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Aliases for FAM35A Gene

Aliases for FAM35A Gene

  • Family With Sequence Similarity 35 Member A 2 3 5
  • Family With Sequence Similarity 35, Member A 2
  • Protein FAM35A 3
  • BA163M19.1 3
  • FAM35A1 3

External Ids for FAM35A Gene

Previous GeneCards Identifiers for FAM35A Gene

  • GC10P088520
  • GC10P088845
  • GC10P082753

Summaries for FAM35A Gene

GeneCards Summary for FAM35A Gene

FAM35A (Family With Sequence Similarity 35 Member A) is a Protein Coding gene.

Additional gene information for FAM35A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM35A Gene

Genomics for FAM35A Gene

Regulatory Elements for FAM35A Gene

Enhancers for FAM35A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H087840 1.6 FANTOM5 Ensembl ENCODE 32.5 +749.7 749741 6 ATF1 FOXA2 ARNT FEZF1 BRCA1 ZNF2 GTF3C2 ZNF121 GLIS2 KLF7 FAM35A NUTM2A-AS1 RPL11P3 RN7SL78P ENSG00000196566 RPS26P38 ENSG00000223761 FAM25A NUTM2A ENSG00000261011
GH10H087091 1.4 ENCODE dbSUPER 31.5 -0.3 -266 6 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 NUTM2A-AS1 WAPL ENSG00000272631 FAM35A RN7SL78P BMPR1A CFL1P1 RPL11P3 ENSG00000223761 RPS26P38
GH10H087860 1.4 ENCODE dbSUPER 20.3 +770.6 770576 8 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF548 SP3 NFYC GLIS1 NUTM2A-AS1 FAM35A RPL11P3 ADIRF-AS1 PTEN LIPJ KLLN ENSG00000224745
GH10H086752 2 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -338.1 -338071 7 HDGF FOXA2 MLX ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143 WAPL ENSG00000272631 ENSG00000223761 RPS26P38 ENSG00000196566 NUTM2A-AS1 BMPR1A FAM35A GLUD1
GH10H087585 1 ENCODE 21.8 +492.2 492220 2 PKNOX1 FEZF1 YY1 FOS YY2 TSHZ1 ZNF662 ZNF491 ZNF623 ZNF518A ENSG00000272631 NUTM2A LINC00863 FAM35A CFL1P1 BMPR1A BMS1P3 NUTM2A-AS1 ATAD1 GC10P087578
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM35A on UCSC Golden Path with GeneCards custom track

Promoters for FAM35A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for FAM35A Gene

87,094,161 bp from pter
87,191,469 bp from pter
97,309 bases
Plus strand

Genomic View for FAM35A Gene

Genes around FAM35A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM35A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM35A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM35A Gene

Proteins for FAM35A Gene

  • Protein details for FAM35A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM35A
    Protein Accession:
    Secondary Accessions:
    • O95885
    • Q9H991

    Protein attributes for FAM35A Gene

    835 amino acids
    Molecular mass:
    93705 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM35A Gene


neXtProt entry for FAM35A Gene

Post-translational modifications for FAM35A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM35A Gene

Domains & Families for FAM35A Gene

Gene Families for FAM35A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FAM35A Gene


Suggested Antigen Peptide Sequences for FAM35A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM35 family.
  • Belongs to the FAM35 family.
genes like me logo Genes that share domains with FAM35A: view

Function for FAM35A Gene

Phenotypes From GWAS Catalog for FAM35A Gene

genes like me logo Genes that share phenotypes with FAM35A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM35A Gene

Localization for FAM35A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM35A gene
Compartment Confidence
cytoskeleton 2
nucleus 2
cytosol 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM35A Gene

Pathways & Interactions for FAM35A Gene

SuperPathways for FAM35A Gene

No Data Available

Interacting Proteins for FAM35A Gene

Selected Interacting proteins: Q86V20-FA35A_HUMAN for FAM35A Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for FAM35A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM35A Gene

Drugs & Compounds for FAM35A Gene

No Compound Related Data Available

Transcripts for FAM35A Gene

Unigene Clusters for FAM35A Gene

Family with sequence similarity 35, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM35A Gene

No ASD Table

Relevant External Links for FAM35A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM35A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM35A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM35A Gene:


SOURCE GeneReport for Unigene cluster for FAM35A Gene:

genes like me logo Genes that share expression patterns with FAM35A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM35A Gene

Orthologs for FAM35A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM35A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM35A 33 34
  • 99.24 (n)
(Canis familiaris)
Mammalia FAM35A 33 34
  • 81.52 (n)
(Bos Taurus)
Mammalia FAM35A 33 34
  • 81.43 (n)
(Mus musculus)
Mammalia Fam35a 33 16 34
  • 77.04 (n)
(Rattus norvegicus)
Mammalia Fam35a 33
  • 76.05 (n)
(Monodelphis domestica)
Mammalia FAM35A 34
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia FAM35A 34
  • 43 (a)
(Gallus gallus)
Aves FAM35A 34 33
  • 58.56 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 34 (a)
-- 34
  • 28 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486838 33
  • 54.75 (n)
(Danio rerio)
Actinopterygii fam35a 33
  • 48.92 (n)
FAM35A 34
  • 28 (a)
Species where no ortholog for FAM35A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM35A Gene

Gene Tree for FAM35A (if available)
Gene Tree for FAM35A (if available)

Paralogs for FAM35A Gene Pseudogenes for FAM35A Gene

genes like me logo Genes that share paralogs with FAM35A: view

No data available for Paralogs for FAM35A Gene

Variants for FAM35A Gene

Sequence variations from dbSNP and Humsavar for FAM35A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs139579928 Likely benign 87,094,394(+) GCCGT(C/G/T)GTCGC upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs142544510 Likely benign 87,094,428(+) AGCAC(A/G)TGGTT upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime
rs552066337 Likely benign 87,094,666(+) GCTGT(C/T)CCCGG upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs750420022 Uncertain significance 87,094,616(+) GTAGT(G/T)GCGCC upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs797045598 Uncertain significance 87,094,318(-) TGAGC(A/G)TCGGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM35A Gene

Variant ID Type Subtype PubMed ID
esv2759774 CNV gain+loss 17122850
esv2764246 CNV gain+loss 21179565
esv27973 CNV gain+loss 19812545
esv3577571 CNV gain 25503493
esv3577583 CNV gain 25503493
esv3624104 CNV loss 21293372
nsv1040871 CNV gain 25217958
nsv1055013 CNV gain 25217958
nsv1141879 OTHER inversion 24896259
nsv428236 CNV loss 18775914
nsv551812 CNV gain 21841781
nsv825493 CNV gain 20364138
nsv831939 CNV gain 17160897
nsv8715 CNV gain+loss 18304495
nsv948114 CNV duplication 23825009
nsv948115 CNV duplication 23825009
nsv948116 CNV duplication 23825009
nsv948117 CNV duplication 23825009
nsv948118 CNV duplication 23825009
nsv948119 CNV duplication 23825009

Variation tolerance for FAM35A Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.98; 94.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM35A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM35A Gene

Disorders for FAM35A Gene

Relevant External Links for FAM35A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM35A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM35A Gene

Publications for FAM35A Gene

  1. GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes. (PMID: 27899376) Nakayama A … Matsuo H (Annals of the rheumatic diseases 2017) 2 3 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for FAM35A Gene

Sources for FAM35A Gene

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