Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM3B Gene

protein-coding   GIFtS: 51
GCID: GC21P042676

Family With Sequence Similarity 3, Member B

(Previous name: chromosome 21 open reading frame 11)
(Previous symbol: C21orf11)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Family With Sequence Similarity 3, Member B1 2     Chromosome 21 Open Reading Frame 111
C21orf111 2 3     2-212
Cytokine-Like Protein 2-212 3     D21M16SJHU19e2
Pancreatic-Derived Factor2 3     ORF92
C21orf762 3     Pancreatic Derived Factor2
PANDER2 3     Protein FAM3B2

External Ids:    HGNC: 12531   Entrez Gene: 540972   Ensembl: ENSG000001838447   OMIM: 6086175   UniProtKB: P584993   

Export aliases for FAM3B gene to outside databases

Previous GC identifers: GC21P039262 GC21P041609 GC21P041596 GC21P041610 GC21P028157


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM3B Gene: 
FAM3B (family with sequence similarity 3, member B) is a protein-coding gene. Diseases associated with FAM3B include chickenpox, and herpes zoster. GO annotations related to this gene include cytokine activity. An important paralog of this gene is FAM3D.

UniProtKB/Swiss-Prot: FAM3B_HUMAN, P58499
Function: Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner

Gene Wiki entry for FAM3B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.2  NT_011512.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM3B gene promoter:
         CREB   STAT1   deltaCREB   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM3B promoter sequence
   Search SABiosciences Chromatin IP Primers for FAM3B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3

FAM3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM3B gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21P042676:  view genomic region     (about GC identifiers)

Start:
42,676,139 bp from pter      End:
42,729,654 bp from pter
Size:
53,516 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FAM3B_HUMAN, P58499 (See protein sequence)
Recommended Name: Protein FAM3B precursor  
Size: 235 amino acids; 25982 Da
Subcellular location: Secreted. Note=Present in insulin secretory granules and likely cosecreted with insulin.
Localized in discrete vesicular and perinuclear structure
Alternative splicing: 3 isoforms:  P58499-1   P58499-2   P58499-3   

Explore the universe of human proteins at neXtProt for FAM3B: NX_P58499

Explore proteomics data for FAM3B at MOPED 

Post-translational modifications:

  • UniProtKB: 2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage,
    the second at Ser-46
  • UniProtKB: O-glycosylated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P58499

  • FAM3B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAM3B Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_478066.3  NP_996847.1  

    ENSEMBL proteins: 
     ENSP00000350673   ENSP00000381646   ENSP00000381642   ENSP00000381641  

    Human Recombinant Protein Products for FAM3B: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for FAM3B
    OriGene Protein Over-expression Lysate for FAM3B
    OriGene MassSpec for FAM3B 
    OriGene Custom Protein Services for FAM3B
    GenScript Custom Purified and Recombinant Proteins Services for FAM3B
    Novus Biologicals FAM3B Proteins
    Novus Biologicals FAM3B Lysates
    Sino Biological Recombinant Protein for FAM3B
    Sino Biological Cell Lysate for FAM3B 
    ProSpec Recombinant Protein for FAM3B
    Cloud-Clone Corp. Proteins for FAM3B 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS12160727
    GO:0005615extracellular space IEA--

    FAM3B for ontologies           About GeneDecksing



    FAM3B Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for FAM3B
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FAM3B
    GenScript Custom Superior Antibodies Services for FAM3B
    Novus Biologicals FAM3B Antibodies
    Abcam antibodies for FAM3B
    Cloud-Clone Corp. Antibodies for FAM3B 
    Search ThermoFisher Antibodies for FAM3B
    LSBio Antibodies in human, mouse, rat for FAM3B 

    Assay Products for FAM3B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FAM3B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FAM3B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FAM3B 
    Cloud-Clone Corp. CLIAs for FAM3B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026101 FAM3

    Graphical View of Domain Structure for InterPro Entry P58499

    ProtoNet protein and cluster: P58499

    UniProtKB/Swiss-Prot: FAM3B_HUMAN, P58499
    Similarity: Belongs to the FAM3 family


    FAM3B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FAM3B_HUMAN, P58499
    Function: Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity NAS12160727
         
    FAM3B for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fam3b):
     endocrine/exocrine gland  homeostasis/metabolism 

    FAM3B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Fam3btm1Bkht for FAM3B

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM3B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FAM3B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM3B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM3B 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FAM3B
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate FAM3B
    SwitchGear 3'UTR luciferase reporter plasmidFAM3B 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FAM3B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM3B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FAM3B
    Sirion Biotech Customized adenovirus for overexpression of FAM3B

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for FAM3B (see all 11)
    OriGene ORF clones in mouse, rat for FAM3B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FAM3B (NM_206964)
    Sino Biological Human cDNA Clone for FAM3B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM3B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM3B
    Sirion Biotech Customized lentivirus for stable overexpression of FAM3B 
                         Customized lentivirus expression plasmids for stable overexpression of FAM3B 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FAM3B
    Search LifeMap BioReagents cell lines for FAM3B
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM3B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM3B

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0030073insulin secretion IDA12160727

    FAM3B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM3B

    Search CenterWatch for drugs/clinical trials and news about FAM3B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAM3B gene (2 alternative transcripts): 
    NM_058186.3  NM_206964.1  

    Unigene Cluster for FAM3B:

    Family with sequence similarity 3, member B
    Hs.473877  [show with all ESTs]
    Unigene Representative Sequence: BC036314
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000479810(uc002yza.2) ENST00000518236(uc011aeq.2) ENST00000357985(uc002yzb.1 uc002yzc.1)
    ENST00000398652 ENST00000398647 ENST00000398646
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FAM3B
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate FAM3B
    SwitchGear 3'UTR luciferase reporter plasmidFAM3B 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FAM3B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM3B
    Clone
    Products:
         
    OriGene clones in human, mouse for FAM3B (see all 11)
    OriGene ORF clones in mouse, rat for FAM3B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FAM3B (NM_206964)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM3B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM3B
    Sirion Biotech Customized lentivirus for stable overexpression of FAM3B 
                         Customized lentivirus expression plasmids for stable overexpression of FAM3B 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM3B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM3B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM3B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM3B

    Additional mRNA sequence: 

    AF375989.1 AF494379.1 AJ409094.1 AK125528.1 AK302095.1 AY040086.1 AY358459.1 BC036314.1 
    BC057829.1 

    6 DOTS entries:

    DT.100754154  DT.100754153  DT.91788643  DT.312108  DT.91815058  DT.91991259 

    24/72 AceView cDNA sequences (see all 72):

    BE468170 NM_206964 BM817844 CR614130 AA402000 AJ409094 AW183920 BM854693 
    CR626702 CR590284 NM_058186 BG654551 BU784728 BX398745 BU784784 AI186263 
    BU786456 AA515600 AA705037 CA309683 AY358459 R74138 BC036314 BF873682 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FAM3B    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
    SP1:              -                             -                                       
    SP2:              -     -                       -                                       
    SP3:                                            -                                       
    SP4:                                                                                    


    ECgene alternative splicing isoforms for FAM3B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAM3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTCAGGT
    FAM3B Expression
    About this image


    See FAM3B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAM3B

    SOURCE GeneReport for Unigene cluster: Hs.473877

    UniProtKB/Swiss-Prot: FAM3B_HUMAN, P58499
    Tissue specificity: Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine
    and testis

        SABiosciences Expression via Pathway-Focused PCR Array including FAM3B: 
              Common Cytokines in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM3B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM3B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM3B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM3B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM3B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FAM3B gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam3b1 , 5 family with sequence similarity 3, member B1, 5 79.02(n)1
    79.31(a)1
      16 (57.47 cM)5
    527931  NM_020622.21  NP_065647.11 
     974710505 
    chicken
    (Gallus gallus)
    Aves FAM3B1 family with sequence similarity 3, member B 67.86(n)
    64.29(a)
      418527  XM_416736.2  XP_416736.2 
    lizard
    (Anolis carolinensis)
    Reptilia FAM3B6
    Uncharacterized protein
    58(a)
    1 ↔ 1
    3(138500582-138514812)
    worm
    (Caenorhabditis elegans)
    Secernentea M70.46
    Y73B3A.36
    Protein Y73B3A.3
    8(a)
    7(a)
    many ↔ many
    many ↔ many
    IV(2253004-2263662)
    X(84043-93664)


    ENSEMBL Gene Tree for FAM3B (if available)
    TreeFam Gene Tree for FAM3B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAM3B gene
    FAM3D2  FAM3C2  FAM3A2  
    3 SIMAP similar genes for FAM3B using alignment to 2 protein entries:     FAM3B_HUMAN (see all proteins):
    FAM3C    FAM3A    FAM3D

    FAM3B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/902 SNPs in FAM3B are shown (see all 902)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs665131291,2
    C--28188933(-) CATTA-/AGATTT
            
    AGAGG
    2 -- int11Minor allele frequency- AGATTT:0.00NA 2
    rs346151451,2
    C--42686690(+) CTATT-/AAAAAA 2 -- us2k11Minor allele frequency- A:0.00CSA 2
    rs28984481,2
    C--42686701(+) AAAAAA/GAGAGA 2 -- us2k1 trp30--------
    rs1162122101,2
    F--42686772(+) GATTAT/CAAAAT 2 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1394824341,2
    --42686779(+) AAATTA/GTGCAG 2 -- us2k10--------
    rs1816079711,2
    --42686803(+) TATGGC/TGATTC 2 -- us2k10--------
    rs1496575771,2
    --42686834(+) ATTATC/TGTATG 2 -- us2k10--------
    rs791778141,2
    C--42686835(+) TTATCG/ATATGA 2 -- us2k13Minor allele frequency- A:0.20CSA WA 121
    rs1454197671,2
    --42686916(+) CCCATA/GTTCAT 2 -- us2k10--------
    rs99850791,2
    C,F,A,H--42687136(+) TGATTG/CCGCTT 2 -- us2k128Minor allele frequency- C:0.45NS EA NA WA CSA 2774

    HapMap Linkage Disequilibrium report for FAM3B (42676139 - 42729654 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FAM3B:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2723486CNV Deletion23290073
    esv274983CNV Loss21479260
    nsv834102CNV Loss17160897
    nsv913757CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM3B
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM3B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608617    OMIM disorders: --

    9 diseases for FAM3B:    About MalaCards
    chickenpox    herpes zoster    muscle eye brain disease    brain disease
    pancreatitis    hepatitis b    hepatitis    colon cancer
    prostatitis


    FAM3B for disorders           About GeneDecksing

    Genetic Association Database (GAD): FAM3B
    Human Genome Epidemiology (HuGE) Navigator: FAM3B (2 documents)

    Export disorders for FAM3B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAM3B gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with FAM3B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression, and initial characterization of a novel cytokine-like gene family. (PubMed id 12160727)1, 2, 9 Zhu Y.... Young P.R. (2002)
    2. Structure-function studies of PANDER, an islet specific cytokine inducing cell death of insulin-secreting beta cells. (PubMed id 16114871)1, 2, 9 Yang J....Wolf B.A. (2005)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. (PubMed id 11707072)1, 2 Reymond A....Antonarakis S.E. (2001)
    7. Knockdown of FAM3B triggers cell apoptosis through p53 -dependent pathway. (PubMed id 23246487)1 Mou H....Le Y. (2013)
    8. A genome wide association study of genetic loci that i nfluence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and a f etoprotein and their associations with cancer risk. (PubMed id 23300138)1 He M....Wu T. (2013)
    9. A non-secretory form of FAM3B promotes invasion and me tastasis of human colon cancer cells by upregulating Slug expression. (PubMed id 23059759)1 Li Z....Le Y. (2013)
    10. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54097 HGNC: 1253 AceView: FAM3B Ensembl:ENSG00000183844 euGenes: HUgn54097
    ECgene: FAM3B H-InvDB: FAM3B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM3B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAM3B gene:
    Search GeneIP for patents involving FAM3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for FAM3B (FAM3B)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FAM3B  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for FAM3B  
     OriGene MassSpec something-or-other for FAM3B   OriGene clones in human, mouse for FAM3B  
     OriGene qSTAR qPCR primer pairs in human, mouse for FAM3B   OriGene Purified Protein for FAM3B  
     OriGene ORF clones in mouse, rat for FAM3B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FAM3B   OriGene Custom Protein Services for FAM3B  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM3B
     QIAGEN SeqTarget long-range PCR primers for resequencing FAM3B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM3B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM3B
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM3B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM3B
     GenScript Custom Purified and Recombinant Proteins Services for FAM3B GenScript cDNA clones with any tag delivered in your preferred vector for FAM3B
     GenScript Custom Assay Services for FAM3B GenScript Custom Superior Antibodies Services for FAM3B
     GenScript Custom overexpressing Cell Line Services for FAM3B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FAM3B promoter
     Search Chromatin IP Primers for FAM3B
     RT2 qPCR Primer Assay in human, mouse, rat FAM3B
     Search GNC Networks for FAM3B
     SABiosciences PCR Arrays including human, mouse, rat FAM3B
     Search Tocris compounds for FAM3B
     Proteins and Antibodies for FAM3B
     Cell Lysates for FAM3B
     cDNA Clones for FAM3B
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FAM3B antibodies
     FAM3B proteins
     FAM3B lysates
     Antibodies for FAM3B
     See all of Abcam's Antibodies, Kits and Proteins for FAM3B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for FAM3B




     Proteins for FAM3B
     Antibodies for FAM3B
     ELISAs for FAM3B
     CLIAs for FAM3B
     Search LifeMap BioReagents cell lines for FAM3B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM3B
     SwitchGear 3'UTR luciferase reporter plasmids for FAM3B
     SwitchGear Promoter luciferase reporter plasmids for FAM3B
     Search ThermoFisher Antibodies for FAM3B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM3B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM3B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FAM3B
    Customized:
     lentivirus for stable overexpression of FAM3B
     lentivirus expression plasmids for stable overexpression of FAM3B
     adenovirus for overexpression of FAM3B
     LSBio Antibodies in human, mouse, rat for FAM3B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FAM3B gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4