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Aliases for FAM30A Gene

Subcategory (RNA class) for FAM30A Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for FAM30A Gene

  • Family With Sequence Similarity 30 Member A 2 3 5
  • KIAA0125 2 3 4
  • C14orf110 3 4
  • Chromosome 14 Open Reading Frame 110 2
  • HSPC053 3

External Ids for FAM30A Gene

Previous HGNC Symbols for FAM30A Gene

  • C14orf110
  • KIAA0125

Previous GeneCards Identifiers for FAM30A Gene

  • GC14U900537
  • GC14P105455
  • GC14P106355

Summaries for FAM30A Gene

GeneCards Summary for FAM30A Gene

FAM30A (Family With Sequence Similarity 30 Member A) is an RNA Gene, and is affiliated with the non-coding RNA class.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM30A Gene

Genomics for FAM30A Gene

Genomic Location for FAM30A Gene

Chromosome:
14
Start:
105,917,979 bp from pter
End:
105,932,642 bp from pter
Size:
14,664 bases
Orientation:
Plus strand

Genomic View for FAM30A Gene

Genes around FAM30A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM30A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM30A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM30A Gene

No data available for Regulatory Elements for FAM30A Gene

Proteins for FAM30A Gene

  • Protein details for FAM30A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZY2-FA30A_HUMAN
    Recommended name:
    Putative uncharacterized protein FAM30A
    Protein Accession:
    Q9NZY2
    Secondary Accessions:
    • C9J8W9

    Protein attributes for FAM30A Gene

    Size:
    134 amino acids
    Molecular mass:
    14626 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF29025.1; Type=Frameshift; Positions=6, 61, 72; Evidence={ECO:0000305};

neXtProt entry for FAM30A Gene

Post-translational modifications for FAM30A Gene

No Post-translational modifications

No data available for DME Specific Peptides for FAM30A Gene

Domains & Families for FAM30A Gene

Protein Domains for FAM30A Gene

ProtoNet:

Suggested Antigen Peptide Sequences for FAM30A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FAM30A: view

No data available for Gene Families and UniProtKB/Swiss-Prot for FAM30A Gene

Function for FAM30A Gene

Molecular function for FAM30A Gene

UniProtKB/Swiss-Prot Induction:
Down-regulated when the beta-APP42/beta-APP40 ratio is high, which is typical of Alzheimers disease.
genes like me logo Genes that share phenotypes with FAM30A: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM30A Gene

Localization for FAM30A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM30A gene
Compartment Confidence
extracellular 2
plasma membrane 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM30A Gene

Pathways & Interactions for FAM30A Gene

SuperPathways for FAM30A Gene

No Data Available

Interacting Proteins for FAM30A Gene

Gene Ontology (GO) - Biological Process for FAM30A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM30A Gene

Drugs & Compounds for FAM30A Gene

No Compound Related Data Available

Transcripts for FAM30A Gene

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM30A Gene

No ASD Table

Relevant External Links for FAM30A Gene

GeneLoc Exon Structure for
FAM30A
ECgene alternative splicing isoforms for
FAM30A

Expression for FAM30A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM30A Gene:

FAM30A
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM30A Gene

Orthologs for FAM30A Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for FAM30A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA0125 35
  • 91 (a)
OneToOne
Species where no ortholog for FAM30A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM30A Gene

ENSEMBL:
Gene Tree for FAM30A (if available)
TreeFam:
Gene Tree for FAM30A (if available)

Paralogs for FAM30A Gene

(1) SIMAP similar genes for FAM30A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM30A: view

No data available for Paralogs for FAM30A Gene

Variants for FAM30A Gene

Sequence variations from dbSNP and Humsavar for FAM30A Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1008794672 -- 105,930,662(+) ATAAG(C/T)AGAAG nc-transcript-variant
rs1009239217 -- 105,931,228(+) AAGCC(A/G)GATTT nc-transcript-variant
rs1012742731 -- 105,932,573(+) TTCCA(C/T)GTAAC nc-transcript-variant
rs10139478 -- 105,928,336(+) CATGC(C/T)CTGGG nc-transcript-variant
rs10140357 -- 105,916,057(+) gtttt(C/T)cttca upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM30A Gene

Variant ID Type Subtype PubMed ID
dgv1982n100 CNV gain 25217958
dgv1985n100 CNV loss 25217958
dgv1995n100 CNV gain 25217958
dgv1996n100 CNV loss 25217958
dgv2004n100 CNV gain 25217958
dgv2005n100 CNV gain 25217958
dgv2012n100 CNV gain 25217958
dgv2013n100 CNV loss 25217958
dgv2014n100 CNV gain 25217958
dgv2015n100 CNV loss 25217958
dgv2016n100 CNV loss 25217958
dgv2017n100 CNV gain 25217958
dgv2018n100 CNV loss 25217958
dgv2019n100 CNV loss 25217958
dgv2020n100 CNV gain 25217958
dgv2021n100 CNV loss 25217958
dgv2022n100 CNV loss 25217958
dgv2023n100 CNV loss 25217958
dgv2024n100 CNV gain+loss 25217958
dgv2025n100 CNV gain 25217958
dgv2026n100 CNV loss 25217958
dgv27n68 CNV gain+loss 17160897
dgv392n67 CNV loss 20364138
dgv394n67 CNV loss 20364138
dgv404n67 CNV gain 20364138
dgv422e199 CNV deletion 23128226
dgv423e199 CNV deletion 23128226
esv1001368 CNV loss 20482838
esv1002625 CNV gain 20482838
esv27023 CNV gain+loss 19812545
esv29981 CNV gain 17803354
esv32669 CNV gain+loss 17666407
esv3568731 CNV gain 25503493
esv3581458 CNV loss 25503493
esv3581459 CNV loss 25503493
esv3581461 CNV loss 25503493
esv3635665 CNV loss 21293372
esv3892583 CNV gain 25118596
esv3892584 CNV gain 25118596
esv3892585 CNV gain 25118596
nsv1036179 CNV gain+loss 25217958
nsv1039720 CNV gain 25217958
nsv1047682 CNV gain+loss 25217958
nsv1050165 CNV gain+loss 25217958
nsv1053673 CNV loss 25217958
nsv1054255 CNV loss 25217958
nsv1055016 CNV loss 25217958
nsv1070252 CNV deletion 25765185
nsv1443 CNV deletion 18451855
nsv436179 CNV deletion 17901297
nsv436184 CNV deletion 17901297
nsv456477 CNV loss 19166990
nsv469723 CNV gain+loss 16826518
nsv471673 CNV gain+loss 15918152
nsv511534 CNV gain 21212237
nsv514717 CNV loss 21397061
nsv517055 CNV gain+loss 19592680
nsv566351 CNV loss 21841781
nsv566484 CNV loss 21841781
nsv566485 CNV gain 21841781
nsv817649 CNV loss 17921354
nsv819133 CNV gain 19587683
nsv821677 CNV gain 15273396
nsv827099 CNV loss 20364138
nsv827111 CNV loss 20364138
nsv827137 CNV loss 20364138
nsv827138 CNV loss 20364138
nsv827146 CNV loss 20364138
nsv827147 CNV loss 20364138
nsv827148 CNV loss 20364138
nsv95 CNV deletion 15895083
nsv952290 CNV deletion 24416366
nsv976375 CNV duplication 23825009
nsv977505 CNV duplication 23825009
nsv983973 CNV deletion 23825009

Variation tolerance for FAM30A Gene

Gene Damage Index Score: 0.93; 19.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM30A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM30A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM30A Gene

Disorders for FAM30A Gene

Relevant External Links for FAM30A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM30A

No disorders were found for FAM30A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM30A Gene

Publications for FAM30A Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 2 3 64
  3. Long Noncoding RNA KIAA0125 Potentiates Cell Migration and Invasion in Gallbladder Cancer. (PMID: 26448925) Lv W. … Dong P. (Biomed Res Int 2015) 3 64
  4. New Alzheimer amyloid beta responsive genes identified in human neuroblastoma cells by hierarchical clustering. (PMID: 19707560) Uhrig M. … Hartmann T. (PLoS ONE 2009) 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64

Products for FAM30A Gene

Sources for FAM30A Gene

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