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Aliases for FAM222B Gene

Aliases for FAM222B Gene

  • Family With Sequence Similarity 222, Member B 2 3
  • C17orf63 3 4
  • Chromosome 17 Open Reading Frame 63 2
  • Uncharacterized Protein C17orf63 3

External Ids for FAM222B Gene

Previous HGNC Symbols for FAM222B Gene

  • C17orf63

Previous GeneCards Identifiers for FAM222B Gene

  • GC17M027086
  • GC17M027145

Summaries for FAM222B Gene

GeneCards Summary for FAM222B Gene

FAM222B (Family With Sequence Similarity 222, Member B) is a Protein Coding gene. An important paralog of this gene is FAM222A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM222B Gene

Genomics for FAM222B Gene

Genomic Location for FAM222B Gene

Chromosome:
17
Start:
28,755,978 bp from pter
End:
28,855,232 bp from pter
Size:
99,255 bases
Orientation:
Minus strand

Genomic View for FAM222B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM222B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM222B Gene

No data available for Regulatory Elements for FAM222B Gene

Proteins for FAM222B Gene

  • Protein details for FAM222B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WU58-F222B_HUMAN
    Recommended name:
    Protein FAM222B
    Protein Accession:
    Q8WU58
    Secondary Accessions:
    • Q9H6F3
    • Q9NVJ4
    • Q9NXN6

    Protein attributes for FAM222B Gene

    Size:
    562 amino acids
    Molecular mass:
    59652 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA90974.1; Type=Frameshift; Positions=433; Evidence={ECO:0000305}; Sequence=BAB15306.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FAM222B Gene

Proteomics data for FAM222B Gene at MOPED

Post-translational modifications for FAM222B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM222B Gene

Domains & Families for FAM222B Gene

Protein Domains for FAM222B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8WU58

UniProtKB/Swiss-Prot:

F222B_HUMAN :
  • Belongs to the FAM222 family.
Family:
  • Belongs to the FAM222 family.
genes like me logo Genes that share domains with FAM222B: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for FAM222B Gene

Function for FAM222B Gene

Phenotypes for FAM222B Gene

genes like me logo Genes that share phenotypes with FAM222B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM222B Gene

Localization for FAM222B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM222B Gene COMPARTMENTS Subcellular localization image for FAM222B gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for FAM222B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with FAM222B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM222B Gene

Pathways & Interactions for FAM222B Gene

SuperPathways for FAM222B Gene

No Data Available

Interacting Proteins for FAM222B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000343115%0d%0a9606.ENSP00000384625%0d%0a
Selected Interacting proteins: ENSP00000343115 for FAM222B Gene via STRING

Symbol External ID(s) Details
NLK

Gene Ontology (GO) - Biological Process for FAM222B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM222B Gene

Drugs & Compounds for FAM222B Gene

No Compound Related Data Available

Transcripts for FAM222B Gene

Unigene Clusters for FAM222B Gene

Family with sequence similarity 222, member B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM222B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM222B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
SP1: - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - - - - - -
SP6: -
SP7: - -
SP8:

Relevant External Links for FAM222B Gene

GeneLoc Exon Structure for
FAM222B
ECgene alternative splicing isoforms for
FAM222B

Expression for FAM222B Gene

mRNA expression in normal human tissues for FAM222B Gene

mRNA differential expression in normal tissues according to GTEx for FAM222B Gene

This gene is overexpressed in Muscle - Skeletal (x4.2).

Protein differential expression in normal tissues from HIPED for FAM222B Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM222B Gene



SOURCE GeneReport for Unigene cluster for FAM222B Gene Hs.564533

genes like me logo Genes that share expression patterns with FAM222B: view

Protein tissue co-expression partners for FAM222B Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FAM222B Gene

Orthologs for FAM222B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM222B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C19H17orf63 35
  • 95.14 (n)
  • 96.09 (a)
FAM222B 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM222B 35
  • 96.68 (n)
  • 97.69 (a)
FAM222B 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam222b 35
  • 95.43 (n)
  • 97.33 (a)
Fam222b 16
Fam222b 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM222B 35
  • 99.64 (n)
  • 100 (a)
FAM222B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam222b 35
  • 95.73 (n)
  • 97.69 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM222B 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves C19H17ORF63 35
  • 75.08 (n)
  • 78.28 (a)
lizard
(Anolis carolinensis)
Reptilia FAM222B 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam222b 35
  • 67.97 (n)
  • 69.27 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC793183 35
  • 65.92 (n)
  • 62.29 (a)
fam222ba 36
  • 48 (a)
OneToMany
fam222bb 36
  • 52 (a)
OneToMany
Species with no ortholog for FAM222B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM222B Gene

ENSEMBL:
Gene Tree for FAM222B (if available)
TreeFam:
Gene Tree for FAM222B (if available)

Paralogs for FAM222B Gene

Paralogs for FAM222B Gene

genes like me logo Genes that share paralogs with FAM222B: view

Variants for FAM222B Gene

Sequence variations from dbSNP and Humsavar for FAM222B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs14529 -- 28,756,898(+) TTCCC(A/C)AGAGA utr-variant-3-prime
rs1023682 -- 28,787,582(+) GGCCC(A/G)AGAAT intron-variant
rs1035989 -- 28,816,792(-) CTTGA(A/C)GTCTA intron-variant
rs1047141 -- 28,756,746(-) TAAAA(A/G)GAAAA utr-variant-3-prime
rs1047142 -- 28,756,739(-) AAAAA(A/G)AAAAA utr-variant-3-prime

Variation tolerance for FAM222B Gene

Residual Variation Intolerance Score: 53.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.12; 38.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM222B Gene

HapMap Linkage Disequilibrium report
FAM222B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM222B Gene

Disorders for FAM222B Gene

Relevant External Links for FAM222B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM222B
genes like me logo Genes that share disorders with FAM222B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM222B Gene

Publications for FAM222B Gene

  1. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 67
  2. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 67
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for FAM222B Gene

Sources for FAM222B Gene

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