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Aliases for FAM25A Gene

Aliases for FAM25A Gene

  • Family With Sequence Similarity 25 Member A 2 3 5
  • Family With Sequence Similarity 25, Member A 2 3
  • Protein FAM25 3
  • BA96C23.5 3

External Ids for FAM25A Gene

Previous GeneCards Identifiers for FAM25A Gene

  • GC10U900468
  • GC10P047872
  • GC10P088776
  • GC10P082633
  • GC10P088784
  • GC10P088787
  • GC10P088793
  • GC10P088798
  • GC10P088806

Summaries for FAM25A Gene

GeneCards Summary for FAM25A Gene

FAM25A (Family With Sequence Similarity 25 Member A) is a Protein Coding gene. An important paralog of this gene is FAM25C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM25A Gene

Genomics for FAM25A Gene

Regulatory Elements for FAM25A Gene

Enhancers for FAM25A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM25A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM25A Gene

87,020,289 bp from pter
87,024,730 bp from pter
4,442 bases
Plus strand

Genomic View for FAM25A Gene

Genes around FAM25A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM25A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM25A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM25A Gene

Proteins for FAM25A Gene

  • Protein details for FAM25A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM25A
    Protein Accession:
    Secondary Accessions:
    • B2RV02
    • Q5VTM1

    Protein attributes for FAM25A Gene

    89 amino acids
    Molecular mass:
    9320 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI17119.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for FAM25A Gene

Proteomics data for FAM25A Gene at MOPED

Post-translational modifications for FAM25A Gene

No Post-translational modifications

Other Protein References for FAM25A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM25A Gene

Domains & Families for FAM25A Gene

Protein Domains for FAM25A Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM25 family.
  • Belongs to the FAM25 family.
genes like me logo Genes that share domains with FAM25A: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for FAM25A Gene

Function for FAM25A Gene

Phenotypes for FAM25A Gene

GenomeRNAi human phenotypes for FAM25A:
genes like me logo Genes that share phenotypes with FAM25A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM25A Gene

Localization for FAM25A Gene

Subcellular locations from

Jensen Localization Image for FAM25A Gene COMPARTMENTS Subcellular localization image for FAM25A gene
Compartment Confidence
cytosol 3
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM25A Gene

Pathways & Interactions for FAM25A Gene

SuperPathways for FAM25A Gene

No Data Available

Interacting Proteins for FAM25A Gene

Gene Ontology (GO) - Biological Process for FAM25A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM25A Gene

Drugs & Compounds for FAM25A Gene

No Compound Related Data Available

Transcripts for FAM25A Gene

mRNA/cDNA for FAM25A Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM25A Gene

Family with sequence similarity 25, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM25A Gene

No ASD Table

Relevant External Links for FAM25A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM25A Gene

mRNA expression in normal human tissues for FAM25A Gene

mRNA differential expression in normal tissues according to GTEx for FAM25A Gene

This gene is overexpressed in Esophagus - Mucosa (x22.8), Cervix - Ectocervix (x8.0), Vagina (x7.1), Skin - Sun Exposed (Lower leg) (x6.3), and Skin - Not Sun Exposed (Suprapubic) (x4.9).

Protein differential expression in normal tissues from HIPED for FAM25A Gene

This gene is overexpressed in Cervix (54.8) and Saliva (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM25A Gene

SOURCE GeneReport for Unigene cluster for FAM25A Gene Hs.729945

genes like me logo Genes that share expression patterns with FAM25A: view

Protein tissue co-expression partners for FAM25A Gene

- Elite partner

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FAM25A Gene

Orthologs for FAM25A Gene

This gene was present in the common ancestor of mammals.

Orthologs for FAM25A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 36
  • 82 (a)
(Canis familiaris)
Mammalia -- 36
  • 70 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 66 (a)
(Mus musculus)
Mammalia Fam25c 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
(Pan troglodytes)
Mammalia -- 36
  • 100 (a)
Species with no ortholog for FAM25A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM25A Gene

Gene Tree for FAM25A (if available)
Gene Tree for FAM25A (if available)

Paralogs for FAM25A Gene

Paralogs for FAM25A Gene

(5) SIMAP similar genes for FAM25A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM25A: view

Variants for FAM25A Gene

Sequence variations from dbSNP and Humsavar for FAM25A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs7079587 - 87,022,343(+) AGGAG(C/G)TGGTG reference, missense
rs1815273 -- 87,022,750(-) atggg(A/G)tttca intron-variant
rs1923940 -- 87,018,292(-) CCCAC(C/T)GCAGC upstream-variant-2KB
rs3802665 -- 87,022,219(+) GACTG(A/G)GAGGG intron-variant
rs3802666 -- 87,022,327(+) GTGGA(A/G)GAAGT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for FAM25A Gene

Variant ID Type Subtype PubMed ID
dgv310e1 CNV Complex 17122850
dgv311e1 CNV Complex 17122850
dgv312e1 CNV Complex 17122850
nsv428236 CNV Loss 18775914
essv23924 CNV CNV 17122850
dgv313e1 CNV Complex 17122850
dgv314e1 CNV Complex 17122850
esv27213 CNV Loss 19812545
nsv831939 CNV Gain 17160897
nsv8712 CNV Loss 18304495

Variation tolerance for FAM25A Gene

Gene Damage Index Score: 3.20; 52.19% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FAM25A Gene

Disorders for FAM25A Gene

Relevant External Links for FAM25A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM25A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM25A Gene

Publications for FAM25A Gene

  1. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3

Products for FAM25A Gene

Sources for FAM25A Gene