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Aliases for FAM3C Gene

Aliases for FAM3C Gene

  • Family With Sequence Similarity 3, Member C 2 3
  • Interleukin-Like EMT Inducer 2 3 4
  • Interleukin-Like Epithelial-Mesenchymal Transition Inducer 2 3
  • Predicted Osteoblast Protein 2 3
  • ILEI 3 4
  • Protein FAM3C 3
  • GS3786 3

External Ids for FAM3C Gene

Previous GeneCards Identifiers for FAM3C Gene

  • GC07M119466
  • GC07M120529
  • GC07M120543
  • GC07M120582
  • GC07M120776
  • GC07M120988
  • GC07M115352

Summaries for FAM3C Gene

Entrez Gene Summary for FAM3C Gene

  • This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. [provided by RefSeq, Mar 2010]

GeneCards Summary for FAM3C Gene

FAM3C (Family With Sequence Similarity 3, Member C) is a Protein Coding gene. Diseases associated with FAM3C include intestinal atresia and coffin-siris syndrome. GO annotations related to this gene include cytokine activity. An important paralog of this gene is FAM3B.

UniProtKB/Swiss-Prot for FAM3C Gene

  • May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition

Gene Wiki entry for FAM3C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM3C Gene

Genomics for FAM3C Gene

Regulatory Elements for FAM3C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM3C Gene

Start:
121,348,851 bp from pter
End:
121,396,368 bp from pter
Size:
47,518 bases
Orientation:
Minus strand

Genomic View for FAM3C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM3C Gene

Proteins for FAM3C Gene

  • Protein details for FAM3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92520-FAM3C_HUMAN
    Recommended name:
    Protein FAM3C
    Protein Accession:
    Q92520
    Secondary Accessions:
    • A6NDN2
    • A8K3R7

    Protein attributes for FAM3C Gene

    Size:
    227 amino acids
    Molecular mass:
    24680 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Up-regulation and/or mislocalization in breast cancer and liver carcinoma cells is strongly correlated with metastasis formation and survival

neXtProt entry for FAM3C Gene

Proteomics data for FAM3C Gene at MOPED

Post-translational modifications for FAM3C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM3C Gene

Antibody Products

No data available for DME Specific Peptides for FAM3C Gene

Domains for FAM3C Gene

Protein Domains for FAM3C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM3C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92520

UniProtKB/Swiss-Prot:

FAM3C_HUMAN :
  • Q92520
Family:
  • Belongs to the FAM3 family.
genes like me logo Genes that share domains with FAM3C: view

No data available for Gene Families for FAM3C Gene

Function for FAM3C Gene

Molecular function for FAM3C Gene

UniProtKB/Swiss-Prot Function:
May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition

Gene Ontology (GO) - Molecular Function for FAM3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity NAS 12160727
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM3C: view

Phenotypes for FAM3C Gene

MGI mutant phenotypes for FAM3C:
inferred from 3 alleles
GenomeRNAi human phenotypes for FAM3C:
genes like me logo Genes that share phenotypes with FAM3C: view

Animal Models for FAM3C Gene

MGI Knock Outs for FAM3C:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM3C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FAM3C Gene

Localization for FAM3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM3C Gene

Secreted. Cytoplasmic vesicle. Note=Cytoplasmic in some cancer cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM3C Gene COMPARTMENTS Subcellular localization image for FAM3C gene
Compartment Confidence
extracellular 5
golgi apparatus 4

Gene Ontology (GO) - Cellular Components for FAM3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 12160727
GO:0005794 Golgi apparatus IDA --
GO:0016023 cytoplasmic membrane-bounded vesicle IEA --
GO:0031410 cytoplasmic vesicle --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FAM3C: view

Pathways for FAM3C Gene

SuperPathways for FAM3C Gene

No Data Available

Interacting Proteins for FAM3C Gene

Gene Ontology (GO) - Biological Process for FAM3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with FAM3C: view

No data available for Pathways by source for FAM3C Gene

Transcripts for FAM3C Gene

Unigene Clusters for FAM3C Gene

Family with sequence similarity 3, member C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM3C

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM3C Gene

No ASD Table

Relevant External Links for FAM3C Gene

GeneLoc Exon Structure for
FAM3C
ECgene alternative splicing isoforms for
FAM3C

Expression for FAM3C Gene

mRNA expression in normal human tissues for FAM3C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for FAM3C Gene

This gene is overexpressed in Bone (38.8) and Cerebrospinal fluid (9.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM3C Gene

SOURCE GeneReport for Unigene cluster for FAM3C Gene Hs.434053

mRNA Expression by UniProt/SwissProt for FAM3C Gene

Q92520-FAM3C_HUMAN
Tissue specificity: Present in most secretory epithelia (at protein level).
genes like me logo Genes that share expressions with FAM3C: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for FAM3C Gene

Orthologs for FAM3C Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM3C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM3C 35
  • 93.83 (n)
  • 95.15 (a)
FAM3C 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM3C 35
  • 94.27 (n)
  • 98.68 (a)
FAM3C 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam3c 35
  • 88.25 (n)
  • 94.27 (a)
Fam3c 16
Fam3c 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM3C 35
  • 99.71 (n)
  • 99.56 (a)
FAM3C 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam3c 35
  • 86.64 (n)
  • 94.27 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM3C 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM3C 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM3C 35
  • 84.43 (n)
  • 92.07 (a)
FAM3C 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM3C 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam3c 35
  • 78.67 (n)
  • 80.44 (a)
Str.17429 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.29483 35
zebrafish
(Danio rerio)
Actinopterygii Dr.4343 35
fam3c 35
  • 65.56 (n)
  • 66.82 (a)
fam3c 36
  • 66 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea M70.4 36
  • 8 (a)
ManyToMany
Y73B3A.3 36
  • 8 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.67 36
  • 32 (a)
OneToMany
Species with no ortholog for FAM3C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM3C Gene

ENSEMBL:
Gene Tree for FAM3C (if available)
TreeFam:
Gene Tree for FAM3C (if available)

Paralogs for FAM3C Gene

Paralogs for FAM3C Gene

Selected SIMAP similar genes for FAM3C Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FAM3C: view

Variants for FAM3C Gene

Sequence variations from dbSNP and Humsavar for FAM3C Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs15426 -- 121,350,068(-) CTTTT(A/T)TGTTT utr-variant-3-prime
rs718766 -- 121,385,448(+) GACAA(C/T)GAAAC intron-variant
rs917726 -- 121,378,803(-) GATTA(A/T)TATAT intron-variant
rs917727 -- 121,378,525(-) GTCAC(A/G)GTAAT intron-variant
rs997782 -- 121,354,046(+) TTGGT(G/T)GATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM3C Gene

Variant ID Type Subtype PubMed ID
nsv7405 OTHER Inversion 18451855
dgv2132e1 CNV Complex 17122850

Relevant External Links for FAM3C Gene

HapMap Linkage Disequilibrium report
FAM3C
Human Gene Mutation Database (HGMD)
FAM3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM3C Gene

Disorders for FAM3C Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for FAM3C Gene in MalaCards »

(3) Diseases for FAM3C Gene including...

(3) University of Copenhagen DISEASES for FAM3C Gene

Relevant External Links for FAM3C

Genetic Association Database (GAD)
FAM3C
Human Genome Epidemiology (HuGE) Navigator
FAM3C
genes like me logo Genes that share disorders with FAM3C: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for FAM3C Gene

Publications for FAM3C Gene

  1. Cloning, expression, and initial characterization of a novel cytokine-like gene family. (PMID: 12160727) Zhu Y. … Young P.R. (Genomics 2002) 2 3 4 23
  2. Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach. (PMID: 16215274) GrA … Pandey A. (Mol. Cell Proteomics 2006) 3 23
  3. GG: a domain involved in phage LTF apparatus and implicated in human MEB and non-syndromic hearing loss diseases. (PMID: 16406369) Guo J. … Yu L. (FEBS Lett. 2006) 3 23
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for FAM3C Gene

Sources for FAM3C Gene

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