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Aliases for FAM227A Gene

Aliases for FAM227A Gene

  • Family With Sequence Similarity 227 Member A 2 3 5
  • Family With Sequence Similarity 227, Member A 2

External Ids for FAM227A Gene

Previous GeneCards Identifiers for FAM227A Gene

  • GC22M038974

Summaries for FAM227A Gene

GeneCards Summary for FAM227A Gene

FAM227A (Family With Sequence Similarity 227 Member A) is a Protein Coding gene. An important paralog of this gene is FAM227B.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM227A Gene

Genomics for FAM227A Gene

Regulatory Elements for FAM227A Gene

Enhancers for FAM227A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G038702 1.6 Ensembl ENCODE dbSUPER 32.7 -49.1 -49087 6.2 HDGF PKNOX1 FOXA2 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 CBY1 FAM227A ENSG00000228274 JOSD1 SNORD83B GTPBP1 GC22M041764
GH22G038750 1.7 FANTOM5 ENCODE dbSUPER 28.5 -98.0 -98039 9.7 HDGF PKNOX1 FOXA2 MLX ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 FAM227A CBY1 ENSG00000228274 SUN2 GTPBP1 DNAL4 JOSD1 APOBEC3G APOBEC3D ENSG00000273076
GH22G038691 1.4 ENCODE dbSUPER 32.8 -40.0 -39991 10.9 MLX CREB3L1 DMAP1 FEZF1 YY1 ZNF416 ZNF143 ZNF263 SP3 TBX21 CBY1 ENSG00000228274 FAM227A TAB1 CBX7 CBX6 NPTXR ENSG00000230912 ENSG00000225450 SUN2
GH22G038732 1.1 ENCODE dbSUPER 32.4 -77.1 -77085 2.8 HDGF ELF3 RAD21 YY1 RARA SCRT2 ZNF143 PAF1 ZNF654 ZNF398 FAM227A ENSG00000228274 CBY1 GTPBP1 DNAL4 GC22P038732 ENSG00000244491
GH22G038567 1 ENCODE 34.4 +87.2 87242 4.7 HDGF PKNOX1 E2F7 ARID4B GLI4 ZNF2 TCF12 GLIS2 KLF7 ZNF263 FAM227A ENSG00000230149 ENSG00000273076 SNORD83B ENSG00000272669 ENSG00000225450 APOBEC3D PRDX3P1 APOBEC3C SNORD83A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM227A on UCSC Golden Path with GeneCards custom track

Promoters for FAM227A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000146205 29 1601 PKNOX1 CREB3L1 ARNT ARID4B SIN3A BRCA1 SLC30A9 GLIS2 ZNF207 ZNF263

Genomic Location for FAM227A Gene

Chromosome:
22
Start:
38,578,120 bp from pter
End:
38,656,629 bp from pter
Size:
78,510 bases
Orientation:
Minus strand

Genomic View for FAM227A Gene

Genes around FAM227A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM227A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM227A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM227A Gene

Proteins for FAM227A Gene

  • Protein details for FAM227A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    F5H4B4-F227A_HUMAN
    Recommended name:
    Protein FAM227A
    Protein Accession:
    F5H4B4
    Secondary Accessions:
    • B0QY52
    • B7Z7C6
    • Q5TG08

    Protein attributes for FAM227A Gene

    Size:
    570 amino acids
    Molecular mass:
    66188 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM227A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM227A Gene

Post-translational modifications for FAM227A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM227A Gene

Domains & Families for FAM227A Gene

Protein Domains for FAM227A Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

F5H4B4

UniProtKB/Swiss-Prot:

F227A_HUMAN :
  • Belongs to the FAM227 family.
Family:
  • Belongs to the FAM227 family.
genes like me logo Genes that share domains with FAM227A: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for FAM227A Gene

Function for FAM227A Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM227A Gene

Localization for FAM227A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM227A gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM227A Gene

Pathways & Interactions for FAM227A Gene

SuperPathways for FAM227A Gene

No Data Available

Interacting Proteins for FAM227A Gene

Gene Ontology (GO) - Biological Process for FAM227A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM227A Gene

Drugs & Compounds for FAM227A Gene

No Compound Related Data Available

Transcripts for FAM227A Gene

mRNA/cDNA for FAM227A Gene

(14) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM227A Gene

Family with sequence similarity 227, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM227A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2:
SP3: - -

Relevant External Links for FAM227A Gene

GeneLoc Exon Structure for
FAM227A
ECgene alternative splicing isoforms for
FAM227A

Expression for FAM227A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM227A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM227A Gene

This gene is overexpressed in Pituitary (x6.0) and Testis (x5.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM227A Gene



NURSA nuclear receptor signaling pathways regulating expression of FAM227A Gene:

FAM227A

SOURCE GeneReport for Unigene cluster for FAM227A Gene:

Hs.542707
genes like me logo Genes that share expression patterns with FAM227A: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM227A Gene

Orthologs for FAM227A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM227A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM227A 34 35
  • 98.89 (n)
cow
(Bos Taurus)
Mammalia FAM227A 34 35
  • 78.33 (n)
rat
(Rattus norvegicus)
Mammalia Fam227a 34
  • 68.1 (n)
mouse
(Mus musculus)
Mammalia Fam227a 34 16 35
  • 68.09 (n)
dog
(Canis familiaris)
Mammalia FAM227A 35
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM227A 35
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM227A 35
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM227A 35
  • 25 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam227a 34
  • 47.7 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
OneToOne
Species where no ortholog for FAM227A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM227A Gene

ENSEMBL:
Gene Tree for FAM227A (if available)
TreeFam:
Gene Tree for FAM227A (if available)

Paralogs for FAM227A Gene

Paralogs for FAM227A Gene

genes like me logo Genes that share paralogs with FAM227A: view

Variants for FAM227A Gene

Sequence variations from dbSNP and Humsavar for FAM227A Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000014531 -- 38,632,237(+) CATGT(A/G)GGAAT intron-variant
rs1000087048 -- 38,639,456(+) CTGGT(A/G)CCACA intron-variant
rs1000090830 -- 38,598,887(+) GAACC(C/T)GTGTT intron-variant
rs1000117809 -- 38,615,761(+) CCCCA(A/T)CTGAT intron-variant
rs1000147590 -- 38,622,465(+) ATTAT(A/G)GGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM227A Gene

Variant ID Type Subtype PubMed ID
esv1691892 CNV insertion 17803354
esv2678533 CNV deletion 23128226
esv2724231 CNV deletion 23290073
esv28880 CNV gain 19812545
esv3558160 CNV deletion 23714750
esv3647739 CNV gain 21293372
esv3647740 CNV loss 21293372
esv997907 CNV insertion 20482838
nsv3624 CNV deletion 18451855
nsv3625 CNV insertion 18451855
nsv499372 CNV gain 21111241
nsv508733 CNV insertion 20534489
nsv955156 CNV deletion 24416366

Variation tolerance for FAM227A Gene

Gene Damage Index Score: 4.01; 60.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM227A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM227A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM227A Gene

Disorders for FAM227A Gene

Relevant External Links for FAM227A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM227A

No disorders were found for FAM227A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM227A Gene

Publications for FAM227A Gene

  1. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4 64
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for FAM227A Gene

Sources for FAM227A Gene

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