FAM22B Gene
protein-coding GIFtS: 24
GCID: GC10P081462
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family with sequence similarity 22, member B
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Aliases
for FAM22B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 22, Member B1 2 | | BA119F19.11 |
Export aliases for FAM22B gene to outside databasesPrevious GC identifers: GC10U900470 GC10P081134 GC10P081461 |
Summaries
for FAM22B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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-- |
Genomic Views
for FAM22B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM22B gene promoter:
AREB6 SRF c-Rel SRF (504 AA) FOXO1a STAT5A RORalpha2
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM22B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM22B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q22.3 Ensembl cytogenetic band: 10q22.3 HGNC cytogenetic band: 10q22.3FAM22B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P081462: view genomic region
(about GC identifiers)
Start:
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81,462,983 bp from pter |
End:
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81,474,437 bp from pter |
Size:
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11,455 bases |
Orientation:
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plus strand |
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Proteins
for FAM22B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: FA22B_HUMAN, A6NNL0 (See
protein sequence)Recommended Name: Protein FAM22B Size: 878 amino acids; 93984 Da
Sequence caution: Sequence=CAQ08562.1; Type=Erroneous gene model prediction; Sequence=CAQ08563.1; Type=Erroneous genemodel prediction;
Secondary accessions: A6NM73Alternative splicing: 2 isoforms: A6NNL0-1 A6NNL0-2 Explore the universe of human proteins at neXtProt for FAM22B: NX_A6NNL0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6NNL0
FAM22B Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000361396 ENSP00000344811 ENSP00000391631 ENSP00000394623
Human Recombinant Protein Products:
FAM22B Antibody Products:
Assay Products for FAM22B: |
Protein
Domains /
Families
for FAM22B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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FAM22B for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A6NNL0ProtoNet protein and cluster: A6NNL0 UniProtKB/Swiss-Prot: FA22B_HUMAN, A6NNL0Similarity: Belongs to the FAM22 family |
Function
for FAM22B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Pathways & Interactions
for FAM22B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM22B
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Drugs & Compounds
for FAM22B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM22B
Search CenterWatch for drugs/clinical trials and news about FAM22B / FA22B 
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Transcripts
for FAM22B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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5 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372321 ENST00000342531 ENST00000465857 ENST00000448135 ENST00000429828
GeneLoc Exon Structure
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Expression
for FAM22B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM22B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See FAM22B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM22B
SABiosciences Custom PCR Arrays for FAM22B
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FAM22B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM22B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM22B |
Orthologs
for FAM22B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for FAM22B gene from 1/5 species (see all 5) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
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-- |
49(a) |
1 → many |
GL343220.1(852503-857458) |
ENSEMBL Gene Tree for FAM22B (if available)
TreeFam Gene Tree for FAM22B (if available) |
Paralogs
for FAM22B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM22B gene
- FAM22A2 FAM22D2 FAM22G2 C15orf552 FAM22E2 FAM22F2
7 SIMAP similar genes for FAM22B using alignment to 1 protein entry: FA22B_HUMAN:FAM22E FAM22A FAM22F FAM22G FAM22D C15orf55
NUT
FAM22B for paralogs About GeneDecksing
|
Genomic Variants
for FAM22B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for FAM22B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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FAM22B for disorders About GeneDecksing
3  diseases for FAM22B: About MalaCardsendometrial stromal sarcoma kidney sarcoma sarcoma
2 diseases from the University of Copenhagen DISEASES database for FAM22B:Kidney sarcoma Endometrial stromal sarcoma Export disorders for FAM22B gene to outside databases
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Publications
for FAM22B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for FAM22B gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM22B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
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External Searches for FAM22B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing FAM22B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing FAM22B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM22B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM22B | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for FAM22B gene:
Search GeneIP for patents involving FAM22B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for FAM22B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM22B | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM22B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM22B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM22B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM22B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM22B |
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| | | | Search Tocris compounds for FAM22B |
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 | | | FAM22B Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for FAM22B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM22B |
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