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Aliases for FAM222A Gene

Aliases for FAM222A Gene

  • Family With Sequence Similarity 222 Member A 2 3 5
  • Family With Sequence Similarity 222, Member A 2 3
  • C12orf34 3 4
  • Chromosome 12 Open Reading Frame 34 2

External Ids for FAM222A Gene

Previous HGNC Symbols for FAM222A Gene

  • C12orf34

Previous GeneCards Identifiers for FAM222A Gene

  • GC12P110152

Summaries for FAM222A Gene

GeneCards Summary for FAM222A Gene

FAM222A (Family With Sequence Similarity 222 Member A) is a Protein Coding gene. An important paralog of this gene is FAM222B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM222A Gene

Genomics for FAM222A Gene

Regulatory Elements for FAM222A Gene

Enhancers for FAM222A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM222A on UCSC Golden Path with GeneCards custom track

Promoters for FAM222A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM222A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM222A Gene

109,714,228 bp from pter
109,770,509 bp from pter
56,282 bases
Plus strand

Genomic View for FAM222A Gene

Genes around FAM222A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM222A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM222A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM222A Gene

Proteins for FAM222A Gene

  • Protein details for FAM222A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM222A
    Protein Accession:
    Secondary Accessions:
    • Q8NCD5
    • Q96SP6

    Protein attributes for FAM222A Gene

    452 amino acids
    Molecular mass:
    46792 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC11219.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FAM222A Gene

Proteomics data for FAM222A Gene at MOPED

Post-translational modifications for FAM222A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM222A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM222A Gene

Domains & Families for FAM222A Gene

Protein Domains for FAM222A Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM222 family.
  • Belongs to the FAM222 family.
genes like me logo Genes that share domains with FAM222A: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for FAM222A Gene

Function for FAM222A Gene

Phenotypes for FAM222A Gene

genes like me logo Genes that share phenotypes with FAM222A: view

Animal Model Products

CRISPR Products

miRNA for FAM222A Gene

miRTarBase miRNAs that target FAM222A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM222A Gene

Localization for FAM222A Gene

Subcellular locations from

Jensen Localization Image for FAM222A Gene COMPARTMENTS Subcellular localization image for FAM222A gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytosol 2
plasma membrane 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM222A Gene

Pathways & Interactions for FAM222A Gene

SuperPathways for FAM222A Gene

No Data Available

Interacting Proteins for FAM222A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000351783 for FAM222A Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for FAM222A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM222A Gene

Drugs & Compounds for FAM222A Gene

No Compound Related Data Available

Transcripts for FAM222A Gene

Unigene Clusters for FAM222A Gene

Family with sequence similarity 222, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM222A Gene

No ASD Table

Relevant External Links for FAM222A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM222A Gene

mRNA expression in normal human tissues for FAM222A Gene

mRNA differential expression in normal tissues according to GTEx for FAM222A Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.6).

Protein differential expression in normal tissues from HIPED for FAM222A Gene

This gene is overexpressed in Bone (42.7) and Fetal testis (26.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM222A Gene

SOURCE GeneReport for Unigene cluster for FAM222A Gene Hs.661785

genes like me logo Genes that share expression patterns with FAM222A: view

Protein tissue co-expression partners for FAM222A Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FAM222A Gene

Orthologs for FAM222A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM222A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C17H12orf34 35
  • 86.28 (n)
  • 87.83 (a)
FAM222A 36
  • 78 (a)
(Canis familiaris)
Mammalia FAM222A 35
  • 89.03 (n)
  • 91.07 (a)
FAM222A 36
  • 85 (a)
(Mus musculus)
Mammalia Fam222a 35
  • 85.22 (n)
  • 91.13 (a)
Fam222a 16
Fam222a 36
  • 91 (a)
(Pan troglodytes)
Mammalia FAM222A 35
  • 99.19 (n)
  • 99.12 (a)
FAM222A 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fam222a 35
  • 85.22 (n)
  • 89.36 (a)
(Monodelphis domestica)
Mammalia FAM222A 36
  • 61 (a)
(Gallus gallus)
Aves C12ORF34 35
  • 74.45 (n)
  • 72.51 (a)
FAM222A 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam222a 35
  • 64.35 (n)
  • 64.75 (a)
(Danio rerio)
Actinopterygii fam222a 35
  • 65.22 (n)
  • 63.39 (a)
fam222a 36
  • 47 (a)
FAM222A (1 of 2) 36
  • 40 (a)
Species with no ortholog for FAM222A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM222A Gene

Gene Tree for FAM222A (if available)
Gene Tree for FAM222A (if available)

Paralogs for FAM222A Gene

Paralogs for FAM222A Gene

genes like me logo Genes that share paralogs with FAM222A: view

Variants for FAM222A Gene

Sequence variations from dbSNP and Humsavar for FAM222A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1990768 -- 109,724,943(-) AGGGA(C/G)TAAAA intron-variant
rs7136742 -- 109,726,511(+) CCTCC(C/T)GCACC intron-variant
rs7138802 -- 109,719,874(+) ATCCC(A/G)GTGCC intron-variant
rs10850607 -- 109,720,776(+) TCGAG(C/T)GCACC intron-variant
rs10850634 -- 109,732,223(+) TGCCG(A/G)GTGGG intron-variant

Variation tolerance for FAM222A Gene

Residual Variation Intolerance Score: 83.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.81; 47.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM222A Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM222A Gene

Disorders for FAM222A Gene

Relevant External Links for FAM222A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM222A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM222A Gene

Publications for FAM222A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for FAM222A Gene

Sources for FAM222A Gene