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Aliases for FAM25A Gene

Aliases for FAM25A Gene

  • Family With Sequence Similarity 25 Member A 2 3 5
  • Family With Sequence Similarity 25, Member A 2
  • Protein FAM25A 3
  • Protein FAM25 3
  • BA96C23.5 3

External Ids for FAM25A Gene

Previous GeneCards Identifiers for FAM25A Gene

  • GC10U900468
  • GC10P047872
  • GC10P088776
  • GC10P082633
  • GC10P088784
  • GC10P088787
  • GC10P088793
  • GC10P088798
  • GC10P088806

Summaries for FAM25A Gene

GeneCards Summary for FAM25A Gene

FAM25A (Family With Sequence Similarity 25 Member A) is a Protein Coding gene. An important paralog of this gene is FAM25G.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM25A Gene

Genomics for FAM25A Gene

Regulatory Elements for FAM25A Gene

Enhancers for FAM25A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F087840 1.4 FANTOM5 Ensembl ENCODE 18.9 +823.6 823613 6.8 FEZF1 BRCA1 ZNF2 YY1 GTF3C2 ZNF121 GLIS2 KLF7 FOS ZNF263 NUTM2A-AS1 FAM35A RPL11P3 RN7SL78P FAM25A ENSG00000196566 RPS26P38 ENSG00000223761 ADIRF-AS1 ENSG00000261011
GH10F087091 0.7 ENCODE 10.5 +73.6 73607 6.2 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 NUTM2A-AS1 FAM35A ENSG00000272631 BMPR1A RN7SL78P RPL11P3 ENSG00000223761 ENSG00000196566 RPS26P38 CFL1P1
GH10F087701 0.9 Ensembl ENCODE 10.3 +681.8 681758 1.3 ZNF133 FEZF1 ZNF2 GLIS2 KLF7 FOS ZNF202 ZNF263 SP3 TSHZ1 NUTM2A-AS1 RPL11P3 ADIRF-AS1 FAM35A FAM25A ADIRF GC10P087721 ENSG00000196566
GH10F087017 0.2 Ensembl 0.8 -2.8 -2788 0.6 RFX1 ESRRA FOS ENSG00000229969 FAM25A
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FAM25A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM25A Gene

87,020,289 bp from pter
87,024,730 bp from pter
4,442 bases
Plus strand

Genomic View for FAM25A Gene

Genes around FAM25A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM25A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM25A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM25A Gene

Proteins for FAM25A Gene

  • Protein details for FAM25A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM25A
    Protein Accession:
    Secondary Accessions:
    • B2RV02
    • Q5VTM1

    Protein attributes for FAM25A Gene

    89 amino acids
    Molecular mass:
    9320 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI17119.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for FAM25A Gene

Post-translational modifications for FAM25A Gene

No Post-translational modifications

Other Protein References for FAM25A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM25A Gene

Domains & Families for FAM25A Gene

Protein Domains for FAM25A Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM25 family.
  • Belongs to the FAM25 family.
genes like me logo Genes that share domains with FAM25A: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for FAM25A Gene

Function for FAM25A Gene

Phenotypes for FAM25A Gene

GenomeRNAi human phenotypes for FAM25A:
genes like me logo Genes that share phenotypes with FAM25A: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM25A Gene

Localization for FAM25A Gene

Subcellular locations from

Jensen Localization Image for FAM25A Gene COMPARTMENTS Subcellular localization image for FAM25A gene
Compartment Confidence
cytosol 3
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM25A Gene

Pathways & Interactions for FAM25A Gene

SuperPathways for FAM25A Gene

No Data Available

Interacting Proteins for FAM25A Gene

Gene Ontology (GO) - Biological Process for FAM25A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM25A Gene

Transcripts for FAM25A Gene

mRNA/cDNA for FAM25A Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM25A Gene

Family with sequence similarity 25, member A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM25A Gene

No ASD Table

Relevant External Links for FAM25A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM25A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM25A Gene

mRNA differential expression in normal tissues according to GTEx for FAM25A Gene

This gene is overexpressed in Esophagus - Mucosa (x22.8), Cervix - Ectocervix (x8.0), Vagina (x7.1), Skin - Sun Exposed (Lower leg) (x6.3), and Skin - Not Sun Exposed (Suprapubic) (x4.9).

Protein differential expression in normal tissues from HIPED for FAM25A Gene

This gene is overexpressed in Cervix (54.8) and Saliva (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM25A Gene

Protein tissue co-expression partners for FAM25A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM25A Gene:


SOURCE GeneReport for Unigene cluster for FAM25A Gene:

genes like me logo Genes that share expression patterns with FAM25A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FAM25A Gene

Orthologs for FAM25A Gene

This gene was present in the common ancestor of mammals.

Orthologs for FAM25A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 35
  • 100 (a)
(Bos Taurus)
Mammalia -- 35
  • 82 (a)
(Mus musculus)
Mammalia Fam25c 35
  • 80 (a)
(Canis familiaris)
Mammalia -- 35
  • 70 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 60 (a)
Species where no ortholog for FAM25A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM25A Gene

Gene Tree for FAM25A (if available)
Gene Tree for FAM25A (if available)

Paralogs for FAM25A Gene

Paralogs for FAM25A Gene

(5) SIMAP similar genes for FAM25A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM25A: view

Variants for FAM25A Gene

Sequence variations from dbSNP and Humsavar for FAM25A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10218973 -- 87,020,430(+) GGGCT(A/G)GGGGG intron-variant
rs10219136 -- 87,020,375(+) CGCAC(C/G/T)GAGAA reference, synonymous-codon
rs10646505 -- 87,023,766(+) AATTT(-/ATTT/TTT)CTCAC intron-variant
rs111328347 -- 87,023,519(+) AGTTC(A/G)AGACC intron-variant
rs11202299 -- 87,020,706(+) GAAGA(C/T)GGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM25A Gene

Variant ID Type Subtype PubMed ID
esv27213 CNV loss 19812545
esv2759774 CNV gain+loss 17122850
nsv1141879 OTHER inversion 24896259
nsv428236 CNV loss 18775914
nsv831939 CNV gain 17160897
nsv8712 CNV loss 18304495
nsv948111 CNV duplication 23825009

Variation tolerance for FAM25A Gene

Gene Damage Index Score: 3.20; 52.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM25A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM25A Gene

Disorders for FAM25A Gene

Relevant External Links for FAM25A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM25A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM25A Gene

Publications for FAM25A Gene

  1. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  4. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3 64

Products for FAM25A Gene

Sources for FAM25A Gene

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