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Aliases for FAM3A Gene

Aliases for FAM3A Gene

  • Family With Sequence Similarity 3 Member A 2 3 5
  • Cytokine-Like Protein 2-19 3 4
  • 2.19 3 4
  • Family With Sequence Similarity 3, Member A 2
  • Protein FAM3A 3
  • DXS560S 3
  • XAP-7 3
  • 2-19 4
  • DLD 3

External Ids for FAM3A Gene

Previous GeneCards Identifiers for FAM3A Gene

  • GC0XM147792
  • GC0XM150115
  • GC0XM151320
  • GC0XM152202
  • GC0XM153298
  • GC0XM153387
  • GC0XM153734
  • GC0XM142310

Summaries for FAM3A Gene

Entrez Gene Summary for FAM3A Gene

  • This gene encodes a cytokine-like protein. The expression of this gene may be regulated by peroxisome proliferator-activated receptor gamma, and the encoded protein may be involved in the regulation of glucose and lipid metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for FAM3A Gene

FAM3A (Family With Sequence Similarity 3 Member A) is a Protein Coding gene. An important paralog of this gene is FAM3D.

UniProtKB/Swiss-Prot for FAM3A Gene

  • May act as a defensin against invading fungal microorganisms.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM3A Gene

Genomics for FAM3A Gene

Regulatory Elements for FAM3A Gene

Enhancers for FAM3A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF154540 1.1 FANTOM5 ENCODE 68.7 -26.1 -26091 3.7 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 FOS SP5 JUNB REST FAM3A IKBKG F8A1 F8A2 GAB3 MECP2 MPP1 EMD DNASE1L1 IRAK1
GH0XF154599 0.8 Ensembl ENCODE 68 -84.6 -84641 2.0 TBP RAD21 ZNF335 GLIS2 FOS EGR2 SMARCC1 USF2 GLIS1 ZNF341 FAM3A GAB3 ENSG00000232155 CTAG1A
GH0XF154530 0.7 ENCODE 63.9 -15.3 -15323 1.7 POLR2A SUPT5H FAM3A GC0XM154533 ENSG00000261773
GH0XF154514 0.8 ENCODE 63.7 -0.4 -393 3.7 ATF1 PKNOX1 ARID4B SIN3A FEZF1 YY1 GLIS2 ELK1 KLF7 SP3 FAM3A ENSG00000261773
GH0XF154483 0.4 ENCODE 55.6 +30.4 30413 3.8 ATF1 PKNOX1 SIN3A GLIS2 ELK1 FOS SP3 SMARCA4 PBX2 GLIS1 FAM3A FAM50A EMD GDI1 ATP6AP1 CH17-340M24.3 HCFC1 GC0XM154482 UBL4A
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FAM3A on UCSC Golden Path with GeneCards custom track

Promoters for FAM3A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000483227 47 2001 ATF1 PKNOX1 SIN3A FEZF1 ZNF2 YY1 GLIS2 ELK1 KLF7 SP3

Genomic Location for FAM3A Gene

Chromosome:
X
Start:
154,506,159 bp from pter
End:
154,516,247 bp from pter
Size:
10,089 bases
Orientation:
Minus strand

Genomic View for FAM3A Gene

Genes around FAM3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM3A Gene

Proteins for FAM3A Gene

  • Protein details for FAM3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P98173-FAM3A_HUMAN
    Recommended name:
    Protein FAM3A
    Protein Accession:
    P98173
    Secondary Accessions:
    • A6QRH6
    • B2RBI7
    • B4DFI8
    • D3DWX4
    • Q5HY76
    • Q96H51

    Protein attributes for FAM3A Gene

    Size:
    230 amino acids
    Molecular mass:
    25152 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM3A Gene

Post-translational modifications for FAM3A Gene

No Post-translational modifications

No data available for DME Specific Peptides for FAM3A Gene

Domains & Families for FAM3A Gene

Protein Domains for FAM3A Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P98173

UniProtKB/Swiss-Prot:

FAM3A_HUMAN :
  • Belongs to the FAM3 family.
Family:
  • Belongs to the FAM3 family.
genes like me logo Genes that share domains with FAM3A: view

No data available for Gene Families for FAM3A Gene

Function for FAM3A Gene

Molecular function for FAM3A Gene

UniProtKB/Swiss-Prot Function:
May act as a defensin against invading fungal microorganisms.

Gene Ontology (GO) - Molecular Function for FAM3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with FAM3A: view

Phenotypes for FAM3A Gene

genes like me logo Genes that share phenotypes with FAM3A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM3A

miRNA for FAM3A Gene

miRTarBase miRNAs that target FAM3A

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM3A Gene

Localization for FAM3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM3A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM3A Gene COMPARTMENTS Subcellular localization image for FAM3A gene
Compartment Confidence
extracellular 5
nucleus 2
golgi apparatus 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FAM3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM3A: view

Pathways & Interactions for FAM3A Gene

SuperPathways for FAM3A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with FAM3A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM3A Gene

Transcripts for FAM3A Gene

Unigene Clusters for FAM3A Gene

Family with sequence similarity 3, member A:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM3A Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - -
SP5:
SP6: -
SP7: -
SP8:

Relevant External Links for FAM3A Gene

GeneLoc Exon Structure for
FAM3A
ECgene alternative splicing isoforms for
FAM3A

Expression for FAM3A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM3A Gene

This gene is overexpressed in Nasal epithelium (59.3) and Bone (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM3A Gene



NURSA nuclear receptor signaling pathways regulating expression of FAM3A Gene:

FAM3A

SOURCE GeneReport for Unigene cluster for FAM3A Gene:

Hs.289108

mRNA Expression by UniProt/SwissProt for FAM3A Gene:

P98173-FAM3A_HUMAN
Tissue specificity: In similar amounts in testis, pancreas, adrenal, placenta, brain, fetal brain, liver, kidney, skeletal muscle and heart.
genes like me logo Genes that share expression patterns with FAM3A: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for FAM3A Gene

Orthologs for FAM3A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM3A 34 35
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia FAM3A 34 35
  • 89.23 (n)
rat
(Rattus norvegicus)
Mammalia Fam3a 34
  • 87.37 (n)
cow
(Bos Taurus)
Mammalia FAM3A 34 35
  • 86.99 (n)
mouse
(Mus musculus)
Mammalia Fam3a 34 16 35
  • 86.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM3A 35
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM3A 35
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM3A 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam3a 34
  • 68.29 (n)
Str.6172 34
African clawed frog
(Xenopus laevis)
Amphibia fam3a-prov 34
zebrafish
(Danio rerio)
Actinopterygii fam3a 34 35
  • 66.07 (n)
zgc73350 34
worm
(Caenorhabditis elegans)
Secernentea M70.4 35
  • 7 (a)
ManyToMany
Y73B3A.3 35
  • 7 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.67 35
  • 28 (a)
OneToMany
Species where no ortholog for FAM3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM3A Gene

ENSEMBL:
Gene Tree for FAM3A (if available)
TreeFam:
Gene Tree for FAM3A (if available)

Paralogs for FAM3A Gene

Paralogs for FAM3A Gene

genes like me logo Genes that share paralogs with FAM3A: view

Variants for FAM3A Gene

Sequence variations from dbSNP and Humsavar for FAM3A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1050788 -- 154,506,865(-) GGCTG(C/G)CCCGA reference, missense
rs1050810 -- 154,506,395(-) CCACT(C/T)TGCAC utr-variant-3-prime
rs1050820 -- 154,506,212(-) GGCCC(A/C)CCTTC utr-variant-3-prime
rs111272818 -- 154,515,267(+) CCTGG(A/G)TATGT intron-variant
rs111420995 -- 154,508,821(+) TGGGA(G/T)AAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM3A Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV gain+loss 17666407
esv33784 CNV gain+loss 17666407
nsv508816 CNV insertion 20534489
nsv519042 CNV gain 19592680

Variation tolerance for FAM3A Gene

Residual Variation Intolerance Score: 28.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM3A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM3A Gene

Disorders for FAM3A Gene

Relevant External Links for FAM3A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM3A

No disorders were found for FAM3A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM3A Gene

Publications for FAM3A Gene

  1. Cloning, expression, and initial characterization of a novel cytokine-like gene family. (PMID: 12160727) Zhu Y. … Young P.R. (Genomics 2002) 3 4 22 64
  2. Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. (PMID: 8733135) Chen E.Y. … D'Urso M. (Hum. Mol. Genet. 1996) 2 3 4 64
  3. GG: a domain involved in phage LTF apparatus and implicated in human MEB and non-syndromic hearing loss diseases. (PMID: 16406369) Guo J. … Yu L. (FEBS Lett. 2006) 3 22 64
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for FAM3A Gene

Sources for FAM3A Gene

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