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Aliases for FAM26F Gene

Aliases for FAM26F Gene

  • Family With Sequence Similarity 26 Member F 2 3 5
  • IFN Regulatory Factor 3-Dependent NK-Activating Molecule 2 3
  • C6orf187 3 4
  • Family With Sequence Similarity 26, Member F 2
  • Chromosome 6 Open Reading Frame 187 2
  • Protein FAM26F 3
  • DJ93H18.5 3
  • INAM 3

External Ids for FAM26F Gene

Previous HGNC Symbols for FAM26F Gene

  • C6orf187

Previous GeneCards Identifiers for FAM26F Gene

  • GC06P116891
  • GC06P116782
  • GC06P114362

Summaries for FAM26F Gene

GeneCards Summary for FAM26F Gene

FAM26F (Family With Sequence Similarity 26 Member F) is a Protein Coding gene. GO annotations related to this gene include cation channel activity. An important paralog of this gene is FAM26E.

UniProtKB/Swiss-Prot for FAM26F Gene

  • Pore-forming subunit of a voltage-gated ion channel.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM26F Gene

Genomics for FAM26F Gene

Regulatory Elements for FAM26F Gene

Enhancers for FAM26F Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G116461 1.4 FANTOM5 Ensembl ENCODE 41.7 +2.3 2285 4.5 BMI1 SCRT2 FOS IKZF2 CBFB REST GATAD2B TBX21 NR2F2 MTA1 FAM26F DSE ENSG00000234117 TRAPPC3L RWDD1 TSPYL1 ZUFSP ENSG00000244158
GH06G116384 1.9 FANTOM5 Ensembl ENCODE dbSUPER 24.2 -71.9 -71914 9.7 PKNOX1 WRNIP1 ZNF2 GATA2 FOS ZNF263 YY2 JUNB PBX2 MYNN DSE FAM26F FAM26D CBX3P9 KRT18P22 ENSG00000244158 ENSG00000234117 TRAPPC3L ENSG00000240050 TSPYL1
GH06G116450 1.3 FANTOM5 Ensembl ENCODE 35.3 -10.1 -10060 1.0 L3MBTL2 GTF2E2 MAX MAFG NFIC ZNF316 EED IKZF1 ZNF24 MLLT1 FAM26F ENSG00000234117 FAM26D RSPH4A DSE ZUFSP CBX3P9 PIR34878
GH06G116409 1.6 FANTOM5 Ensembl ENCODE dbSUPER 20.9 -50.3 -50306 3.1 TBP ZSCAN4 CBX5 RELB ETV6 IKZF2 CREM USF2 TBX21 PRDM6 FAM26F DSE CBX3P9 KRT18P22 ENSG00000244158 FAM26D ENSG00000234117 RWDD1 PIR34878 PIR33476
GH06G116446 1.3 FANTOM5 Ensembl ENCODE 25.7 -14.1 -14105 2.3 CTCF PKNOX1 NFIA BHLHE40 CEBPB CEBPG RAD21 FOXA1 PRDM6 ZBTB48 FAM26F FAM26D ENSG00000234117 DSE ZUFSP CBX3P9 PIR34878
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM26F on UCSC Golden Path with GeneCards custom track

Promoters for FAM26F Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000201674 830 801 CTCF MXI1 SUZ12 TEAD4 BACH1 ASH2L MAX BMI1 RBBP5 E2F1

Genomic Location for FAM26F Gene

Chromosome:
6
Start:
116,461,370 bp from pter
End:
116,463,782 bp from pter
Size:
2,413 bases
Orientation:
Plus strand

Genomic View for FAM26F Gene

Genes around FAM26F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM26F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM26F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM26F Gene

Proteins for FAM26F Gene

  • Protein details for FAM26F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5R3K3-FA26F_HUMAN
    Recommended name:
    Protein FAM26F
    Protein Accession:
    Q5R3K3
    Secondary Accessions:
    • B9EJB0
    • Q5R3K4

    Protein attributes for FAM26F Gene

    Size:
    315 amino acids
    Molecular mass:
    34458 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM26F Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM26F Gene

Post-translational modifications for FAM26F Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM26F Gene

No data available for DME Specific Peptides for FAM26F Gene

Domains & Families for FAM26F Gene

Protein Domains for FAM26F Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM26F Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5R3K3

UniProtKB/Swiss-Prot:

FA26F_HUMAN :
  • Belongs to the FAM26 family.
Family:
  • Belongs to the FAM26 family.
genes like me logo Genes that share domains with FAM26F: view

No data available for Gene Families for FAM26F Gene

Function for FAM26F Gene

Molecular function for FAM26F Gene

UniProtKB/Swiss-Prot Function:
Pore-forming subunit of a voltage-gated ion channel.

Gene Ontology (GO) - Molecular Function for FAM26F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005261 cation channel activity IBA --
genes like me logo Genes that share ontologies with FAM26F: view
genes like me logo Genes that share phenotypes with FAM26F: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM26F Gene

Localization for FAM26F Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM26F Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM26F gene
Compartment Confidence
plasma membrane 5
nucleus 2

Gene Ontology (GO) - Cellular Components for FAM26F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM26F: view

Pathways & Interactions for FAM26F Gene

SuperPathways for FAM26F Gene

No Data Available

Interacting Proteins for FAM26F Gene

Gene Ontology (GO) - Biological Process for FAM26F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0034220 ion transmembrane transport IBA --
GO:0098655 cation transmembrane transport IEA --
genes like me logo Genes that share ontologies with FAM26F: view

No data available for Pathways by source and SIGNOR curated interactions for FAM26F Gene

Transcripts for FAM26F Gene

Unigene Clusters for FAM26F Gene

Family with sequence similarity 26, member F:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM26F Gene

No ASD Table

Relevant External Links for FAM26F Gene

GeneLoc Exon Structure for
FAM26F
ECgene alternative splicing isoforms for
FAM26F

Expression for FAM26F Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM26F Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM26F Gene

This gene is overexpressed in Spleen (x19.5) and Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for FAM26F Gene

This gene is overexpressed in Ovary (49.2) and Skin (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM26F Gene



Protein tissue co-expression partners for FAM26F Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM26F Gene:

FAM26F

SOURCE GeneReport for Unigene cluster for FAM26F Gene:

Hs.381220

Evidence on tissue expression from TISSUES for FAM26F Gene

  • Lung(2.9)
  • Spleen(2.3)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with FAM26F: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM26F Gene

Orthologs for FAM26F Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM26F Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM26F 34 35
  • 99.47 (n)
dog
(Canis familiaris)
Mammalia FAM26F 34 35
  • 85.38 (n)
cow
(Bos Taurus)
Mammalia FAM26F 34 35
  • 85.36 (n)
rat
(Rattus norvegicus)
Mammalia Fam26f 34
  • 77.38 (n)
mouse
(Mus musculus)
Mammalia Fam26f 34 16 35
  • 77.14 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 59 (a)
OneToMany
-- 35
  • 42 (a)
OneToMany
chicken
(Gallus gallus)
Aves FAM26F 34 35
  • 59.41 (n)
lizard
(Anolis carolinensis)
Reptilia FAM26F 35
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731134 34
  • 58.88 (n)
zebrafish
(Danio rerio)
Actinopterygii fam26f 34 35
  • 51.08 (n)
worm
(Caenorhabditis elegans)
Secernentea clhm-1 35
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 16 (a)
OneToMany
Species where no ortholog for FAM26F was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM26F Gene

ENSEMBL:
Gene Tree for FAM26F (if available)
TreeFam:
Gene Tree for FAM26F (if available)

Paralogs for FAM26F Gene

Paralogs for FAM26F Gene

(3) SIMAP similar genes for FAM26F Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FAM26F: view

Variants for FAM26F Gene

Sequence variations from dbSNP and Humsavar for FAM26F Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000611244 -- 116,463,212(+) AACTT(C/T)ATCTG intron-variant
rs1000937351 -- 116,460,701(+) GTCTA(G/T)TCCCC upstream-variant-2KB
rs1000955888 -- 116,463,462(+) AAAGA(A/G)AATAT reference, synonymous-codon
rs1001389699 -- 116,461,087(+) TGGGT(A/T)CAACT upstream-variant-2KB
rs1001442558 -- 116,462,463(+) TGCCG(C/T)TGGCG intron-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for FAM26F Gene

Variant ID Type Subtype PubMed ID
nsv523972 CNV gain 19592680
nsv830783 CNV gain 17160897

Variation tolerance for FAM26F Gene

Gene Damage Index Score: 9.46; 88.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM26F Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM26F

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM26F Gene

Disorders for FAM26F Gene

Relevant External Links for FAM26F

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM26F

No disorders were found for FAM26F Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM26F Gene

Publications for FAM26F Gene

  1. Structural and functional annotation of human FAM26F: A multifaceted protein having a critical role in the immune system. (PMID: 27784631) Malik U. … Asghar K. (Gene 2017) 2 3 64
  2. FAM26F: An Enigmatic Protein Having a Complex Role in the Immune System. (PMID: 27645024) Malik U. … Javed A. (Int. Rev. Immunol. 2016) 2 3 64
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  4. A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis. (PMID: 25082827) JuliA A. … Marsal S. (Hum. Mol. Genet. 2014) 3 64
  5. CBFI^ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. (PMID: 23333304) Kim D.Y. … Gross J.D. (Mol. Cell 2013) 3 64

Products for FAM26F Gene

Sources for FAM26F Gene

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