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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FAM24B Gene

protein-coding GIFtS: 38
GCID: GC10M124599

family with sequence similarity 24, member B

Search for FAM24B
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Family With Sequence Similarity 24, Member B¹ ²
AC073585.2¹
MGC45962¹
Protein FAM24B²

External Ids:	HGNC: 23475¹	Entrez Gene: 196792²	Ensembl: ENSG00000213185⁷	UniProtKB: Q8N5W8³

ORGUL members:
	NONCODE:n410668 n410665 n410664

Export aliases for FAM24B gene to outside databases

Previous GC identifers: GC10M124149 GC10M124581 GC10M118226

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FAM24B gene promoter:
Nkx3-1 Nkx3-1 v4 HTF Nkx3-1 v1 NF-kappaB Nkx3-1 v2 POU2F1 POU2F1a Nkx3-1 v3 NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FAM24B promoter sequence

Search SABiosciences Chromatin IP Primers for FAM24B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM24B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.13 Ensembl cytogenetic band: 10q26.13 HGNC cytogenetic band: 10q26.13

FAM24B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM24B gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M124599: view genomic region (about GC identifiers)

Start:	124,608,594 bp from pter	End:	124,639,157 bp from pter
Size:	30,564 bases	Orientation:	minus strand

ORGUL member locations:
Legend (see complete legend)

n410665
n410668

lncRNA
Full Legend

124591670 124615414 124639157 chr10

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FA24B_HUMAN, Q8N5W8 (See protein sequence)

Recommended Name: Protein FAM24B precursor

Size: 94 amino acids; 10147 Da

Subcellular location: Secreted (Potential)

Secondary accessions: Q5JPG1

Explore the universe of human proteins at neXtProt for FAM24B: NX_Q8N5W8

FAM24B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001191293.1 NP_689857.2

ENSEMBL proteins:

ENSP00000357894 ENSP00000357892

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	Uscn Proteins for FAM24B

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

FAM24B for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q8N5W8

UniProtKB/Swiss-Prot: FA24B_HUMAN, Q8N5W8

Similarity: Belongs to the FAM24 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FAM24B

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAM24B
Search CenterWatch for drugs/clinical trials and news about FAM24B / FA24B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for FAM24B gene (2 alternative transcripts):

NM_001204364.1 NM_152644.2

Unigene Cluster for FAM24B:

Family with sequence similarity 24, member B

Hs.114648 [show with all ESTs]

Unigene Representative Sequence: AL832795

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000368898(uc001lgt.3) ENST00000462859 ENST00000368896(uc021qai.1)

ENST00000489000

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Additional cDNA sequence:

AL832795.1 BC031343.1 NR_037911.1

5 DOTS entries:

DT.109373 DT.97808431 DT.100022502 DT.99946150 DT.100751656

24/65 AceView cDNA sequences (see all 65):

AI378918 AA732367 AY260050 AL703960 BQ018236 AA723941 BQ778339 AY260047

AA917882 AL832386 BX495744 BX096610 AY260049 AY260048 AA417006 AL832795

AI005145 AY358556 BU602099 AW663660 AV745453 CB104562 AA927889 NM_152644

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM24B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCAATACTT

About this image

FAM24B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FAM24B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM24B

SOURCE GeneReport for Unigene cluster: Hs.114648

SABiosciences Custom PCR Arrays for FAM24B

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In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for FAM24B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for FAM24B (if available)
TreeFam Gene Tree for FAM24B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FAM24B gene

FAM24A²

1 SIMAP similar gene for FAM24B using alignment to 1 protein entry: FA24B_HUMAN:

FAM24A

FAM24B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147427263^1,2	C,F,	other	124608862(+)	`GACTCC/TGTGGC`	6	T	syn¹ int¹		1		NA	4550
rs143203406^1,2		--	124608133(+)	`ATCCAC/TGCAGG`	4	--	ds500¹ int¹		0	--	--	--	--
rs146659257^1,2		--	124608138(+)	`CGCAGA/GAGCCA`	4	--	int¹ ds500¹		0	--	--	--	--
rs139771012^1,2		--	124608149(+)	`CATGCC/TCTGGA`	4	--	ds500¹ int¹		0	--	--	--	--
rs142957582^1,2		--	124608158(+)	`GAGATC/TTGGGG`	4	--	int¹ ds500¹		0	--	--	--	--
rs187123418^1,2		--	124608382(+)	`ACGAGC/TGACTC`	4	--	int¹ ds500¹		0	--	--	--	--
rs112829689^1,2	C,	--	124608520(+)	`CTAATC/-CCCCC`	4	--	int¹ ds500¹		1		CSA	2
rs72839720^1,2	C,	--	124608525(+)	`TCCCCC/TCCCAC`	4	--	int¹ ds500¹		2		NA	122
rs192413155^1,2		--	124608528(+)	`CCCCCC/TACATT`	4	--	int¹ ds500¹		0	--	--	--	--
rs182457008^1,2		--	124608634(+)	`TTTATC/TCAAAA`	4	--	int¹ ut3¹ nc-transcript-variant		0	--	--	--	--

HapMap Linkage Disequilibrium report for FAM24B (124608594 - 124639157 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FAM24B
1 CNV: 4714
1 Indel: 60031

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FAM24B for disorders About MalaCards

FAM24B for disorders About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: FAM24B (1 document)

Export disorders for FAM24B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FAM24B gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM24B)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)¹ Clark H.F.... Gray A.M. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 196792	HGNC: 23475	AceView: CUZD1	Ensembl:ENSG00000213185	euGenes: HUgn196792
ECgene: FAM24B	H-InvDB: FAM24B

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FAM24B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FAM24B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FAM24B gene:
Search GeneIP for patents involving FAM24B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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Advanced Cell Diagnostics
About This Section


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FAM24B Gene

family with sequence similarity 24, member B

Aliases
for FAM24B gene

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for FAM24B gene

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for FAM24B gene

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for FAM24B gene

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for FAM24B gene

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for FAM24B gene

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for FAM24B gene

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for FAM24B gene

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for FAM24B gene

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for FAM24B gene

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for FAM24B gene

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for FAM24B gene

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for FAM24B gene

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for FAM24B gene

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for FAM24B gene

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FAM24B Gene

family with sequence similarity 24, member B

Aliasesfor FAM24B gene

Summariesfor FAM24B gene

Genomic Viewsfor FAM24B gene

Proteinsfor FAM24B gene

Protein Domains /Familiesfor FAM24B gene

Functionfor FAM24B gene

Pathways & Interactionsfor FAM24B gene

Drugs & Compoundsfor FAM24B gene

Transcriptsfor FAM24B gene

Expression for FAM24B gene

Orthologsfor FAM24B gene

Paralogsfor FAM24B gene

Genomic Variantsfor FAM24B gene

Disorders / Diseasesfor FAM24B gene

Publicationsfor FAM24B gene

External Searches for FAM24B gene

Genome Databases showing FAM24B gene

Other Databases showing FAM24B gene

Specialized Databases showing FAM24B gene

Intellectual Propertyfor FAM24B gene

Productsfor FAM24B gene

View Random Gene

Aliases
for FAM24B gene

Summaries
for FAM24B gene

Genomic Views
for FAM24B gene

Proteins
for FAM24B gene

Protein Domains /
Families
for FAM24B gene

Function
for FAM24B gene

Pathways & Interactions
for FAM24B gene

Drugs & Compounds
for FAM24B gene

Transcripts
for FAM24B gene

Expression
for FAM24B gene

Orthologs
for FAM24B gene

Paralogs
for FAM24B gene

Genomic Variants
for FAM24B gene

Disorders / Diseases
for FAM24B gene

Publications
for FAM24B gene

Intellectual Property
for FAM24B gene

Products
for FAM24B gene