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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM24A Gene

protein-coding   GIFtS: 36
GCID: GC10P124660          (predicted)

family with sequence similarity 24, member A
  Search for FAM24A
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FAM24A    

Aliases
for FAM24A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Family With Sequence Similarity 24, Member A1 2
AC073585.41
Protein FAM24A2

External Ids:    HGNC: 234701   Entrez Gene: 1186702   Ensembl: ENSG000002037957   UniProtKB: A6NFZ43   

Export aliases for FAM24A gene to outside databases

Previous GC identifers: GC10P124211 GC10P118289


Summaries
for FAM24A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for FAM24A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM24A gene promoter:
         POU2F1a   HTF   NRSF form 1   NF-kappaB   NF-kappaB1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FAM24A promoter sequence
   Search SABiosciences Chromatin IP Primers for FAM24A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM24A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.13   Ensembl cytogenetic band:  10q26.13   HGNC cytogenetic band: 10q26.13

FAM24A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM24A gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P124660:  view genomic region     (about GC identifiers)

Start:
 124,670,217 bp from pter      End:
 124,672,627 bp from pter
Size:
 2,411 bases      Orientation:
 plus strand

Proteins
for FAM24A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FA24A_HUMAN, A6NFZ4 (See protein sequence)
Recommended Name: Protein FAM24A precursor  
Size: 105 amino acids; 11258 Da
Subcellular location: Secreted (Potential)

Explore the universe of human proteins at neXtProt for FAM24A: NX_A6NFZ4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_A6NFZ4

    • FAM24A Protein expression data from MOPED and PaxDb:    About this image 
    FAM24A Protein Expression
    REFSEQ proteins: NP_001025059.1  
    ENSEMBL proteins: 
     ENSP00000357889  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    FAM24A for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for FAM24A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: A6NFZ4

    UniProtKB/Swiss-Prot: FA24A_HUMAN, A6NFZ4
    Similarity: Belongs to the FAM24 family


    Function
    for FAM24A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FAM24A 

    miRNA
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    In Situ Assay
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    Pathways & Interactions
    for FAM24A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM24A

    Drugs & Compounds
    for FAM24A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM24A
    Search CenterWatch for drugs/clinical trials and news about FAM24A / FA24A 

    Transcripts
    for FAM24A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    REFSEQ mRNAs for FAM24A gene: 
    NM_001029888.1  

    Unigene Cluster for FAM24A:

    Family with sequence similarity 24, member A
    Hs.369829  [show with all ESTs]
    Unigene Representative Sequence: BX109949
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000368894(uc001lgv.3)

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    Inhib. RNA
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    Clone
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    1 DOTS entry:

    DT.102613 

    4 AceView cDNA sequences:

    BX109949 AA912169 AA620800 AI810124 

    GeneLoc Exon Structure


    Expression
    for FAM24A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAM24A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGCAATATTT
    FAM24A Expression
    About this image

    FAM24A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesMature Sertoli CellsTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See FAM24A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAM24A

    SOURCE GeneReport for Unigene cluster: Hs.369829
        SABiosciences Custom PCR Arrays for FAM24A
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    In Situ
    Assay Products:     
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    Orthologs
    for FAM24A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of human and mouse.

    Orthologs for FAM24A gene from 1/3 species (see all 3)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Fam24a1 , 5 family with sequence similarity 24, member A1, 5 65.99(n)1
    50(a)1    		   7 (73.86 cM)5
    682231  NM_183272.21  NP_899095.11 
     1313346225 


    ENSEMBL Gene Tree for FAM24A (if available)
    TreeFam Gene Tree for FAM24A (if available) 

    Paralogs
    for FAM24A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAM24A gene
    FAM24B2  
    1 SIMAP similar gene for FAM24A using alignment to 1 protein entry:     FA24A_HUMAN:
    FAM24B

    FAM24A for paralogs           About GeneDecksing



    Genomic Variants
    for FAM24A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/83 NCBI SNPs in FAM24A are shown (see all 83)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1871811321,2
    		--124668319(+) TCCCTA/CCTTCC 1 -- us2k10--------
    rs1393708951,2
    		--124668429(+) ATACAG/TGCTCA 1 -- us2k10--------
    rs1131678561,2
    		C--124668495(+) TAGTC-/ACTTAC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs780801171,2
    		C,F--124668541(+) CTTGAC/TCTCAG 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1919950621,2
    		--124668607(+) TTGCAC/TGAGTT 1 -- us2k10--------
    rs112483311,2
    		C,F,H--124668629(+) TCCCAA/GTCAAC 1 -- us2k112Minor allele frequency- G:0.04NS EA NA 1432
    rs1829971201,2
    		--124668786(+) TTTTCG/TTGTTC 1 -- us2k10--------
    rs1875988391,2
    		--124668850(+) TCATTC/TGGGCG 1 -- us2k10--------
    rs1931187911,2
    		--124668851(+) CATTCA/GGGCGT 1 -- us2k10--------
    rs1432798701,2
    		--124668885(+) CGGGCA/GATAAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FAM24A (124670217 - 124672627 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for FAM24A
         1 CNV: 4714
         1 Inversion: 59683

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    Disorders / Diseases
    for FAM24A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for FAM24A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed article for FAM24A gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FAM24A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)

    External Searches for FAM24A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FAM24A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 118670 HGNC: 23470 AceView: FAM24A Ensembl:ENSG00000203795 euGenes: HUgn118670
    ECgene: FAM24A H-InvDB: FAM24A

    Other Databases showing FAM24A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FAM24A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM24A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FAM24A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FAM24A gene:
    Search GeneIP for patents involving FAM24A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    for FAM24A gene

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    About This Section

     
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     FAM24A Proteins, Antibodies, CLIAs, and ELISAs
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     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for FAM24A
     SwitchGear 3'UTR luciferase reporter plasmids for FAM24A
     SwitchGear Promoter luciferase reporter plasmids for FAM24A
     Search ThermoFisher Antibodies for FAM24A
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM24A
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FAM24A
    Sirion Biotech Customized:
     stable knockdown cell line services for FAM24A
     inducible knockdown cell line services for FAM24A
     design and validation of potent shRNA sequences against FAM24A
     adenovirus for potent knockdown of FAM24A
     adenovirus for overexpression of FAM24A
     stable overexpressing cell line services for FAM24A
     inducible overexpressing cell line services for FAM24A
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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    VWF
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    von Willebrand factor
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