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FAM3B Gene

protein-coding   GIFtS: 53
GCID: GC21P042676

Family With Sequence Similarity 3, Member B

(Previous name: chromosome 21 open reading frame 11)
(Previous symbol: C21orf11)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Family With Sequence Similarity 3, Member B1 2     Chromosome 21 Open Reading Frame 111
C21orf111 2 3     2-212
Cytokine-Like Protein 2-212 3     D21M16SJHU19e2
Pancreatic-Derived Factor2 3     ORF92
C21orf762 3     Pancreatic Derived Factor2
PANDER2 3     Protein FAM3B2

External Ids:    HGNC: 12531   Entrez Gene: 540972   Ensembl: ENSG000001838447   OMIM: 6086175   UniProtKB: P584993   
ORGUL members:         

Export aliases for FAM3B gene to outside databases

Previous GC identifers: GC21P039262 GC21P041609 GC21P041596 GC21P041610 GC21P028157


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM3B Gene:
FAM3B (family with sequence similarity 3, member B) is a protein-coding gene. Diseases associated with FAM3B include chickenpox, and muscle eye brain disease. GO annotations related to this gene include cytokine activity. An important paralog of this gene is FAM3D.

UniProtKB/Swiss-Prot: FAM3B_HUMAN, P58499
Function: Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner

Gene Wiki entry for FAM3B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000021.9  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM3B gene promoter:
         CREB   STAT1   deltaCREB   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM3B promoter sequence
   Search Chromatin IP Primers for FAM3B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3

FAM3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM3B gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21P042676:  view genomic region     (about GC identifiers)

Start:
42,676,139 bp from pter      End:
42,729,654 bp from pter
Size:
53,516 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FAM3B_HUMAN, P58499 (See protein sequence)
Recommended Name: Protein FAM3B precursor  
Size: 235 amino acids; 25982 Da
Alternative splicing: 3 isoforms:  P58499-1   P58499-2   P58499-3   

Explore the universe of human proteins at neXtProt for FAM3B: NX_P58499

Explore proteomics data for FAM3B at MOPED

Post-translational modifications: 

  • 2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage,
    the second at Ser-461
  • O-glycosylated (By similarity)1
  • Glycosylation2 at Asn120, Asn208
  • Modification sites at PhosphoSitePlus

  • See FAM3B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_478066.3  NP_996847.1  

    ENSEMBL proteins: 
     ENSP00000350673   ENSP00000381646   ENSP00000381642   ENSP00000381641  

    FAM3B Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals FAM3B Proteins
    Novus Biologicals FAM3B Lysates
    Sino Biological Recombinant Protein for FAM3B
    Sino Biological Cell Lysate for FAM3B
    ProSpec Recombinant Protein for FAM3B
    Cloud-Clone Corp. Proteins for FAM3B

    FAM3B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for FAM3B
    Cloud-Clone Corp. Antibodies for FAM3B
    Search ThermoFisher Antibodies for FAM3B
    LSBio Antibodies in human, mouse, rat for FAM3B

    FAM3B Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FAM3B
    Cloud-Clone Corp. CLIAs for FAM3B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026101 FAM3

    Graphical View of Domain Structure for InterPro Entry P58499

    ProtoNet protein and cluster: P58499

    UniProtKB/Swiss-Prot: FAM3B_HUMAN, P58499
    Similarity: Belongs to the FAM3 family


    FAM3B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FAM3B_HUMAN, P58499
    Function: Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity NAS12160727
         
    FAM3B for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fam3b):
     endocrine/exocrine gland  homeostasis/metabolism 

    FAM3B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Fam3btm1Bkht for FAM3B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM3B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FAM3B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM3B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM3B

    miRNA
    Products:
        
    miRTarBase miRNAs that target FAM3B:
    hsa-mir-335-5p (MIRT019077)

    Block miRNA regulation of human, mouse, rat FAM3B using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate FAM3B
    SwitchGear 3'UTR luciferase reporter plasmidFAM3B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FAM3B
    Predesigned siRNA for gene silencing in human, mouse, rat FAM3B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FAM3B

    Clone
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    OriGene clones in human, mouse for FAM3B (see all 10)
    OriGene ORF clones in mouse, rat for FAM3B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FAM3B (NM_206964)
    Sino Biological Human cDNA Clone for FAM3B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM3B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM3B

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for FAM3B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM3B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FAM3B_HUMAN, P58499: Secreted. Note=Present in insulin secretory granules and likely cosecreted with insulin.
    Localized in discrete vesicular and perinuclear structure
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS12160727
    GO:0005615extracellular space IEA--
    GO:0070062extracellular vesicular exosome IDA19199708

    FAM3B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including FAM3B: 
              Common Cytokines in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FAM3B

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0030073insulin secretion IDA12160727

    FAM3B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM3B



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FAM3B gene (2 alternative transcripts): 
    NM_058186.3  NM_206964.1  

    Unigene Cluster for FAM3B:

    Family with sequence similarity 3, member B
    Hs.473877  [show with all ESTs]
    Unigene Representative Sequence: BC036314
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000479810(uc002yza.2) ENST00000518236(uc011aeq.2) ENST00000357985(uc002yzb.1 uc002yzc.1)
    ENST00000398652 ENST00000398647 ENST00000398646
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FAM3B using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate FAM3B
    SwitchGear 3'UTR luciferase reporter plasmidFAM3B 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for FAM3B
    Predesigned siRNA for gene silencing in human, mouse, rat FAM3B
    Clone
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    OriGene clones in human, mouse for FAM3B (see all 10)
    OriGene ORF clones in mouse, rat for FAM3B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FAM3B (NM_206964)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM3B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM3B
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM3B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM3B
      QuantiTect SYBR Green Assays in human, mouse, rat FAM3B
      QuantiFast Probe-based Assays in human, mouse, rat FAM3B

    Additional mRNA sequence: 

    AF375989.1 AF494379.1 AJ409094.1 AK125528.1 AK302095.1 AY040086.1 AY358459.1 BC036314.1 
    BC057829.1 

    6 DOTS entries:

    DT.100754154  DT.100754153  DT.91788643  DT.312108  DT.91815058  DT.91991259 

    Selected AceView cDNA sequences (see all 72):

    CA309683 BU784728 AW183920 BX398745 BU784784 BM817844 AA515600 AI186263 
    BM854693 BU786456 CR590284 BG654551 CR626702 CR614130 AJ409094 BE468170 
    AA705037 NM_058186 NM_206964 AA402000 BX109048 AW072419 AF494379 BI712971 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FAM3B    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
    SP1:              -                             -                                       
    SP2:              -     -                       -                                       
    SP3:                                            -                                       
    SP4:                                                                                    


    ECgene alternative splicing isoforms for FAM3B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM3B expression in normal human tissues (normalized intensities)      FAM3B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTCAGGT
    FAM3B Expression
    About this image


    FAM3B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Testis (Reproductive System)
             Spermatid Seminiferous Tubules
     
     Gonad
             Spermatid Seminiferous Tubules
     
     Stomach (Gastrointestinal Tract)
    FAM3B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM3B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.473877

    UniProtKB/Swiss-Prot: FAM3B_HUMAN, P58499
    Tissue specificity: Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine
    and testis

        Pathway & Disease-focused RT2 Profiler PCR Array including FAM3B: 
              Common Cytokines in human mouse rat

    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM3B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM3B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FAM3B gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam3b1 , 5 family with sequence similarity 3, member B1, 5 79.02(n)1
    79.31(a)1
      16 (57.47 cM)5
    527931  NM_020622.21  NP_065647.11 
     974710505 
    chicken
    (Gallus gallus)
    Aves FAM3B1 family with sequence similarity 3, member B 67.7(n)
    64(a)
      418527  XM_416736.3  XP_416736.2 
    lizard
    (Anolis carolinensis)
    Reptilia FAM3B6
    family with sequence similarity 3, member B
    58(a)
    1 ↔ 1
    3(138500582-138514812)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fam3b1 family with sequence similarity 3, member B 58.7(n)
    50.43(a)
      548744  NM_001015990.2  NP_001015990.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkeyp-67f1.26
    si:dkeyp-67f1.2
    21(a)
    many ↔ many
    6(46257877-46274280) ENSDARG00000091625
    worm
    (Caenorhabditis elegans)
    Secernentea M70.46
    Y73B3A.36
    Protein Y73B3A.3 (Y73B3A.3) mRNA, complete cds
    8(a)
    8(a)
    many ↔ many
    many ↔ many
    IV(2253004-2263660) WBGene00019786
    X(84043-93664) WBGene00022205


    ENSEMBL Gene Tree for FAM3B (if available)
    TreeFam Gene Tree for FAM3B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM3B gene
    FAM3D2  FAM3C2  FAM3A2  
    3 SIMAP similar genes for FAM3B using alignment to 2 protein entries:     FAM3B_HUMAN (see all proteins):
    FAM3C    FAM3A    FAM3D

    FAM3B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM3B (see all 902)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs665131291,2
    C--28188933(-) CATTA-/AGATTT
            
    AGAGG
    2 -- int11Minor allele frequency- AGATTT:0.00NA 2
    rs346151451,2
    C--42686690(+) CTATT-/AAAAAA 2 -- us2k11Minor allele frequency- A:0.00CSA 2
    rs28984481,2
    C--42686701(+) AAAAAA/GAGAGA 2 -- us2k1 trp30--------
    rs1162122101,2
    F--42686772(+) GATTAT/CAAAAT 2 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1394824341,2
    --42686779(+) AAATTA/GTGCAG 2 -- us2k10--------
    rs1816079711,2
    --42686803(+) TATGGC/TGATTC 2 -- us2k10--------
    rs1496575771,2
    --42686834(+) ATTATC/TGTATG 2 -- us2k10--------
    rs791778141,2
    C--42686835(+) TTATCG/ATATGA 2 -- us2k13Minor allele frequency- A:0.20CSA WA 121
    rs1454197671,2
    --42686916(+) CCCATA/GTTCAT 2 -- us2k10--------
    rs99850791,2
    C,F,A,H--42687136(+) TGATTG/CCGCTT 2 -- us2k128Minor allele frequency- C:0.45NS EA NA WA CSA 2774

    HapMap Linkage Disequilibrium report for FAM3B (42676139 - 42729654 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FAM3B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2723486CNV Deletion23290073
    esv274983CNV Loss21479260
    nsv834102CNV Loss17160897
    nsv913757CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM3B
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM3B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608617    OMIM disorders: --

    8 diseases for FAM3B:    About MalaCards
    chickenpox    muscle eye brain disease    herpes zoster    brain disease
    pancreatitis    hepatitis b    hepatitis    prostatitis


    FAM3B for disorders           About GeneDecksing

    Genetic Association Database (GAD): FAM3B
    Human Genome Epidemiology (HuGE) Navigator: FAM3B (2 documents)

    Export disorders for FAM3B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM3B gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with FAM3B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression, and initial characterization of a novel cytokine-like gene family. (PubMed id 12160727)1, 2, 9 Zhu Y.... Young P.R. (Genomics 2002)
    2. Structure-function studies of PANDER, an islet specific cytokine inducing cell death of insulin-secreting beta cells. (PubMed id 16114871)1, 2, 9 Yang J.... Wolf B.A. (Biochemistry 2005)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. (PubMed id 11707072)1, 2 Reymond A....Antonarakis S.E. (Genomics 2001)
    7. A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and I+ fetoprotein and their associations with cancer risk. (PubMed id 23300138)1 He M....Wu T. (Gut 2014)
    8. Knockdown of FAM3B triggers cell apoptosis through p53-dependent pathway. (PubMed id 23246487)1 Mou H....Le Y. (amp 2013)
    9. A non-secretory form of FAM3B promotes invasion and metastasis of human colon cancer cells by upregulating Slug expression. (PubMed id 23059759)1 Li Z....Le Y. (Cancer Lett. 2013)
    10. Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies. (PubMed id 23903356)1 Hayes M.G....Lowe W.L. (Diabetes 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54097 HGNC: 1253 AceView: FAM3B Ensembl:ENSG00000183844 euGenes: HUgn54097
    ECgene: FAM3B H-InvDB: FAM3B

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM3B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM3B gene:
    Search GeneIP for patents involving FAM3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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