Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM24B Gene

Aliases for FAM24B Gene

  • Family With Sequence Similarity 24 Member B 2 3 5
  • Family With Sequence Similarity 24, Member B 2

External Ids for FAM24B Gene

Previous GeneCards Identifiers for FAM24B Gene

  • GC10M124149
  • GC10M124581
  • GC10M124599
  • GC10M118226

Summaries for FAM24B Gene

GeneCards Summary for FAM24B Gene

FAM24B (Family With Sequence Similarity 24 Member B) is a Protein Coding gene. An important paralog of this gene is FAM24A.

Additional gene information for FAM24B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM24B Gene

Genomics for FAM24B Gene

Regulatory Elements for FAM24B Gene

Enhancers for FAM24B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H122849 1.3 Ensembl ENCODE dbSUPER 11.5 +26.1 26095 7 JUN INSM2 ZIC2 ZFHX2 ZNF316 POLR2A SCRT2 FOS ZNF600 NFE2 C10orf88 FAM24B LOC399815 ACADSB IKZF5 CUZD1
GH10H122331 1.1 ENCODE dbSUPER 10.9 +548.0 548012 0 TBP FOXA2 ARID4B DMAP1 RAD21 DNMT3B RARA SLC30A9 CREM MIXL1 IKZF5 BUB3 FAM24B C10orf88 ARMS2 GC10P122346 BTBD16
GH10H122847 0.7 ENCODE dbSUPER 11.4 +31.2 31168 2 POLR2A SCRT2 CEBPB ACADSB LOC399815 FAM24B IKZF5 CUZD1 ENSG00000272135
GH10H122845 0.5 ENCODE 11.4 +33.3 33287 1 POLR2A GLIS1 CTBP2 ZIC2 ACADSB LOC399815 FAM24B C10orf88 IKZF5 CUZD1 ENSG00000272135
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM24B on UCSC Golden Path with GeneCards custom track

Promoters for FAM24B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000034629 41 1601 HDGF ATF1 ARID4B SIN3A GLI4 YY1 GLIS2 ZNF143 ZNF207 ATF7

Genomic Location for FAM24B Gene

Chromosome:
10
Start:
122,849,078 bp from pter
End:
122,879,641 bp from pter
Size:
30,564 bases
Orientation:
Minus strand

Genomic View for FAM24B Gene

Genes around FAM24B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM24B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM24B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM24B Gene

Proteins for FAM24B Gene

  • Protein details for FAM24B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5W8-FA24B_HUMAN
    Recommended name:
    Protein FAM24B
    Protein Accession:
    Q8N5W8
    Secondary Accessions:
    • Q5JPG1

    Protein attributes for FAM24B Gene

    Size:
    94 amino acids
    Molecular mass:
    10147 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM24B Gene

Post-translational modifications for FAM24B Gene

No Post-translational modifications

Other Protein References for FAM24B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM24B Gene

Domains & Families for FAM24B Gene

Gene Families for FAM24B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM24B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM24B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N5W8

UniProtKB/Swiss-Prot:

FA24B_HUMAN :
  • Belongs to the FAM24 family.
Family:
  • Belongs to the FAM24 family.
genes like me logo Genes that share domains with FAM24B: view

Function for FAM24B Gene

genes like me logo Genes that share phenotypes with FAM24B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM24B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM24B Gene

Localization for FAM24B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM24B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM24B gene
Compartment Confidence
extracellular 5
plasma membrane 2

Gene Ontology (GO) - Cellular Components for FAM24B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with FAM24B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FAM24B Gene

Pathways & Interactions for FAM24B Gene

SuperPathways for FAM24B Gene

No Data Available

Interacting Proteins for FAM24B Gene

Gene Ontology (GO) - Biological Process for FAM24B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM24B Gene

Drugs & Compounds for FAM24B Gene

No Compound Related Data Available

Transcripts for FAM24B Gene

Unigene Clusters for FAM24B Gene

Family with sequence similarity 24, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM24B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FAM24B Gene

No ASD Table

Relevant External Links for FAM24B Gene

GeneLoc Exon Structure for
FAM24B
ECgene alternative splicing isoforms for
FAM24B

Expression for FAM24B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM24B Gene

mRNA expression in normal human tissues for FAM24B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM24B Gene:

FAM24B

SOURCE GeneReport for Unigene cluster for FAM24B Gene:

Hs.114648

Evidence on tissue expression from TISSUES for FAM24B Gene

  • Lymph node(4.1)
genes like me logo Genes that share expression patterns with FAM24B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM24B Gene

Orthologs for FAM24B Gene

This gene was present in the common ancestor of mammals.

Orthologs for FAM24B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100610674 33
  • 97.75 (n)
FAM24B 34
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam24a 34
  • 41 (a)
ManyToMany
1700007K09Rik 34
  • 37 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 36 (a)
OneToMany
Species where no ortholog for FAM24B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM24B Gene

ENSEMBL:
Gene Tree for FAM24B (if available)
TreeFam:
Gene Tree for FAM24B (if available)

Paralogs for FAM24B Gene

Paralogs for FAM24B Gene

(1) SIMAP similar genes for FAM24B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM24B: view

Variants for FAM24B Gene

Sequence variations from dbSNP and Humsavar for FAM24B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000127218 -- 122,850,849(+) TATGC(A/G)GCTGG intron-variant
rs1000154764 -- 122,870,367(+) GAGGA(A/G)CTGGT intron-variant
rs1000207777 -- 122,879,948(+) CCTCA(C/T)CCGGG nc-transcript-variant, upstream-variant-2KB
rs1000268125 -- 122,857,116(+) CCTTC(A/C)CAGGC intron-variant
rs1000276702 -- 122,875,697(+) AATGT(A/G)GTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM24B Gene

Variant ID Type Subtype PubMed ID
esv3624789 CNV gain 21293372
esv7958 CNV gain 19470904
nsv1054197 CNV loss 25217958
nsv832010 CNV gain 17160897

Variation tolerance for FAM24B Gene

Residual Variation Intolerance Score: 81.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.11; 2.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM24B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM24B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM24B Gene

Disorders for FAM24B Gene

Relevant External Links for FAM24B

Genetic Association Database (GAD)
FAM24B
Human Genome Epidemiology (HuGE) Navigator
FAM24B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM24B

No disorders were found for FAM24B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM24B Gene

Publications for FAM24B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  4. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 60
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 60

Products for FAM24B Gene

Sources for FAM24B Gene

Content
Loading form....