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Aliases for FAM27C Gene

Subcategory (RNA class) for FAM27C Gene

non-coding RNA

Quality Score for this RNA gene is


Aliases for FAM27C Gene

  • Family With Sequence Similarity 27 Member C 2 3 5
  • Family With Sequence Similarity 27, Member A 2 3
  • FAM27A1 3 4
  • FAM27A3 3 4
  • FAM27A 3 4
  • Family With Sequence Similarity 27, Member C 2
  • FAM27B FAM27C 4
  • BA7G23.5 3
  • FAM27A2 4

External Ids for FAM27C Gene

Previous HGNC Symbols for FAM27C Gene

  • FAM27A

Previous GeneCards Identifiers for FAM27C Gene

  • GC00U921574
  • GC09U900684
  • GC09P044931
  • GC09P044990

Summaries for FAM27C Gene

GeneCards Summary for FAM27C Gene

FAM27C (Family With Sequence Similarity 27 Member C) is an RNA Gene, and is affiliated with the non-coding RNA class.

Additional gene information for FAM27C Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM27C Gene

Genomics for FAM27C Gene

GeneHancer (GH) Regulatory Elements for FAM27C Gene

Promoters and enhancers for FAM27C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I061853 Promoter 1 Ensembl 550.8 +0.0 17 1.4 HDGF HDAC1 BCOR ZSCAN4 CDC5L ATF7 SRF ZNF639 RFX1 MCM3 FAM27C GC09P061856 GC09P061857 GC09P061859 GC09P061860 GC09P061870 GC09P061871 PIR55649
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM27C on UCSC Golden Path with GeneCards custom track

Genomic Locations for FAM27C Gene

Genomic Locations for FAM27C Gene
1,257 bases
Plus strand

Genomic View for FAM27C Gene

Genes around FAM27C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM27C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM27C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM27C Gene

Proteins for FAM27C Gene

  • Protein details for FAM27C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM27A/B/C
    Protein Accession:

    Protein attributes for FAM27C Gene

    67 amino acids
    Molecular mass:
    7388 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM27C Gene

Post-translational modifications for FAM27C Gene

No Post-translational modifications

No data available for DME Specific Peptides for FAM27C Gene

Domains & Families for FAM27C Gene

Protein Domains for FAM27C Gene


Suggested Antigen Peptide Sequences for FAM27C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM27 family.
  • Belongs to the FAM27 family.
genes like me logo Genes that share domains with FAM27C: view

No data available for Gene Families for FAM27C Gene

Function for FAM27C Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM27C Gene

Localization for FAM27C Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM27C gene
Compartment Confidence
extracellular 3
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM27C Gene

Pathways & Interactions for FAM27C Gene

SuperPathways for FAM27C Gene

No Data Available

Interacting Proteins for FAM27C Gene

Gene Ontology (GO) - Biological Process for FAM27C Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM27C Gene

Drugs & Compounds for FAM27C Gene

No Compound Related Data Available

Transcripts for FAM27C Gene

mRNA/cDNA for FAM27C Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM27C Gene

Family with sequence similarity 27, member C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM27C Gene

No ASD Table

Relevant External Links for FAM27C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM27C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM27C Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM27C Gene:


SOURCE GeneReport for Unigene cluster for FAM27C Gene:


Evidence on tissue expression from TISSUES for FAM27C Gene

  • Nervous system(3.3)
  • Liver(2)
genes like me logo Genes that share expression patterns with FAM27C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM27C Gene

Orthologs for FAM27C Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for FAM27C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 82 (a)
Species where no ortholog for FAM27C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM27C Gene

Gene Tree for FAM27C (if available)
Gene Tree for FAM27C (if available)

Paralogs for FAM27C Gene

(1) SIMAP similar genes for FAM27C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM27C: view

No data available for Paralogs for FAM27C Gene

Variants for FAM27C Gene

Sequence variations from dbSNP and Humsavar for FAM27C Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1004994674 -- 61,853,903(+) G/A upstream_transcript_variant
rs1012264263 -- 61,853,830(+) C/G upstream_transcript_variant
rs1015085979 -- 61,853,920(+) G/T upstream_transcript_variant
rs1022448777 -- 61,854,011(+) A/T upstream_transcript_variant
rs1029259387 -- 61,853,965(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM27C Gene

Variant ID Type Subtype PubMed ID
dgv36n14 CNV gain 18776910
dgv4357e59 CNV duplication 20981092
dgv4402e59 CNV duplication 20981092
dgv7604n100 CNV gain 25217958
esv21770 CNV gain+loss 19812545
nsv1017514 CNV gain 25217958
nsv1150581 CNV duplication 26484159
nsv469618 CNV gain+loss 16826518
nsv831586 CNV loss 17160897
nsv831593 CNV loss 17160897
nsv831599 CNV loss 17160897
nsv8474 CNV gain+loss 18304495
nsv8503 CNV gain 18304495
nsv972359 CNV duplication 23825009

Variation tolerance for FAM27C Gene

Gene Damage Index Score: 0.00; 0.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM27C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM27C Gene

Disorders for FAM27C Gene

Additional Disease Information for FAM27C

No disorders were found for FAM27C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM27C Gene

Publications for FAM27C Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  3. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 58

Products for FAM27C Gene

Sources for FAM27C Gene

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