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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM32A Gene

protein-coding   GIFtS: 50
GCID: GC19P017362          (predicted)

Family With Sequence Similarity 32, Member A

  Search for FAM32A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Family With Sequence Similarity 32, Member A1 2
Ovarian Tumor-Associated Gene 122 3
OTAG-122 3
OTAG122 3
Ovarian Tumor Associated Gene-122
Protein FAM32A2

External Ids:    HGNC: 245631   Entrez Gene: 260172   Ensembl: ENSG000001050587   OMIM: 6145545   UniProtKB: Q9Y4213   

Export aliases for FAM32A gene to outside databases

Previous GC identifers: GC19P016157 GC19P016297 GC19P015867 GC19P016301 GC19P016431 GC19P017106


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM32A Gene: 
FAM32A (family with sequence similarity 32, member A) is a protein-coding gene. GO annotations related to this gene include molecular_function.

UniProtKB/Swiss-Prot: FA32A_HUMAN, Q9Y421
Function: Isoform 1, but not isoform 2 or isoform 3, may induce G2 arrest and apoptosis. May also increase cell
sensitivity to apoptotic stimuli

Gene Wiki entry for FAM32A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM32A gene promoter:
         RFX1   Pbx1a   AML1a   SREBP-1c   POU6F1 (c2)   LUN-1   POU3F2   C/EBPalpha   GATA-2   Pax-3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM32A promoter sequence
   Search SABiosciences Chromatin IP Primers for FAM32A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM32A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19pter-p13.3   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.12-p13.11

FAM32A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM32A gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P017362:  view genomic region     (about GC identifiers)

Start:
16,296,191 bp from pter      End:
16,302,857 bp from pter
Size:
6,667 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FA32A_HUMAN, Q9Y421 (See protein sequence)
Recommended Name: Protein FAM32A  
Size: 112 amino acids; 13178 Da
Subcellular location: Isoform 1: Nucleus
Subcellular location: Isoform 2: Nucleus
Secondary accessions: Q9BT02
Alternative splicing: 3 isoforms:  Q9Y421-1   Q9Y421-2   Q9Y421-3   

Explore the universe of human proteins at neXtProt for FAM32A: NX_Q9Y421

Explore proteomics data for FAM32A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y421

  • FAM32A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAM32A Protein Expression
    REFSEQ proteins: NP_054796.1  
    ENSEMBL proteins: 
     ENSP00000465969   ENSP00000263384   ENSP00000464939   ENSP00000467027   ENSP00000466294  

    Human Recombinant Protein Products for FAM32A: 
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    Novus Biologicals FAM32A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for FAM32A 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--

    FAM32A for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for FAM32A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR013865 DUF1754_euk

    Graphical View of Domain Structure for InterPro Entry Q9Y421

    ProtoNet protein and cluster: Q9Y421

    1 Blocks protein domain: IPB013865 Protein of unknown function DUF1754

    UniProtKB/Swiss-Prot: FA32A_HUMAN, Q9Y421
    Similarity: Belongs to the FAM32 family


    FAM32A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FA32A_HUMAN, Q9Y421
    Function: Isoform 1, but not isoform 2 or isoform 3, may induce G2 arrest and apoptosis. May also increase cell
    sensitivity to apoptotic stimuli
    Induction: By etoposide, puromycin or carboplatin

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding IPI--
         
    FAM32A for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM32A 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM32A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM32A 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM32A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM32A

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for FAM32A (Q9Y4212, 3 ENSP000002633844) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CWC22Q9HCG82, ENSP000003870064MINT-8332020 MINT-8337706 STRING: ENSP00000387006
    NSFL1CQ9UNZ23I2D: score=3 
    MAP3K2Q9Y2U53I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007049cell cycle IEA--
    GO:0008150biological_process ND--

    FAM32A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM32A (FA32A)

    Search CenterWatch for drugs/clinical trials and news about FAM32A / FA32A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAM32A gene: 
    NM_014077.2  

    Unigene Cluster for FAM32A:

    Family with sequence similarity 32, member A
    Hs.631614  [show with all ESTs]
    Unigene Representative Sequence: BM923512
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589852 ENST00000263384(uc002ndt.3) ENST00000588367 ENST00000585831
    ENST00000587351
    miRNA
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM32A

    Additional mRNA sequence: 

    AF151902.1 AK312058.1 AL050157.1 BC000639.1 BC004447.1 BC017286.1 

    12 DOTS entries:

    DT.445450  DT.97864266  DT.95156694  DT.92445142  DT.100879214  DT.100879221  DT.92445137  DT.100668640 
    DT.100879210  DT.100644856  DT.100879204  DT.121452605 

    24/396 AceView cDNA sequences (see all 396):

    CR607046 BE793780 Z42304 AA478466 BM556151 BG251372 CA429622 CA307375 
    BQ676840 BQ231047 CR614913 BI768718 BF438571 CR601203 BM051460 CR606857 
    CR597639 AI951369 AL697793 AI830295 BU541528 CR625808 CB163290 BM991557 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FAM32A    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
    SP1:                                                                  
    SP2:                                -                                 
    SP3:                                -                                 
    SP4:                                -     -                           


    ECgene alternative splicing isoforms for FAM32A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAM32A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGCCTGCA
    FAM32A Expression
    About this image


    See FAM32A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAM32A

    SOURCE GeneReport for Unigene cluster: Hs.631614

    UniProtKB/Swiss-Prot: FA32A_HUMAN, Q9Y421
    Tissue specificity: Expressed in ovary, with isoform 1 being predominant

        SABiosciences Custom PCR Arrays for FAM32A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM32A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FAM32A gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam32a1 , 5 family with sequence similarity 32, member A1, 5 88.69(n)1
    97.32(a)1
      8 (34.90 cM)5
    679221  NM_026455.41  NP_080731.11 
     722197305 
    chicken
    (Gallus gallus)
    Aves FAM32A1 family with sequence similarity 32, member A 80.18(n)
    81.08(a)
      420150  XM_418266.3  XP_418266.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.132142 Xenopus laevis transcribed sequence with moderate similarity more 78.27(n)    BJ096063.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc30d062 Transcribed sequence with weak similarity to protein more 83.91(n)    CK019336.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG154321 CG15432 55.26(n)
    49.55(a)
      33647  NM_134988.2  NP_608832.1 
    worm
    (Caenorhabditis elegans)
    Secernentea K01G5.86
    Protein K01G5.8, isoform a
    36(a)
    1 ↔ 1
    III(10740280-10740772)


    ENSEMBL Gene Tree for FAM32A (if available)
    TreeFam Gene Tree for FAM32A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAM32A gene

    FAM32A for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for FAM32A
    PGOHUM00000238538 PGOHUM00000239452 PGOHUM00000239604 PGOHUM00000234954 PGOHUM00000246391


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/214 SNPs in FAM32A are shown (see all 214)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs106313501,2
    C--16294293(+) aatag-/T/TT  
            
    tTTTT
    1 -- us2k1 tfbs3 trp31CSA 2
    rs1838659971,2
    --16294309(+) TACTAA/GGTTTT 1 -- us2k10--------
    rs1899900741,2
    --16294324(+) ACAGAG/TGGAAA 1 -- us2k10--------
    rs1807928351,2
    --16294399(+) GGCACA/GGTGGC 1 -- us2k10--------
    rs1430309811,2
    --16294481(+) GCCTGA/GACAAC 1 -- us2k10--------
    rs1511664531,2
    C--16294527(+) TTAGCA/GGGGCA 1 -- us2k10--------
    rs6452811,2
    C,A,H--16294677(+) aaaaaG/Aaaaaa 1 -- us2k1 trp310Minor allele frequency- A:0.31NA WA CSA 253
    rs1402411681,2
    --16294690(+) AGATAC/TATGCA 1 -- us2k10--------
    rs1504507301,2
    --16294757(+) GAAAGC/GGCCAG 1 -- us2k10--------
    rs730091351,2
    --16294777(+) CTCACA/GCCTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FAM32A (16296191 - 16302857 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FAM32A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833767CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FAM32A for disorders           About MalaCards
    OMIM gene information: 614554    OMIM disorders: --


    FAM32A for disorders           About GeneDecksing

    Genetic Association Database (GAD): FAM32A
    Human Genome Epidemiology (HuGE) Navigator: FAM32A (3 documents)

    Export disorders for FAM32A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAM32A gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with FAM32A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
    3. Anti-proliferative and pro-apoptotic actions of a nov el human and mouse ovarian tumor-associated gene OTAG-12: downregulation, alter native splicing and drug sensitization. (PubMed id 21339736)1, 2 Chen X....Sairam M.R. (2011)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Dynamic protein-protein interaction wiring of the huma n spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    9. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    10. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26017 HGNC: 24563 AceView: FAM32A Ensembl:ENSG00000105058 euGenes: HUgn26017
    ECgene: FAM32A H-InvDB: FAM32A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM32A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAM32A gene:
    Search GeneIP for patents involving FAM32A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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