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Aliases for FAM3A Gene

Aliases for FAM3A Gene

  • Family With Sequence Similarity 3 Member A 2 3 5
  • Family With Sequence Similarity 3, Member A 2 3
  • Cytokine-Like Protein 2-19 3 4
  • 2.19 3 4
  • DXS560S 3
  • XAP-7 3
  • 2-19 4
  • DLD 3

External Ids for FAM3A Gene

Previous GeneCards Identifiers for FAM3A Gene

  • GC0XM147792
  • GC0XM150115
  • GC0XM151320
  • GC0XM152202
  • GC0XM153298
  • GC0XM153387
  • GC0XM153734
  • GC0XM142310

Summaries for FAM3A Gene

Entrez Gene Summary for FAM3A Gene

  • This gene encodes a cytokine-like protein. The expression of this gene may be regulated by peroxisome proliferator-activated receptor gamma, and the encoded protein may be involved in the regulation of glucose and lipid metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for FAM3A Gene

FAM3A (Family With Sequence Similarity 3 Member A) is a Protein Coding gene. An important paralog of this gene is FAM3B.

UniProtKB/Swiss-Prot for FAM3A Gene

  • May act as a defensin against invading fungal microorganisms.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM3A Gene

Genomics for FAM3A Gene

Regulatory Elements for FAM3A Gene

Enhancers for FAM3A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM3A on UCSC Golden Path with GeneCards custom track

Promoters for FAM3A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM3A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM3A Gene

Chromosome:
X
Start:
154,506,159 bp from pter
End:
154,516,247 bp from pter
Size:
10,089 bases
Orientation:
Minus strand

Genomic View for FAM3A Gene

Genes around FAM3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM3A Gene

Proteins for FAM3A Gene

  • Protein details for FAM3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P98173-FAM3A_HUMAN
    Recommended name:
    Protein FAM3A
    Protein Accession:
    P98173
    Secondary Accessions:
    • A6QRH6
    • B2RBI7
    • B4DFI8
    • D3DWX4
    • Q5HY76
    • Q96H51

    Protein attributes for FAM3A Gene

    Size:
    230 amino acids
    Molecular mass:
    25152 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM3A Gene

Proteomics data for FAM3A Gene at MOPED

Post-translational modifications for FAM3A Gene

No Post-translational modifications

Antibody Products

  • Abcam antibodies for Fam3a

No data available for DME Specific Peptides for FAM3A Gene

Domains & Families for FAM3A Gene

Protein Domains for FAM3A Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P98173

UniProtKB/Swiss-Prot:

FAM3A_HUMAN :
  • Belongs to the FAM3 family.
Family:
  • Belongs to the FAM3 family.
genes like me logo Genes that share domains with FAM3A: view

No data available for Gene Families for FAM3A Gene

Function for FAM3A Gene

Molecular function for FAM3A Gene

UniProtKB/Swiss-Prot Function:
May act as a defensin against invading fungal microorganisms.

Phenotypes for FAM3A Gene

genes like me logo Genes that share phenotypes with FAM3A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM3A

CRISPR Products

miRNA for FAM3A Gene

miRTarBase miRNAs that target FAM3A

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM3A Gene

Localization for FAM3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM3A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM3A Gene COMPARTMENTS Subcellular localization image for FAM3A gene
Compartment Confidence
extracellular 5
nucleus 2
golgi apparatus 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FAM3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with FAM3A: view

Pathways & Interactions for FAM3A Gene

SuperPathways for FAM3A Gene

No Data Available

Interacting Proteins for FAM3A Gene

Gene Ontology (GO) - Biological Process for FAM3A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM3A Gene

Drugs & Compounds for FAM3A Gene

No Compound Related Data Available

Transcripts for FAM3A Gene

Unigene Clusters for FAM3A Gene

Family with sequence similarity 3, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM3A Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - -
SP5:
SP6: -
SP7: -
SP8:

Relevant External Links for FAM3A Gene

GeneLoc Exon Structure for
FAM3A
ECgene alternative splicing isoforms for
FAM3A

Expression for FAM3A Gene

mRNA expression in normal human tissues for FAM3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM3A Gene

This gene is overexpressed in Nasal epithelium (59.3) and Bone (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM3A Gene



SOURCE GeneReport for Unigene cluster for FAM3A Gene Hs.289108

mRNA Expression by UniProt/SwissProt for FAM3A Gene

P98173-FAM3A_HUMAN
Tissue specificity: In similar amounts in testis, pancreas, adrenal, placenta, brain, fetal brain, liver, kidney, skeletal muscle and heart.
genes like me logo Genes that share expression patterns with FAM3A: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for FAM3A Gene

Orthologs for FAM3A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM3A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM3A 35
  • 86.99 (n)
  • 89.91 (a)
FAM3A 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM3A 35
  • 89.23 (n)
  • 91.27 (a)
FAM3A 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam3a 35
  • 86.32 (n)
  • 91.27 (a)
Fam3a 16
Fam3a 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM3A 35
  • 99.63 (n)
  • 100 (a)
FAM3A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam3a 35
  • 87.37 (n)
  • 92.07 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM3A 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM3A 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM3A 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam3a 35
  • 68.29 (n)
  • 69.91 (a)
Str.6172 35
African clawed frog
(Xenopus laevis)
Amphibia fam3a-prov 35
zebrafish
(Danio rerio)
Actinopterygii fam3a 35
  • 66.07 (n)
  • 68.44 (a)
zgc73350 35
fam3a 36
  • 67 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea M70.4 36
  • 7 (a)
ManyToMany
Y73B3A.3 36
  • 7 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.67 36
  • 28 (a)
OneToMany
Species with no ortholog for FAM3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM3A Gene

ENSEMBL:
Gene Tree for FAM3A (if available)
TreeFam:
Gene Tree for FAM3A (if available)

Paralogs for FAM3A Gene

Paralogs for FAM3A Gene

Pseudogenes.org Pseudogenes for FAM3A Gene

genes like me logo Genes that share paralogs with FAM3A: view

Variants for FAM3A Gene

Sequence variations from dbSNP and Humsavar for FAM3A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1050788 - 154,506,865(-) GGCTG(C/G)CCCGA reference, missense
rs35985994 - 154,512,887(-) TGGAT(C/G/T)GTGGT intron-variant, reference, synonymous-codon, missense, utr-variant-5-prime
rs7611 -- 154,506,456(-) GTGCA(A/T)CTCTG utr-variant-3-prime
rs1009938 -- 154,507,957(+) AAAGC(A/C/G/T)TCCAG intron-variant
rs1050810 -- 154,506,395(-) CCACT(C/T)TGCAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM3A Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV Gain+Loss 17666407
esv33784 CNV Gain+Loss 17666407
nsv519042 CNV Gain 19592680
nsv508816 CNV Insertion 20534489

Variation tolerance for FAM3A Gene

Residual Variation Intolerance Score: 28.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.59% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FAM3A Gene

Disorders for FAM3A Gene

Relevant External Links for FAM3A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM3A

No disorders were found for FAM3A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM3A Gene

Publications for FAM3A Gene

  1. Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. (PMID: 8733135) Chen E.Y. … D'Urso M. (Hum. Mol. Genet. 1996) 2 3 4 67
  2. GG: a domain involved in phage LTF apparatus and implicated in human MEB and non-syndromic hearing loss diseases. (PMID: 16406369) Guo J. … Yu L. (FEBS Lett. 2006) 3 23
  3. Cloning, expression, and initial characterization of a novel cytokine-like gene family. (PMID: 12160727) Zhu Y. … Young P.R. (Genomics 2002) 3 23
  4. Construction of a transcription map of a 300 kb region around the human G6PD locus by direct cDNA selection. (PMID: 8281148) Sedlacek Z. … Poustka A. (Hum. Mol. Genet. 1993) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for FAM3A Gene

Sources for FAM3A Gene

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