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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM227A Gene

protein-coding   GIFtS: 26
GCID: GC22M038974

Family With Sequence Similarity 227, Member A

  Search for FAM227A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Family With Sequence Similarity 227, Member A1 2
Putative Uncharacterized Protein LOC3889002

External Ids:    HGNC: 441971   Entrez Gene: 6468512   Ensembl: ENSG000001849497   UniProtKB: F5H4B43   

Export aliases for FAM227A gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM227A Gene: 
FAM227A (family with sequence similarity 227, member A) is a protein-coding gene. An important paralog of this gene is FAM227B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for FAM227A
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FAM227A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM227A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

FAM227A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM227A gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M038974:  view genomic region     (about GC identifiers)

Start:
38,974,125 bp from pter      End:
39,052,634 bp from pter
Size:
78,510 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F227A_HUMAN, F5H4B4 (See protein sequence)
Recommended Name: Protein FAM227A  
Size: 570 amino acids; 66188 Da
Secondary accessions: B7Z7C6
Alternative splicing: 2 isoforms:  F5H4B4-1   F5H4B4-2   

Explore the universe of human proteins at neXtProt for FAM227A: NX_F5H4B4

Explore proteomics data for FAM227A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_F5H4B4

  • FAM227A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAM227A Protein Expression
    REFSEQ proteins: NP_001013669.1  
    ENSEMBL proteins: 
     ENSP00000348086   ENSP00000385758   ENSP00000445093  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: F5H4B4

    UniProtKB/Swiss-Prot: F227A_HUMAN, F5H4B4
    Similarity: Belongs to the FAM227 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM227A 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM227A

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM227A (F227A)

    Search CenterWatch for drugs/clinical trials and news about FAM227A / F227A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAM227A gene: 
    NM_001013647.1  

    Unigene Cluster for FAM227A:

    Family with sequence similarity 227, member A
    Hs.542707  [show with all ESTs]
    Unigene Representative Sequence: NM_001013647
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000543828 ENST00000355830 ENST00000540952(uc011anx.1) ENST00000544346
    ENST00000541689 ENST00000543295 ENST00000424706 ENST00000484582 ENST00000490082
    ENST00000406767 ENST00000535113(uc011anw.1)
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                         Customized lentivirus expression plasmids for stable overexpression of FAM227A 
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    Additional mRNA sequence: 

    AK095080.1 AK301819.1 

    11 DOTS entries:

    DT.75177644  DT.95152229  DT.65284504  DT.120639393  DT.102819499  DT.120639391  DT.120639394  DT.86848459 
    DT.120663129  DT.95082899  DT.95093793 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FAM227A    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
    SP1:                    -                           
    SP2:                                                
    SP3:              -     -                           


    ECgene alternative splicing isoforms for FAM227A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    FAM227A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood

    See FAM227A Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.542707
        SABiosciences Custom PCR Arrays for FAM227A
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM227A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FAM227A gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam227a1 , 5 RIKEN cDNA 4933432B09 gene5
    family with sequence similarity 227, member A1
    67.76(n)1
    55.19(a)1
      15 (37.81 cM)5
    757291  NM_029407.11  NP_083683.11 
     796095765 
    lizard
    (Anolis carolinensis)
    Reptilia FAM227A6
    family with sequence similarity 227, member A
    27(a)
    1 ↔ 1
    5(24113914-24129866)


    ENSEMBL Gene Tree for FAM227A (if available)
    TreeFam Gene Tree for FAM227A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAM227A gene
    FAM227B2  

    FAM227A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1588 SNPs in FAM227A are shown (see all 1588)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs356184991,2
    C--38973766(+) GCCAA-/TTTTTT 1 -- ds50011Minor allele frequency- T:0.00NA 2
    rs1809608851,2
    --38973876(+) CTTCCA/GCTTCC 1 -- ds50010--------
    rs81386431,2
    C,F--38973910(+) ctctgC/Tggcaa 1 -- ds50011Minor allele frequency- T:0.50NA 2
    rs558296131,2
    C,F--38973956(+) ATGCCG/TTCTTC 1 -- ds50011Minor allele frequency- T:0.00WA 2
    rs567380771,2
    C,F--38973957(+) TGCCTC/TCTTCT 1 -- ds50011Minor allele frequency- T:0.00WA 2
    rs1852436531,2
    --38974123(+) AAACAC/TAAACC 1 -- ds50010--------
    rs772928071,2
    C--38974135(+) GTAACA/GGTCAT 1 -- ut310--------
    rs10133381,2
    C,F,A,H--38974154(+) attacC/Accagt 1 -- ut3112Minor allele frequency- A:0.44NS EA NA WA 786
    rs1897053181,2
    --38974201(+) CAGTAC/TATTTG 1 -- ut310--------
    rs1827468371,2
    --38974274(+) AGAGTC/TGCTAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FAM227A (38974125 - 39052634 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FAM227A: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM227A
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM227A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAM227A gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FAM227A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    3. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)1 Dephoure N.... Gygi S.P. (2008)
    4. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 646851 HGNC: 44197 Ensembl:ENSG00000184949 euGenes: HUgn646851 ECgene: FAM227A
    H-InvDB: FAM227A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM227A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAM227A gene:
    Search GeneIP for patents involving FAM227A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for FAM227A
     Browse SwitchGear Promoter luciferase reporter plasmids for FAM227A
     Search ThermoFisher Antibodies for FAM227A
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM227A
     inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM227A
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FAM227A
    Customized:
     lentivirus for stable overexpression of FAM227A
     lentivirus expression plasmids for stable overexpression of FAM227A
     adenovirus for overexpression of FAM227A
     Search LSBio for Antibodies for FAM227A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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