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Aliases for FAM32A Gene

Aliases for FAM32A Gene

  • Family With Sequence Similarity 32 Member A 2 3 5
  • Family With Sequence Similarity 32, Member A 2 3
  • Ovarian Tumor-Associated Gene 12 3 4
  • OTAG-12 3 4
  • OTAG12 3 4
  • Ovarian Tumor Associated Gene-12 3

External Ids for FAM32A Gene

Previous GeneCards Identifiers for FAM32A Gene

  • GC19P016157
  • GC19P016297
  • GC19P015867
  • GC19P016301
  • GC19P016431
  • GC19P017106
  • GC19P017362
  • GC19P017894
  • GC19P016574
  • GC19P016811

Summaries for FAM32A Gene

GeneCards Summary for FAM32A Gene

FAM32A (Family With Sequence Similarity 32 Member A) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for FAM32A Gene

  • Isoform 1, but not isoform 2 or isoform 3, may induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli.

Gene Wiki entry for FAM32A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM32A Gene

Genomics for FAM32A Gene

Regulatory Elements for FAM32A Gene

Promoters for FAM32A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM32A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM32A Gene

Chromosome:
19
Start:
16,185,184 bp from pter
End:
16,192,046 bp from pter
Size:
6,863 bases
Orientation:
Plus strand

Genomic View for FAM32A Gene

Genes around FAM32A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM32A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM32A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM32A Gene

Proteins for FAM32A Gene

  • Protein details for FAM32A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y421-FA32A_HUMAN
    Recommended name:
    Protein FAM32A
    Protein Accession:
    Q9Y421
    Secondary Accessions:
    • Q9BT02

    Protein attributes for FAM32A Gene

    Size:
    112 amino acids
    Molecular mass:
    13178 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM32A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM32A Gene

Proteomics data for FAM32A Gene at MOPED

Post-translational modifications for FAM32A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM32A Gene

No data available for DME Specific Peptides for FAM32A Gene

Domains & Families for FAM32A Gene

Protein Domains for FAM32A Gene

Suggested Antigen Peptide Sequences for FAM32A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y421

UniProtKB/Swiss-Prot:

FA32A_HUMAN :
  • Belongs to the FAM32 family.
Family:
  • Belongs to the FAM32 family.
genes like me logo Genes that share domains with FAM32A: view

No data available for Gene Families for FAM32A Gene

Function for FAM32A Gene

Molecular function for FAM32A Gene

UniProtKB/Swiss-Prot Function:
Isoform 1, but not isoform 2 or isoform 3, may induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli.
UniProtKB/Swiss-Prot Induction:
By etoposide, puromycin or carboplatin.

Phenotypes for FAM32A Gene

genes like me logo Genes that share phenotypes with FAM32A: view

Animal Model Products

CRISPR Products

miRNA for FAM32A Gene

miRTarBase miRNAs that target FAM32A

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM32A Gene

Localization for FAM32A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM32A Gene

Isoform 1: Nucleus.
Isoform 2: Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM32A Gene COMPARTMENTS Subcellular localization image for FAM32A gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for FAM32A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with FAM32A: view

Pathways & Interactions for FAM32A Gene

SuperPathways for FAM32A Gene

No Data Available

Interacting Proteins for FAM32A Gene

Gene Ontology (GO) - Biological Process for FAM32A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM32A Gene

Drugs & Compounds for FAM32A Gene

No Compound Related Data Available

Transcripts for FAM32A Gene

Unigene Clusters for FAM32A Gene

Family with sequence similarity 32, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM32A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP1:
SP2: -
SP3: -
SP4: - -

Relevant External Links for FAM32A Gene

GeneLoc Exon Structure for
FAM32A
ECgene alternative splicing isoforms for
FAM32A

Expression for FAM32A Gene

mRNA expression in normal human tissues for FAM32A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM32A Gene

This gene is overexpressed in Plasma (19.1), Blymphocyte (15.1), Lung (6.6), CD8 Tcells (6.6), and Peripheral blood mononuclear cells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM32A Gene



SOURCE GeneReport for Unigene cluster for FAM32A Gene Hs.631614

mRNA Expression by UniProt/SwissProt for FAM32A Gene

Q9Y421-FA32A_HUMAN
Tissue specificity: Expressed in ovary, with isoform 1 being predominant.
genes like me logo Genes that share expression patterns with FAM32A: view

Protein tissue co-expression partners for FAM32A Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for FAM32A Gene

Orthologs for FAM32A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM32A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM32A 35
  • 93.75 (n)
  • 100 (a)
FAM32A 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM32A 35
  • 93.45 (n)
  • 99.11 (a)
FAM32A 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam32a 35
  • 88.69 (n)
  • 97.32 (a)
Fam32a 16
Fam32a 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM32A 35
  • 99.7 (n)
  • 100 (a)
FAM32A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam32a 35
  • 89.58 (n)
  • 98.21 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM32A 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM32A 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM32A 35
  • 78.68 (n)
  • 78.38 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam32a 35
  • 68.47 (n)
  • 74.77 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13214 35
zebrafish
(Danio rerio)
Actinopterygii fam32a 35
  • 66.97 (n)
  • 70.64 (a)
wufc30d06 35
fam32al 36
  • 71 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9554 35
fruit fly
(Drosophila melanogaster)
Insecta CG15432 36
  • 46 (a)
OneToOne
Species with no ortholog for FAM32A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM32A Gene

ENSEMBL:
Gene Tree for FAM32A (if available)
TreeFam:
Gene Tree for FAM32A (if available)

Paralogs for FAM32A Gene

genes like me logo Genes that share paralogs with FAM32A: view

No data available for Paralogs for FAM32A Gene

Variants for FAM32A Gene

Sequence variations from dbSNP and Humsavar for FAM32A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs645281 -- 16,183,866(+) aaaaa(A/G)aaaaa upstream-variant-2KB
rs410499 -- 16,183,276(+) TATAC(G/T)TTCAT upstream-variant-2KB
rs421193 -- 16,184,862(+) gaagg(A/C)cgaag upstream-variant-2KB
rs811723 -- 16,184,272(+) ataca(A/G)ggttt upstream-variant-2KB
rs4353575 -- 16,184,299(-) ttgga(A/G)accag upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM32A Gene

Variant ID Type Subtype PubMed ID
nsv833767 CNV Loss 17160897

Variation tolerance for FAM32A Gene

Gene Damage Index Score: 0.52; 11.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM32A Gene

HapMap Linkage Disequilibrium report
FAM32A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM32A Gene

Disorders for FAM32A Gene

Relevant External Links for FAM32A

Genetic Association Database (GAD)
FAM32A
Human Genome Epidemiology (HuGE) Navigator
FAM32A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM32A

No disorders were found for FAM32A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM32A Gene

Publications for FAM32A Gene

  1. Anti-proliferative and pro-apoptotic actions of a novel human and mouse ovarian tumor-associated gene OTAG-12: downregulation, alternative splicing and drug sensitization. (PMID: 21339736) Chen X. … Sairam M.R. (Oncogene 2011) 2 3 4 67
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3
  3. Dynamic protein-protein interaction wiring of the human spliceosome. (PMID: 22365833) Hegele A. … Stelzl U. (Mol. Cell 2012) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for FAM32A Gene

Sources for FAM32A Gene

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