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Aliases for FAM220A Gene

Aliases for FAM220A Gene

  • Family With Sequence Similarity 220 Member A 2 3 5
  • STAT3-Interacting Protein As A Repressor 2 3 4
  • Acrosomal Protein 1 2 3
  • C7orf70 3 4
  • SIPAR 3 4
  • Family With Sequence Similarity 220, Member A 2
  • Chromosome 7 Open Reading Frame 70 2
  • Protein FAM220A 3
  • ACPIN1 3

External Ids for FAM220A Gene

Previous HGNC Symbols for FAM220A Gene

  • C7orf70

Summaries for FAM220A Gene

GeneCards Summary for FAM220A Gene

FAM220A (Family With Sequence Similarity 220 Member A) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FAM220A Gene

  • May negatively regulate STAT3.

Additional gene information for FAM220A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM220A Gene

Genomics for FAM220A Gene

GeneHancer (GH) Regulatory Elements for FAM220A Gene

Promoters and enhancers for FAM220A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I006347 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.6 -604 3.2 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF213 FAM220A DAGLB ANKRD61 RAC1 CCZ1 USP42 PMS2 CCZ1B ZDHHC4 TNRC18
GH07I006381 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.4 -36.4 -36384 7.5 HDGF ATF1 CLOCK FOXA2 ARID4B NEUROD1 SIN3A FEZF1 YY1 SLC30A9 DAGLB FAM220A RAC1 CCZ1 ZDHHC4 USP42 PIR50924
GH07I006270 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 6.7 +76.6 76550 3.5 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF121 GLIS2 ZNF143 ZNF207 MXD4 GC07P006271 CYTH3 ZNF12 C7orf26 TNRC18 ZNF316 USP42 FAM220A
GH07I006317 Enhancer 1 Ensembl ENCODE 12.9 +30.9 30947 1.5 ARID4B ZNF48 RARA EGR1 HMG20B RXRA SP5 CEBPB NFYC ZC3H11A CYTH3 ZNF316 ZNF12 C7orf26 FAM220A USP42 EIF2AK1 RNU6-218P ANKRD61 GC07P006327
GH07I006254 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 5.2 +90.1 90080 9 PKNOX1 FOXA2 SMAD1 BMI1 BATF IRF4 RAD21 ATF7 RCOR1 ETV6 PMS2CL EIF2AK1 FAM220A CCZ1 GC07M006227 CYTH3 GC07P006271
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM220A on UCSC Golden Path with GeneCards custom track

Genomic Locations for FAM220A Gene

Genomic Locations for FAM220A Gene
chr7:6,329,409-6,348,981
(GRCh38/hg38)
Size:
19,573 bases
Orientation:
Minus strand
chr7:6,369,040-6,388,612
(GRCh37/hg19)

Genomic View for FAM220A Gene

Genes around FAM220A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM220A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM220A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM220A Gene

Proteins for FAM220A Gene

  • Protein details for FAM220A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4H9-F220A_HUMAN
    Recommended name:
    Protein FAM220A
    Protein Accession:
    Q7Z4H9
    Secondary Accessions:
    • Q75ML2
    • Q8NA52
    • Q9BRR7

    Protein attributes for FAM220A Gene

    Size:
    259 amino acids
    Molecular mass:
    28021 Da
    Quaternary structure:
    • Interacts with STAT3.
    SequenceCaution:
    • Sequence=AAS07509.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAG34819.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

neXtProt entry for FAM220A Gene

Post-translational modifications for FAM220A Gene

No Post-translational modifications

Other Protein References for FAM220A Gene

No data available for DME Specific Peptides for FAM220A Gene

Domains & Families for FAM220A Gene

Gene Families for FAM220A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FAM220A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM220A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FAM220A: view

No data available for UniProtKB/Swiss-Prot for FAM220A Gene

Function for FAM220A Gene

Molecular function for FAM220A Gene

UniProtKB/Swiss-Prot Function:
May negatively regulate STAT3.

Phenotypes From GWAS Catalog for FAM220A Gene

Phenotypes for FAM220A Gene

GenomeRNAi human phenotypes for FAM220A:
genes like me logo Genes that share phenotypes with FAM220A: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM220A Gene

Localization for FAM220A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM220A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM220A gene
Compartment Confidence
nucleus 4
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FAM220A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with FAM220A: view

Pathways & Interactions for FAM220A Gene

SuperPathways for FAM220A Gene

No Data Available

Interacting Proteins for FAM220A Gene

Gene Ontology (GO) - Biological Process for FAM220A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM220A Gene

Drugs & Compounds for FAM220A Gene

No Compound Related Data Available

Transcripts for FAM220A Gene

Unigene Clusters for FAM220A Gene

Family with sequence similarity 220, member A:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM220A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
SP1: -
SP2:
SP3: - -
SP4: - - -

Relevant External Links for FAM220A Gene

GeneLoc Exon Structure for
FAM220A
ECgene alternative splicing isoforms for
FAM220A

Expression for FAM220A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM220A Gene

mRNA differential expression in normal tissues according to GTEx for FAM220A Gene

This gene is overexpressed in Testis (x5.6) and Muscle - Skeletal (x4.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM220A Gene



NURSA nuclear receptor signaling pathways regulating expression of FAM220A Gene:

FAM220A

SOURCE GeneReport for Unigene cluster for FAM220A Gene:

Hs.696146

Evidence on tissue expression from TISSUES for FAM220A Gene

  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with FAM220A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM220A Gene

Orthologs for FAM220A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM220A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM220A 33 34
  • 98.71 (n)
dog
(Canis familiaris)
Mammalia FAM220A 33 34
  • 73.54 (n)
rat
(Rattus norvegicus)
Mammalia Fam220a 33
  • 64.55 (n)
mouse
(Mus musculus)
Mammalia Fam220a 33 16 34
  • 64.33 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM220A 34
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM220A 34
  • 30 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1877 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.27282 33
zebrafish
(Danio rerio)
Actinopterygii Dr.14199 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3854 33
Species where no ortholog for FAM220A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM220A Gene

ENSEMBL:
Gene Tree for FAM220A (if available)
TreeFam:
Gene Tree for FAM220A (if available)

Paralogs for FAM220A Gene

(2) SIMAP similar genes for FAM220A Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for FAM220A Gene

genes like me logo Genes that share paralogs with FAM220A: view

No data available for Paralogs for FAM220A Gene

Variants for FAM220A Gene

Sequence variations from dbSNP and Humsavar for FAM220A Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000065705 -- 6,339,876(-) G/A intron_variant
rs1000137293 -- 6,348,798(-) T/C 5_prime_UTR_variant
rs1000416847 -- 6,340,009(-) T/C intron_variant
rs1000483518 -- 6,332,952(-) A/G intron_variant
rs1000717823 -- 6,347,527(-) AAAGA/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM220A Gene

Variant ID Type Subtype PubMed ID
esv1914954 OTHER inversion 16254605
esv2668165 CNV deletion 23128226
esv3541120 CNV deletion 23714750
esv3612023 CNV loss 21293372
nsv1020236 CNV gain 25217958
nsv1020251 CNV loss 25217958
nsv1025381 CNV loss 25217958
nsv436904 CNV insertion 17901297
nsv7392 OTHER inversion 18451855
nsv970442 CNV duplication 23825009

Variation tolerance for FAM220A Gene

Residual Variation Intolerance Score: 69.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.24; 85.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM220A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM220A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM220A Gene

Disorders for FAM220A Gene

Additional Disease Information for FAM220A

No disorders were found for FAM220A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM220A Gene

Publications for FAM220A Gene

  1. Nuclear termination of STAT3 signaling through SIPAR (STAT3-Interacting Protein As a Repressor)-dependent recruitment of T cell tyrosine phosphatase TC-PTP. (PMID: 26026268) Ren F … Chang Z (FEBS letters 2015) 2 3 58
  2. SIPAR negatively regulates STAT3 signaling and inhibits progression of melanoma. (PMID: 23917203) Ren F … Chang Z (Cellular signalling 2013) 2 3 58
  3. Unique alternative translation from two open reading frames on Acpin1 mRNA yields an acrosomal protein and a salivary-gland-specific protein. (PMID: 19659802) Ueda T … Tanaka H (International journal of urology : official journal of the Japanese Urological Association 2009) 2 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58

Products for FAM220A Gene

Sources for FAM220A Gene

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