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Aliases for FAM3B Gene

Aliases for FAM3B Gene

  • Family With Sequence Similarity 3 Member B 2 3 5
  • Pancreatic-Derived Factor 2 3 4
  • Family With Sequence Similarity 3, Member B 2 3
  • Cytokine-Like Protein 2-21 3 4
  • C21orf11 3 4
  • C21orf76 3 4
  • PANDER 3 4
  • Chromosome 21 Open Reading Frame 11 2
  • Pancreatic Derived Factor 3
  • D21M16SJHU19e 3
  • PRED44 3
  • 2-21 3
  • ORF9 3

External Ids for FAM3B Gene

Previous HGNC Symbols for FAM3B Gene

  • C21orf11

Previous GeneCards Identifiers for FAM3B Gene

  • GC21P039262
  • GC21P041609
  • GC21P041596
  • GC21P041610
  • GC21P042676
  • GC21P028157

Summaries for FAM3B Gene

GeneCards Summary for FAM3B Gene

FAM3B (Family With Sequence Similarity 3 Member B) is a Protein Coding gene. Diseases associated with FAM3B include Reticulate Acropigmentation Of Kitamura. GO annotations related to this gene include cytokine activity. An important paralog of this gene is FAM3D.

UniProtKB/Swiss-Prot for FAM3B Gene

  • Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.

Gene Wiki entry for FAM3B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM3B Gene

Genomics for FAM3B Gene

Regulatory Elements for FAM3B Gene

Enhancers for FAM3B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM3B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM3B Gene

41,304,212 bp from pter
41,357,727 bp from pter
53,516 bases
Plus strand

Genomic View for FAM3B Gene

Genes around FAM3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM3B Gene

Proteins for FAM3B Gene

  • Protein details for FAM3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM3B
    Protein Accession:

    Protein attributes for FAM3B Gene

    235 amino acids
    Molecular mass:
    25982 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM3B Gene


neXtProt entry for FAM3B Gene

Proteomics data for FAM3B Gene at MOPED

Post-translational modifications for FAM3B Gene

  • 2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage, the second at Ser-46.
  • O-glycosylated.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM3B Gene

Antibody Products

  • Abcam antibodies for FAM3B

No data available for DME Specific Peptides for FAM3B Gene

Domains & Families for FAM3B Gene

Protein Domains for FAM3B Gene


Suggested Antigen Peptide Sequences for FAM3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM3 family.
  • Belongs to the FAM3 family.
genes like me logo Genes that share domains with FAM3B: view

No data available for Gene Families for FAM3B Gene

Function for FAM3B Gene

Molecular function for FAM3B Gene

UniProtKB/Swiss-Prot Function:
Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.
genes like me logo Genes that share phenotypes with FAM3B: view

Animal Models for FAM3B Gene

MGI Knock Outs for FAM3B:

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM3B

miRNA for FAM3B Gene

miRTarBase miRNAs that target FAM3B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM3B Gene

Localization for FAM3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM3B Gene

Secreted. Note=Present in insulin secretory granules and likely cosecreted with insulin. Localized in discrete vesicular and perinuclear structure.

Subcellular locations from

Jensen Localization Image for FAM3B Gene COMPARTMENTS Subcellular localization image for FAM3B gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FAM3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 12160727
genes like me logo Genes that share ontologies with FAM3B: view

Pathways & Interactions for FAM3B Gene

SuperPathways for FAM3B Gene

No Data Available

Interacting Proteins for FAM3B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000350673 for FAM3B Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for FAM3B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM3B Gene

Drugs & Compounds for FAM3B Gene

No Compound Related Data Available

Transcripts for FAM3B Gene

Unigene Clusters for FAM3B Gene

Family with sequence similarity 3, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM3B Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - -
SP2: - - -
SP3: -

Relevant External Links for FAM3B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM3B Gene

mRNA expression in normal human tissues for FAM3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM3B Gene

This gene is overexpressed in Pancreas (x15.4), Stomach (x6.2), Small Intestine - Terminal Ileum (x6.1), Esophagus - Mucosa (x4.8), Minor Salivary Gland (x4.7), and Bladder (x4.6).

Protein differential expression in normal tissues from HIPED for FAM3B Gene

This gene is overexpressed in Oral epithelium (26.4), Milk (10.7), Pancreatic juice (6.3), and Salivary gland (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM3B Gene

SOURCE GeneReport for Unigene cluster for FAM3B Gene Hs.473877

mRNA Expression by UniProt/SwissProt for FAM3B Gene

Tissue specificity: Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis.
genes like me logo Genes that share expression patterns with FAM3B: view

Primer Products

No data available for Protein tissue co-expression partners for FAM3B Gene

Orthologs for FAM3B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM3B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM3B 35
  • 82.76 (n)
  • 81.9 (a)
FAM3B 36
  • 80 (a)
(Canis familiaris)
Mammalia FAM3B 35
  • 79.89 (n)
  • 73.28 (a)
FAM3B 36
  • 69 (a)
(Mus musculus)
Mammalia Fam3b 35
  • 79.02 (n)
  • 79.31 (a)
Fam3b 16
Fam3b 36
  • 77 (a)
(Pan troglodytes)
Mammalia FAM3B 35
  • 99.57 (n)
  • 99.57 (a)
FAM3B 36
  • 87 (a)
(Rattus norvegicus)
Mammalia Fam3b 35
  • 77.07 (n)
  • 75.61 (a)
(Monodelphis domestica)
Mammalia FAM3B 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia FAM3B 36
  • 73 (a)
(Gallus gallus)
Aves FAM3B 35
  • 67.7 (n)
  • 64 (a)
FAM3B 36
  • 61 (a)
(Anolis carolinensis)
Reptilia FAM3B 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam3b 35
  • 58.7 (n)
  • 50.43 (a)
(Danio rerio)
Actinopterygii si:dkeyp-67f1.2 36
  • 21 (a)
(Caenorhabditis elegans)
Secernentea M70.4 36
  • 8 (a)
Y73B3A.3 36
  • 8 (a)
Species with no ortholog for FAM3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM3B Gene

Gene Tree for FAM3B (if available)
Gene Tree for FAM3B (if available)

Paralogs for FAM3B Gene

Paralogs for FAM3B Gene

(3) SIMAP similar genes for FAM3B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM3B: view

Variants for FAM3B Gene

Sequence variations from dbSNP and Humsavar for FAM3B Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs2838012 - 41,322,943(+) TGTTC(A/G)TGGTC intron-variant, nc-transcript-variant, reference, missense
rs2253894 -- 41,338,639(+) CATCC(A/G)AGTGG intron-variant
rs367571 -- 41,334,303(+) AAAAG(G/T)CTCCA intron-variant
rs369413 -- 41,328,219(+) TCCCA(C/T)TCATG intron-variant
rs370051 -- 41,343,389(+) CAACA(A/C)CAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM3B Gene

Variant ID Type Subtype PubMed ID
nsv913757 CNV Loss 21882294
nsv834102 CNV Loss 17160897
esv2723486 CNV Deletion 23290073
esv274983 CNV Loss 21479260

Variation tolerance for FAM3B Gene

Residual Variation Intolerance Score: 78.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.58; 56.17% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FAM3B Gene

Disorders for FAM3B Gene

MalaCards: The human disease database

(1) MalaCards diseases for FAM3B Gene - From: DISEASES

Disorder Aliases PubMed IDs
reticulate acropigmentation of kitamura
  • rapk
- elite association - COSMIC cancer census association via MalaCards
Search FAM3B in MalaCards View complete list of genes associated with diseases

Relevant External Links for FAM3B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FAM3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM3B Gene

Publications for FAM3B Gene

  1. Cloning, expression, and initial characterization of a novel cytokine-like gene family. (PMID: 12160727) Zhu Y. … Young P.R. (Genomics 2002) 3 4 23 67
  2. Structure-function studies of PANDER, an islet specific cytokine inducing cell death of insulin-secreting beta cells. (PMID: 16114871) Yang J. … Wolf B.A. (Biochemistry 2005) 3 23
  3. Hepatic nutrient and hormonal regulation of the PANcreatic-DERived factor (PANDER) promoter. (PMID: 26123584) Ratliff W.A. … Burkhardt B.R. (Mol. Cell. Endocrinol. 2015) 3
  4. A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and I+ fetoprotein and their associations with cancer risk. (PMID: 23300138) He M. … Wu T. (Gut 2014) 3
  5. PANDER transgenic mice display fasting hyperglycemia and hepatic insulin resistance. (PMID: 24468680) Robert-Cooperman C.E. … Burkhardt B.R. (J. Endocrinol. 2014) 3

Products for FAM3B Gene

Sources for FAM3B Gene