FAM227B Gene
protein-coding GIFtS: 35
GCID: GC15M049619
|
|
family with sequence similarity 227, member B(Previous name: chromosome 15 open reading frame 33 )
(Previous symbol: C15orf33)
| |
Aliases
for FAM227B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 227, Member B1 2 | | C15orf331 2 3 | | FLJ328001 | | Chromosome 15 Open Reading Frame 331 | | Protein FAM227B2 |
Export aliases for FAM227B gene to outside databases |
Summaries
for FAM227B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM227B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for FAM227B
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM227B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM227B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q21.2 Ensembl cytogenetic band: 15q21.2 HGNC cytogenetic band: 15q21.2FAM227B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M049619: view genomic region
(about GC identifiers)
Start:
|
49,619,159 bp from pter |
End:
|
49,913,128 bp from pter |
Size:
|
293,970 bases |
Orientation:
|
minus strand |
|
Proteins
for FAM227B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F227B_HUMAN, Q96M60 (See
protein sequence)Recommended Name: Protein FAM227B Size: 508 amino acids; 59956 Da
Secondary accessions: Q86WS2Alternative splicing: 2 isoforms: Q96M60-1 Q96M60-2 Explore the universe of human proteins at neXtProt for FAM227B: NX_Q96M60
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96M60
FAM227B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689860.2
ENSEMBL proteins: ENSP00000453251 ENSP00000299338 ENSP00000453028 ENSP00000453787 ENSP00000452616 ENSP00000453748 ENSP00000453379 ENSP00000454081
Human Recombinant Protein Products:
FAM227B Antibody Products:
Assay Products for FAM227B: |
Protein
Domains /
Families
for FAM227B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q96M60 UniProtKB/Swiss-Prot: F227B_HUMAN, Q96M60Similarity: Belongs to the FAM227 family |
Function
for FAM227B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM227B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM227B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for FAM227B | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM227B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM227B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM227B |
|
Pathways & Interactions
for FAM227B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM227B
|
Drugs & Compounds
for FAM227B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM227B
Search CenterWatch for drugs/clinical trials and news about FAM227B / F227B
|
Transcripts
for FAM227B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM227B gene: NM_152647.2 Unigene Cluster for FAM227B: Family with sequence similarity 227, member B Hs.712959 [show with all ESTs]Unigene Representative Sequence: NM_15264714 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000559573 ENST00000299338(uc001zxl.2) ENST00000560557 ENST00000561064(uc001zxm.3)
ENST00000559351 ENST00000561319 ENST00000558615 ENST00000558579 ENST00000558594
ENST00000561116 ENST00000559905 ENST00000560246 ENST00000558862 ENST00000557892
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM227B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM227B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for FAM227B | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM227B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM227B |
Additional cDNA sequence: AK023699.1 AK057362.1 BC048125.1 BC048139.1 18 DOTS entries: DT.95143971 DT.91708976 DT.121049769 DT.97840251 DT.100799639 DT.95354113 DT.100643407 DT.121049827 DT.309627 DT.91894574 DT.92429030 DT.100818969 DT.121049779 DT.121049796 DT.65287126 DT.75132870 DT.309626 DT.92015290 24/54 AceView cDNA sequences (see all 54): BM967140 BM805097 BQ637753 CA950229 BC048125 BU856872 CK823514 AI423767 CA950455 AI247411 BC048139 BM967303 BI464533 AI632141 AA781157 BG188246 CD241855 BM893958 BI832668 AK023699 AK057362 BQ574649 CF594290 BX095775
GeneLoc Exon Structure
|
Expression
for FAM227B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See FAM227B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM227B
SOURCE GeneReport for Unigene cluster: Hs.712959
SABiosciences Custom PCR Arrays for FAM227B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM227B
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat FAM227B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM227B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM227B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM227B |
Orthologs
for FAM227B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for FAM227B gene from 1/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Fam227b1 , 5 |
RIKEN cDNA 4930525F21 gene5
family with sequence similarity 227, member B1 |
72.91(n)1
61.51(a)1 |
|
2 (61.76 cM)5
758231 NM_029455.21 NP_083731.21
1259834835 |
ENSEMBL Gene Tree for FAM227B (if available)
TreeFam Gene Tree for FAM227B (if available) |
Paralogs
for FAM227B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM227B gene
- FAM227A2
3 SIMAP similar genes for FAM227B using alignment to 7 protein entries: F227B_HUMAN (see all proteins):NF2 GYG2P1 ZNF169
FAM227B for paralogs About GeneDecksing
|
Genomic Variants
for FAM227B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM227B (49619159 - 49869159 bp, first 250kb of FAM227B)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM227B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM227B |
|
Disorders
/ Diseases
for FAM227B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAM227B for disorders About GeneDecksing
2  diseases for FAM227B: About MalaCardsgoiter thyroiditis
Export disorders for FAM227B gene to outside databases
|
Publications
for FAM227B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM227B gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM227B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Genome-wide association study identifies four genetic loci associated with thyroid volume and goiter risk. (PubMed id 21565293)1 Teumer A....VAPlzke H. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Creation of genome-wide protein expression libraries using random activation of gene expression. (PubMed id 11329013)1 Harrington J.J.... Ducar M. (2001)
|
External Searches for FAM227B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM227B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM227B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM227B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM227B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM227B gene:
Search GeneIP for patents involving FAM227B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM227B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM227B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM227B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM227B | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM227B | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM227B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM227B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM227B | | OriGene Custom Protein Services for FAM227B | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM227B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM227B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM227B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM227B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM227B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM227B |
| |
 |  |  |  | |
| | | | Search Tocris compounds for FAM227B |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | FAM227B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM227B |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM227B |
|
|
|
|
