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Aliases for FAM3B Gene

Aliases for FAM3B Gene

  • Family With Sequence Similarity 3 Member B 2 3 5
  • Cytokine-Like Protein 2-21 3 4
  • Pancreatic-Derived Factor 2 4
  • C21orf11 3 4
  • C21orf76 3 4
  • PANDER 3 4
  • Family With Sequence Similarity 3, Member B 2
  • Chromosome 21 Open Reading Frame 11 2
  • Pancreatic Derived Factor 3
  • Protein FAM3B 3
  • D21M16SJHU19e 3
  • PRED44 3
  • 2-21 3
  • ORF9 3

External Ids for FAM3B Gene

Previous HGNC Symbols for FAM3B Gene

  • C21orf11

Previous GeneCards Identifiers for FAM3B Gene

  • GC21P039262
  • GC21P041609
  • GC21P041596
  • GC21P041610
  • GC21P042676
  • GC21P028157

Summaries for FAM3B Gene

GeneCards Summary for FAM3B Gene

FAM3B (Family With Sequence Similarity 3 Member B) is a Protein Coding gene. Diseases associated with FAM3B include Reticulate Acropigmentation Of Kitamura and Voyeurism. GO annotations related to this gene include cytokine activity. An important paralog of this gene is FAM3C.

UniProtKB/Swiss-Prot for FAM3B Gene

  • Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.

Gene Wiki entry for FAM3B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM3B Gene

Genomics for FAM3B Gene

Regulatory Elements for FAM3B Gene

Enhancers for FAM3B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21G041316 1 Ensembl ENCODE 53.3 +12.9 12916 2.1 CTCF SUZ12 YBX1 RBBP5 ZBTB7B RAD21 CTBP1 SCRT2 NFE2 EZH2 FAM3B MX2 MX1 GC21P041316 GC21P041320 PIR47206
GH21G041320 1.2 FANTOM5 ENCODE 41 +18.4 18364 3.9 FOXA2 MLX ARID4B DMAP1 ZNF48 SP5 MIER2 PPARG KAT8 MIER3 FAM3B GC21P041320 PIR47206 MX2
GH21G041318 0.7 ENCODE 42.6 +15.1 15089 1.0 ZNF473 ZNF266 ZNF175 BMI1 SALL2 YBX1 ZNF791 ZNF239 ZNF169 ZNF680 FAM3B PRDM15 MX2 GC21P041316 GC21P041320 PIR47206
GH21G041325 0.7 ENCODE 34.2 +21.9 21883 1.9 SOX13 FOXA2 ZFP64 TAL1 EBF1 ZNF644 ZFHX2 NCOR1 EGR2 SOX5 FAM3B TMPRSS2 PIR47206 GC21P041320 MX2
GH21G041496 1.7 FANTOM5 ENCODE dbSUPER 8.7 +199.6 199582 14.6 CREB3L1 MLX AGO1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC ZNF610 PRDM15 MX2 TMPRSS2 ENSG00000207503 FAM3B ABCG1 GC21P041463
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM3B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM3B Gene

Chromosome:
21
Start:
41,304,212 bp from pter
End:
41,357,727 bp from pter
Size:
53,516 bases
Orientation:
Plus strand

Genomic View for FAM3B Gene

Genes around FAM3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM3B Gene

Proteins for FAM3B Gene

  • Protein details for FAM3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58499-FAM3B_HUMAN
    Recommended name:
    Protein FAM3B
    Protein Accession:
    P58499

    Protein attributes for FAM3B Gene

    Size:
    235 amino acids
    Molecular mass:
    25982 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM3B Gene

Post-translational modifications for FAM3B Gene

  • 2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage, the second at Ser-46.
  • O-glycosylated.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM3B Gene

Antibody Products

  • Abcam antibodies for FAM3B
  • Santa Cruz Biotechnology (SCBT) Antibodies for FAM3B

Protein Products

  • Abcam proteins for FAM3B

No data available for DME Specific Peptides for FAM3B Gene

Domains & Families for FAM3B Gene

Protein Domains for FAM3B Gene

ProtoNet:

Suggested Antigen Peptide Sequences for FAM3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P58499

UniProtKB/Swiss-Prot:

FAM3B_HUMAN :
  • Belongs to the FAM3 family.
Family:
  • Belongs to the FAM3 family.
genes like me logo Genes that share domains with FAM3B: view

No data available for Gene Families for FAM3B Gene

Function for FAM3B Gene

Molecular function for FAM3B Gene

UniProtKB/Swiss-Prot Function:
Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.

Gene Ontology (GO) - Molecular Function for FAM3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity NAS 12160727
genes like me logo Genes that share ontologies with FAM3B: view
genes like me logo Genes that share phenotypes with FAM3B: view

Animal Models for FAM3B Gene

MGI Knock Outs for FAM3B:

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM3B

CRISPR Products

miRNA for FAM3B Gene

miRTarBase miRNAs that target FAM3B

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM3B Gene

Localization for FAM3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM3B Gene

Secreted. Note=Present in insulin secretory granules and likely cosecreted with insulin. Localized in discrete vesicular and perinuclear structure.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM3B gene
Compartment Confidence
extracellular 5
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FAM3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 12160727
GO:0005615 extracellular space IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with FAM3B: view

Pathways & Interactions for FAM3B Gene

SuperPathways for FAM3B Gene

No Data Available

Interacting Proteins for FAM3B Gene

Selected Interacting proteins: P58499-FAM3B_HUMAN for FAM3B Gene via IID

Gene Ontology (GO) - Biological Process for FAM3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0030073 insulin secretion IDA 12160727
genes like me logo Genes that share ontologies with FAM3B: view

No data available for Pathways by source and SIGNOR curated interactions for FAM3B Gene

Drugs & Compounds for FAM3B Gene

No Compound Related Data Available

Transcripts for FAM3B Gene

Unigene Clusters for FAM3B Gene

Family with sequence similarity 3, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM3B Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for FAM3B Gene

GeneLoc Exon Structure for
FAM3B
ECgene alternative splicing isoforms for
FAM3B

Expression for FAM3B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM3B Gene

This gene is overexpressed in Pancreas (x15.4), Stomach (x6.2), Small Intestine - Terminal Ileum (x6.1), Esophagus - Mucosa (x4.8), Minor Salivary Gland (x4.7), and Bladder (x4.6).

Protein differential expression in normal tissues from HIPED for FAM3B Gene

This gene is overexpressed in Oral epithelium (26.4), Milk (10.7), Pancreatic juice (6.3), and Salivary gland (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM3B Gene



NURSA nuclear receptor signaling pathways regulating expression of FAM3B Gene:

FAM3B

SOURCE GeneReport for Unigene cluster for FAM3B Gene:

Hs.473877

mRNA Expression by UniProt/SwissProt for FAM3B Gene:

P58499-FAM3B_HUMAN
Tissue specificity: Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis.

Evidence on tissue expression from TISSUES for FAM3B Gene

  • Pancreas(3.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with FAM3B: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM3B Gene

Orthologs for FAM3B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM3B 34 35
  • 99.57 (n)
cow
(Bos Taurus)
Mammalia FAM3B 34 35
  • 82.76 (n)
dog
(Canis familiaris)
Mammalia FAM3B 34 35
  • 79.89 (n)
mouse
(Mus musculus)
Mammalia Fam3b 34 16 35
  • 79.02 (n)
rat
(Rattus norvegicus)
Mammalia Fam3b 34
  • 77.07 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM3B 35
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM3B 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM3B 34 35
  • 67.7 (n)
lizard
(Anolis carolinensis)
Reptilia FAM3B 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam3b 34
  • 58.7 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-67f1.2 35
  • 21 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea M70.4 35
  • 8 (a)
ManyToMany
Y73B3A.3 35
  • 8 (a)
ManyToMany
Species where no ortholog for FAM3B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM3B Gene

ENSEMBL:
Gene Tree for FAM3B (if available)
TreeFam:
Gene Tree for FAM3B (if available)

Paralogs for FAM3B Gene

Paralogs for FAM3B Gene

(3) SIMAP similar genes for FAM3B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM3B: view

Variants for FAM3B Gene

Sequence variations from dbSNP and Humsavar for FAM3B Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1000000431 -- 41,321,285(+) CTGGA(A/G)GGAAG intron-variant
rs1000111401 -- 41,344,319(+) ATGGG(A/G)GTGGC intron-variant
rs1000353278 -- 41,349,799(+) CGGAG(G/T)CCCGG intron-variant
rs1000417134 -- 41,343,981(+) CTGTT(A/C/G)TAGTG intron-variant
rs1000437671 -- 41,304,077(+) AAGGG(A/G)AGATG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM3B Gene

Variant ID Type Subtype PubMed ID
esv2723486 CNV deletion 23290073
esv274983 CNV loss 21479260
esv3647058 CNV loss 21293372
esv3647059 CNV loss 21293372
esv3647060 CNV gain 21293372
esv3647061 CNV gain 21293372
nsv1057981 CNV loss 25217958
nsv834102 CNV loss 17160897

Variation tolerance for FAM3B Gene

Residual Variation Intolerance Score: 78.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.58; 56.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM3B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM3B Gene

Disorders for FAM3B Gene

MalaCards: The human disease database

(2) MalaCards diseases for FAM3B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
reticulate acropigmentation of kitamura
  • rapk
voyeurism
- elite association - COSMIC cancer census association via MalaCards
Search FAM3B in MalaCards View complete list of genes associated with diseases

Relevant External Links for FAM3B

Genetic Association Database (GAD)
FAM3B
Human Genome Epidemiology (HuGE) Navigator
FAM3B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM3B
genes like me logo Genes that share disorders with FAM3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM3B Gene

Publications for FAM3B Gene

  1. Structure-function studies of PANDER, an islet specific cytokine inducing cell death of insulin-secreting beta cells. (PMID: 16114871) Yang J. … Wolf B.A. (Biochemistry 2005) 3 4 22 64
  2. Cloning, expression, and initial characterization of a novel cytokine-like gene family. (PMID: 12160727) Zhu Y. … Young P.R. (Genomics 2002) 3 4 22 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for FAM3B Gene

Sources for FAM3B Gene

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