FAM222B Gene
protein-coding GIFtS: 34
GCID: GC17M027086
|
|
family with sequence similarity 222, member B(Previous name: chromosome 17 open reading frame 63 )
(Previous symbol: C17orf63)
| |
Aliases
for FAM222B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 222, Member B1 2 | | C17orf631 2 3 | | FLJ107001 | | Chromosome 17 Open Reading Frame 631 | | Protein FAM222B2 | | Uncharacterized Protein C17orf632 |
Export aliases for FAM222B gene to outside databases |
Summaries
for FAM222B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM222B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010799.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for FAM222B
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM222B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM222B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q11.2 HGNC cytogenetic band: 17q11.2FAM222B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M027086: view genomic region
(about GC identifiers)
Start:
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27,082,996 bp from pter |
End:
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27,182,250 bp from pter |
Size:
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99,255 bases |
Orientation:
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minus strand |
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Proteins
for FAM222B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F222B_HUMAN, Q8WU58 (See
protein sequence)Recommended Name: Protein FAM222B Size: 562 amino acids; 59652 Da
Sequence caution: Sequence=BAA90974.1; Type=Frameshift; Positions=433; Sequence=BAB15306.1; Type=Erroneous initiation;Note=Translation N-terminally extended;
Secondary accessions: Q9H6F3 Q9NVJ4 Q9NXN6Explore the universe of human proteins at neXtProt for FAM222B: NX_Q8WU58
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WU58
FAM222B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001070966.1 NP_060652.2
ENSEMBL proteins: ENSP00000462419 ENSP00000462534 ENSP00000413645 ENSP00000463296 ENSP00000462251 ENSP00000463753 ENSP00000464355 ENSP00000463278 ENSP00000464299 ENSP00000463642 ENSP00000462540 ENSP00000463136 ENSP00000464019 ENSP00000464291 ENSP00000343115
Human Recombinant Protein Products for FAM222B:
FAM222B Antibody Products:
Assay Products for FAM222B: |
Protein
Domains /
Families
for FAM222B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8WU58 UniProtKB/Swiss-Prot: F222B_HUMAN, Q8WU58Similarity: Belongs to the FAM222 family |
Function
for FAM222B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM222B (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM222B (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for FAM222B | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM222B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM222B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM222B |
|
Pathways & Interactions
for FAM222B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM222B
|
Drugs & Compounds
for FAM222B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM222B
Search CenterWatch for drugs/clinical trials and news about FAM222B / F222B
|
Transcripts
for FAM222B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM222B gene (2 alternative transcripts): NM_001077498.1 NM_018182.2 Unigene Cluster for FAM222B: Family with sequence similarity 222, member B Hs.564533 [show with all ESTs]Unigene Representative Sequence: NM_01818215 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000581407(uc002hcw.3) ENST00000582266 ENST00000452648 ENST00000583307
ENST00000582059 ENST00000583953 ENST00000577376 ENST00000577682 ENST00000581229
ENST00000577513 ENST00000583522 ENST00000581381 ENST00000584059 ENST00000579381
ENST00000341217(uc002hct.1 uc010wax.1 uc010way.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM222B (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM222B (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for FAM222B | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM222B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM222B |
Additional cDNA sequence: AK000147.1 AK001562.1 AK025980.1 AK057665.1 AK095569.1 AK299477.1 BC021228.2 BX647766.1 14 DOTS entries: DT.92424700 DT.40296786 DT.100762601 DT.99975900 DT.101977729 DT.92424696 DT.100762600 DT.92424698 DT.92424699 DT.97781477 DT.438187 DT.91828782 DT.92033712 DT.95262445 24/164 AceView cDNA sequences (see all 164): BM680671 BM558716 BM559939 BI438428 BM682299 BM725501 BM912105 AA764979 AA279309 BM680297 AK025980 N45646 BM423512 AA418420 AA203174 BE205996 BQ676593 BU838916 AA777338 BM915394 CB156081 BM728114 AI417327 AA393729
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for FAM222B (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e |
|---|
|
| SP1: | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | - | | - | | | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for FAM222B
|
Expression
for FAM222B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See FAM222B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM222B
SOURCE GeneReport for Unigene cluster: Hs.564533
SABiosciences Custom PCR Arrays for FAM222B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM222B
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat FAM222B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM222B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM222B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM222B |
Orthologs
for FAM222B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FAM222B gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for FAM222B (if available)
TreeFam Gene Tree for FAM222B (if available) |
Paralogs
for FAM222B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM222B gene
- FAM222A2
FAM222B for paralogs About GeneDecksing
|
Genomic Variants
for FAM222B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM222B (27082996 - 27182250 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM222B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM222B |
|
Disorders
/ Diseases
for FAM222B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAM222B for disorders About GeneDecksing
2  diseases for FAM222B: About MalaCardsintrahepatic cholangiocarcinoma cholangiocarcinoma
Export disorders for FAM222B gene to outside databases
|
Publications
for FAM222B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM222B gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM222B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for FAM222B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM222B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM222B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM222B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM222B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM222B gene:
Search GeneIP for patents involving FAM222B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM222B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM222B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM222B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM222B | | | OriGene Protein Over-expression Lysate for FAM222B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM222B | | OriGene 3'-UTR Clone for FAM222B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM222B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM222B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM222B | | OriGene Custom Protein Services for FAM222B | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM222B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM222B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM222B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM222B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM222B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM222B |
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 |  |  |  | |
| | | | Search Tocris compounds for FAM222B |
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 | | | FAM222B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM222B |
|  |  |  |  | | | | Search ThermoFisher Antibodies for FAM222B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM222B |
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