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Aliases for FAM241A Gene

Aliases for FAM241A Gene

  • Family With Sequence Similarity 241 Member A 2 3
  • C4orf32 3 4 5
  • Chromosome 4 Open Reading Frame 32 2 5
  • Uncharacterized Protein C4orf32 3

External Ids for FAM241A Gene

Previous HGNC Symbols for FAM241A Gene

  • C4orf32

Summaries for FAM241A Gene

GeneCards Summary for FAM241A Gene

FAM241A (Family With Sequence Similarity 241 Member A) is a Protein Coding gene.

Additional gene information for FAM241A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM241A Gene

Genomics for FAM241A Gene

Regulatory Elements for FAM241A Gene

Enhancers for FAM241A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H112144 1.3 FANTOM5 ENCODE 28.8 +1.1 1076 3.3 HDGF ATF1 ARID4B SIN3A FEZF1 YY1 ZNF766 CBX5 ATF7 SP3 FAM241A ZGRF1 TIFA LARP7 AP1AR RPL36AP19
GH04H112168 1.2 Ensembl ENCODE 26.6 +24.9 24884 2.8 PKNOX1 FOXA2 ATF1 ARNT TCF12 ZNF766 GATA2 ATF7 FOS ZNF518A FAM241A TIFA RPL36AP19
GH04H112282 1.7 FANTOM5 ENCODE dbSUPER 14.4 +141.0 140957 7.6 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 TIFA FAM241A AP1AR RTEL1P1 LARP7 ALPK1 ZGRF1 GC04P112321
GH04H112082 1.4 FANTOM5 Ensembl ENCODE 16.7 -61.3 -61258 3.4 ELF3 FOXA2 THRB RARA FOS RUNX3 CREM CEBPB PPARG KAT8 FAM241A TIFA TUBB8P3 RPS12P8
GH04H112112 1.3 Ensembl ENCODE 17.6 -32.3 -32320 2 FOXA2 MLX ARID4B DMAP1 YY1 FOS ATF7 SP5 MXD4 REST FAM241A ZGRF1 RPS12P8 TUBB8P3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM241A on UCSC Golden Path with GeneCards custom track

Promoters for FAM241A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000172038 703 2201 HDGF ARID4B SIN3A YY1 ZNF766 CBX5 ATF7 JUNB REST NBN

Genomic Locations for FAM241A Gene

Genomic Locations for FAM241A Gene
chr4:112,145,397-112,195,256
(GRCh38/hg38)
Size:
49,860 bases
Orientation:
Plus strand
chr4:113,066,553-113,116,412
(GRCh37/hg19)

Genomic View for FAM241A Gene

Genes around FAM241A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM241A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM241A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM241A Gene

Proteins for FAM241A Gene

  • Protein details for FAM241A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8J7-CD032_HUMAN
    Recommended name:
    Uncharacterized protein C4orf32
    Protein Accession:
    Q8N8J7
    Secondary Accessions:
    • Q49A91
    • Q4W5C7
    • Q8TBF9

    Protein attributes for FAM241A Gene

    Size:
    132 amino acids
    Molecular mass:
    14653 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM241A Gene

Post-translational modifications for FAM241A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM241A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM241A Gene

Domains & Families for FAM241A Gene

Gene Families for FAM241A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for FAM241A Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FAM241A: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for FAM241A Gene

Function for FAM241A Gene

Phenotypes From GWAS Catalog for FAM241A Gene

Phenotypes for FAM241A Gene

genes like me logo Genes that share phenotypes with FAM241A: view

miRNA for FAM241A Gene

miRTarBase miRNAs that target FAM241A

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM241A Gene

Localization for FAM241A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM241A Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM241A gene
Compartment Confidence
plasma membrane 3
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM241A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM241A: view

Pathways & Interactions for FAM241A Gene

SuperPathways for FAM241A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM241A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM241A Gene

Drugs & Compounds for FAM241A Gene

No Compound Related Data Available

Transcripts for FAM241A Gene

mRNA/cDNA for FAM241A Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM241A Gene

No ASD Table

Relevant External Links for FAM241A Gene

GeneLoc Exon Structure for
FAM241A
ECgene alternative splicing isoforms for
FAM241A

Expression for FAM241A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM241A Gene:

FAM241A

Evidence on tissue expression from TISSUES for FAM241A Gene

  • Nervous system(4.2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM241A Gene

Orthologs for FAM241A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM241A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C4H4orf32 33
  • 98.99 (n)
C4H4ORF32 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C32H4orf32 33
  • 90.99 (n)
C4orf32 34
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C6H4orf32 34 33
  • 87.88 (n)
OneToOne
mouse
(Mus musculus)
Mammalia 5730508B09Rik 16 34 33
  • 87.4 (n)
rat
(Rattus norvegicus)
Mammalia LOC691931 33
  • 85.68 (n)
oppossum
(Monodelphis domestica)
Mammalia C4orf32 34
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C4orf32 34
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C4orf32 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c4orf32 33
  • 67.04 (n)
Str.10017 33
zebrafish
(Danio rerio)
Actinopterygii zgc:113201 33
  • 50.29 (n)
C13H4orf32 34
  • 42 (a)
OneToOne
Species where no ortholog for FAM241A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM241A Gene

ENSEMBL:
Gene Tree for FAM241A (if available)
TreeFam:
Gene Tree for FAM241A (if available)

Paralogs for FAM241A Gene

No data available for Paralogs for FAM241A Gene

Variants for FAM241A Gene

Sequence variations from dbSNP and Humsavar for FAM241A Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000043603 -- 112,145,002(+) GTAGA(C/G)ATGGG upstream-variant-2KB
rs1000054592 -- 112,145,155(+) TCACA(-/CT)CTCTA upstream-variant-2KB
rs1000108840 -- 112,151,982(+) CTCAC(A/T)TCCTT intron-variant
rs1000131133 -- 112,158,722(+) ATATA(A/G)TATTT intron-variant
rs10002700 -- 112,145,675(+) GACCG(A/G)GTGGG reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM241A Gene

Variant ID Type Subtype PubMed ID
nsv980245 CNV duplication 23825009
nsv1119011 CNV deletion 24896259
nsv1073792 CNV deletion 25765185

Variation tolerance for FAM241A Gene

Residual Variation Intolerance Score: 64.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM241A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM241A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM241A Gene

Disorders for FAM241A Gene

Relevant External Links for FAM241A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM241A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM241A

No disorders were found for FAM241A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM241A Gene

Publications for FAM241A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. Gene essentiality and synthetic lethality in haploid human cells. (PMID: 26472760) Blomen VA … Brummelkamp TR (Science (New York, N.Y.) 2015) 3 60

Products for FAM241A Gene

Sources for FAM241A Gene

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