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FAM3C Gene

protein-coding   GIFtS: 58
GCID: GC07M120988

Family With Sequence Similarity 3, Member C

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 3, Member C1 2
Interleukin-Like EMT Inducer1 2 3
Predicted Osteoblast Protein1 2
ILEI2 3
Protein FAM3C2

External Ids:    HGNC: 186641   Entrez Gene: 104472   Ensembl: ENSG000001969377   OMIM: 6086185   UniProtKB: Q925203   

Export aliases for FAM3C gene to outside databases

Previous GC identifers: GC07M119466 GC07M120529 GC07M120543 GC07M120582 GC07M120776 GC07M115352


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FAM3C Gene:
This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a
GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. (provided by
RefSeq, Mar 2010)

GeneCards Summary for FAM3C Gene:
FAM3C (family with sequence similarity 3, member C) is a protein-coding gene. Diseases associated with FAM3C include osteopoikilosis, and fuchs' endothelial dystrophy. GO annotations related to this gene include cytokine activity. An important paralog of this gene is FAM3D.

UniProtKB/Swiss-Prot: FAM3C_HUMAN, Q92520
Function: May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition

Gene Wiki entry for FAM3C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM3C gene promoter:
         NF-YA   NF-YC   HNF-3beta   CBF-C   CBF-A   CBF-B   CP1A   CP1C   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FAM3C promoter sequence
   Search Chromatin IP Primers for FAM3C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM3C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31   Ensembl cytogenetic band:  7q31.31   HGNC cytogenetic band: 7q22.1-q31.1

FAM3C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM3C gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M120988:  view genomic region     (about GC identifiers)

Start:
120,988,905 bp from pter      End:
121,036,422 bp from pter
Size:
47,518 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 120,383,656-120,431,153     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FAM3C_HUMAN, Q92520 (See protein sequence)
Recommended Name: Protein FAM3C precursor  
Size: 227 amino acids; 24680 Da
Miscellaneous: Up-regulation and/or mislocalization in breast cancer and liver carcinoma cells is strongly
correlated with metastasis formation and survival
Secondary accessions: A6NDN2 A8K3R7

Explore the universe of human proteins at neXtProt for FAM3C: NX_Q92520

Explore proteomics data for FAM3C at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM3C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001035109.1  NP_055703.1  

    ENSEMBL proteins: 
     ENSP00000353025   ENSP00000408636   ENSP00000414940  

    FAM3C Human Recombinant Protein Products:

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    Novus Biologicals FAM3C Proteins
    Novus Biologicals FAM3C Lysates
    Sino Biological Recombinant Protein for FAM3C
    Sino Biological Cell Lysate for FAM3C
    ProSpec Recombinant Protein for FAM3C
    Cloud-Clone Corp. Proteins for FAM3C

    FAM3C Antibody Products:

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    Abcam antibodies for FAM3C
    Cloud-Clone Corp. Antibodies for FAM3C
    ThermoFisher Antibody for FAM3C
    LSBio Antibodies in human, mouse, rat for FAM3C

    FAM3C Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FAM3C
    Cloud-Clone Corp. CLIAs for FAM3C


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026101 FAM3

    Graphical View of Domain Structure for InterPro Entry Q92520

    ProtoNet protein and cluster: Q92520

    UniProtKB/Swiss-Prot: FAM3C_HUMAN, Q92520
    Similarity: Belongs to the FAM3 family


    FAM3C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FAM3C_HUMAN, Q92520
    Function: May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity NAS12160727
         
    FAM3C for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FAM3C:
     Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 3 alleles(MGI details for Fam3c):
     skeleton 

    FAM3C for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Fam3ctm1.1Lex for FAM3C

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM3C
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FAM3C

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM3C
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM3C

    miRNA
    Products:
        
    miRTarBase miRNAs that target FAM3C:
    hsa-mir-34a-5p (MIRT025419), hsa-mir-375 (MIRT019826), hsa-mir-769-3p (MIRT039081), hsa-mir-92b-3p (MIRT040705), hsa-mir-93-5p (MIRT048753), hsa-mir-155-5p (MIRT020690), hsa-mir-1227-3p (MIRT036403), hsa-mir-1226-3p (MIRT036499), hsa-mir-21-5p (MIRT002420), hsa-mir-145-5p (MIRT021525), hsa-mir-342-3p (MIRT043707)

    Block miRNA regulation of human, mouse, rat FAM3C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAM3C (see all 27):
    hsa-miR-181c hsa-miR-3942-5p hsa-miR-106a hsa-miR-218 hsa-miR-500a hsa-miR-93 hsa-miR-3908 hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidFAM3C 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FAM3C
    Predesigned siRNA for gene silencing in human, mouse, rat FAM3C

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for FAM3C

    Clone
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    OriGene clones in human, mouse for FAM3C (see all 11)
    OriGene ORF clones in mouse, rat for FAM3C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FAM3C (NM_014888)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM3C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM3C

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for FAM3C
    Browse ESI BIO Cell Lines and PureStem Progenitors for FAM3C 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM3C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FAM3C_HUMAN, Q92520: Secreted (By similarity). Cytoplasmic vesicle. Note=Cytoplasmic in some cancer cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    golgi apparatus4

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS12160727
    GO:0005794Golgi apparatus IDA--
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--

    FAM3C for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM3C
    Interactions:

        Search GeneGlobe Interaction Network for FAM3C

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for FAM3C (Q925203 ENSP000003530254) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLN3Q132863I2D: score=1 
    CREB3O438893I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0008150biological_process ND--

    FAM3C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM3C



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FAM3C gene (2 alternative transcripts): 
    NM_001040020.1  NM_014888.2  

    Unigene Cluster for FAM3C:

    Family with sequence similarity 3, member C
    Hs.434053  [show with all ESTs]
    Unigene Representative Sequence: BC024200
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359943(uc003vjx.3 uc010lkm.3) ENST00000474082 ENST00000412653
    ENST00000426156 ENST00000497622
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FAM3C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAM3C (see all 27):
    hsa-miR-181c hsa-miR-3942-5p hsa-miR-106a hsa-miR-218 hsa-miR-500a hsa-miR-93 hsa-miR-3908 hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidFAM3C 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FAM3C
    Predesigned siRNA for gene silencing in human, mouse, rat FAM3C
    Clone
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    OriGene clones in human, mouse for FAM3C (see all 11)
    OriGene ORF clones in mouse, rat for FAM3C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FAM3C (NM_014888)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM3C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM3C
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM3C
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM3C
      QuantiTect SYBR Green Assays in human, mouse, rat FAM3C
      QuantiFast Probe-based Assays in human, mouse, rat FAM3C

    Additional mRNA sequence: 

    AK290682.1 AK292731.1 BC024200.1 BC046932.1 BC068526.1 D87120.1 DQ786255.1 

    15 DOTS entries:

    DT.100657632  DT.100819551  DT.92452902  DT.121116457  DT.121324334  DT.92452900  DT.447318  DT.436968 
    DT.100819552  DT.121116450  DT.121116420  DT.99964047  DT.121116442  DT.92452891  DT.95160120 

    Selected AceView cDNA sequences (see all 279):

    AA418982 BM670664 BM311956 AA730211 AW953034 Z42697 BU177095 BM722458 
    F10792 NM_014888 CB132714 AW674264 Z38281 BF430932 BU176340 AU135611 
    CB242676 N26151 AI097279 CA405456 AI283632 CA446040 BM750166 AW241945 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM3C expression in normal human tissues (normalized intensities)      FAM3C embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTATTTTGA
    FAM3C Expression
    About this image


    FAM3C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
    FAM3C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM3C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.434053

    UniProtKB/Swiss-Prot: FAM3C_HUMAN, Q92520
    Tissue specificity: Present in most secretory epithelia (at protein level)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM3C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FAM3C gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam3c1 , 5 family with sequence similarity 3, member C1, 5 88.25(n)1
    94.27(a)1
      6 (9.24 cM)5
    279991  NM_138587.41  NP_613053.31 
     223065205 
    chicken
    (Gallus gallus)
    Aves FAM3C1 family with sequence similarity 3, member C 84.43(n)
    92.07(a)
      417758  NM_001097646.1  NP_001091115.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAM3C6
    family with sequence similarity 3, member C
    89(a)
    1 ↔ 1
    5(68796322-68815630)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.294832 Xenopus laevis transcribed sequence with moderate similarity more 79.89(n)    BU900741.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.43432 Danio rerio mRNA similar to DNA segment, Chr 6, Wayne more 74.97(n)    BC044170.1 
    worm
    (Caenorhabditis elegans)
    Secernentea M70.46
    Y73B3A.36
    Protein Y73B3A.3 (Y73B3A.3) mRNA, complete cds
    8(a)
    8(a)
    many ↔ many
    many ↔ many
    IV(2253004-2263660) WBGene00019786
    X(84043-93664) WBGene00022205


    ENSEMBL Gene Tree for FAM3C (if available)
    TreeFam Gene Tree for FAM3C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM3C gene
    FAM3D2  FAM3A2  FAM3B2  
    3 SIMAP similar genes for FAM3C using alignment to 3 protein entries:     FAM3C_HUMAN (see all proteins):
    FAM3A    FAM3D    FAM3B

    FAM3C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM3C (see all 864)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs587505321,2
    C--115394187(+) GGGGG-/G/GGG 
     
    /GGGGGG
    AAGGT
    4 -- int1 cds11NA 2
    rs1929824211,2
    --120988690(+) AGCTAC/TCCTTT 2 -- ds50010--------
    rs25361841,2
    C,F,H--120988757(-) GATGTG/ATCTTA 2 -- ds500116Minor allele frequency- A:0.28NS EA NA WA CSA 1497
    rs1846122501,2
    --120988783(+) TTTAAC/GCACAG 2 -- ds50010--------
    rs760402501,2
    C,F--120988801(+) TTTTTT/CTCCAA 2 -- ds50011Minor allele frequency- C:0.03NA 120
    rs1453529731,2
    --120988837(+) AAAACA/CTTGTG 2 -- ds50010--------
    rs711702471,2
    C--120988890(-) TTTTT-/TGTATT 2 -- ds50011Minor allele frequency- T:0.00NA 2
    rs1476674701,2
    C--120989162(+) AAACAC/GTACTC 2 -- ut310--------
    rs1408615181,2
    C--120989198(+) TATCCA/GAATAG 2 -- ut310--------
    rs1176350091,2
    C,F--120989517(+) ATCAGT/CCCGCC 2 -- ut311Minor allele frequency- C:0.06EA 120

    HapMap Linkage Disequilibrium report for FAM3C (120988905 - 121036422 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FAM3C:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2132e1CNV Complex17122850
    nsv7405OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): FAM3C
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM3C
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM3C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608618    OMIM disorders: --

    12 diseases for FAM3C:    About MalaCards
    osteopoikilosis    fuchs' endothelial dystrophy    intestinal atresia    coffin-siris syndrome
    muscle eye brain disease    pancreatic cancer    brain disease    temporal lobe epilepsy
    pancreatitis    endotheliitis    retinitis    breast cancer

    3 diseases from the University of Copenhagen DISEASES database for FAM3C:
    Coffin-Siris syndrome     Osteopoikilosis     Intestinal atresia

    FAM3C for disorders           About GeneDecksing

    Genetic Association Database (GAD): FAM3C
    Human Genome Epidemiology (HuGE) Navigator: FAM3C (2 documents)

    Export disorders for FAM3C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM3C gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with FAM3C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression, and initial characterization of a novel cytokine-like gene family. (PubMed id 12160727)1, 2, 3, 9 Zhu Y.... Young P.R. (Genomics 2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. (PubMed id 19396169)1, 4 Cho Y.S....Kim H.L. (Nat. Genet. 2009)
    4. ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells. (PubMed id 16959614)1, 2 Waerner T.... Beug H. (Cancer Cell 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    7. Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach. (PubMed id 16215274)1, 9 GrA...Pandey A. (amp 2006)
    8. GG: a domain involved in phage LTF apparatus and implicated in human MEB and non-syndromic hearing loss diseases. (PubMed id 16406369)1, 9 Guo J....Yu L. (FEBS Lett. 2006)
    9. A follow-up association study of two genetic variants for bone mineral density variation in Caucasians. (PubMed id 22159821)1 Zhang L.S....Deng H.W. (Osteoporos Int 2012)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10447 HGNC: 18664 AceView: FAM3C Ensembl:ENSG00000196937 euGenes: HUgn10447
    ECgene: FAM3C H-InvDB: FAM3C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FAM3C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM3C gene:
    Search GeneIP for patents involving FAM3C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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