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Aliases for FAM26D Gene

Aliases for FAM26D Gene

  • Family With Sequence Similarity 26 Member D 2 3 5
  • C6orf78 3 4
  • Family With Sequence Similarity 26, Member D 2
  • Chromosome 6 Open Reading Frame 78 2
  • Protein FAM26D 3

External Ids for FAM26D Gene

Previous HGNC Symbols for FAM26D Gene

  • C6orf78

Previous GeneCards Identifiers for FAM26D Gene

  • GC06P116957
  • GC06P116851
  • GC06P114429

Summaries for FAM26D Gene

GeneCards Summary for FAM26D Gene

FAM26D (Family With Sequence Similarity 26 Member D) is a Protein Coding gene. GO annotations related to this gene include cation channel activity. An important paralog of this gene is CALHM2.

UniProtKB/Swiss-Prot for FAM26D Gene

  • Pore-forming subunit of a voltage-gated ion channel.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM26D Gene

Genomics for FAM26D Gene

Regulatory Elements for FAM26D Gene

Enhancers for FAM26D Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G116384 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -139.5 -139543 9.7 PKNOX1 WRNIP1 ZNF2 GATA2 FOS ZNF263 YY2 JUNB PBX2 MYNN DSE FAM26F FAM26D CBX3P9 KRT18P22 ENSG00000244158 ENSG00000234117 TRAPPC3L ENSG00000240050 TSPYL1
GH06G116409 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -117.9 -117935 3.1 TBP ZSCAN4 CBX5 RELB ETV6 IKZF2 CREM USF2 TBX21 PRDM6 FAM26F DSE CBX3P9 KRT18P22 ENSG00000244158 FAM26D ENSG00000234117 RWDD1 PIR34878 PIR33476
GH06G116276 1.4 ENCODE dbSUPER 12.3 -249.6 -249573 5.1 HDGF FOXA2 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 FAM26F TSPYL4 FAM26D TSPYL1 TRAPPC3L CBX3P9 KRT18P22 ENSG00000244158 ENSG00000234117 ZUFSP
GH06G116403 1.4 Ensembl ENCODE dbSUPER 11.3 -123.1 -123125 4.5 TBP PKNOX1 ZFP64 SIN3A CBX5 ZSCAN5C ZNF350 ZNF143 FOS RELB KRT18P22 FAM26D CBX3P9 FAM26F ENSG00000244158 ENSG00000234117 TRAPPC3L DSE PIR34878 PIR33476
GH06G116446 1.3 FANTOM5 Ensembl ENCODE 11.8 -81.7 -81734 2.3 CTCF PKNOX1 NFIA BHLHE40 CEBPB CEBPG RAD21 FOXA1 PRDM6 ZBTB48 FAM26F FAM26D ENSG00000234117 DSE ZUFSP CBX3P9 PIR34878
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM26D on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM26D Gene

116,528,999 bp from pter
116,561,123 bp from pter
32,125 bases
Plus strand

Genomic View for FAM26D Gene

Genes around FAM26D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM26D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM26D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM26D Gene

Proteins for FAM26D Gene

  • Protein details for FAM26D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM26D
    Protein Accession:
    Secondary Accessions:
    • B0QZ25
    • B0QZ27
    • B4DTQ0
    • Q96MK0

    Protein attributes for FAM26D Gene

    314 amino acids
    Molecular mass:
    35060 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM26D Gene


neXtProt entry for FAM26D Gene

Post-translational modifications for FAM26D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM26D Gene

Domains & Families for FAM26D Gene

Protein Domains for FAM26D Gene


Suggested Antigen Peptide Sequences for FAM26D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM26 family.
  • Belongs to the FAM26 family.
genes like me logo Genes that share domains with FAM26D: view

No data available for Gene Families for FAM26D Gene

Function for FAM26D Gene

Molecular function for FAM26D Gene

UniProtKB/Swiss-Prot Function:
Pore-forming subunit of a voltage-gated ion channel.

Gene Ontology (GO) - Molecular Function for FAM26D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005261 cation channel activity IBA --
genes like me logo Genes that share ontologies with FAM26D: view
genes like me logo Genes that share phenotypes with FAM26D: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM26D Gene

Localization for FAM26D Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM26D Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM26D gene
Compartment Confidence
plasma membrane 3
extracellular 3

Gene Ontology (GO) - Cellular Components for FAM26D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM26D: view

Pathways & Interactions for FAM26D Gene

SuperPathways for FAM26D Gene

No Data Available

Interacting Proteins for FAM26D Gene

Gene Ontology (GO) - Biological Process for FAM26D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0034220 ion transmembrane transport IBA --
GO:0098655 cation transmembrane transport IEA --
genes like me logo Genes that share ontologies with FAM26D: view

No data available for Pathways by source and SIGNOR curated interactions for FAM26D Gene

Drugs & Compounds for FAM26D Gene

No Compound Related Data Available

Transcripts for FAM26D Gene

mRNA/cDNA for FAM26D Gene

(13) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM26D Gene

Family with sequence similarity 26, member D:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM26D Gene

No ASD Table

Relevant External Links for FAM26D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM26D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM26D Gene

mRNA differential expression in normal tissues according to GTEx for FAM26D Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x36.1) and Skin - Sun Exposed (Lower leg) (x6.4).

Protein differential expression in normal tissues from HIPED for FAM26D Gene

This gene is overexpressed in Hair follicle (67.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM26D Gene

Protein tissue co-expression partners for FAM26D Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM26D Gene:


SOURCE GeneReport for Unigene cluster for FAM26D Gene:

genes like me logo Genes that share expression patterns with FAM26D: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM26D Gene

Orthologs for FAM26D Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM26D Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM26D 34 35
  • 99.61 (n)
(Canis familiaris)
Mammalia FAM26D 34 35
  • 86.94 (n)
(Bos Taurus)
Mammalia FAM26D 34 35
  • 84.12 (n)
(Mus musculus)
Mammalia Fam26d 34 16 35
  • 80.51 (n)
(Rattus norvegicus)
Mammalia Fam26d 34
  • 80.31 (n)
(Monodelphis domestica)
Mammalia FAM26D 35
  • 35 (a)
(Gallus gallus)
Aves FAM26D 35
  • 23 (a)
(Caenorhabditis elegans)
Secernentea clhm-1 35
  • 9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 6 (a)
Species where no ortholog for FAM26D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for FAM26D Gene

Gene Tree for FAM26D (if available)
Gene Tree for FAM26D (if available)

Paralogs for FAM26D Gene

Paralogs for FAM26D Gene

(2) SIMAP similar genes for FAM26D Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM26D: view

Variants for FAM26D Gene

Sequence variations from dbSNP and Humsavar for FAM26D Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000057975 -- 116,528,385(+) CCAGA(A/G)GTACA intron-variant, upstream-variant-2KB
rs1000100044 -- 116,554,642(+) ATACA(A/T)TACCA intron-variant
rs1000160627 -- 116,553,060(+) CAGAG(C/G)GAGAC intron-variant, upstream-variant-2KB
rs1000213322 -- 116,553,606(+) TCAGC(C/T)GTAAT intron-variant, utr-variant-5-prime
rs1000388554 -- 116,559,689(+) TAAAA(A/G)GGATG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM26D Gene

Variant ID Type Subtype PubMed ID
nsv523972 CNV gain 19592680
nsv830783 CNV gain 17160897

Variation tolerance for FAM26D Gene

Residual Variation Intolerance Score: 78.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.19; 69.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM26D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM26D Gene

Disorders for FAM26D Gene

Relevant External Links for FAM26D

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM26D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM26D Gene

Publications for FAM26D Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for FAM26D Gene

Sources for FAM26D Gene

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