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Aliases for FAM35A Gene

Aliases for FAM35A Gene

  • Family With Sequence Similarity 35 Member A 2 3 5
  • Family With Sequence Similarity 35, Member A 2 3
  • BA163M19.1 3
  • FAM35A1 3

External Ids for FAM35A Gene

Previous GeneCards Identifiers for FAM35A Gene

  • GC10P088520
  • GC10P088845
  • GC10P082753

Summaries for FAM35A Gene

GeneCards Summary for FAM35A Gene

FAM35A (Family With Sequence Similarity 35 Member A) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM35A Gene

Genomics for FAM35A Gene

Regulatory Elements for FAM35A Gene

Promoters for FAM35A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM35A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM35A Gene

Chromosome:
10
Start:
87,094,161 bp from pter
End:
87,191,469 bp from pter
Size:
97,309 bases
Orientation:
Plus strand

Genomic View for FAM35A Gene

Genes around FAM35A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM35A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM35A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM35A Gene

Proteins for FAM35A Gene

  • Protein details for FAM35A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86V20-FA35A_HUMAN
    Recommended name:
    Protein FAM35A
    Protein Accession:
    Q86V20
    Secondary Accessions:
    • O95885
    • Q9H991

    Protein attributes for FAM35A Gene

    Size:
    835 amino acids
    Molecular mass:
    93705 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM35A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM35A Gene

Proteomics data for FAM35A Gene at MOPED

Post-translational modifications for FAM35A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM35A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM35A Gene

Domains & Families for FAM35A Gene

Protein Domains for FAM35A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM35A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86V20

UniProtKB/Swiss-Prot:

FA35A_HUMAN :
  • Belongs to the FAM35 family.
Family:
  • Belongs to the FAM35 family.
genes like me logo Genes that share domains with FAM35A: view

No data available for Gene Families for FAM35A Gene

Function for FAM35A Gene

genes like me logo Genes that share phenotypes with FAM35A: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM35A Gene

Localization for FAM35A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM35A Gene COMPARTMENTS Subcellular localization image for FAM35A gene
Compartment Confidence
cytoskeleton 2
cytosol 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM35A Gene

Pathways & Interactions for FAM35A Gene

SuperPathways for FAM35A Gene

No Data Available

Interacting Proteins for FAM35A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000298784%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000298784 for FAM35A Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for FAM35A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM35A Gene

Drugs & Compounds for FAM35A Gene

No Compound Related Data Available

Transcripts for FAM35A Gene

Unigene Clusters for FAM35A Gene

Family with sequence similarity 35, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM35A Gene

No ASD Table

Relevant External Links for FAM35A Gene

GeneLoc Exon Structure for
FAM35A
ECgene alternative splicing isoforms for
FAM35A

Expression for FAM35A Gene

mRNA expression in normal human tissues for FAM35A Gene

SOURCE GeneReport for Unigene cluster for FAM35A Gene Hs.500419

genes like me logo Genes that share expression patterns with FAM35A: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FAM35A Gene

Orthologs for FAM35A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM35A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM35A 35
  • 81.43 (n)
  • 70.36 (a)
FAM35A 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM35A 35
  • 81.52 (n)
  • 69.47 (a)
FAM35A 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam35a 35
  • 77.04 (n)
  • 66.62 (a)
Fam35a 16
Fam35a 36
  • 59 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM35A 35
  • 99.24 (n)
  • 98.56 (a)
FAM35A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam35a 35
  • 76.05 (n)
  • 63.82 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM35A 36
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM35A 36
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM35A 35
  • 58.56 (n)
  • 45.04 (a)
FAM35A 36
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 28 (a)
OneToMany
-- 36
  • 34 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486838 35
  • 54.75 (n)
  • 45.01 (a)
zebrafish
(Danio rerio)
Actinopterygii fam35a 35
  • 48.92 (n)
  • 40.73 (a)
FAM35A 36
  • 28 (a)
OneToOne
Species with no ortholog for FAM35A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM35A Gene

ENSEMBL:
Gene Tree for FAM35A (if available)
TreeFam:
Gene Tree for FAM35A (if available)

Paralogs for FAM35A Gene

Pseudogenes.org Pseudogenes for FAM35A Gene

genes like me logo Genes that share paralogs with FAM35A: view

No data available for Paralogs for FAM35A Gene

Variants for FAM35A Gene

Sequence variations from dbSNP and Humsavar for FAM35A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs3129520 - 87,151,750(-) TCGGT(G/T)AAATG intron-variant, reference, missense
VAR_053998 -
rs11816168 - 87,187,132(+) TATCC(A/G/T)TGTAG reference, missense
rs972305 -- 87,181,528(+) AAAAT(A/G)TTGCT intron-variant
rs1414571 -- 87,186,563(-) AACAA(C/T)ATGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM35A Gene

Variant ID Type Subtype PubMed ID
dgv310e1 CNV Complex 17122850
dgv311e1 CNV Complex 17122850
dgv312e1 CNV Complex 17122850
nsv428236 CNV Loss 18775914
essv23924 CNV CNV 17122850
dgv313e1 CNV Complex 17122850
dgv314e1 CNV Complex 17122850
nsv831939 CNV Gain 17160897
nsv825493 CNV Gain 20364138
nsv895863 CNV Gain 21882294
nsv8715 CNV Gain+Loss 18304495
esv27973 CNV Gain+Loss 19812545
dgv315e1 CNV Complex 17122850
dgv316e1 CNV Complex 17122850
dgv798n71 CNV Gain 21882294
dgv799n71 CNV Gain 21882294
dgv800n71 CNV Gain 21882294

Variation tolerance for FAM35A Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.98; 94.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM35A Gene

HapMap Linkage Disequilibrium report
FAM35A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM35A Gene

Disorders for FAM35A Gene

Relevant External Links for FAM35A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM35A

No disorders were found for FAM35A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM35A Gene

Publications for FAM35A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3
  3. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  4. hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling. (PMID: 25324306) Roy R. … Pardo O.E. (Nucleic Acids Res. 2014) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for FAM35A Gene

Sources for FAM35A Gene

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