FAM35A Gene
protein-coding GIFtS: 38
GCID: GC10P088845
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family with sequence similarity 35, member A
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Aliases
for FAM35A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 35, Member A1 2 | | FAM35A11 2 | | BA163M19.11 | | MGC55601 | | Protein FAM35A2 |
Export aliases for FAM35A gene to outside databasesPrevious GC identifers: GC10P088520 GC10P082753 |
Summaries
for FAM35A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
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Genomic Views
for FAM35A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM35A gene promoter:
HOXA9B HOXA9 ER-alpha Elk-1 Pax-5 Pax-2 Pax-2a ZIC2/Zic2 Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM35A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM35A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q23.2 Ensembl cytogenetic band: 10q23.2 HGNC cytogenetic band: 10q23.2FAM35A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P088845: view genomic region
(about GC identifiers)
Start:
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88,854,953 bp from pter |
End:
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88,951,225 bp from pter |
Size:
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96,273 bases |
Orientation:
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plus strand |
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Proteins
for FAM35A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FA35A_HUMAN, Q86V20 (See
protein sequence)Recommended Name: Protein FAM35A Size: 835 amino acids; 93705 Da
Secondary accessions: O95885 Q9H991Alternative splicing: 2 isoforms: Q86V20-1 Q86V20-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FAM35A: NX_Q86V20
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86V20
FAM35A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_061927.2
ENSEMBL proteins: ENSP00000351064 ENSP00000339800 ENSP00000298786 ENSP00000298784
Human Recombinant Protein Products:
FAM35A Antibody Products:
Assay Products for FAM35A: |
Protein
Domains /
Families
for FAM35A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q86V20 UniProtKB/Swiss-Prot: FA35A_HUMAN, Q86V20Similarity: Belongs to the FAM35 family |
Function
for FAM35A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM35A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM35A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FAM35A (NM_019054) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM35A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM35A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM35A |
|
Pathways & Interactions
for FAM35A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM35A
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for FAM35A (ENSP000002987844) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FAM35A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM35A
Search CenterWatch for drugs/clinical trials and news about FAM35A / FA35A
|
Transcripts
for FAM35A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM35A gene: NM_019054.2 Unigene Cluster for FAM35A: Family with sequence similarity 35, member A Hs.500419 [show with all ESTs]Unigene Representative Sequence: NM_0190544 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000358313 ENST00000342900(uc001kej.4) ENST00000298786 ENST00000298784(uc001kei.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM35A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM35A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FAM35A (NM_019054) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM35A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM35A |
Additional cDNA sequence: AF131775.1 AK022978.1 AK025471.1 AK025606.1 BC051863.2 15 DOTS entries: DT.75117452 DT.414036 DT.121227649 DT.100676477 DT.121227606 DT.75137651 DT.100785622 DT.121227625 DT.121227292 DT.91780760 DT.100785621 DT.121227219 DT.446053 DT.91780762 DT.91780772 24/138 AceView cDNA sequences (see all 138): BU167544 AA281828 BM997122 AI476477 AV701696 AA404984 BM828781 AU128957 BC051863 BM148218 AK025606 BE883093 BQ015333 AW504622 BV204941 BM726755 BQ005384 AI480136 R67193 AA971071 AI250236 BV204942 BM564679 AI908086
GeneLoc Exon Structure
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Expression
for FAM35A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM35A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTCAATTTA
About this image
See FAM35A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM35A
SOURCE GeneReport for Unigene cluster: Hs.500419
SABiosciences Custom PCR Arrays for FAM35A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM35A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM35A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM35A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM35A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM35A |
Orthologs
for FAM35A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FAM35A gene from 4/12 species (see all 12) About this table
ENSEMBL Gene Tree for FAM35A (if available)
TreeFam Gene Tree for FAM35A (if available) |
Paralogs
for FAM35A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM35A gene
FAM35A for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for FAM35A
PGOHUM00000238772 PGOHUM00000238782 PGOHUM00000248250
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Genomic Variants
for FAM35A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM35A (88854953 - 88951225 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for FAM35A
11 CNVs: 85412 2885 85409 4706 31770 85410 75336 3815 71075 75335 85411 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM35A |
|
Disorders
/ Diseases
for FAM35A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for FAM35A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM35A gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM35A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (1997)
- A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (1996)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for FAM35A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing FAM35A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM35A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM35A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM35A | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for FAM35A gene:
Search GeneIP for patents involving FAM35A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM35A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM35A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM35A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM35A | | | OriGene Protein Over-expression Lysate for FAM35A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM35A | | OriGene 3'-UTR Clone for FAM35A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM35A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM35A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM35A | | OriGene Custom Protein Services for FAM35A | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM35A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM35A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM35A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM35A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM35A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM35A |
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| | | | Search Tocris compounds for FAM35A |
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 | | | FAM35A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM35A |
|  |  |  | | | | Search ThermoFisher Antibodies for FAM35A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM35A |
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