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Aliases for FAM221B Gene

Aliases for FAM221B Gene

  • Family With Sequence Similarity 221, Member B 2 3
  • C9orf128 3 4
  • Chromosome 9 Open Reading Frame 128 2
  • Uncharacterized Protein C9orf128 3
  • Protein FAM221B 3

External Ids for FAM221B Gene

Previous Symbols for FAM221B Gene

  • C9orf128

Summaries for FAM221B Gene

GeneCards Summary for FAM221B Gene

FAM221B (Family With Sequence Similarity 221, Member B) is a Protein Coding gene. Diseases associated with FAM221B include cartilage-hair hypoplasia.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM221B Gene

Genomics for FAM221B Gene

Genomic Location for FAM221B Gene

Start:
35,816,391 bp from pter
End:
35,833,375 bp from pter
Size:
16,985 bases
Orientation:
Minus strand

Genomic View for FAM221B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM221B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM221B Gene

No data available for Regulatory Elements for FAM221B Gene

Proteins for FAM221B Gene

  • Protein details for FAM221B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6H8Z2-F221B_HUMAN
    Recommended name:
    Protein FAM221B
    Protein Accession:
    A6H8Z2
    Secondary Accessions:
    • Q5TCW2

    Protein attributes for FAM221B Gene

    Size:
    402 amino acids
    Molecular mass:
    45394 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM221B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM221B Gene

Proteomics data for FAM221B Gene at MOPED

Post-translational modifications for FAM221B Gene

No Post-translational modifications

Other Protein References for FAM221B Gene

No data available for DME Specific Peptides for FAM221B Gene

Domains for FAM221B Gene

Protein Domains for FAM221B Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

F221B_HUMAN
Family:
  • Belongs to the FAM221 family.:
    • A6H8Z2
genes like me logo Genes that share domains with FAM221B: view

No data available for Gene Families for FAM221B Gene

Function for FAM221B Gene

miRNA for FAM221B Gene

miRTarBase miRNAs that target FAM221B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM221B Gene

Localization for FAM221B Gene

No data available for Gene Ontology (GO) - Cellular Components for FAM221B Gene

Pathways for FAM221B Gene

SuperPathways for FAM221B Gene

No Data Available

Interacting Proteins for FAM221B Gene

Gene Ontology (GO) - Biological Process for FAM221B Gene

None

No data available for Pathways by source for FAM221B Gene

Transcripts for FAM221B Gene

mRNA/cDNA for FAM221B Gene

(5) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM221B Gene

Family with sequence similarity 221, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM221B Gene

No ASD Table

Relevant External Links for FAM221B Gene

GeneLoc Exon Structure for
FAM221B
ECgene alternative splicing isoforms for
FAM221B

Expression for FAM221B Gene

mRNA expression in normal human tissues for FAM221B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM221B Gene

This gene is overexpressed in Testis (38.4).

SOURCE GeneReport for Unigene cluster for FAM221B Gene Hs.128075

genes like me logo Genes that share expressions with FAM221B: view

Orthologs for FAM221B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM221B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM221B 36
  • 99.36 (n)
  • 99.36 (a)
cow
(Bos Taurus)
Mammalia FAM221B 36
  • 79.65 (n)
  • 66.58 (a)
FAM221B 37
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM221B 36
  • 82.16 (n)
  • 73.64 (a)
FAM221B 37
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam221b 36
  • 72.48 (n)
  • 60 (a)
Fam221b 16
Fam221b 37
  • 46 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM221B 37
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM221B 37
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam221b 36
  • 69.85 (n)
  • 59.8 (a)
lizard
(Anolis carolinensis)
Reptilia FAM221B 37
  • 66 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1299 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 39 (a)
OneToOne
Species with no ortholog for FAM221B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM221B Gene

ENSEMBL:
Gene Tree for FAM221B (if available)
TreeFam:
Gene Tree for FAM221B (if available)

Paralogs for FAM221B Gene

No data available for Paralogs for FAM221B Gene

Variants for FAM221B Gene

Sequence variations from dbSNP and Humsavar for FAM221B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs734158 -- 35,823,012(-) AGCCC(A/G)CTCTG intron-variant
rs2273714 -- 35,820,109(+) TCTCC(C/T)CACCC intron-variant
rs2281646 -- 35,818,650(+) GGCCT(A/G)GAAGT intron-variant, downstream-variant-500B
rs2295799 -- 35,821,800(+) AGATT(C/G)TGTTA intron-variant
rs3860996 -- 35,824,720(+) TCTGT(C/T)GCCCA intron-variant

Relevant External Links for FAM221B Gene

HapMap Linkage Disequilibrium report
FAM221B

No data available for Structural Variations from Database of Genomic Variants (DGV) for FAM221B Gene

Disorders for FAM221B Gene

(1) MalaCards Diseases for FAM221B Gene

Search for FAM221B Gene in MalaCards »
genes like me logo Genes that share disorders with FAM221B: view

No data available for UniProtKB/Swiss-Prot for FAM221B Gene

Publications for FAM221B Gene

  1. Mutations in the RNA component of RNase MRP cause a pleiotropic human disease, cartilage-hair hypoplasia. (PMID: 11207361) RidanpAoAo M. … de la Chapelle A. (Cell 2001) 3
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4

Products for FAM221B Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate FAM221B
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for FAM221B
    • Block miRNA regulation of FAM221B using miScript Target Protectors

    Sources for FAM221B Gene

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