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Aliases for FAM26D Gene

Aliases for FAM26D Gene

  • Family With Sequence Similarity 26, Member D 2 3
  • C6orf78 3 4
  • Chromosome 6 Open Reading Frame 78 2
  • Protein FAM26D 3

External Ids for FAM26D Gene

Previous HGNC Symbols for FAM26D Gene

  • C6orf78

Previous GeneCards Identifiers for FAM26D Gene

  • GC06P116957
  • GC06P116851
  • GC06P114429

Summaries for FAM26D Gene

GeneCards Summary for FAM26D Gene

FAM26D (Family With Sequence Similarity 26, Member D) is a Protein Coding gene. An important paralog of this gene is FAM26F.

UniProtKB/Swiss-Prot for FAM26D Gene

  • Pore-forming subunit of a voltage-gated ion channel.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM26D Gene

Genomics for FAM26D Gene

Regulatory Elements for FAM26D Gene

Genomic Location for FAM26D Gene

116,529,013 bp from pter
116,558,868 bp from pter
29,856 bases
Plus strand

Genomic View for FAM26D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM26D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM26D Gene

Proteins for FAM26D Gene

  • Protein details for FAM26D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM26D
    Protein Accession:
    Secondary Accessions:
    • B0QZ25
    • B0QZ27
    • B4DTQ0
    • Q96MK0

    Protein attributes for FAM26D Gene

    314 amino acids
    Molecular mass:
    35060 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM26D Gene


neXtProt entry for FAM26D Gene

Proteomics data for FAM26D Gene at MOPED

Post-translational modifications for FAM26D Gene

No Post-translational modifications

Other Protein References for FAM26D Gene

No data available for DME Specific Peptides for FAM26D Gene

Domains for FAM26D Gene

Protein Domains for FAM26D Gene


Suggested Antigen Peptide Sequences for FAM26D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q5JW98
  • Belongs to the FAM26 family.
genes like me logo Genes that share domains with FAM26D: view

No data available for Gene Families for FAM26D Gene

Function for FAM26D Gene

Molecular function for FAM26D Gene

UniProtKB/Swiss-Prot Function: Pore-forming subunit of a voltage-gated ion channel.

Gene Ontology (GO) - Molecular Function for FAM26D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005261 cation channel activity IBA --
genes like me logo Genes that share ontologies with FAM26D: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FAM26D Gene

Localization for FAM26D Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM26D Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for FAM26D Gene COMPARTMENTS Subcellular localization image for FAM26D gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for FAM26D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with FAM26D: view

Pathways for FAM26D Gene

SuperPathways for FAM26D Gene

No Data Available

Interacting Proteins for FAM26D Gene

Gene Ontology (GO) - Biological Process for FAM26D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0006812 cation transport IBA --
GO:0034220 ion transmembrane transport IBA --
GO:0098655 cation transmembrane transport IBA --
genes like me logo Genes that share ontologies with FAM26D: view

No data available for Pathways by source for FAM26D Gene

Transcripts for FAM26D Gene

mRNA/cDNA for FAM26D Gene

(9) Selected AceView cDNA sequences:
(10) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM26D Gene

Family with sequence similarity 26, member D:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM26D

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for FAM26D

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM26D Gene

No ASD Table

Relevant External Links for FAM26D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM26D Gene

mRNA expression in normal human tissues for FAM26D Gene

mRNA differential expression in normal tissues according to GTEx for FAM26D Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (36.1) and Skin - Sun Exposed (Lower leg) (6.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FAM26D Gene

SOURCE GeneReport for Unigene cluster for FAM26D Gene Hs.350750

genes like me logo Genes that share expressions with FAM26D: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FAM26D Gene

Orthologs for FAM26D Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM26D Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM26D 35
  • 99.61 (n)
  • 100 (a)
FAM26D 36
  • 100 (a)
(Bos Taurus)
Mammalia FAM26D 35
  • 84.12 (n)
  • 77.06 (a)
FAM26D 36
  • 41 (a)
(Canis familiaris)
Mammalia FAM26D 35
  • 86.94 (n)
  • 83.63 (a)
FAM26D 36
  • 46 (a)
(Mus musculus)
Mammalia Fam26d 35
  • 80.51 (n)
  • 76.02 (a)
Fam26d 16
Fam26d 36
  • 41 (a)
(Monodelphis domestica)
Mammalia FAM26D 36
  • 35 (a)
(Rattus norvegicus)
Mammalia Fam26d 35
  • 80.31 (n)
  • 77.78 (a)
(Gallus gallus)
Aves FAM26D 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea clhm-1 36
  • 9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 6 (a)
Species with no ortholog for FAM26D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for FAM26D Gene

Gene Tree for FAM26D (if available)
Gene Tree for FAM26D (if available)

Paralogs for FAM26D Gene

Paralogs for FAM26D Gene

Selected SIMAP similar genes for FAM26D Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM26D: view

Variants for FAM26D Gene

Sequence variations from dbSNP and Humsavar for FAM26D Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1033721 -- 116,557,124(+) gtaga(A/G)atagg intron-variant
rs1570067 -- 116,554,976(+) AAAGA(A/G)TGACA intron-variant
rs2024977 -- 116,550,019(+) atata(C/T)atata intron-variant
rs2024978 -- 116,550,025(+) atata(C/T)acaca intron-variant
rs2024979 -- 116,550,711(+) TGAAT(G/T)ATCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM26D Gene

Variant ID Type Subtype PubMed ID
nsv523972 CNV Gain 19592680
nsv830783 CNV Gain 17160897

Relevant External Links for FAM26D Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM26D Gene

Disorders for FAM26D Gene

No disorders were found for FAM26D Gene.

No data available for UniProtKB/Swiss-Prot for FAM26D Gene

Publications for FAM26D Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for FAM26D Gene

Sources for FAM26D Gene

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