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Aliases for FAM228B Gene

Aliases for FAM228B Gene

  • Family With Sequence Similarity 228 Member B 2 3 5
  • Family With Sequence Similarity 228, Member B 2

External Ids for FAM228B Gene

Previous GeneCards Identifiers for FAM228B Gene

  • GC02P024302

Summaries for FAM228B Gene

GeneCards Summary for FAM228B Gene

FAM228B (Family With Sequence Similarity 228 Member B) is a Protein Coding gene. An important paralog of this gene is FAM228A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM228B Gene

Genomics for FAM228B Gene

Regulatory Elements for FAM228B Gene

Enhancers for FAM228B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM228B on UCSC Golden Path with GeneCards custom track

Promoters for FAM228B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM228B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM228B Gene

24,076,526 bp from pter
24,169,640 bp from pter
93,115 bases
Plus strand

Genomic View for FAM228B Gene

Genes around FAM228B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM228B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM228B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM228B Gene

Proteins for FAM228B Gene

  • Protein details for FAM228B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM228B
    Protein Accession:

    Protein attributes for FAM228B Gene

    321 amino acids
    Molecular mass:
    37405 Da
    Quaternary structure:
    No Data Available
    • Sequence=AK055413; Type=Frameshift; Positions=267; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM228B Gene


neXtProt entry for FAM228B Gene

Proteomics data for FAM228B Gene at MOPED

Post-translational modifications for FAM228B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM228B Gene

No data available for DME Specific Peptides for FAM228B Gene

Domains & Families for FAM228B Gene

Protein Domains for FAM228B Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM228 family.
  • Belongs to the FAM228 family.
genes like me logo Genes that share domains with FAM228B: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for FAM228B Gene

Function for FAM228B Gene

Phenotypes for FAM228B Gene

GenomeRNAi human phenotypes for FAM228B:
genes like me logo Genes that share phenotypes with FAM228B: view

Animal Model Products

CRISPR Products

miRNA for FAM228B Gene

miRTarBase miRNAs that target FAM228B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM228B Gene

Localization for FAM228B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for FAM228B Gene

Pathways & Interactions for FAM228B Gene

SuperPathways for FAM228B Gene

No Data Available

Interacting Proteins for FAM228B Gene

Gene Ontology (GO) - Biological Process for FAM228B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM228B Gene

Drugs & Compounds for FAM228B Gene

No Compound Related Data Available

Transcripts for FAM228B Gene

Unigene Clusters for FAM228B Gene

Family with sequence similarity 228, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM228B Gene

No ASD Table

Relevant External Links for FAM228B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM228B Gene

mRNA expression in normal human tissues for FAM228B Gene

Protein differential expression in normal tissues from HIPED for FAM228B Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM228B Gene

SOURCE GeneReport for Unigene cluster for FAM228B Gene Hs.710370

genes like me logo Genes that share expression patterns with FAM228B: view

Protein tissue co-expression partners for FAM228B Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM228B Gene

Orthologs for FAM228B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM228B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM228B 35
  • 86.18 (n)
  • 77.91 (a)
FAM228B 36
  • 76 (a)
(Canis familiaris)
Mammalia FAM228B 35
  • 84.03 (n)
  • 74.12 (a)
-- 36
  • 71 (a)
(Mus musculus)
Mammalia Fam228b 35
  • 84.13 (n)
  • 79.04 (a)
Fam228b 16
Fam228b 36
  • 78 (a)
(Pan troglodytes)
Mammalia FAM228B 35
  • 99.38 (n)
  • 99.07 (a)
-- 36
  • 94 (a)
(Rattus norvegicus)
Mammalia Fam228b 35
  • 79.11 (n)
  • 71.43 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 17 (a)
-- 36
  • 32 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 39 (a)
(Gallus gallus)
Aves LOC421978 35
  • 57 (n)
  • 42.51 (a)
-- 36
  • 32 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam228b 35
  • 51.52 (n)
  • 41.36 (a)
(Danio rerio)
Actinopterygii fam228a 35
  • 48.28 (n)
  • 34.55 (a)
fam228a 36
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
Species with no ortholog for FAM228B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM228B Gene

Gene Tree for FAM228B (if available)
Gene Tree for FAM228B (if available)

Paralogs for FAM228B Gene

Paralogs for FAM228B Gene

(2) SIMAP similar genes for FAM228B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FAM228B: view

Variants for FAM228B Gene

Sequence variations from dbSNP and Humsavar for FAM228B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1582614 -- 24,106,160(+) taatc(A/G)tcaga intron-variant
rs1834127 -- 24,135,998(+) TTCCA(A/T)AGAAT intron-variant
rs967639 -- 24,093,181(+) ttgaa(A/G)gtgca intron-variant
rs1025078 -- 24,104,316(+) GACGT(A/T)TTATA intron-variant
rs1025079 -- 24,104,320(+) TATTA(C/T)AGGGC intron-variant

Variation tolerance for FAM228B Gene

Gene Damage Index Score: 5.98; 74.78% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for FAM228B Gene

Disorders for FAM228B Gene

Relevant External Links for FAM228B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM228B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM228B Gene

Publications for FAM228B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Identification of host proteins required for HIV infection through a functional genomic screen. (PMID: 18187620) Brass A.L. … Elledge S.J. (Science 2008) 3
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for FAM228B Gene

Sources for FAM228B Gene