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FAM35A Gene

protein-coding   GIFtS: 39
GCID: GC10P088845

Family With Sequence Similarity 35, Member A

  Search for FAM35A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 35, Member A1 2
FAM35A12
bA163M19.12
Protein FAM35A2

External Ids:    HGNC: 287731   Entrez Gene: 545372   Ensembl: ENSG000001223767   UniProtKB: Q86V203   

Export aliases for FAM35A gene to outside databases

Previous GC identifers: GC10P088520 GC10P082753


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM35A Gene:
FAM35A (family with sequence similarity 35, member A) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM35A gene promoter:
         HOXA9B   HOXA9   ER-alpha   Elk-1   Pax-5   Pax-2   Pax-2a   ZIC2/Zic2   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM35A promoter sequence
   Search Chromatin IP Primers for FAM35A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM35A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.2   Ensembl cytogenetic band:  10q23.2   HGNC cytogenetic band: 10q23.2

FAM35A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM35A gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P088845:  view genomic region     (about GC identifiers)

Start:
88,853,918 bp from pter      End:
88,951,225 bp from pter
Size:
97,308 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FA35A_HUMAN, Q86V20 (See protein sequence)
Recommended Name: Protein FAM35A  
Size: 835 amino acids; 93705 Da
Secondary accessions: O95885 Q9H991
Alternative splicing: 2 isoforms:  Q86V20-1   Q86V20-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAM35A: NX_Q86V20

Explore proteomics data for FAM35A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM35A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061927.2  
    ENSEMBL proteins: 
     ENSP00000475647   ENSP00000298784   ENSP00000298786  

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    Cloud-Clone Corp. CLIAs for FAM35A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q86V20

    UniProtKB/Swiss-Prot: FA35A_HUMAN, Q86V20
    Similarity: Belongs to the FAM35 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM35A
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    hsa-mir-124-3p (MIRT002673)

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM35A

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM35A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    cytoskeleton1
    endoplasmic reticulum1
    mitochondrion1
    nucleus1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM35A
    Interactions:

        Search GeneGlobe Interaction Network for FAM35A

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for FAM35A (ENSP000002987844) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM35A (FA35A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FAM35A gene: 
    NM_019054.2  

    Unigene Cluster for FAM35A:

    Family with sequence similarity 35, member A
    Hs.500419  [show with all ESTs]
    Unigene Representative Sequence: NM_019054
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000437629 ENST00000298784(uc001kei.4) ENST00000298786
    miRNA
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    Primer
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    OriGene qPCR primer pairs and template standards for FAM35A
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM35A
      QuantiTect SYBR Green Assays in human, mouse, rat FAM35A
      QuantiFast Probe-based Assays in human, mouse, rat FAM35A

    Additional mRNA sequence: 

    AF131775.1 AK022978.1 AK025471.1 AK025606.1 BC051863.2 

    15 DOTS entries:

    DT.75117452  DT.414036  DT.121227649  DT.100676477  DT.121227606  DT.75137651  DT.100785622  DT.121227625 
    DT.121227292  DT.91780760  DT.100785621  DT.121227219  DT.446053  DT.91780762  DT.91780772 

    Selected AceView cDNA sequences (see all 138):

    BM997122 BU167544 AA404984 AV701696 AI476477 BM828781 BC051863 AA281828 
    AU128957 BM726755 BQ230131 AA936301 BM710900 BM806615 BQ015333 BU678649 
    AI480136 CF529247 BU854004 BM747048 AI198739 NM_019054 BX347388 BE884483 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM35A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCAATTTA
    FAM35A Expression
    About this image

    FAM35A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM35A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.500419
        Custom PCR Arrays for FAM35A
    Primer
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    OriGene qPCR primer pairs and template standards for FAM35A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM35A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FAM35A gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam35a1 , 5 family with sequence similarity 35, member A1, 5 77.04(n)1
    66.62(a)1
      14 (20.80 cM)5
    756981  NM_029389.21  NP_083665.21 
     342370415 
    chicken
    (Gallus gallus)
    Aves FAM35A1 family with sequence similarity 35, member A 58.56(n)
    45.04(a)
      423613  XM_421498.3  XP_421498.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    34(a)
    28(a)
    many → 1
    many → 1
    GL343199.1(4046915-4074805)
    AAWZ02038354(1275-2683)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004868381 protein FAM35A-like 54.75(n)
    45.01(a)
      100486838  XM_002934711.2  XP_002934757.2 
    zebrafish
    (Danio rerio)
    Actinopterygii fam35a1 family with sequence similarity 35, member A 48.92(n)
    40.73(a)
      100149820  NM_001145633.1  NP_001139105.1 


    ENSEMBL Gene Tree for FAM35A (if available)
    TreeFam Gene Tree for FAM35A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM35A gene

    FAM35A for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for FAM35A
    PGOHUM00000238772 PGOHUM00000238782 PGOHUM00000248250


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM35A (see all 1386)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1826469111,2
    --88856958(+) TATAAA/CCTTAG 1 -- int10--------
    rs1476594361,2
    --88857015(+) CACCTA/GAATTC 1 -- int10--------
    rs1865277471,2
    --88857099(+) GATCAC/GTTGAG 1 -- int10--------
    rs43090671,2
    C,F,A,H--88857179(+) caagcG/Ttggtg 1 -- int113Minor allele frequency- T:0.11NS EA NA WA 762
    rs1423493051,2
    --88857209(+) CCAGGC/TGTGGT 1 -- int10--------
    rs1897899321,2
    --88857336(+) AGAGCA/GAGTCT 1 -- int10--------
    rs1838608021,2
    --88857338(+) AGCGAA/GTCTTC 1 -- int10--------
    rs615452671,2
    C--88857414(+) TTACTT/ATTTTT 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1932932861,2
    --88857444(+) TGTGTA/GTAGGT 1 -- int10--------
    rs1132682771,2
    C,F--88857476(+) AGTACC/TCTATA 1 -- int14Minor allele frequency- T:0.09NA CSA WA 242

    HapMap Linkage Disequilibrium report for FAM35A (88853918 - 88951225 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FAM35A (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv428236CNV Loss18775914
    dgv799n71CNV Gain21882294
    dgv798n71CNV Gain21882294
    dgv800n71CNV Gain21882294
    nsv831939CNV Gain17160897
    nsv895863CNV Gain21882294
    nsv825493CNV Gain20364138
    nsv8715CNV Gain+Loss18304495
    esv27973CNV Gain+Loss19812545
    essv23924CNV CNV17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM35A gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM35A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (Genome Res. 1997)
    5. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (Anal. Biochem. 1996)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54537 HGNC: 28773 AceView: FAM35A Ensembl:ENSG00000122376 euGenes: HUgn54537
    ECgene: FAM35A H-InvDB: FAM35A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM35A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM35A gene:
    Search GeneIP for patents involving FAM35A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Custom PCR Arrays for FAM35A Search Chromatin IP Primers for FAM35A
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