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Aliases for FAM26E Gene

Aliases for FAM26E Gene

  • Family With Sequence Similarity 26 Member E 2 3 5
  • C6orf188 3 4
  • Family With Sequence Similarity 26, Member E 2
  • Chromosome 6 Open Reading Frame 188 2
  • Protein FAM26E 3
  • DJ493F7.3 3

External Ids for FAM26E Gene

Previous HGNC Symbols for FAM26E Gene

  • C6orf188

Previous GeneCards Identifiers for FAM26E Gene

  • GC06P116940
  • GC06P116833
  • GC06P114412

Summaries for FAM26E Gene

GeneCards Summary for FAM26E Gene

FAM26E (Family With Sequence Similarity 26 Member E) is a Protein Coding gene. GO annotations related to this gene include cation channel activity. An important paralog of this gene is FAM26F.

UniProtKB/Swiss-Prot for FAM26E Gene

  • Pore-forming subunit of a voltage-gated ion channel.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM26E Gene

Genomics for FAM26E Gene

Regulatory Elements for FAM26E Gene

Enhancers for FAM26E Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G116555 1.2 Ensembl ENCODE 9.2 +45.8 45757 3.6 PKNOX1 NFIB SIN3A ZNF335 GLIS2 ZNF366 SCRT2 RCOR1 FOS SP3 RSPH4A FAM26F FAM26D ENSG00000244158 KRT18P22 CBX3P9 ENSG00000234117 FAM26E TRAPPC3L RWDD1
GH06G116475 1.1 Ensembl ENCODE 7.3 -35.7 -35728 1.8 ELF3 BMI1 RARA CBX5 RELB ETV6 IKZF2 CREM ELF4 JUNB FAM26F DSE FAM26E ENSG00000244158 ENSG00000234117
GH06G116384 1.9 FANTOM5 Ensembl ENCODE dbSUPER 4 -122.2 -122189 9.7 PKNOX1 WRNIP1 ZNF2 GATA2 FOS ZNF263 YY2 JUNB PBX2 MYNN DSE FAM26F FAM26D CBX3P9 KRT18P22 ENSG00000244158 ENSG00000234117 TRAPPC3L ENSG00000240050 TSPYL1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM26E on UCSC Golden Path with GeneCards custom track

Promoters for FAM26E Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000201680 655 1801 CBX3 SIN3A ZNF2 RAD21 ZBTB40 CHAMP1 YY1 GATA2 ZNF366 FOS

Genomic Location for FAM26E Gene

116,511,645 bp from pter
116,524,792 bp from pter
13,148 bases
Plus strand

Genomic View for FAM26E Gene

Genes around FAM26E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM26E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM26E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM26E Gene

Proteins for FAM26E Gene

  • Protein details for FAM26E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM26E
    Protein Accession:
    Secondary Accessions:
    • B2RDJ9
    • B3KSR3

    Protein attributes for FAM26E Gene

    309 amino acids
    Molecular mass:
    35170 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM26E Gene

Post-translational modifications for FAM26E Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM26E Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM26E Gene

Domains & Families for FAM26E Gene

Protein Domains for FAM26E Gene


Suggested Antigen Peptide Sequences for FAM26E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM26 family.
  • Belongs to the FAM26 family.
genes like me logo Genes that share domains with FAM26E: view

No data available for Gene Families for FAM26E Gene

Function for FAM26E Gene

Molecular function for FAM26E Gene

UniProtKB/Swiss-Prot Function:
Pore-forming subunit of a voltage-gated ion channel.

Gene Ontology (GO) - Molecular Function for FAM26E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005261 cation channel activity IBA --
genes like me logo Genes that share ontologies with FAM26E: view

Phenotypes for FAM26E Gene

GenomeRNAi human phenotypes for FAM26E:
genes like me logo Genes that share phenotypes with FAM26E: view

Animal Model Products

CRISPR Products

miRNA for FAM26E Gene

miRTarBase miRNAs that target FAM26E

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM26E Gene

Localization for FAM26E Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM26E Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM26E gene
Compartment Confidence
extracellular 5
plasma membrane 4

Gene Ontology (GO) - Cellular Components for FAM26E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FAM26E: view

Pathways & Interactions for FAM26E Gene

SuperPathways for FAM26E Gene

No Data Available

Interacting Proteins for FAM26E Gene

Gene Ontology (GO) - Biological Process for FAM26E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0034220 ion transmembrane transport IBA --
GO:0098655 cation transmembrane transport IEA --
genes like me logo Genes that share ontologies with FAM26E: view

No data available for Pathways by source and SIGNOR curated interactions for FAM26E Gene

Drugs & Compounds for FAM26E Gene

No Compound Related Data Available

Transcripts for FAM26E Gene

mRNA/cDNA for FAM26E Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(64) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM26E Gene

Family with sequence similarity 26, member E:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM26E Gene

No ASD Table

Relevant External Links for FAM26E Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM26E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM26E Gene

mRNA differential expression in normal tissues according to GTEx for FAM26E Gene

This gene is overexpressed in Artery - Aorta (x7.0), Artery - Coronary (x4.8), and Artery - Tibial (x4.3).

Protein differential expression in normal tissues from HIPED for FAM26E Gene

This gene is overexpressed in Placenta (27.5) and Peripheral blood mononuclear cells (17.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM26E Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM26E Gene:


SOURCE GeneReport for Unigene cluster for FAM26E Gene:

genes like me logo Genes that share expression patterns with FAM26E: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM26E Gene

Orthologs for FAM26E Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM26E Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM26E 34 35
  • 99.57 (n)
(Canis familiaris)
Mammalia FAM26E 34 35
  • 87.49 (n)
(Bos Taurus)
Mammalia FAM26E 34 35
  • 87.27 (n)
(Rattus norvegicus)
Mammalia Fam26e 34
  • 84.9 (n)
(Mus musculus)
Mammalia Fam26e 34 16 35
  • 83.6 (n)
(Monodelphis domestica)
Mammalia FAM26E 35
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia FAM26E 35
  • 57 (a)
(Gallus gallus)
Aves FAM26E 34 35
  • 69.52 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730841 34
  • 58.94 (n)
(Danio rerio)
Actinopterygii fam26e.1 34
  • 59.87 (n)
fam26e 35
  • 50 (a)
FAM26E (1 of 2) 35
  • 50 (a)
(Caenorhabditis elegans)
Secernentea clhm-1 34 35
  • 40.16 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 15 (a)
Species where no ortholog for FAM26E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM26E Gene

Gene Tree for FAM26E (if available)
Gene Tree for FAM26E (if available)

Paralogs for FAM26E Gene

Paralogs for FAM26E Gene

(1) SIMAP similar genes for FAM26E Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM26E: view

Variants for FAM26E Gene

Sequence variations from dbSNP and Humsavar for FAM26E Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000148544 -- 116,517,635(+) TATTT(G/T)GTCTT intron-variant, utr-variant-3-prime
rs1000343394 -- 116,521,338(+) AGGGT(G/T)GCTCA intron-variant, utr-variant-3-prime
rs1000378580 -- 116,514,237(+) AGTTT(A/G)TAATT intron-variant
rs1000543462 -- 116,521,197(+) AACAA(A/G)ATATA intron-variant, utr-variant-3-prime
rs1000914622 -- 116,520,958(+) AATTT(C/T)GGAGT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM26E Gene

Variant ID Type Subtype PubMed ID
esv2663254 CNV deletion 23128226
esv3610471 CNV loss 21293372
nsv523972 CNV gain 19592680
nsv830783 CNV gain 17160897

Variation tolerance for FAM26E Gene

Residual Variation Intolerance Score: 64.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.65; 31.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM26E Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM26E Gene

Disorders for FAM26E Gene

Relevant External Links for FAM26E

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM26E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM26E Gene

Publications for FAM26E Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for FAM26E Gene

Sources for FAM26E Gene

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