FAM32A Gene
protein-coding GIFtS: 50
GCID: GC19P017106 (predicted)
|
|
family with sequence similarity 32, member A
| |
Aliases
for FAM32A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 32, Member A1 2 | | DKFZP586O01201 | | Ovarian Tumor-Associated Gene 122 3 | | Ovarian Tumor Associated Gene-122 | | OTAG-122 3 | | Protein FAM32A2 | | OTAG122 3 | | |
Export aliases for FAM32A gene to outside databasesPrevious GC identifers: GC19P016157 GC19P016297 GC19P015867 GC19P016301 GC19P016431 |
Summaries
for FAM32A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FA32A_HUMAN, Q9Y421Function: Isoform 1, but not isoform 2 or isoform 3, may induce G2 arrest and apoptosis. May also increase cellsensitivity to apoptotic stimuli
Gene Wiki entry for FAM32A
|
Genomic Views
for FAM32A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM32A gene promoter:
RFX1 Pbx1a AML1a SREBP-1c POU6F1 (c2) LUN-1 POU3F2 C/EBPalpha GATA-2 Pax-3
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM32A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM32A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19pter-p13.3 Ensembl cytogenetic band: 19p13.12 HGNC cytogenetic band: 19pter-p13.3FAM32A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P017106: view genomic region
(about GC identifiers)
Start:
|
16,296,191 bp from pter |
End:
|
16,302,857 bp from pter |
Size:
|
6,667 bases |
Orientation:
|
plus strand |
|
Proteins
for FAM32A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FA32A_HUMAN, Q9Y421 (See
protein sequence)Recommended Name: Protein FAM32A Size: 112 amino acids; 13178 Da
Subcellular location: Isoform 1: Nucleus
Subcellular location: Isoform 2: Nucleus
Secondary accessions: Q9BT02Alternative splicing: 3 isoforms: Q9Y421-1 Q9Y421-2 Q9Y421-3 Explore the universe of human proteins at neXtProt for FAM32A: NX_Q9Y421
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y421
FAM32A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_054796.1
ENSEMBL proteins: ENSP00000465969 ENSP00000263384 ENSP00000464939 ENSP00000467027 ENSP00000466294
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005730 | nucleolus |
IDA | -- |
FAM32A for ontologies About GeneDecksing
FAM32A Antibody Products:
Assay Products for FAM32A: |
Protein
Domains /
Families
for FAM32A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM32A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9Y421ProtoNet protein and cluster: Q9Y421 1 Blocks protein family: IPB013865 Protein of unknown function DUF1754
UniProtKB/Swiss-Prot: FA32A_HUMAN, Q9Y421Similarity: Belongs to the FAM32 family |
Function
for FAM32A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FA32A_HUMAN, Q9Y421Function: Isoform 1, but not isoform 2 or isoform 3, may induce G2 arrest and apoptosis. May also increase cellsensitivity to apoptotic stimuliInduction: By etoposide, puromycin or carboplatin
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM32A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for FAM32A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM32A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM32A |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
FAM32A for ontologies About GeneDecksing
|
Pathways & Interactions
for FAM32A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM32A
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
3 Interacting proteins for FAM32A (Q9Y4212, 3 ENSP000002633844) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
FAM32A for ontologies About GeneDecksing
|
Drugs & Compounds
for FAM32A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM32A
Search CenterWatch for drugs/clinical trials and news about FAM32A / FA32A
|
Transcripts
for FAM32A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM32A gene: NM_014077.2 Unigene Cluster for FAM32A: Family with sequence similarity 32, member A Hs.631614 [show with all ESTs]Unigene Representative Sequence: BM9235125 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000589852 ENST00000263384(uc002ndt.3) ENST00000588367 ENST00000585831
ENST00000587351
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM32A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM32A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FAM32A (NM_014077) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM32A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM32A |
Additional cDNA sequence: AF151902.1 AK312058.1 AL050157.1 BC000639.1 BC004447.1 BC017286.1 12 DOTS entries: DT.445450 DT.97864266 DT.95156694 DT.92445142 DT.100879214 DT.100879221 DT.92445137 DT.100668640 DT.100879210 DT.100644856 DT.100879204 DT.121452605 24/396 AceView cDNA sequences (see all 396): CR594783 BX380615 BU184409 BF477363 BI766794 BQ941629 CR621715 CB159583 BI771412 CR606857 BI259635 BE886671 BM455209 AI017417 AI744386 CA307375 BM989201 BQ682046 AW054889 BE793780 BF992486 BM713785 BM051460 CR597639
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for FAM32A About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | | | | | | | | |
ECgene alternative splicing isoforms for FAM32A
|
Expression
for FAM32A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM32A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGCCTGCA
About this image
See FAM32A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM32A
SOURCE GeneReport for Unigene cluster: Hs.631614
UniProtKB/Swiss-Prot: FA32A_HUMAN, Q9Y421Tissue specificity: Expressed in ovary, with isoform 1 being predominant
SABiosciences Custom PCR Arrays for FAM32A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM32A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM32A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM32A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM32A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM32A |
Orthologs
for FAM32A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for FAM32A gene from 8/27 species (see all 27) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Fam32a1 , 5 |
family with sequence similarity 32, member A1, 5 |
88.69(n)1
97.32(a)1 |
|
8 (34.90 cM)5
679221 NM_026455.41 NP_080731.11
722197305 |
chicken
(Gallus gallus) |
Aves |
FAM32A1 |
family with sequence similarity 32, member A |
80.18(n)
81.08(a) |
|
420150 XM_418266.3 XP_418266.2 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.132142 |
Xenopus laevis transcribed sequence with moderate similarity more |
78.27(n) |
|
BJ096063.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufc30d062 |
Transcribed sequence with weak similarity to protein more |
83.91(n) |
|
CK019336.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG154321 |
CG15432 |
55.26(n)
49.55(a) |
|
33647 NM_134988.2 NP_608832.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
K01G5.86 |
-- |
35(a) |
1 ↔ 1 |
III(10740181-10740673) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G168106 |
uncharacterized protein |
25(a) |
1 ↔ 1 |
1(5755588-5756895) |
rice
(Oryza sativa) |
Liliopsida |
-- |
AGAP000425-PA, putative, expressed |
29(a) |
1 ↔ 1 |
2(30270471-30273458) |
ENSEMBL Gene Tree for FAM32A (if available)
TreeFam Gene Tree for FAM32A (if available) |
Paralogs
for FAM32A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM32A gene
FAM32A for paralogs About GeneDecksing
5 Pseudogenes.org Pseudogenes for FAM32A
PGOHUM00000238538 PGOHUM00000239452 PGOHUM00000239604 PGOHUM00000234954 PGOHUM00000246391
|
Genomic Variants
for FAM32A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM32A (16296191 - 16302857 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM32A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM32A |
|
Disorders
/ Diseases
for FAM32A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAM32A for disorders About GeneDecksing
OMIM gene information: 614554
OMIM disorders: --
1  disease for FAM32A: About MalaCardsmalaria
Human Genome Epidemiology (HuGE) Navigator: FAM32A (3 documents)
Export disorders for FAM32A gene to outside databases
|
Publications
for FAM32A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM32A gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with FAM32A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
- Anti-proliferative and pro-apoptotic actions of a nov el human and mouse ovarian tumor-associated gene OTAG-12: downregulation, alter native splicing and drug sensitization. (PubMed id 21339736)1, 2 Chen X....Sairam M.R. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
|
External Searches for FAM32A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM32A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM32A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM32A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM32A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM32A gene:
Search GeneIP for patents involving FAM32A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM32A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |  |  |  |  | | | | |
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 |
 |
 | | | FAM32A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM32A |
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|
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|
