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FAM26F Gene

protein-coding   GIFtS: 40
GCID: GC06P116782

Family With Sequence Similarity 26, Member F

(Previous name: chromosome 6 open reading frame 187)
(Previous symbol: C6orf187)
  Search for FAM26F
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 26, Member F1 2
C6orf1871 2 3
Chromosome 6 Open Reading Frame 1871
dJ93H18.52
Protein FAM26F2

External Ids:    HGNC: 333911   Entrez Gene: 4411682   Ensembl: ENSG000001888207   UniProtKB: Q5R3K33   

Export aliases for FAM26F gene to outside databases

Previous GC identifers: GC06P116891 GC06P114362


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM26F Gene:
FAM26F (family with sequence similarity 26, member F) is a protein-coding gene. An important paralog of this gene is CALHM1.

UniProtKB/Swiss-Prot: FA26F_HUMAN, Q5R3K3
Function: Pore-forming subunit of a voltage-gated ion channel (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM26F gene promoter:
         USF1   STAT1   AML1a   HTF   STAT1beta   Lmo2   IRF-1   STAT1alpha   AREB6   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM26F promoter sequence
   Search Chromatin IP Primers for FAM26F

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM26F


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.1   Ensembl cytogenetic band:  6q22.1   HGNC cytogenetic band: 6q22.1

FAM26F Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM26F gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P116782:  view genomic region     (about GC identifiers)

Start:
116,782,533 bp from pter      End:
116,784,934 bp from pter
Size:
2,402 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FA26F_HUMAN, Q5R3K3 (See protein sequence)
Recommended Name: Protein FAM26F  
Size: 315 amino acids; 34458 Da

Explore the universe of human proteins at neXtProt for FAM26F: NX_Q5R3K3

Explore proteomics data for FAM26F at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM26F Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001010919.1  NP_001263389.1  

    ENSEMBL proteins: 
     ENSP00000357595   ENSP00000357594   ENSP00000357593  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q5R3K3

    UniProtKB/Swiss-Prot: FA26F_HUMAN, Q5R3K3
    Similarity: Belongs to the FAM26 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FA26F_HUMAN, Q5R3K3
    Function: Pore-forming subunit of a voltage-gated ion channel (By similarity)

    Phenotypes:
         1 MGI phenotypic allele for Fam26f (no phenotypes)


    FAM26F for phenotypes           About GeneDecksing

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FA26F_HUMAN, Q5R3K3: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    FAM26F for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM26F
    Interactions:

        Search GeneGlobe Interaction Network for FAM26F

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport IEA--

    FAM26F for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for FAM26F (FA26F)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FAM26F gene (2 alternative transcripts): 
    NM_001010919.2  NM_001276460.1  

    Unigene Cluster for FAM26F:

    Family with sequence similarity 26, member F
    Hs.381220  [show with all ESTs]
    Unigene Representative Sequence: NM_001010919
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368606 ENST00000368605(uc003pwv.3) ENST00000368604
    miRNA
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    Additional mRNA sequence: 

    AF086130.1 BC146842.1 

    5 DOTS entries:

    DT.213442  DT.121389497  DT.91899180  DT.92456593  DT.95163019 

    Selected AceView cDNA sequences (see all 53):

    N70619 BM671675 AI263774 AI371347 T90087 BQ890660 AF086130 CD742930 
    AI371349 AI140672 AI708155 BF001929 AI335924 AA682624 BI824254 BM704529 
    BU852543 AI224563 BE675649 BG745634 AI702542 BE676002 BG702138 AI347361 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM26F expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGCACAAAT
    FAM26F Expression
    About this image


    FAM26F expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    FAM26F Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM26F Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.381220
        Custom PCR Arrays for FAM26F
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM26F

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FAM26F gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam26f1 , 5 family with sequence similarity 26, member F1, 5 77.14(n)1
    69.87(a)1
      10 (18.85 cM)5
    2159001  NM_175449.41  NP_780658.21 
     341260695 
    chicken
    (Gallus gallus)
    Aves FAM26F1 family with sequence similarity 26, member F 59.41(n)
    51.16(a)
      421744  XM_419776.2  XP_419776.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAM26F6
    family with sequence similarity 26, member F
    51(a)
    1 ↔ 1
    1(186215599-186224771)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017311341 protein FAM26F-like 58.88(n)
    51.09(a)
      101731134  XM_004919989.1  XP_004920046.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fam26f1 family with sequence similarity 26, member F 51.08(n)
    41.23(a)
      780840  NM_001079661.1  NP_001073129.1 
    worm
    (Caenorhabditis elegans)
    Secernentea clhm-16
    Protein CLHM-1 (clhm-1) mRNA, complete cds
    20(a)
    1 → many
    II(6868942-6870839) WBGene00016626


    ENSEMBL Gene Tree for FAM26F (if available)
    TreeFam Gene Tree for FAM26F (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM26F gene
    CALHM12  CALHM32  FAM26D2  FAM26E2  CALHM22  
    3 SIMAP similar genes for FAM26F using alignment to 4 protein entries:     FA26F_HUMAN (see all proteins):
    FAM26E    FAM26D    CALHM2

    FAM26F for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM26F (see all 123)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1873549661,2
    --116780564(+) AAAGAC/TGGCAG 2 -- us2k10--------
    rs737677811,2
    C,F--116780642(+) TCTGAG/ATACTT 2 -- us2k12Minor allele frequency- A:0.50WA CSA 4
    rs1407807531,2
    --116780693(+) AATTAA/GTAACT 2 -- us2k10--------
    rs791810151,2
    C,F--116780718(+) TTAATC/TTAGTT 2 -- us2k11Minor allele frequency- T:0.12EA 120
    rs1501014851,2
    --116780834(+) GAGTCC/TTAAAA 2 -- us2k10--------
    rs1477962591,2
    --116780863(+) AGACCA/GTAGGA 2 -- us2k10--------
    rs1411663471,2
    --116780912(+) CTCAGG/TGGATG 2 -- us2k10--------
    rs121993941,2
    C,F,A--116780929(+) TATTAC/TAGCAC 2 -- us2k1 tfbs310Minor allele frequency- T:0.43NA CSA WA EA 371
    rs1909427171,2
    --116780952(+) CTGGTA/GTGGCT 2 -- us2k10--------
    rs1158664591,2
    F--116780953(+) TGGTAT/CGGCTA 2 -- us2k11Minor allele frequency- C:0.01WA 118

    HapMap Linkage Disequilibrium report for FAM26F (116782533 - 116784934 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FAM26F:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv523972CNV Gain19592680
    nsv830783CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM26F
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM26F gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM26F)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 441168 HGNC: 33391 AceView: LOC441168 Ensembl:ENSG00000188820 euGenes: HUgn441168
    ECgene: FAM26F H-InvDB: FAM26F

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM26F Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM26F gene:
    Search GeneIP for patents involving FAM26F

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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