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FAM222A Gene

protein-coding   GIFtS: 30
GCID: GC12P110152

Family With Sequence Similarity 222, Member A

(Previous name: chromosome 12 open reading frame 34)
(Previous symbol: C12orf34)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 222, Member A1 2
C12orf341 2 3
Chromosome 12 Open Reading Frame 341
Protein FAM222A2
Uncharacterized Protein C12orf342

External Ids:    HGNC: 259151   Entrez Gene: 849152   Ensembl: ENSG000001394387   UniProtKB: Q5U5X83   

Export aliases for FAM222A gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM222A Gene:
FAM222A (family with sequence similarity 222, member A) is a protein-coding gene. An important paralog of this gene is FAM222B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for FAM222A
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FAM222A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM222A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.11   Ensembl cytogenetic band:  12q24.11   HGNC cytogenetic band: 12q24.11

FAM222A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM222A gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P110152:  view genomic region     (about GC identifiers)

Start:
110,152,033 bp from pter      End:
110,208,312 bp from pter
Size:
56,280 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: F222A_HUMAN, Q5U5X8 (See protein sequence)
Recommended Name: Protein FAM222A  
Size: 452 amino acids; 46792 Da
Sequence caution: Sequence=BAC11219.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q8NCD5 Q96SP6

Explore the universe of human proteins at neXtProt for FAM222A: NX_Q5U5X8

Explore proteomics data for FAM222A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM222A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_116218.2  
    ENSEMBL proteins: 
     ENSP00000443292   ENSP00000351783  

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    antibodies-online peptides for FAM222A

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    antibodies-online antibodies for FAM222A (4 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q5U5X8

    UniProtKB/Swiss-Prot: F222A_HUMAN, Q5U5X8
    Similarity: Belongs to the FAM222 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FAM222A

    miRNA
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    miRTarBase miRNAs that target FAM222A:
    hsa-mir-215-5p (MIRT024272), hsa-mir-192-5p (MIRT026251)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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      --

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM222A
    Interactions:

        Search GeneGlobe Interaction Network for FAM222A

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM222A (F222A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM222A gene: 
    NM_032829.2  

    Unigene Cluster for FAM222A:

    Family with sequence similarity 222, member A
    Hs.661785  [show with all ESTs]
    Unigene Representative Sequence: NM_032829
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000538780(uc001tpd.2) ENST00000543653 ENST00000358906
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat FAM222A

    Additional mRNA sequence: 

    AK027627.1 AK074806.1 BC007844.2 BC020193.1 BC037221.1 

    3 DOTS entries:

    DT.75151464  DT.100813424  DT.91690222 

    Selected AceView cDNA sequences (see all 99):

    BM715180 BE795978 AK074806 BE551088 BC007844 BC020193 BE551131 BE327348 
    AI359250 AI632708 CR626164 BQ890270 AW271946 AI361422 BI467309 BF740065 
    AW296653 BU742511 BF223936 AI564073 AW665468 BX391543 AI671405 BC037221 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM222A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FAM222A Expression
    About this image

    FAM222A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM222A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.661785
        Custom PCR Arrays for FAM222A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM222A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FAM222A gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam222a1 , 5 cDNA sequence BC0570225
    family with sequence similarity 222, member A1
    85.22(n)1
    91.13(a)1
      5 (55.99 cM)5
    4339401  NM_001004180.11  NP_001004180.11 
     1145680165 
    chicken
    (Gallus gallus)
    Aves C12ORF341 chromosome 15 open reading frame, human C12orf34 74.45(n)
    72.51(a)
      768548  XM_001231227.2  XP_001231228.2 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fam222a1 family with sequence similarity 222, member A 64.35(n)
    64.75(a)
      780041  NM_001079118.1  NP_001072586.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fam222a1 family with sequence similarity 222, member A 65.22(n)
    63.39(a)
      793922  NM_001126454.1  NP_001119926.1 


    ENSEMBL Gene Tree for FAM222A (if available)
    TreeFam Gene Tree for FAM222A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM222A gene
    FAM222B2  

    Find genes that share paralogs with FAM222A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM222A (see all 389)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1423262801,2
    --110150296(+) CCGGGC/TGAGTA 1 -- us2k10--------
    rs1833718501,2
    --110150455(+) ATGGCC/TAAGAC 1 -- us2k10--------
    rs79597371,2
    C,F,A,H--110150552(+) GTCTGG/ACTGCT 1 -- us2k125Minor allele frequency- A:0.18NS EA NA WA CSA 2355
    rs1181608061,2
    F--110150659(+) ACCCAG/AGACTC 1 -- us2k11Minor allele frequency- A:0.04EA 120
    rs1885326271,2
    --110150696(+) CTAGAC/TGGGCC 1 -- us2k10--------
    rs1927527681,2
    --110150760(+) CAGTAC/TAGTTT 1 -- us2k10--------
    rs1847058091,2
    --110150821(+) CCCTAC/TCTATT 1 -- us2k10--------
    rs1172386861,2
    F--110151018(+) TTCACA/TTCTCC 1 -- us2k11Minor allele frequency- T:0.01EA 120
    rs763891031,2
    C,F--110151077(+) GTATCA/GGTTTT 1 -- us2k11Minor allele frequency- G:0.08WA 118
    rs1463104441,2
    --110151158(+) GCTACA/GTAAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FAM222A (110152033 - 110208312 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FAM222A: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM222A
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM222A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM222A gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM222A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    5. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84915 HGNC: 25915 AceView: FLJ14721 Ensembl:ENSG00000139438 euGenes: HUgn84915
    ECgene: FAM222A H-InvDB: FAM222A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM222A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM222A gene:
    Search GeneIP for patents involving FAM222A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM222A
     Browse compounds at ApexBio
     Search Addgene for plasmids for FAM222A
      Search eBioscience for proteins for FAM222A
      Search eBioscience for elisas for FAM222A
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for FAM222A
     antibodies-online antibodies for FAM222A (4 products)
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     antibodies-online peptides for FAM222A
      Search antibodies-online for proteins for FAM222A
           
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