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Aliases for FAM222B Gene

Aliases for FAM222B Gene

  • Family With Sequence Similarity 222, Member B 2 3
  • C17orf63 3 4
  • Chromosome 17 Open Reading Frame 63 2
  • Uncharacterized Protein C17orf63 3
  • Protein FAM222B 3

External Ids for FAM222B Gene

Previous HGNC Symbols for FAM222B Gene

  • C17orf63

Previous GeneCards Identifiers for FAM222B Gene

  • GC17M027086
  • GC17M027145

Summaries for FAM222B Gene

GeneCards Summary for FAM222B Gene

FAM222B (Family With Sequence Similarity 222, Member B) is a Protein Coding gene. An important paralog of this gene is FAM222A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM222B Gene

Genomics for FAM222B Gene

Genomic Location for FAM222B Gene

28,755,978 bp from pter
28,855,232 bp from pter
99,255 bases
Minus strand

Genomic View for FAM222B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM222B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM222B Gene

No data available for Regulatory Elements for FAM222B Gene

Proteins for FAM222B Gene

  • Protein details for FAM222B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM222B
    Protein Accession:
    Secondary Accessions:
    • Q9H6F3
    • Q9NVJ4
    • Q9NXN6

    Protein attributes for FAM222B Gene

    562 amino acids
    Molecular mass:
    59652 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA90974.1; Type=Frameshift; Positions=433; Evidence={ECO:0000305}; Sequence=BAB15306.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FAM222B Gene

Proteomics data for FAM222B Gene at MOPED

Post-translational modifications for FAM222B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM222B Gene

Domains for FAM222B Gene

Protein Domains for FAM222B Gene


Graphical View of Domain Structure for InterPro Entry



  • Q8WU58
  • Belongs to the FAM222 family.
genes like me logo Genes that share domains with FAM222B: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for FAM222B Gene

Function for FAM222B Gene

Animal Model Products

CRISPR Products

miRNA for FAM222B Gene

miRTarBase miRNAs that target FAM222B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM222B Gene

Localization for FAM222B Gene

Gene Ontology (GO) - Cellular Components for FAM222B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with FAM222B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for FAM222B Gene

Pathways for FAM222B Gene

SuperPathways for FAM222B Gene

No Data Available

Interacting Proteins for FAM222B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000343115 for FAM222B Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for FAM222B Gene


No data available for Pathways by source for FAM222B Gene

Transcripts for FAM222B Gene

Unigene Clusters for FAM222B Gene

Family with sequence similarity 222, member B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM222B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM222B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
SP1: - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - - - - - -
SP6: -
SP7: - -

Relevant External Links for FAM222B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM222B Gene

mRNA expression in normal human tissues for FAM222B Gene

mRNA differential expression in normal tissues according to GTEx for FAM222B Gene

This gene is overexpressed in Muscle - Skeletal (4.2).

Protein differential expression in normal tissues for FAM222B Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FAM222B Gene

SOURCE GeneReport for Unigene cluster for FAM222B Gene Hs.564533

genes like me logo Genes that share expressions with FAM222B: view

Expression partners for FAM222B Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FAM222B Gene

Orthologs for FAM222B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM222B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C19H17orf63 35
  • 95.14 (n)
  • 96.09 (a)
FAM222B 36
  • 95 (a)
(Canis familiaris)
Mammalia FAM222B 35
  • 96.68 (n)
  • 97.69 (a)
FAM222B 36
  • 98 (a)
(Mus musculus)
Mammalia Fam222b 35
  • 95.43 (n)
  • 97.33 (a)
Fam222b 16
Fam222b 36
  • 97 (a)
(Pan troglodytes)
Mammalia FAM222B 35
  • 99.64 (n)
  • 100 (a)
FAM222B 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fam222b 35
  • 95.73 (n)
  • 97.69 (a)
(Monodelphis domestica)
Mammalia FAM222B 36
  • 90 (a)
(Gallus gallus)
Aves C19H17ORF63 35
  • 75.08 (n)
  • 78.28 (a)
(Anolis carolinensis)
Reptilia FAM222B 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam222b 35
  • 67.97 (n)
  • 69.27 (a)
(Danio rerio)
Actinopterygii LOC793183 35
  • 65.92 (n)
  • 62.29 (a)
fam222ba 36
  • 48 (a)
fam222bb 36
  • 52 (a)
Species with no ortholog for FAM222B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM222B Gene

Gene Tree for FAM222B (if available)
Gene Tree for FAM222B (if available)

Paralogs for FAM222B Gene

Paralogs for FAM222B Gene

genes like me logo Genes that share paralogs with FAM222B: view

Variants for FAM222B Gene

Sequence variations from dbSNP and Humsavar for FAM222B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs14529 -- 28,756,898(+) TTCCC(A/C)AGAGA utr-variant-3-prime
rs1023682 -- 28,787,582(+) GGCCC(A/G)AGAAT intron-variant
rs1035989 -- 28,816,792(-) CTTGA(A/C)GTCTA intron-variant
rs1047141 -- 28,756,746(-) TAAAA(A/G)GAAAA utr-variant-3-prime
rs1047142 -- 28,756,739(-) AAAAA(A/G)AAAAA utr-variant-3-prime

Relevant External Links for FAM222B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM222B Gene

Disorders for FAM222B Gene

No disorders were found for FAM222B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FAM222B Gene

Publications for FAM222B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 3
  5. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3

Products for FAM222B Gene

Sources for FAM222B Gene

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