FAM22A Gene
protein-coding GIFtS: 37
GCID: GC10P088974
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|
family with sequence similarity 22, member A
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Aliases
for FAM22A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 22, Member A1 2 | | Protein FAM22A2 | | KIAA20203 |
Export aliases for FAM22A gene to outside databasesPrevious GC identifers: GC10P088649 GC10P081589 |
Summaries
for FAM22A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM22A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM22A gene promoter:
AREB6 c-Rel USF1 USF-1 USF2 USF-1:USF-2 Pax-4a RORalpha2
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM22A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM22A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q23.2 Ensembl cytogenetic band: 10q23.2 HGNC cytogenetic band: 10q23.2FAM22A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P088974: view genomic region
(about GC identifiers)
Start:
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88,985,205 bp from pter |
End:
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88,994,912 bp from pter |
Size:
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9,708 bases |
Orientation:
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plus strand |
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Proteins
for FAM22A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FA22A_HUMAN, Q8IVF1 (See
protein sequence)Recommended Name: Protein FAM22A Size: 878 amino acids; 93890 Da
Sequence caution: Sequence=BAC23116.1; Type=Frameshift; Positions=83; Sequence=CAH72466.1; Type=Erroneous gene modelprediction;
Secondary accessions: A6NMX5 C9JDI1 Q5VZW1Alternative splicing: 2 isoforms: Q8IVF1-1 Q8IVF1-2 Explore the universe of human proteins at neXtProt for FAM22A: NX_Q8IVF1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IVF1
FAM22A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001092808.1
ENSEMBL proteins: ENSP00000390723 ENSP00000371107 ENSP00000371126
Human Recombinant Protein Products:
FAM22A Antibody Products:
Assay Products for FAM22A: |
Protein
Domains /
Families
for FAM22A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM22A for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IVF1ProtoNet protein and cluster: Q8IVF1 UniProtKB/Swiss-Prot: FA22A_HUMAN, Q8IVF1Similarity: Belongs to the FAM22 family |
Function
for FAM22A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM22A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM22A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FAM22A (NM_001099338) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM22A | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM22A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM22A |
|
Pathways & Interactions
for FAM22A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM22A
|
Drugs & Compounds
for FAM22A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM22A
Search CenterWatch for drugs/clinical trials and news about FAM22A / FA22A
|
Transcripts
for FAM22A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM22A gene: NM_001099338.1 Unigene Cluster for FAM22A: Family with sequence similarity 22, member A Hs.710565 [show with all ESTs]Unigene Representative Sequence: AB0959403 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000451286 ENST00000381689 ENST00000381707(uc001kek.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM22A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM22A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FAM22A (NM_001099338) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM22A | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM22A |
Additional cDNA sequence: AB095940.1 BC033231.1 BC092519.1 7 DOTS entries: DT.102838481 DT.208297 DT.121227235 DT.121224397 DT.121286886 DT.91884540 DT.91895673
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for FAM22A About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 |
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| SP1: | | | | | | | | | | | - | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | | | - | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FAM22A
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Expression
for FAM22A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM22A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCTGGCTCA
About this image
See FAM22A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM22A
SOURCE GeneReport for Unigene cluster: Hs.710565
SABiosciences Custom PCR Arrays for FAM22A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM22A
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat FAM22A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM22A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM22A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM22A |
Orthologs
for FAM22A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FAM22A gene from 1/5 species (see all 5) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
49(a) |
1 → many |
GL343220.1(852503-857458) |
ENSEMBL Gene Tree for FAM22A (if available)
TreeFam Gene Tree for FAM22A (if available) |
Paralogs
for FAM22A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM22A gene
- FAM22D2 FAM22G2 C15orf552 FAM22B2 FAM22E2 FAM22F2
7 SIMAP similar genes for FAM22A using alignment to 2 protein entries: FA22A_HUMAN (see all proteins):FAM22B FAM22E FAM22F FAM22G FAM22D C15orf55
NUT
FAM22A for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for FAM22A
PGOHUM00000236269
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Genomic Variants
for FAM22A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM22A (88985205 - 88994912 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for FAM22A
11 CNVs: 2885 85391 31761 71079 75323 34898 71076 31770 3815 71078 85393 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM22A |
|
Disorders
/ Diseases
for FAM22A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAM22A for disorders About GeneDecksing
2  diseases for FAM22A: About MalaCardsendometrial stromal sarcoma sarcoma
1 disease from the University of Copenhagen DISEASES database for FAM22A:Endometrial stromal sarcoma Export disorders for FAM22A gene to outside databases
|
Publications
for FAM22A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM22A gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM22A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for FAM22A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing FAM22A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM22A gene
(According to HUGE)
About This Section
| |
Specialized Databases showing FAM22A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM22A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM22A gene:
Search GeneIP for patents involving FAM22A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM22A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM22A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM22A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM22A | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM22A | | OriGene 3'-UTR Clone for FAM22A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM22A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM22A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM22A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM22A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM22A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM22A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM22A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM22A |
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 |  |  |  | |
| | | | Search Tocris compounds for FAM22A |
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 | | | FAM22A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM22A |
|  |  |  | | | | Search ThermoFisher Antibodies for FAM22A |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM22A |
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