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Aliases for FAM229B Gene

Aliases for FAM229B Gene

  • Family With Sequence Similarity 229 Member B 2 3 5
  • C6orf225 3 4
  • Family With Sequence Similarity 229, Member B 2
  • Chromosome 6 Open Reading Frame 225 2
  • UPF0731 Protein C6orf225 3
  • Protein FAM229B 3

External Ids for FAM229B Gene

Previous HGNC Symbols for FAM229B Gene

  • C6orf225

Previous GeneCards Identifiers for FAM229B Gene

  • GC06P112409

Summaries for FAM229B Gene

GeneCards Summary for FAM229B Gene

FAM229B (Family With Sequence Similarity 229 Member B) is a Protein Coding gene. An important paralog of this gene is FAM229A.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM229B Gene

Genomics for FAM229B Gene

Regulatory Elements for FAM229B Gene

Enhancers for FAM229B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G112041 1.9 FANTOM5 Ensembl ENCODE dbSUPER 15.3 -43.5 -43507 4.4 FOXA2 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 WISP3 ENSG00000255389 FAM229B TRAF3IP2-AS1 TUBE1 FYN TRAF3IP2 GC06M111982
GH06G112036 1.6 FANTOM5 Ensembl ENCODE dbSUPER 15.9 -48.8 -48814 4.1 FOXA2 JUN SIN3A ZIC2 OSR2 E2F1 JUND ZFHX2 GATA3 GATA2 WISP3 FAM229B TRAF3IP2 FYN TUBE1 GC06M111982
GH06G112153 1 ENCODE dbSUPER 15.1 +68.0 68049 3.4 ZNF384 FOSL1 ZNF664 ZNF316 POLR2A ZSCAN5C SCRT2 FOSL2 PRDM10 FOS TUBE1 FAM229B ENSG00000237234 RNU6-1226P GC06M112197
GH06G112149 1.1 FANTOM5 ENCODE dbSUPER 13.7 +62.7 62743 2.0 CTCF ZFHX2 ZSCAN5C SCRT2 ZSCAN4 KLF4 WT1 NFE2L2 TUBE1 FAM229B ENSG00000255389 ENSG00000237234
GH06G112112 0.8 dbSUPER 18.7 +26.6 26601 2.7 FEZF1 BCL11B ZIC2 YY1 ZNF664 ZNF366 ZNF350 HNF4G ZNF10 ZNF843 WISP3 FAM229B ENSG00000237234 TUBE1 RNU6-1226P LAMA4 LOC100128588
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM229B on UCSC Golden Path with GeneCards custom track

Promoters for FAM229B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for FAM229B Gene

112,087,471 bp from pter
112,102,790 bp from pter
15,320 bases
Plus strand

Genomic View for FAM229B Gene

Genes around FAM229B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM229B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM229B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM229B Gene

Proteins for FAM229B Gene

  • Protein details for FAM229B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM229B
    Protein Accession:
    Secondary Accessions:
    • B8ZZ33

    Protein attributes for FAM229B Gene

    80 amino acids
    Molecular mass:
    8717 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM229B Gene

Post-translational modifications for FAM229B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM229B Gene

No data available for DME Specific Peptides for FAM229B Gene

Domains & Families for FAM229B Gene

Protein Domains for FAM229B Gene


Suggested Antigen Peptide Sequences for FAM229B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM229 family.
  • Belongs to the FAM229 family.
genes like me logo Genes that share domains with FAM229B: view

No data available for Gene Families for FAM229B Gene

Function for FAM229B Gene

Phenotypes for FAM229B Gene

GenomeRNAi human phenotypes for FAM229B:
genes like me logo Genes that share phenotypes with FAM229B: view

Animal Model Products

CRISPR Products

miRNA for FAM229B Gene

miRTarBase miRNAs that target FAM229B

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM229B Gene

Localization for FAM229B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM229B gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM229B Gene

Pathways & Interactions for FAM229B Gene

SuperPathways for FAM229B Gene

No Data Available

Interacting Proteins for FAM229B Gene

Gene Ontology (GO) - Biological Process for FAM229B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM229B Gene

Drugs & Compounds for FAM229B Gene

No Compound Related Data Available

Transcripts for FAM229B Gene

mRNA/cDNA for FAM229B Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM229B Gene

Family with sequence similarity 229, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM229B Gene

No ASD Table

Relevant External Links for FAM229B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM229B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM229B Gene

mRNA differential expression in normal tissues according to GTEx for FAM229B Gene

This gene is overexpressed in Testis (x8.7) and Brain - Spinal cord (cervical c-1) (x4.2).

Protein differential expression in normal tissues from HIPED for FAM229B Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM229B Gene

Protein tissue co-expression partners for FAM229B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM229B Gene:


SOURCE GeneReport for Unigene cluster for FAM229B Gene:


Evidence on tissue expression from TISSUES for FAM229B Gene

  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with FAM229B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM229B Gene

Orthologs for FAM229B Gene

This gene was present in the common ancestor of mammals.

Orthologs for FAM229B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C6H6orf225 34
  • 97.92 (n)
FAM229B 35
  • 96 (a)
(Canis familiaris)
Mammalia FAM229B 35
  • 94 (a)
C12H6orf225 34
  • 93.75 (n)
(Bos Taurus)
Mammalia FAM229B 34 35
  • 90.83 (n)
(Rattus norvegicus)
Mammalia Fam229b 34
  • 90.42 (n)
(Mus musculus)
Mammalia Fam229b 34 16 35
  • 89.58 (n)
(Monodelphis domestica)
Mammalia FAM229B 35
  • 86 (a)
Species where no ortholog for FAM229B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM229B Gene

Gene Tree for FAM229B (if available)
Gene Tree for FAM229B (if available)

Paralogs for FAM229B Gene

Paralogs for FAM229B Gene

(1) SIMAP similar genes for FAM229B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM229B: view

Variants for FAM229B Gene

Sequence variations from dbSNP and Humsavar for FAM229B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000085628 -- 112,089,430(+) AGAAC(G/T)TAAGA intron-variant, upstream-variant-2KB
rs1000288557 -- 112,102,831(+) TAATA(A/G)AAAGT downstream-variant-500B
rs1000385038 -- 112,096,056(+) ATCGG(A/T)TATGA intron-variant
rs1000735222 -- 112,100,930(+) GACAG(A/C)AATGT downstream-variant-500B, utr-variant-3-prime
rs1001127249 -- 112,094,371(+) TGCTT(A/T)TGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM229B Gene

Variant ID Type Subtype PubMed ID
esv2676434 CNV deletion 23128226
esv28804 CNV loss 19812545
esv3571360 CNV loss 25503493
esv3610388 CNV loss 21293372
nsv950495 CNV duplication 24416366

Variation tolerance for FAM229B Gene

Residual Variation Intolerance Score: 76.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.18; 51.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM229B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM229B Gene

Disorders for FAM229B Gene

Relevant External Links for FAM229B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM229B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM229B Gene

Publications for FAM229B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for FAM229B Gene

Sources for FAM229B Gene

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