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Aliases for FAM228B Gene

Aliases for FAM228B Gene

  • Family With Sequence Similarity 228 Member B 2 3 5
  • Family With Sequence Similarity 228, Member B 2

External Ids for FAM228B Gene

Previous GeneCards Identifiers for FAM228B Gene

  • GC02P024302

Summaries for FAM228B Gene

GeneCards Summary for FAM228B Gene

FAM228B (Family With Sequence Similarity 228 Member B) is a Protein Coding gene. An important paralog of this gene is ENSG00000276087.

Additional gene information for FAM228B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM228B Gene

Genomics for FAM228B Gene

Regulatory Elements for FAM228B Gene

Enhancers for FAM228B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H024082 1.4 ENCODE dbSUPER 38 +7.5 7464 3 HDGF MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 FAM228B TP53I3 ATAD2B PFN4 WDCP ENSG00000271936 FAM228A
GH02H024075 1.4 ENCODE dbSUPER 37.3 +0.5 450 3 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A SSRP1 FAM228B TP53I3 ATAD2B PFN4 WDCP ENSG00000271936
GH02H024121 1.1 ENCODE 43 +46.5 46506 3 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF143 ZNF207 ZNF548 FAM228B ATAD2B PFN4 ENSG00000223530 WDCP ENSG00000271936 CENPO TP53I3 GC02M024111 PIR36243
GH02H024048 0.9 ENCODE 46.6 -26.7 -26725 1 ELF3 ARID4B KLF17 ZNF2 ZNF121 GLIS2 ZNF366 ZNF391 RUNX3 THAP11 FAM228B SF3B6 MFSD2B TP53I3 ATAD2B UBXN2A PFN4 FKBP1B PIR43014 GC02M024079
GH02H024045 1.1 ENCODE 34.7 -29.6 -29593 2 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 FAM228B WDCP ATAD2B PFN4 ENSG00000271936 FAM228A RNU6-370P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM228B on UCSC Golden Path with GeneCards custom track

Promoters for FAM228B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000114011 -26 2201 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A SSRP1

Genomic Location for FAM228B Gene

Chromosome:
2
Start:
24,076,526 bp from pter
End:
24,169,640 bp from pter
Size:
93,115 bases
Orientation:
Plus strand

Genomic View for FAM228B Gene

Genes around FAM228B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM228B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM228B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM228B Gene

Proteins for FAM228B Gene

  • Protein details for FAM228B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C875-F228B_HUMAN
    Recommended name:
    Protein FAM228B
    Protein Accession:
    P0C875

    Protein attributes for FAM228B Gene

    Size:
    321 amino acids
    Molecular mass:
    37405 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AK055413; Type=Frameshift; Positions=267; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM228B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM228B Gene

Post-translational modifications for FAM228B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM228B Gene

No data available for DME Specific Peptides for FAM228B Gene

Domains & Families for FAM228B Gene

Gene Families for FAM228B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM228B Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P0C875

UniProtKB/Swiss-Prot:

F228B_HUMAN :
  • Belongs to the FAM228 family.
Family:
  • Belongs to the FAM228 family.
genes like me logo Genes that share domains with FAM228B: view

No data available for Suggested Antigen Peptide Sequences for FAM228B Gene

Function for FAM228B Gene

Phenotypes From GWAS Catalog for FAM228B Gene

Phenotypes for FAM228B Gene

GenomeRNAi human phenotypes for FAM228B:
genes like me logo Genes that share phenotypes with FAM228B: view

Animal Model Products

CRISPR Products

miRNA for FAM228B Gene

miRTarBase miRNAs that target FAM228B

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM228B Gene

Localization for FAM228B Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for FAM228B Gene

Pathways & Interactions for FAM228B Gene

SuperPathways for FAM228B Gene

No Data Available

Interacting Proteins for FAM228B Gene

Gene Ontology (GO) - Biological Process for FAM228B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM228B Gene

Drugs & Compounds for FAM228B Gene

No Compound Related Data Available

Transcripts for FAM228B Gene

Unigene Clusters for FAM228B Gene

Family with sequence similarity 228, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM228B Gene

No ASD Table

Relevant External Links for FAM228B Gene

GeneLoc Exon Structure for
FAM228B
ECgene alternative splicing isoforms for
FAM228B

Expression for FAM228B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM228B Gene

Protein differential expression in normal tissues from HIPED for FAM228B Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM228B Gene



Protein tissue co-expression partners for FAM228B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM228B Gene:

FAM228B

SOURCE GeneReport for Unigene cluster for FAM228B Gene:

Hs.710370
genes like me logo Genes that share expression patterns with FAM228B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM228B Gene

Orthologs for FAM228B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM228B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM228B 33
  • 99.38 (n)
-- 34
  • 94 (a)
OneToMany
cow
(Bos Taurus)
Mammalia FAM228B 33 34
  • 86.18 (n)
mouse
(Mus musculus)
Mammalia Fam228b 33 16 34
  • 84.13 (n)
dog
(Canis familiaris)
Mammalia FAM228B 33
  • 84.03 (n)
-- 34
  • 71 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Fam228b 33
  • 79.11 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 39 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 32 (a)
ManyToMany
-- 34
  • 17 (a)
ManyToMany
chicken
(Gallus gallus)
Aves LOC421978 33
  • 57 (n)
-- 34
  • 32 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fam228b 33
  • 51.52 (n)
zebrafish
(Danio rerio)
Actinopterygii fam228a 33 34
  • 48.28 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 19 (a)
OneToMany
Species where no ortholog for FAM228B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM228B Gene

ENSEMBL:
Gene Tree for FAM228B (if available)
TreeFam:
Gene Tree for FAM228B (if available)

Paralogs for FAM228B Gene

Paralogs for FAM228B Gene

(2) SIMAP similar genes for FAM228B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FAM228B: view

Variants for FAM228B Gene

Sequence variations from dbSNP and Humsavar for FAM228B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000012539 -- 24,081,068(+) TTGCA(A/G)CTGCT intron-variant
rs1000118848 -- 24,087,158(+) TGTAA(C/T)AAGAA intron-variant, upstream-variant-2KB
rs1000149442 -- 24,164,450(+) AGGCA(G/T)TGGGG intron-variant
rs1000201539 -- 24,106,398(+) CACTG(C/T)AACCT intron-variant
rs1000205395 -- 24,084,410(+) ACAGG(A/G)CAGGG intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM228B Gene

Variant ID Type Subtype PubMed ID
esv2719814 CNV deletion 23290073
esv32848 CNV gain 17666407
nsv1072930 CNV deletion 25765185
nsv1138759 CNV deletion 24896259
nsv2641 CNV deletion 18451855
nsv455897 CNV gain 19166990
nsv581179 CNV gain 21841781
nsv997445 CNV gain 25217958
nsv997725 CNV gain 25217958

Variation tolerance for FAM228B Gene

Gene Damage Index Score: 5.98; 74.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM228B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM228B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM228B Gene

Disorders for FAM228B Gene

Relevant External Links for FAM228B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM228B

No disorders were found for FAM228B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM228B Gene

Publications for FAM228B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Identification of host proteins required for HIV infection through a functional genomic screen. (PMID: 18187620) Brass AL … Elledge SJ (Science (New York, N.Y.) 2008) 3 60
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 60
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 60
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R … Stanton LW (Nature biotechnology 2004) 3 60

Products for FAM228B Gene

Sources for FAM228B Gene

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