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Aliases for FAM229B Gene

Aliases for FAM229B Gene

  • Family With Sequence Similarity 229 Member B 2 3 5
  • C6orf225 3 4
  • Family With Sequence Similarity 229, Member B 2
  • Chromosome 6 Open Reading Frame 225 2
  • UPF0731 Protein C6orf225 3
  • Protein FAM229B 3

External Ids for FAM229B Gene

Previous HGNC Symbols for FAM229B Gene

  • C6orf225

Previous GeneCards Identifiers for FAM229B Gene

  • GC06P112409

Summaries for FAM229B Gene

GeneCards Summary for FAM229B Gene

FAM229B (Family With Sequence Similarity 229 Member B) is a Protein Coding gene. An important paralog of this gene is FAM229A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM229B Gene

Genomics for FAM229B Gene

Regulatory Elements for FAM229B Gene

Enhancers for FAM229B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F112036 1 FANTOM5 Ensembl ENCODE 15.9 -48.9 -48909 4.3 JUN SIN3A ZIC2 OSR2 E2F1 JUND ZFHX2 GATA3 POLR2A ZNF692 WISP3 FAM229B TRAF3IP2 FYN TUBE1 GC06M111982
GH06F112040 1.5 FANTOM5 Ensembl ENCODE 15.3 -44.0 -44000 5.3 ATF1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 ZNF143 WISP3 FAM229B TUBE1 FYN ENSG00000255389 TRAF3IP2 GC06M111982
GH06F112153 0.9 Ensembl ENCODE 15 +68.0 68049 3.4 ZNF384 ZNF664 ZNF316 POLR2A SCRT2 PRDM10 NFE2 FOSL2 FOS MAFK TUBE1 FAM229B ENSG00000237234 GC06M112197 RNU6-1226P
GH06F112149 0.8 FANTOM5 ENCODE 13.6 +62.7 62743 2.0 CTCF ZFHX2 SCRT2 KLF4 WT1 NFE2L2 TUBE1 FAM229B ENSG00000255389 ENSG00000237234
GH06F112163 0.7 ENCODE 11.6 +76.0 76043 0.2 CTCF ARID4B ZNF48 RAD21 GATAD1 ZNF143 SMC3 NR2F6 GATAD2A ZNF202 ENSG00000220506 MFSD4B FAM229B TUBE1 FCF1P5 RNU6-1226P ENSG00000272356 LAMA4 ENSG00000237234 GC06M112197
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FAM229B on UCSC Golden Path with GeneCards custom track

Promoters for FAM229B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001224697 -71 2400 HDGF PKNOX1 ATF1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF2

Genomic Location for FAM229B Gene

Chromosome:
6
Start:
112,087,471 bp from pter
End:
112,102,790 bp from pter
Size:
15,320 bases
Orientation:
Plus strand

Genomic View for FAM229B Gene

Genes around FAM229B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM229B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM229B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM229B Gene

Proteins for FAM229B Gene

  • Protein details for FAM229B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4G0N7-F229B_HUMAN
    Recommended name:
    Protein FAM229B
    Protein Accession:
    Q4G0N7
    Secondary Accessions:
    • B8ZZ33

    Protein attributes for FAM229B Gene

    Size:
    80 amino acids
    Molecular mass:
    8717 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM229B Gene

Post-translational modifications for FAM229B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM229B Gene

No data available for DME Specific Peptides for FAM229B Gene

Domains & Families for FAM229B Gene

Protein Domains for FAM229B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM229B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4G0N7

UniProtKB/Swiss-Prot:

F229B_HUMAN :
  • Belongs to the FAM229 family.
Family:
  • Belongs to the FAM229 family.
genes like me logo Genes that share domains with FAM229B: view

No data available for Gene Families for FAM229B Gene

Function for FAM229B Gene

Phenotypes for FAM229B Gene

GenomeRNAi human phenotypes for FAM229B:
genes like me logo Genes that share phenotypes with FAM229B: view

Animal Model Products

miRNA for FAM229B Gene

miRTarBase miRNAs that target FAM229B

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM229B Gene

Localization for FAM229B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for FAM229B Gene

Pathways & Interactions for FAM229B Gene

SuperPathways for FAM229B Gene

No Data Available

Interacting Proteins for FAM229B Gene

Gene Ontology (GO) - Biological Process for FAM229B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM229B Gene

Transcripts for FAM229B Gene

mRNA/cDNA for FAM229B Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM229B Gene

Family with sequence similarity 229, member B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM229B Gene

No ASD Table

Relevant External Links for FAM229B Gene

GeneLoc Exon Structure for
FAM229B
ECgene alternative splicing isoforms for
FAM229B

Expression for FAM229B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM229B Gene

mRNA differential expression in normal tissues according to GTEx for FAM229B Gene

This gene is overexpressed in Testis (x8.7) and Brain - Spinal cord (cervical c-1) (x4.2).

Protein differential expression in normal tissues from HIPED for FAM229B Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM229B Gene



Protein tissue co-expression partners for FAM229B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM229B Gene:

FAM229B

SOURCE GeneReport for Unigene cluster for FAM229B Gene:

Hs.591340
genes like me logo Genes that share expression patterns with FAM229B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FAM229B Gene

Orthologs for FAM229B Gene

This gene was present in the common ancestor of mammals.

Orthologs for FAM229B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C6H6orf225 34
  • 97.92 (n)
FAM229B 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM229B 35
  • 94 (a)
OneToOne
C12H6orf225 34
  • 93.75 (n)
cow
(Bos Taurus)
Mammalia FAM229B 34 35
  • 90.83 (n)
rat
(Rattus norvegicus)
Mammalia Fam229b 34
  • 90.42 (n)
mouse
(Mus musculus)
Mammalia Fam229b 34 16 35
  • 89.58 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM229B 35
  • 86 (a)
OneToOne
Species where no ortholog for FAM229B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM229B Gene

ENSEMBL:
Gene Tree for FAM229B (if available)
TreeFam:
Gene Tree for FAM229B (if available)

Paralogs for FAM229B Gene

Paralogs for FAM229B Gene

(1) SIMAP similar genes for FAM229B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM229B: view

Variants for FAM229B Gene

Sequence variations from dbSNP and Humsavar for FAM229B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1014479 -- 112,101,365(+) ATCTG(C/G)GCTCC downstream-variant-500B, utr-variant-3-prime
rs1044181 -- 112,100,751(+) AAGCC(A/C)CCTGC reference, synonymous-codon
rs11153336 -- 112,091,975(+) attag(A/G)caaaa intron-variant
rs11153337 -- 112,092,217(+) gtgaa(A/C)cttag intron-variant
rs11153338 -- 112,092,313(+) ccaga(G/T)aaaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM229B Gene

Variant ID Type Subtype PubMed ID
esv2676434 CNV deletion 23128226
esv28804 CNV loss 19812545
esv3571360 CNV loss 25503493
esv3610388 CNV loss 21293372
nsv950495 CNV duplication 24416366

Variation tolerance for FAM229B Gene

Residual Variation Intolerance Score: 76.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.18; 51.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM229B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM229B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM229B Gene

Disorders for FAM229B Gene

Relevant External Links for FAM229B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM229B

No disorders were found for FAM229B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM229B Gene

Publications for FAM229B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for FAM229B Gene

Sources for FAM229B Gene

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