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FAM26E Gene

protein-coding   GIFtS: 42
GCID: GC06P116833

Family With Sequence Similarity 26, Member E

(Previous name: chromosome 6 open reading frame 188)
(Previous symbol: C6orf188)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 26, Member E1 2
C6orf1881 2 3
Chromosome 6 Open Reading Frame 1881
dJ493F7.32
Protein FAM26E2

External Ids:    HGNC: 215681   Entrez Gene: 2542282   Ensembl: ENSG000001780337   UniProtKB: Q8N5C13   

Export aliases for FAM26E gene to outside databases

Previous GC identifers: GC06P116940 GC06P114412


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM26E Gene:
FAM26E (family with sequence similarity 26, member E) is a protein-coding gene. An important paralog of this gene is CALHM1.

UniProtKB/Swiss-Prot: FA26E_HUMAN, Q8N5C1
Function: Pore-forming subunit of a voltage-gated ion channel (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM26E gene promoter:
         LHX3b/Lhx3b   GATA-3   FOXD3   GATA-2   GATA-1   SRY   FOXJ2 (long isoform)   LHX3a/Lhx3a   FOXJ2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM26E promoter sequence
   Search Chromatin IP Primers for FAM26E

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM26E


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.1   Ensembl cytogenetic band:  6q22.1   HGNC cytogenetic band: 6q22.31

FAM26E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM26E gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P116833:  view genomic region     (about GC identifiers)

Start:
116,832,808 bp from pter      End:
116,845,955 bp from pter
Size:
13,148 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FA26E_HUMAN, Q8N5C1 (See protein sequence)
Recommended Name: Protein FAM26E  
Size: 309 amino acids; 35170 Da
Secondary accessions: B2RDJ9 B3KSR3

Explore the universe of human proteins at neXtProt for FAM26E: NX_Q8N5C1

Explore proteomics data for FAM26E at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM26E Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_714922.1  
    ENSEMBL proteins: 
     ENSP00000357588  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q8N5C1

    UniProtKB/Swiss-Prot: FA26E_HUMAN, Q8N5C1
    Similarity: Belongs to the FAM26 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FA26E_HUMAN, Q8N5C1
    Function: Pore-forming subunit of a voltage-gated ion channel (By similarity)

    Animal Models:

       genOway: Develop your customized and physiologically relevant rodent model for FAM26E

    miRNA
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    miRTarBase miRNAs that target FAM26E:
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    SwitchGear 3'UTR luciferase reporter plasmidFAM26E 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FA26E_HUMAN, Q8N5C1: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytoskeleton1
    cytosol1
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with FAM26E           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM26E
    Interactions:

        Search GeneGlobe Interaction Network for FAM26E

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport IEA--

    Find genes that share ontologies with FAM26E           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM26E (FA26E)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM26E gene: 
    NM_153711.2  

    Unigene Cluster for FAM26E:

    Family with sequence similarity 26, member E
    Hs.660142  [show with all ESTs]
    Unigene Representative Sequence: NM_153711
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000368599(uc003pwy.3)
    miRNA
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    hsa-miR-3163 hsa-miR-3607-5p hsa-miR-3130-3p hsa-miR-146a hsa-miR-627 hsa-miR-371-5p hsa-miR-504 hsa-miR-511
    SwitchGear 3'UTR luciferase reporter plasmidFAM26E 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat FAM26E

    Additional mRNA sequence: 

    AK023730.1 AK094140.1 AK315572.1 

    2 DOTS entries:

    DT.100746073  DT.40237583 

    Selected AceView cDNA sequences (see all 64):

    BP336609 AW137910 BX105836 AW841397 BG115543 BQ025606 BQ023060 BQ001005 
    AK023730 AI312571 BM478960 CN480577 BX106642 AK094140 BQ893710 BM473669 
    BU620330 BF984974 AW071543 BQ003093 AA313103 CA427440 CB997302 AU120909 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM26E expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAGTGGTG
    FAM26E Expression
    About this image


    FAM26E expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Line H9 (Naive)
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Thymus (Hematopoietic System)
             Thymus
    FAM26E Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM26E Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.660142
        Custom PCR Arrays for FAM26E
    Primer
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    OriGene qPCR primer pairs and template standards for FAM26E
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM26E

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FAM26E gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam26e1 , 5 family with sequence similarity 26, member E1, 5 83.6(n)1
    83.5(a)1
      10 (18.85 cM)5
    1035111  NM_178908.31  NP_849239.21 
     340913525 
    chicken
    (Gallus gallus)
    Aves FAM26E1 family with sequence similarity 26, member E 69.52(n)
    65.46(a)
      769904  NM_001079492.1  NP_001072960.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017310091 protein FAM26E-like 58.94(n)
    52.94(a)
      101731009  XM_004919987.1  XP_004920044.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fam26e.11 family with sequence similarity 26, member E, tandem more 59.87(n)
    53.18(a)
      100037308  NM_001089465.2  NP_001082934.2 
    worm
    (Caenorhabditis elegans)
    Secernentea clhm-11 clhm-1 40.16(n)
    26.64(a)
      183429  NM_063002.3  NP_495403.2 


    ENSEMBL Gene Tree for FAM26E (if available)
    TreeFam Gene Tree for FAM26E (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM26E gene
    CALHM12  CALHM32  FAM26D2  FAM26F2  CALHM22  
    1 SIMAP similar gene for FAM26E using alignment to 1 protein entry:     FA26E_HUMAN:
    FAM26F

    Find genes that share paralogs with FAM26E           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    4 SNPs for FAM26E    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs94889501,2
    --114410463(+) acttcA/Taatta 1 -- us2k10--------
    rs1472900151,2
    --114410476(+) CTACAA/CAGGTA 1 -- us2k10--------
    rs1171529031,2
    F--114410601(+) GGAAAG/AGACAC 1 -- us2k11Minor allele frequency- A:0.03EA 120
    rs1116259131,2
    ----116830621(+) AAGGTG/ATAGTT 1 -- int11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for FAM26E (116832808 - 116845955 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for FAM26E:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663254CNV Deletion23128226
    nsv523972CNV Gain19592680
    nsv830783CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for FAM26E

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM26E gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM26E)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    3. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 254228 HGNC: 21568 AceView: C6orf188 Ensembl:ENSG00000178033 euGenes: HUgn254228
    ECgene: FAM26E H-InvDB: FAM26E

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM26E Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM26E gene:
    Search GeneIP for patents involving FAM26E

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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