FAM228B Gene
protein-coding GIFtS: 28
GCID: GC02P024302
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|
family with sequence similarity 228, member B
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Aliases
for FAM228B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 228, Member B1 2 | | Protein FAM228B2 | | UPF0638 Protein B2 |
Export aliases for FAM228B gene to outside databases |
Summaries
for FAM228B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM228B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for FAM228B
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM228B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM228B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p23.3 Ensembl cytogenetic band: 2p23.3 HGNC cytogenetic band: 2p23.3FAM228B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P024302: view genomic region
(about GC identifiers)
Start:
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24,299,396 bp from pter |
End:
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24,392,509 bp from pter |
Size:
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93,114 bases |
Orientation:
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plus strand |
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Proteins
for FAM228B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F228B_HUMAN, P0C875 (See
protein sequence)Recommended Name: Protein FAM228B Size: 321 amino acids; 37405 Da
Sequence caution: Sequence=AK055413; Type=Frameshift; Positions=267;Alternative splicing: 2 isoforms: P0C875-1 P0C875-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FAM228B: NX_P0C875
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P0C875
FAM228B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001139182.1
ENSEMBL proteins: ENSP00000383879 ENSP00000394034 ENSP00000403572 ENSP00000403796 ENSP00000389043
Human Recombinant Protein Products:
FAM228B Antibody Products:
Assay Products for FAM228B: |
Protein
Domains /
Families
for FAM228B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: P0C875 UniProtKB/Swiss-Prot: F228B_HUMAN, P0C875Similarity: Belongs to the FAM228 family |
Function
for FAM228B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM228B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM228B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for FAM228B | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM228B | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM228B |
1 GenomeRNAi human phenotype for FAM228B:
|
Pathways & Interactions
for FAM228B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM228B
|
Drugs & Compounds
for FAM228B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM228B
Search CenterWatch for drugs/clinical trials and news about FAM228B / F228B
|
Transcripts
for FAM228B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM228B gene (2 alternative transcripts): NM_001145710.1 NM_198553.1 Unigene Cluster for FAM228B: Family with sequence similarity 228, member B Hs.710370 [show with all ESTs]Unigene Representative Sequence: NM_00114571010 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000469867 ENST00000461972 ENST00000468799(uc002rew.3) ENST00000486967
ENST00000460686 ENST00000407625 ENST00000417898 ENST00000457370 ENST00000448919
ENST00000420135(uc010ykl.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM228B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM228B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for FAM228B | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM228B | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM228B |
Additional cDNA sequence: BC029459.1 9 DOTS entries: DT.86840955 DT.100810042 DT.91687189 DT.101978811 DT.120954630 DT.86847229 DT.92421526 DT.120954577 DT.95157675 24/116 AceView cDNA sequences (see all 116): AI191152 CR597946 AA913705 AI807470 BG150454 BM722814 AA625774 AI700631 AA906368 BC039372 AK092423 BC050462 AI632252 BC029459 AL709923 AI138754 BM479211 AI919144 AI954631 AI652990 BF956246 AI829638 BU958748 AL700974
GeneLoc Exon Structure
|
Expression
for FAM228B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See FAM228B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM228B
SOURCE GeneReport for Unigene cluster: Hs.710370
SABiosciences Custom PCR Arrays for FAM228B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM228B
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat FAM228B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM228B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM228B |
Orthologs
for FAM228B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FAM228B gene from 2/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC4219781 |
UPF0638 protein B-like |
56.49(n)
41.78(a) |
|
421978 XM_419988.3 XP_419988.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
fam228a1 |
family with sequence similarity 228, member A |
47.77(n)
34.39(a) |
|
569576 NM_001045186.2 NP_001038651.2 |
ENSEMBL Gene Tree for FAM228B (if available)
TreeFam Gene Tree for FAM228B (if available) |
Paralogs
for FAM228B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM228B gene
- ENSG000002661182 FAM228A2
2 SIMAP similar genes for FAM228B using alignment to 6 protein entries: F228B_HUMAN (see all proteins):UTY FAM228A
FAM228B for paralogs About GeneDecksing
|
Genomic Variants
for FAM228B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM228B (24299396 - 24392509 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM228B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM228B |
|
Disorders
/ Diseases
for FAM228B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for FAM228B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM228B gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM228B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for FAM228B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM228B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM228B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM228B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for FAM228B gene:
Search GeneIP for patents involving FAM228B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM228B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM228B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM228B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM228B | | | OriGene Protein Over-expression Lysate for FAM228B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM228B | | OriGene 3'-UTR Clone for FAM228B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM228B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM228B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM228B | | OriGene Custom Protein Services for FAM228B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM228B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM228B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM228B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM228B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM228B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM228B |
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 |  |  |  | |
| | | | Search Tocris compounds for FAM228B |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for FAM228B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM228B |
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