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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FAM27L Gene

RNA gene GIFtS: 32
GCID: GC17P021825

family with sequence similarity 27-like

Explore 3 diseases affiliated with
FAM27L via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 3

Aliases
Family With Sequence Similarity 27-Like¹ ²
MGC35151¹

External Ids:	HGNC: 32410¹	Entrez Gene: 284123²	Ensembl: ENSG00000178130⁷	UniProtKB: Q8N5T8³

ORGUL members:
	NONCODE:n375454

Export aliases for FAM27L gene to outside databases

Previous GC identifers: GC17P021750 GC17P021026

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_024862.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FAM27L gene promoter:
AP-1 GCNF HNF-1A POU2F1 GCNF-1 HNF-1 POU2F1a GCNF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FAM27L promoter sequence

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM27L

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2 Ensembl cytogenetic band: 17p11.2 HGNC cytogenetic band: 17p11.2

FAM27L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM27L gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P021825: view genomic region (about GC identifiers)

Start:	21,825,297 bp from pter	End:	21,826,499 bp from pter
Size:	1,203 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FA27L_HUMAN, Q8N5T8 (See protein sequence)

Recommended Name: Protein FAM27L

Size: 71 amino acids; 8147 Da

Explore the universe of human proteins at neXtProt for FAM27L: NX_Q8N5T8

FAM27L Protein expression data from MOPED and PaxDb: --

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q8N5T8

UniProtKB/Swiss-Prot: FA27L_HUMAN, Q8N5T8

Similarity: Belongs to the FAM27 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FAM27L

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAM27L
Search CenterWatch for drugs/clinical trials and news about FAM27L

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for FAM27L gene:

NM_203392.2

Unigene Cluster for FAM27L:

Family with sequence similarity 27-like

Hs.348578

Unigene Representative Sequence: BC031617

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000426869(lincRNA)(uc002gyz.3)

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Additional cDNA sequence:

BC031617.1 NR_028336.1

1 DOTS entry:

DT.95304591

3 AceView cDNA sequences:

NM_203392 BI827418 BC031617

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for FAM27L:none

FAM27L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGCCTCTC

About this image

FAM27L expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

SOURCE GeneReport for Unigene cluster: Hs.348578

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for FAM27L (if available)
TreeFam Gene Tree for FAM27L (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs147653381^1,2	--	21823743(+)	`CCTAAC/TGGATT`	1	--	us2k¹		0	--	--	--	--
rs201990169^1,2	--	21823996(+)	`AAAAT-/ATCATTTT`	1	--	us2k¹		0	--	--	--	--
rs147788783^1,2	--	21824388(+)	`CTTTAC/TGTGTA`	1	--	us2k¹		0	--	--	--	--
rs150285076^1,2	--	21824417(+)	`TAATCA/GTATTC`	1	--	us2k¹		0	--	--	--	--
rs144898749^1,2	--	21824571(+)	`GACCTA/CTGTGG`	1	--	us2k¹		0	--	--	--	--
rs145161972^1,2	--	21824576(+)	`CTGTGG/TCCGGA`	1	--	us2k¹		0	--	--	--	--
rs183452545^1,2	--	21824597(+)	`TCACCA/GGGTTT`	1	--	us2k¹		0	--	--	--	--
rs57632511^1,2	--	21825081(+)	`GATACA/GATGGC`	1	--	us2k¹		0	--	--	--	--
rs186637103^1,2	--	21825158(+)	`TCTCCC/TACGCC`	1	--	us2k¹		0	--	--	--	--
rs150651274^1,2	--	21825321(+)	`AGAGCC/TGCTTC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FAM27L (21825297 - 21826499 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for FAM27L
11 CNVs: 34476 22964 8838 30815 53597 23254 29670 4998 4027 29668 8839
Human Gene Mutation Database (HGMD): FAM27L

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FAM27L for disorders About GeneDecksing

3 diseases for FAM27L: About MalaCards

chronic myeloid leukemia myeloid leukemia leukemia

Export disorders for FAM27L gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FAM27L gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM27L)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A genome-wide association study identifies novel loci associated with susceptibility to chronic myeloid leukemia. (PubMed id 21540461)¹ Kim D.H....Lipton J.H. (2011)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 284123	HGNC: 32410	AceView: LOC284123	Ensembl:ENSG00000178130	euGenes: HUgn284123
ECgene: FAM27L	H-InvDB: FAM27L

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FAM27L	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FAM27L gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FAM27L gene:
Search GeneIP for patents involving FAM27L

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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family with sequence similarity 27-like

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FAM27L Gene

family with sequence similarity 27-like

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