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Aliases for FAM221A Gene

Aliases for FAM221A Gene

  • Family With Sequence Similarity 221 Member A 2 3 5
  • C7orf46 3 4
  • Family With Sequence Similarity 221, Member A 2
  • Chromosome 7 Open Reading Frame 46 2
  • Uncharacterized Protein C7orf46 3
  • Protein FAM221A 3

External Ids for FAM221A Gene

Previous HGNC Symbols for FAM221A Gene

  • C7orf46

Previous GeneCards Identifiers for FAM221A Gene

  • GC07P023720

Summaries for FAM221A Gene

GeneCards Summary for FAM221A Gene

FAM221A (Family With Sequence Similarity 221 Member A) is a Protein Coding gene. An important paralog of this gene is FAM221B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM221A Gene

Genomics for FAM221A Gene

Regulatory Elements for FAM221A Gene

Enhancers for FAM221A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F023679 0.9 ENCODE 23.7 +1.0 1026 1.9 KLF17 SIN3A RAD21 YY1 GLIS2 ZNF143 KLF7 ZNF263 SP3 REST FAM221A STK31 ENSG00000234286
GH07F023865 1 FANTOM5 ENCODE 16.4 +185.7 185712 0.3 TBP JUN RAD21 BRCA1 RFX5 RCOR1 NFE2 FOS MAFK TCF7L2 FAM221A GC07M023895 TPT1P7
GH07F023801 1.3 Ensembl ENCODE 11 +122.7 122736 1.0 PKNOX1 ATF1 ARNT FEZF1 ELK1 GATA2 NCOA1 REST CREB3 MBD2 TRA2A FAM221A STK31 TPT1P7 PCMTD1P3
GH07F023597 1.1 ENCODE 9 -81.3 -81336 2.7 PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 YY1 ZNF143 SP3 SP5 CCDC126 ENSG00000228649 FAM221A FCF1P1
GH07F023759 1.1 Ensembl ENCODE 8.7 +80.8 80759 1.3 HDAC1 PKNOX1 FEZF1 BRCA1 RFX5 YY1 ZNF366 SCRT2 RCOR1 CEBPB STK31 FAM221A PCMTD1P3 TPT1P7
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM221A on UCSC Golden Path with GeneCards custom track

Promoters for FAM221A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000157241 1137 1601 KLF17 SIN3A RAD21 GLIS2 ZNF143 KLF7 ZNF263 SP3 REST ZNF592

Genomic Location for FAM221A Gene

23,679,463 bp from pter
23,703,249 bp from pter
23,787 bases
Plus strand

Genomic View for FAM221A Gene

Genes around FAM221A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM221A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM221A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM221A Gene

Proteins for FAM221A Gene

  • Protein details for FAM221A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM221A
    Protein Accession:
    Secondary Accessions:
    • Q05CG4
    • Q4G0Q7
    • Q6P519

    Protein attributes for FAM221A Gene

    298 amino acids
    Molecular mass:
    33083 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH26000.1; Type=Frameshift; Positions=9; Evidence={ECO:0000305}; Sequence=AAH42034.1; Type=Frameshift; Positions=101; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM221A Gene


neXtProt entry for FAM221A Gene

Post-translational modifications for FAM221A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM221A Gene

Domains & Families for FAM221A Gene

Protein Domains for FAM221A Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM221 family.
  • Belongs to the FAM221 family.
genes like me logo Genes that share domains with FAM221A: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for FAM221A Gene

Function for FAM221A Gene

Phenotypes for FAM221A Gene

GenomeRNAi human phenotypes for FAM221A:
genes like me logo Genes that share phenotypes with FAM221A: view

Animal Model Products

miRNA for FAM221A Gene

miRTarBase miRNAs that target FAM221A

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM221A Gene

Localization for FAM221A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM221A gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM221A Gene

Pathways & Interactions for FAM221A Gene

SuperPathways for FAM221A Gene

No Data Available

Interacting Proteins for FAM221A Gene

Selected Interacting proteins: A4D161-F221A_HUMAN for FAM221A Gene via IID

Gene Ontology (GO) - Biological Process for FAM221A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM221A Gene

Transcripts for FAM221A Gene

Unigene Clusters for FAM221A Gene

Family with sequence similarity 221, member A:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM221A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9
SP1: -
SP2: - -
SP3: - -
SP4: - - -
SP5: - -

Relevant External Links for FAM221A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM221A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM221A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM221A Gene

This gene is overexpressed in Testis (66.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM221A Gene

Protein tissue co-expression partners for FAM221A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM221A Gene:


SOURCE GeneReport for Unigene cluster for FAM221A Gene:

genes like me logo Genes that share expression patterns with FAM221A: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM221A Gene

Orthologs for FAM221A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM221A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM221A 34 35
  • 98.99 (n)
(Canis familiaris)
Mammalia FAM221A 34 35
  • 89.26 (n)
(Bos Taurus)
Mammalia FAM221A 34
  • 88.26 (n)
MGC134574 35
  • 85 (a)
(Mus musculus)
Mammalia Fam221a 34 16 35
  • 84 (n)
(Rattus norvegicus)
Mammalia Fam221a 34
  • 83.13 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 78 (a)
-- 35
  • 76 (a)
(Monodelphis domestica)
Mammalia FAM221A 35
  • 74 (a)
(Gallus gallus)
Aves C2H7ORF46 34
  • 73.1 (n)
FAM221A 35
  • 72 (a)
(Anolis carolinensis)
Reptilia FAM221A 35
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam221a 34
  • 65.06 (n)
Str.617 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.10621 34
(Danio rerio)
Actinopterygii fam221a 34 35
  • 59.78 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 55 (a)
Species where no ortholog for FAM221A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM221A Gene

Gene Tree for FAM221A (if available)
Gene Tree for FAM221A (if available)

Paralogs for FAM221A Gene

Paralogs for FAM221A Gene

(14) SIMAP similar genes for FAM221A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FAM221A: view

Variants for FAM221A Gene

Sequence variations from dbSNP and Humsavar for FAM221A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1013879 -- 23,693,453(+) tgcct(A/G)ttcat intron-variant
rs10228098 -- 23,688,159(+) cctgc(C/T)tcagc intron-variant
rs10228959 -- 23,692,048(+) acata(C/T)gtgta intron-variant
rs10244532 -- 23,700,882(+) TTGAG(C/G)AAATT intron-variant
rs10254411 -- 23,691,213(+) TGGTT(A/C)CTACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM221A Gene

Variant ID Type Subtype PubMed ID
nsv830924 CNV loss 17160897
nsv7393 OTHER inversion 18451855
esv2759519 CNV loss 17122850
esv2673027 CNV deletion 23128226

Variation tolerance for FAM221A Gene

Residual Variation Intolerance Score: 88.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.12; 75.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM221A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM221A Gene

Disorders for FAM221A Gene

Relevant External Links for FAM221A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM221A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM221A Gene

Publications for FAM221A Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 4 64

Products for FAM221A Gene

Sources for FAM221A Gene

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