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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM227B Gene

protein-coding   GIFtS: 32
GCID: GC15M049619

Family With Sequence Similarity 227, Member B

(Previous name: chromosome 15 open reading frame 33)
(Previous symbol: C15orf33)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Family With Sequence Similarity 227, Member B1 2
C15orf331 2 3
Chromosome 15 Open Reading Frame 331
Protein FAM227B2

External Ids:    HGNC: 265431   Entrez Gene: 1969512   Ensembl: ENSG000001662627   UniProtKB: Q96M603   

Export aliases for FAM227B gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM227B Gene: 
FAM227B (family with sequence similarity 227, member B) is a protein-coding gene. Diseases associated with FAM227B include goiter, and thyroiditis. An important paralog of this gene is FAM227A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for FAM227B
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FAM227B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM227B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.2   Ensembl cytogenetic band:  15q21.2   HGNC cytogenetic band: 15q21.2

FAM227B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM227B gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M049619:  view genomic region     (about GC identifiers)

Start:
49,619,159 bp from pter      End:
49,913,128 bp from pter
Size:
293,970 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F227B_HUMAN, Q96M60 (See protein sequence)
Recommended Name: Protein FAM227B  
Size: 508 amino acids; 59956 Da
Secondary accessions: Q86WS2
Alternative splicing: 2 isoforms:  Q96M60-1   Q96M60-2   

Explore the universe of human proteins at neXtProt for FAM227B: NX_Q96M60

Explore proteomics data for FAM227B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96M60

  • FAM227B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAM227B Protein Expression
    REFSEQ proteins: NP_689860.2  
    ENSEMBL proteins: 
     ENSP00000453251   ENSP00000299338   ENSP00000453028   ENSP00000453787   ENSP00000452616  
     ENSP00000453748   ENSP00000453379   ENSP00000454081  

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    Search LSBio for Antibodies for FAM227B 

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    Browse ELISAs at Cloud-Clone Corp. 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q96M60

    UniProtKB/Swiss-Prot: F227B_HUMAN, Q96M60
    Similarity: Belongs to the FAM227 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM227B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FAM227B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM227B 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM227B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM227B (F227B)

    Search CenterWatch for drugs/clinical trials and news about FAM227B / F227B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAM227B gene: 
    NM_152647.2  

    Unigene Cluster for FAM227B:

    Family with sequence similarity 227, member B
    Hs.712959  [show with all ESTs]
    Unigene Representative Sequence: NM_152647
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000559573 ENST00000299338(uc001zxl.2) ENST00000560557 ENST00000561064(uc001zxm.3)
    ENST00000559351 ENST00000561319 ENST00000558615 ENST00000558579 ENST00000558594
    ENST00000561116 ENST00000559905 ENST00000560246 ENST00000558862 ENST00000557892

    miRNA
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    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM227B
    Sirion Biotech Customized lentivirus for stable overexpression of FAM227B 
                         Customized lentivirus expression plasmids for stable overexpression of FAM227B 
    Primer
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    Additional mRNA sequence: 

    AK023699.1 AK057362.1 BC048125.1 BC048139.1 

    16 DOTS entries:

    DT.95143971  DT.91708976  DT.121049769  DT.97840251  DT.95354113  DT.100643407  DT.91894574  DT.100799639 
    DT.100818969  DT.121049796  DT.121049827  DT.65287126  DT.75132870  DT.121049779  DT.309627  DT.92015290 

    24/54 AceView cDNA sequences (see all 54):

    AI423767 AI247411 CK823514 BU856872 BM967140 CA950229 BQ637753 BC048139 
    BM967303 BM805097 BC048125 CA950455 BM805041 AA781157 BG188246 BI832668 
    BM893958 NM_152647 BX095775 CK823515 AK023699 AK057362 CF594290 BQ574649 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    See FAM227B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAM227B

    SOURCE GeneReport for Unigene cluster: Hs.712959
        SABiosciences Custom PCR Arrays for FAM227B
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM227B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FAM227B gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam227b1 , 5 RIKEN cDNA 4930525F21 gene5
    family with sequence similarity 227, member B1
    72.91(n)1
    61.51(a)1
      2 (61.76 cM)5
    758231  NM_029455.21  NP_083731.21 
     1259834835 
    lizard
    (Anolis carolinensis)
    Reptilia FAM227B6
    family with sequence similarity 227, member B
    37(a)
    1 ↔ 1
    GL343506.1(139685-158191)


    ENSEMBL Gene Tree for FAM227B (if available)
    TreeFam Gene Tree for FAM227B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAM227B gene
    FAM227A2  
    3 SIMAP similar genes for FAM227B using alignment to 7 protein entries:     F227B_HUMAN (see all proteins):
    NF2    GYG2P1    ZNF169

    FAM227B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4035 SNPs in FAM227B are shown (see all 4035)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs765576851,2
    Cuntested149709670(+) AAACAA/C/GAGATA 1 -- int11NA 2
    rs675756851,2
    C--26734229(+) AAGTA-/AAAAAA 1 -- int10--------
    rs359943021,2
    C--29848142(+) TATATAG/-AGAGA 1 -- int11Minor allele frequency- -:0.00NA 2
    rs664939171,2
    C--29867856(+) TTTTT-/T/TTTT
            
    GCAAA
    1 -- int11NA 2
    rs1835272051,2
    --49622648(+) TACTCA/GGAATC 1 -- int10--------
    rs1859756561,2
    --49622772(+) TGCGCG/TACAGT 1 -- int10--------
    rs1136359711,2
    --49622940(+) TAGACC/GAAAAA 1 -- int12Minor allele frequency- G:0.14CSA WA 119
    rs1159643751,2
    F--49622958(+) AAAGAG/TAGAAA 1 -- int11Minor allele frequency- T:0.03WA 118
    rs799587371,2
    C--49622973(+) GAATAT/CTTTTG 1 -- int12Minor allele frequency- C:0.14CSA WA 119
    rs1440253631,2
    C--49623029(+) GCCTGC/TTGTCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for FAM227B (49619159 - 49869159 bp, first 250kb of FAM227B)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FAM227B: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM227B
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM227B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for FAM227B:    About MalaCards
    goiter    thyroiditis


    FAM227B for disorders           About GeneDecksing


    Export disorders for FAM227B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAM227B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FAM227B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. A meta-analysis of thyroid-related traits reveals nove l loci and gender-specific differences in the regulation of thyroid function. (PubMed id 23408906)1 Porcu E....Naitza S. (2013)
    4. Genome-wide association study identifies four genetic loci associated with thyroid volume and goiter risk. (PubMed id 21565293)1 Teumer A....VAPlzke H. (2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    6. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (2006)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Creation of genome-wide protein expression libraries using random activation of gene expression. (PubMed id 11329013)1 Harrington J.J.... Ducar M. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 196951 HGNC: 26543 AceView: FLJ32800 Ensembl:ENSG00000166262 euGenes: HUgn196951
    ECgene: FAM227B H-InvDB: FAM227B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM227B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAM227B gene:
    Search GeneIP for patents involving FAM227B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
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     Search for Antibodies for FAM227B at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for FAM227B
     Custom Antibody / Protein Production Service
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     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
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     Search LifeMap BioReagents cell lines for FAM227B
     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM227B
     SwitchGear 3'UTR luciferase reporter plasmids for FAM227B
     Browse SwitchGear Promoter luciferase reporter plasmids for FAM227B
     ThermoFisher Antibodies for FAM227B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM227B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM227B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FAM227B
    Customized:
     lentivirus for stable overexpression of FAM227B
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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