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Aliases for FAM227B Gene

Aliases for FAM227B Gene

  • Family With Sequence Similarity 227 Member B 2 3 5
  • Family With Sequence Similarity 227, Member B 2 3
  • C15orf33 3 4
  • Chromosome 15 Open Reading Frame 33 2

External Ids for FAM227B Gene

Previous HGNC Symbols for FAM227B Gene

  • C15orf33

Previous GeneCards Identifiers for FAM227B Gene

  • GC15M049619

Summaries for FAM227B Gene

GeneCards Summary for FAM227B Gene

FAM227B (Family With Sequence Similarity 227 Member B) is a Protein Coding gene. An important paralog of this gene is FAM227A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM227B Gene

Genomics for FAM227B Gene

Regulatory Elements for FAM227B Gene

Promoters for FAM227B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM227B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM227B Gene

Chromosome:
15
Start:
49,326,962 bp from pter
End:
49,620,931 bp from pter
Size:
293,970 bases
Orientation:
Minus strand

Genomic View for FAM227B Gene

Genes around FAM227B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM227B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM227B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM227B Gene

Proteins for FAM227B Gene

  • Protein details for FAM227B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96M60-F227B_HUMAN
    Recommended name:
    Protein FAM227B
    Protein Accession:
    Q96M60
    Secondary Accessions:
    • Q86WS2

    Protein attributes for FAM227B Gene

    Size:
    508 amino acids
    Molecular mass:
    59956 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM227B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM227B Gene

Proteomics data for FAM227B Gene at MOPED

Post-translational modifications for FAM227B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM227B Gene

No data available for DME Specific Peptides for FAM227B Gene

Domains & Families for FAM227B Gene

Protein Domains for FAM227B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96M60

UniProtKB/Swiss-Prot:

F227B_HUMAN :
  • Belongs to the FAM227 family.
Family:
  • Belongs to the FAM227 family.
genes like me logo Genes that share domains with FAM227B: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for FAM227B Gene

Function for FAM227B Gene

Phenotypes for FAM227B Gene

GenomeRNAi human phenotypes for FAM227B:
genes like me logo Genes that share phenotypes with FAM227B: view

Animal Model Products

CRISPR Products

miRNA for FAM227B Gene

miRTarBase miRNAs that target FAM227B

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM227B Gene

Localization for FAM227B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM227B Gene COMPARTMENTS Subcellular localization image for FAM227B gene
Compartment Confidence
nucleus 3
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM227B Gene

Pathways & Interactions for FAM227B Gene

SuperPathways for FAM227B Gene

No Data Available

Interacting Proteins for FAM227B Gene

Gene Ontology (GO) - Biological Process for FAM227B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM227B Gene

Drugs & Compounds for FAM227B Gene

No Compound Related Data Available

Transcripts for FAM227B Gene

Unigene Clusters for FAM227B Gene

Family with sequence similarity 227, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM227B Gene

No ASD Table

Relevant External Links for FAM227B Gene

GeneLoc Exon Structure for
FAM227B
ECgene alternative splicing isoforms for
FAM227B

Expression for FAM227B Gene

mRNA expression in normal human tissues for FAM227B Gene

SOURCE GeneReport for Unigene cluster for FAM227B Gene Hs.712959

genes like me logo Genes that share expression patterns with FAM227B: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FAM227B Gene

Orthologs for FAM227B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM227B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM227B 35
  • 98.81 (n)
  • 97.82 (a)
FAM227B 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM227B 35
  • 82.05 (n)
  • 73.9 (a)
dog
(Canis familiaris)
Mammalia FAM227B 35
  • 84.96 (n)
  • 77.25 (a)
FAM227B 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam227b 16
Fam227b 36
  • 54 (a)
OneToOne
Fam227b 35
  • 74.27 (n)
  • 63.66 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM227B 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM227B 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam227b 35
  • 74.8 (n)
  • 64.79 (a)
lizard
(Anolis carolinensis)
Reptilia FAM227B 36
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam227b 35
  • 54.31 (n)
  • 38.67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToOne
Species with no ortholog for FAM227B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM227B Gene

ENSEMBL:
Gene Tree for FAM227B (if available)
TreeFam:
Gene Tree for FAM227B (if available)

Paralogs for FAM227B Gene

Paralogs for FAM227B Gene

(2) SIMAP similar genes for FAM227B Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with FAM227B: view

Variants for FAM227B Gene

Sequence variations from dbSNP and Humsavar for FAM227B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1023683 -- 49,415,250(-) TTGTC(A/T)TTATT intron-variant
rs733097 -- 49,565,647(-) CACCA(A/G)TATTC intron-variant
rs1072726 -- 49,571,631(+) tggcg(C/T)ctttg intron-variant
rs1594188 -- 49,377,219(-) gtact(A/G)ttcag intron-variant
rs1507616 -- 49,615,217(-) GAAGC(C/T)TAAGA nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Variation tolerance for FAM227B Gene

Residual Variation Intolerance Score: 75.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM227B Gene

HapMap Linkage Disequilibrium report
FAM227B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM227B Gene

Disorders for FAM227B Gene

Relevant External Links for FAM227B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM227B

No disorders were found for FAM227B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM227B Gene

Publications for FAM227B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. (PMID: 23408906) Porcu E. … Naitza S. (PLoS Genet. 2013) 3
  3. Genome-wide association study identifies four genetic loci associated with thyroid volume and goiter risk. (PMID: 21565293) Teumer A. … VAPlzke H. (Am. J. Hum. Genet. 2011) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for FAM227B Gene

Sources for FAM227B Gene

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