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Aliases for FAM26E Gene

Aliases for FAM26E Gene

  • Family With Sequence Similarity 26, Member E 2 3
  • C6orf188 3 4
  • Chromosome 6 Open Reading Frame 188 2
  • Protein FAM26E 3
  • DJ493F7.3 3

External Ids for FAM26E Gene

Previous HGNC Symbols for FAM26E Gene

  • C6orf188

Previous GeneCards Identifiers for FAM26E Gene

  • GC06P116940
  • GC06P116833
  • GC06P114412

Summaries for FAM26E Gene

GeneCards Summary for FAM26E Gene

FAM26E (Family With Sequence Similarity 26, Member E) is a Protein Coding gene. An important paralog of this gene is FAM26F.

UniProtKB/Swiss-Prot for FAM26E Gene

  • Pore-forming subunit of a voltage-gated ion channel.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM26E Gene

Genomics for FAM26E Gene

Regulatory Elements for FAM26E Gene

Genomic Location for FAM26E Gene

Start:
116,511,645 bp from pter
End:
116,524,792 bp from pter
Size:
13,148 bases
Orientation:
Plus strand

Genomic View for FAM26E Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM26E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM26E Gene

Proteins for FAM26E Gene

  • Protein details for FAM26E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5C1-FA26E_HUMAN
    Recommended name:
    Protein FAM26E
    Protein Accession:
    Q8N5C1
    Secondary Accessions:
    • B2RDJ9
    • B3KSR3

    Protein attributes for FAM26E Gene

    Size:
    309 amino acids
    Molecular mass:
    35170 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM26E Gene

Proteomics data for FAM26E Gene at MOPED

Post-translational modifications for FAM26E Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM26E Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM26E Gene

Domains for FAM26E Gene

Protein Domains for FAM26E Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM26E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N5C1

UniProtKB/Swiss-Prot:

FA26E_HUMAN :
  • Q8N5C1
Family:
  • Belongs to the FAM26 family.
genes like me logo Genes that share domains with FAM26E: view

No data available for Gene Families for FAM26E Gene

Function for FAM26E Gene

Molecular function for FAM26E Gene

UniProtKB/Swiss-Prot Function:
Pore-forming subunit of a voltage-gated ion channel.

Gene Ontology (GO) - Molecular Function for FAM26E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005261 cation channel activity IBA --
genes like me logo Genes that share ontologies with FAM26E: view

Animal Model Products

CRISPR Products

miRNA for FAM26E Gene

miRTarBase miRNAs that target FAM26E

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM26E Gene

Localization for FAM26E Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM26E Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM26E Gene COMPARTMENTS Subcellular localization image for FAM26E gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for FAM26E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FAM26E: view

Pathways for FAM26E Gene

SuperPathways for FAM26E Gene

No Data Available

Interacting Proteins for FAM26E Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357588%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000357588 for FAM26E Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for FAM26E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0006812 cation transport IBA --
GO:0034220 ion transmembrane transport IBA --
GO:0098655 cation transmembrane transport IBA --
genes like me logo Genes that share ontologies with FAM26E: view

No data available for Pathways by source for FAM26E Gene

Transcripts for FAM26E Gene

mRNA/cDNA for FAM26E Gene

(64) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM26E Gene

Family with sequence similarity 26, member E:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM26E

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM26E Gene

No ASD Table

Relevant External Links for FAM26E Gene

GeneLoc Exon Structure for
FAM26E
ECgene alternative splicing isoforms for
FAM26E

Expression for FAM26E Gene

mRNA expression in normal human tissues for FAM26E Gene

mRNA differential expression in normal tissues according to GTEx for FAM26E Gene

This gene is overexpressed in Artery - Aorta (7.0), Artery - Coronary (4.8), and Artery - Tibial (4.3).

Protein differential expression in normal tissues for FAM26E Gene

This gene is overexpressed in Placenta (27.5) and Peripheral blood mononuclear cells (17.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM26E Gene

SOURCE GeneReport for Unigene cluster for FAM26E Gene Hs.660142

genes like me logo Genes that share expressions with FAM26E: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for FAM26E Gene

Orthologs for FAM26E Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM26E Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM26E 35
  • 87.27 (n)
  • 87.38 (a)
FAM26E 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM26E 35
  • 87.49 (n)
  • 89.97 (a)
FAM26E 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam26e 35
  • 83.6 (n)
  • 83.5 (a)
Fam26e 16
Fam26e 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM26E 35
  • 99.57 (n)
  • 99.35 (a)
FAM26E 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam26e 35
  • 84.9 (n)
  • 85.11 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM26E 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM26E 36
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM26E 35
  • 69.52 (n)
  • 65.46 (a)
FAM26E 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731009 35
  • 58.94 (n)
  • 52.94 (a)
zebrafish
(Danio rerio)
Actinopterygii fam26e.1 35
  • 59.87 (n)
  • 53.18 (a)
fam26e 36
  • 50 (a)
OneToMany
FAM26E (1 of 2) 36
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea clhm-1 35
  • 40.16 (n)
  • 26.64 (a)
clhm-1 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 15 (a)
OneToMany
Species with no ortholog for FAM26E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM26E Gene

ENSEMBL:
Gene Tree for FAM26E (if available)
TreeFam:
Gene Tree for FAM26E (if available)

Paralogs for FAM26E Gene

Paralogs for FAM26E Gene

Selected SIMAP similar genes for FAM26E Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM26E: view

Variants for FAM26E Gene

Structural Variations from Database of Genomic Variants (DGV) for FAM26E Gene

Variant ID Type Subtype PubMed ID
nsv523972 CNV Gain 19592680
nsv830783 CNV Gain 17160897
esv2663254 CNV Deletion 23128226

Relevant External Links for FAM26E Gene

HapMap Linkage Disequilibrium report
FAM26E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for FAM26E Gene

Disorders for FAM26E Gene

No disorders were found for FAM26E Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FAM26E Gene

Publications for FAM26E Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PMID: 23000965) Povlsen L.K. … Choudhary C. (Nat. Cell Biol. 2012) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for FAM26E Gene

Sources for FAM26E Gene

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