diseases. (PMID: 16406369) Guo J … Yu L (FEBS letters 2006) 3 22 60

Products for FAM3C Gene

Sources for FAM3C Gene

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