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Aliases for FAM234B Gene

Aliases for FAM234B Gene

  • Family With Sequence Similarity 234 Member B 2 3 5
  • KIAA1467 2 3 4
  • Family With Sequence Similarity 234, Member B 2
  • Protein FAM234B 3

External Ids for FAM234B Gene

Previous HGNC Symbols for FAM234B Gene

  • KIAA1467

Summaries for FAM234B Gene

GeneCards Summary for FAM234B Gene

FAM234B (Family With Sequence Similarity 234 Member B) is a Protein Coding gene. An important paralog of this gene is FAM234A.

Additional gene information for FAM234B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM234B Gene

Genomics for FAM234B Gene

GeneHancer (GH) Regulatory Elements for FAM234B Gene

Promoters and enhancers for FAM234B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I013043 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 571.2 +0.2 220 1.4 ZNF133 ARID4B SIN3A DMAP1 GLI4 ZNF2 ZNF48 YY1 ETS1 GLIS2 FAM234B GC12P013050 HEBP1 ENSG00000255621 HTR7P1 EMP1 MIR614
GH12I013046 Enhancer 0.3 Ensembl 571.5 +1.9 1916 0.4 POLR3A FAM234B GC12P013050 GC12M013049
GH12I013060 Enhancer 1 FANTOM5 ENCODE 21.1 +17.7 17729 2.6 PKNOX1 CLOCK CHAMP1 TCF12 GATA2 NCOA1 GATAD2B ZNF217 NFIC MTA1 FAM234B GSG1 EMP1 MIR614 DUSP16 PIR34161 GC12P013052
GH12I013047 Enhancer 0.6 ENCODE 20.4 +2.8 2833 0.9 OSR2 GATA3 PRDM6 ZNF629 INSM2 FEZF1 ZNF2 ATF2 GC12P013050 FAM234B MIR614 HTR7P1 GC12M013049
GH12I013086 Enhancer 0.7 ENCODE dbSUPER 15.4 +44.0 44017 2.7 SP1 POLR2A MAX POU5F1 CREB1 SIN3A CTBP2 FAM234B HEBP1 EMP1 ENSG00000256011 HTR7P1 ENSG00000255621 MIR614 GPRC5D GC12P013100 GSG1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM234B on UCSC Golden Path with GeneCards custom track

Genomic Locations for FAM234B Gene

Genomic Locations for FAM234B Gene
chr12:13,044,284-13,142,521
(GRCh38/hg38)
Size:
98,238 bases
Orientation:
Plus strand
chr12:13,197,218-13,295,455
(GRCh37/hg19)

Genomic View for FAM234B Gene

Genes around FAM234B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM234B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM234B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM234B Gene

Proteins for FAM234B Gene

  • Protein details for FAM234B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2RU67-F234B_HUMAN
    Recommended name:
    Protein FAM234B
    Protein Accession:
    A2RU67
    Secondary Accessions:
    • Q49AF2
    • Q5CZ81
    • Q6ZUV7
    • Q9P261

    Protein attributes for FAM234B Gene

    Size:
    622 amino acids
    Molecular mass:
    67039 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM234B Gene

Post-translational modifications for FAM234B Gene

No Post-translational modifications

Other Protein References for FAM234B Gene

No data available for DME Specific Peptides for FAM234B Gene

Domains & Families for FAM234B Gene

Gene Families for FAM234B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FAM234B Gene

Graphical View of Domain Structure for InterPro Entry

A2RU67

UniProtKB/Swiss-Prot:

F234B_HUMAN :
  • Belongs to the FAM234 family.
Family:
  • Belongs to the FAM234 family.
genes like me logo Genes that share domains with FAM234B: view

No data available for Suggested Antigen Peptide Sequences for FAM234B Gene

Function for FAM234B Gene

Phenotypes From GWAS Catalog for FAM234B Gene

genes like me logo Genes that share phenotypes with FAM234B: view

Animal Models for FAM234B Gene

MGI Knock Outs for FAM234B:

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM234B Gene

Localization for FAM234B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM234B Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM234B gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM234B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM234B: view

Pathways & Interactions for FAM234B Gene

SuperPathways for FAM234B Gene

No Data Available

Interacting Proteins for FAM234B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000197268%0d%0a9606.ENSP00000310891%0d%0a
Selected Interacting proteins: ENSP00000197268 A2RU67-F234B_HUMAN for FAM234B Gene via STRING IID

Gene Ontology (GO) - Biological Process for FAM234B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM234B Gene

Drugs & Compounds for FAM234B Gene

No Compound Related Data Available

Transcripts for FAM234B Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM234B Gene

No ASD Table

Relevant External Links for FAM234B Gene

GeneLoc Exon Structure for
FAM234B
ECgene alternative splicing isoforms for
FAM234B

Expression for FAM234B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM234B Gene:

FAM234B

Evidence on tissue expression from TISSUES for FAM234B Gene

  • Nervous system(4.7)
  • Liver(4.1)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM234B Gene

Orthologs for FAM234B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FAM234B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1467 33 34
  • 97.36 (n)
dog
(Canis familiaris)
Mammalia KIAA1467 34 33
  • 89.55 (n)
OneToOne
mouse
(Mus musculus)
Mammalia 8430419L09Rik 34 33
  • 85.32 (n)
OneToOne
Fam234b 16
cow
(Bos Taurus)
Mammalia KIAA1467 34 33
  • 85.05 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1306151 33
  • 84.78 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA1467 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 60 (a)
OneToMany
-- 34
  • 57 (a)
OneToMany
chicken
(Gallus gallus)
Aves KIAA1467 33 34
  • 66.61 (n)
lizard
(Anolis carolinensis)
Reptilia KIAA1467 34
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1467 33
  • 55.32 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:77415 33 34
  • 47.81 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.20842 33
corn
(Zea mays)
Liliopsida Zm.6840 33
Species where no ortholog for FAM234B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for FAM234B Gene

ENSEMBL:
Gene Tree for FAM234B (if available)
TreeFam:
Gene Tree for FAM234B (if available)

Paralogs for FAM234B Gene

Paralogs for FAM234B Gene

genes like me logo Genes that share paralogs with FAM234B: view

Variants for FAM234B Gene

Sequence variations from dbSNP and Humsavar for FAM234B Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000005752 -- 12,985,834(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000009124 -- 13,065,443(+) C/T intron_variant
rs1000032634 -- 13,022,311(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000044118 -- 13,034,517(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000047894 -- 13,079,314(+) T/A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM234B Gene

Variant ID Type Subtype PubMed ID
esv2338710 CNV deletion 18987734
esv2745567 CNV deletion 23290073
esv2745571 CNV deletion 23290073
esv2745572 CNV deletion 23290073
esv3366905 CNV insertion 20981092
esv3548784 CNV deletion 23714750
nsv1145800 CNV deletion 26484159
nsv52858 CNV deletion 16902084
nsv832333 CNV gain 17160897

Variation tolerance for FAM234B Gene

Residual Variation Intolerance Score: 34.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.90; 67.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM234B Gene

Human Gene Mutation Database (HGMD)
FAM234B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM234B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM234B Gene

Disorders for FAM234B Gene

No disorders were found for FAM234B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM234B Gene

Publications for FAM234B Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 58

Products for FAM234B Gene

Sources for FAM234B Gene

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