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Aliases for FAM221B Gene

Aliases for FAM221B Gene

  • Family With Sequence Similarity 221 Member B 2 3 5
  • C9orf128 3 4
  • Family With Sequence Similarity 221, Member B 2
  • Chromosome 9 Open Reading Frame 128 2
  • Uncharacterized Protein C9orf128 3
  • Protein FAM221B 3

External Ids for FAM221B Gene

Previous HGNC Symbols for FAM221B Gene

  • C9orf128

Summaries for FAM221B Gene

GeneCards Summary for FAM221B Gene

FAM221B (Family With Sequence Similarity 221 Member B) is a Protein Coding gene. An important paralog of this gene is FAM221A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM221B Gene

Genomics for FAM221B Gene

Regulatory Elements for FAM221B Gene

Enhancers for FAM221B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F036213 0.3 FANTOM5 41.7 -379.6 -379624 0.2 POLR2A GLIS1 CCIN FAM221B CLTA GNE GLIPR2 SPAG8 RNF38 PIR52930
GH09F035882 0.5 ENCODE 11.7 -48.6 -48634 0.2 CTCF BMI1 RAD21 ZNF143 SMC3 ZNF207 NR2F6 DEK ZNF654 RNF2 FAM221B TMEM8B ENSG00000227388 NPR2 HINT2 SPAG8 NDUFA5P4 LOC105376027
GH09F035904 1.3 FANTOM5 Ensembl ENCODE 11.6 -74.3 -74296 7.8 SIN3A ZNF48 YY1 SLC30A9 ZNF121 GLIS2 FOS ZNF263 SP3 REST HRCT1 LINC00961 TMEM8B PIGO OR13J1 FAM221B NDUFA5P4 ENSG00000227388 NPR2 FANCG
GH09F035903 1.2 Ensembl ENCODE 10.8 -69.4 -69448 0.3 CTCF PKNOX1 ARID4B RAD21 RFX5 SCRT2 ZNF143 SMC3 DEK MIXL1 HRCT1 ENSG00000227388 NPR2 FAM221B NDUFA5P4 TMEM8B OR13J1 SPAG8 HINT2 DNAJB5
GH09F035913 0.5 Ensembl ENCODE 10.8 -83.3 -83346 7.9 HDGF PKNOX1 ATF1 ARNT ARID4B YBX1 ZNF48 YY1 ZNF766 ELK1 CREB3 SPAG8 YBX1P10 GBA2 LINC00961 RECK NDUFA5P4 FAM221B OR13J1 TMEM8B
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FAM221B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM221B Gene

Chromosome:
9
Start:
35,816,391 bp from pter
End:
35,833,805 bp from pter
Size:
17,415 bases
Orientation:
Minus strand

Genomic View for FAM221B Gene

Genes around FAM221B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM221B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM221B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM221B Gene

Proteins for FAM221B Gene

  • Protein details for FAM221B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6H8Z2-F221B_HUMAN
    Recommended name:
    Protein FAM221B
    Protein Accession:
    A6H8Z2
    Secondary Accessions:
    • Q5TCW2

    Protein attributes for FAM221B Gene

    Size:
    402 amino acids
    Molecular mass:
    45394 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM221B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM221B Gene

Post-translational modifications for FAM221B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM221B Gene

No data available for DME Specific Peptides for FAM221B Gene

Domains & Families for FAM221B Gene

Protein Domains for FAM221B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

A6H8Z2

UniProtKB/Swiss-Prot:

F221B_HUMAN :
  • Belongs to the FAM221 family.
Family:
  • Belongs to the FAM221 family.
genes like me logo Genes that share domains with FAM221B: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for FAM221B Gene

Function for FAM221B Gene

Phenotypes for FAM221B Gene

genes like me logo Genes that share phenotypes with FAM221B: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM221B Gene

Localization for FAM221B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM221B Gene COMPARTMENTS Subcellular localization image for FAM221B gene
Compartment Confidence
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM221B Gene

Pathways & Interactions for FAM221B Gene

SuperPathways for FAM221B Gene

No Data Available

Interacting Proteins for FAM221B Gene

Gene Ontology (GO) - Biological Process for FAM221B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM221B Gene

Transcripts for FAM221B Gene

mRNA/cDNA for FAM221B Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM221B Gene

Family with sequence similarity 221, member B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM221B Gene

No ASD Table

Relevant External Links for FAM221B Gene

GeneLoc Exon Structure for
FAM221B
ECgene alternative splicing isoforms for
FAM221B

Expression for FAM221B Gene

mRNA expression in normal human tissues for FAM221B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM221B Gene

This gene is overexpressed in Testis (x38.4).

NURSA nuclear receptor signaling pathways regulating expression of FAM221B Gene:

FAM221B

SOURCE GeneReport for Unigene cluster for FAM221B Gene:

Hs.128075
genes like me logo Genes that share expression patterns with FAM221B: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FAM221B Gene

Orthologs for FAM221B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM221B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM221B 34
  • 99.36 (n)
dog
(Canis familiaris)
Mammalia FAM221B 34 35
  • 82.16 (n)
cow
(Bos Taurus)
Mammalia FAM221B 34 35
  • 79.65 (n)
mouse
(Mus musculus)
Mammalia Fam221b 34 16 35
  • 72.48 (n)
rat
(Rattus norvegicus)
Mammalia Fam221b 34
  • 69.85 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM221B 35
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM221B 35
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM221B 35
  • 66 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1299 34
Species where no ortholog for FAM221B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM221B Gene

ENSEMBL:
Gene Tree for FAM221B (if available)
TreeFam:
Gene Tree for FAM221B (if available)

Paralogs for FAM221B Gene

Paralogs for FAM221B Gene

genes like me logo Genes that share paralogs with FAM221B: view

Variants for FAM221B Gene

Sequence variations from dbSNP and Humsavar for FAM221B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10758326 -- 35,831,039(+) ACAGA(A/G)CAGCT intron-variant, upstream-variant-2KB
rs10972590 -- 35,816,893(+) GCCCC(A/G)GAGGC downstream-variant-500B, upstream-variant-2KB
rs10972591 -- 35,818,999(+) CAGCC(A/G)CAGCA nc-transcript-variant, reference, synonymous-codon
rs10972592 -- 35,823,149(+) ATCAG(C/G)TGAGA intron-variant
rs10972593 -- 35,828,338(+) ACTAC(A/T)ACTAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM221B Gene

Variant ID Type Subtype PubMed ID
nsv1125318 OTHER inversion 24896259
nsv831546 CNV loss 17160897

Variation tolerance for FAM221B Gene

Residual Variation Intolerance Score: 83.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.59; 82.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM221B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM221B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM221B Gene

Disorders for FAM221B Gene

Relevant External Links for FAM221B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM221B

No disorders were found for FAM221B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM221B Gene

Publications for FAM221B Gene

  1. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  5. Mutations in the RNA component of RNase MRP cause a pleiotropic human disease, cartilage-hair hypoplasia. (PMID: 11207361) RidanpAoAo M. … de la Chapelle A. (Cell 2001) 3 64

Products for FAM221B Gene

Sources for FAM221B Gene

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