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FAM220A Gene

protein-coding   GIFtS: 28
GCID: GC07M006369

Family With Sequence Similarity 220, Member A

(Previous name: chromosome 7 open reading frame 70)
(Previous symbol: C7orf70)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 220, Member A1 2
C7orf701 2 3
STAT3-Interacting Protein As A Repressor1 2 3
SIPAR2 3
Chromosome 7 Open Reading Frame 701
Protein FAM220A2

External Ids:    HGNC: 224221   Entrez Gene: 847922   Ensembl: ENSG000001783977   UniProtKB: Q7Z4H93   

Export aliases for FAM220A gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM220A Gene:
FAM220A (family with sequence similarity 220, member A) is a protein-coding gene.

UniProtKB/Swiss-Prot: F220A_HUMAN, Q7Z4H9
Function: May negatively regulate STAT3 (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for FAM220A
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FAM220A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM220A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.1   Ensembl cytogenetic band:  7p22.1   HGNC cytogenetic band: 7p22.1

FAM220A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM220A gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M006369:  view genomic region     (about GC identifiers)

Start:
6,369,040 bp from pter      End:
6,388,612 bp from pter
Size:
19,573 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 6,415,393-6,434,949     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: F220A_HUMAN, Q7Z4H9 (See protein sequence)
Recommended Name: Protein FAM220A  
Size: 259 amino acids; 28021 Da
Subunit: Interacts with STAT3 (By similarity)
Sequence caution: Sequence=AAS07509.1; Type=Erroneous gene model prediction; Sequence=BAG34819.1; Type=Erroneous
translation; Note=Wrong choice of CDS;
Secondary accessions: Q75ML2 Q8NA52 Q9BRR7

Explore the universe of human proteins at neXtProt for FAM220A: NX_Q7Z4H9

Explore proteomics data for FAM220A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM220A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001032240.1  
    ENSEMBL proteins: 
     ENSP00000317289   ENSP00000432444   ENSP00000436886   ENSP00000464009  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q7Z4H9


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: F220A_HUMAN, Q7Z4H9
    Function: May negatively regulate STAT3 (By similarity)

    Animal Models:

       genOway: Develop your customized and physiologically relevant rodent model for FAM220A

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    F220A_HUMAN, Q7Z4H9: Nucleus (By similarity)

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with FAM220A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM220A
    Interactions:

        Search GeneGlobe Interaction Network for FAM220A

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM220A (F220A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM220A gene: 
    NM_001037163.1  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000313324(uc003spu.3) ENST00000524898 ENST00000530143 ENST00000533877
    ENST00000578372
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    Selected AceView cDNA sequences (see all 114):

    BP354450 BE671758 BM973183 AI277463 AI201182 AI184179 AA400550 AI250839 
    AA931527 AA889001 BG105467 AI341584 BC006110 BE552089 BQ012670 BM679667 
    CN482926 AA781929 NM_032706 AI204690 AA581598 AA860207 BF435472 BG722490 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FAM220A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
    SP1:                    -                           
    SP2:                                                
    SP3:              -     -                           
    SP4:        -     -     -                           


    ECgene alternative splicing isoforms for FAM220A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM220A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTATTTTA
    FAM220A Expression
    About this image

    FAM220A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM220A Protein Expression
        Custom PCR Arrays for FAM220A
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FAM220A gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam220a1 , 5 RIKEN cDNA 2810453I06 gene5
    family with sequence similarity 220, member A1
    64.33(n)1
    45.61(a)1
      5 (82.27 cM)5
    672381  NM_133703.41  NP_598464.31 
     1435487085 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.272822 Xenopus laevis transcribed sequence with moderate similarity more 79.43(n)    BJ041237.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.141992 Transcribed sequence with weak similarity to protein more 74.52(n)    BI706867.1 


    ENSEMBL Gene Tree for FAM220A (if available)
    TreeFam Gene Tree for FAM220A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM220A gene
    2 SIMAP similar genes for FAM220A using alignment to 3 protein entries:     F220A_HUMAN (see all proteins):
    MGC12966    FAM220BP

    Find genes that share paralogs with FAM220A           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for FAM220A (see all 9)
    PGOHUM00000262876 PGOHUM00000263231 PGOHUM00000263232 PGOHUM00000263244 PGOHUM00000263245


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM220A (see all 644)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1480320531,2
    C--6368744(+) AGTGAC/GCTGAG 1 -- ds50010--------
    rs1922947861,2
    C--6368917(+) TATAGC/TAAGCT 1 -- ds50010--------
    rs1417595691,2
    --6369006(+) CGGCAC/TTAATA 1 -- ds50010--------
    rs69453191,2
    C,H--6369070(+) CTAAAG/AAACAA 1 -- ut316Minor allele frequency- A:0.00NS EA NA 410
    rs1831949761,2
    --6369108(+) TAAAAC/TAGCAC 1 -- ut310--------
    rs1891825851,2
    --6369118(+) CATGGC/TATAGT 1 -- ut310--------
    rs563068171,2
    C--6369125(+) TAGTAA/GTTCAG 1 -- ut310--------
    rs1922277691,2
    --6369159(+) CAATCA/GATAAT 1 -- ut310--------
    rs1845520671,2
    --6369224(+) TGACCC/TTTATT 1 -- ut310--------
    rs1505633061,2
    C--6369246(+) CAGACA/GACAAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FAM220A (6369040 - 6388612 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FAM220A: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM220A
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM220A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM220A gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM220A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84792 HGNC: 22422 AceView: MGC12966 Ensembl:ENSG00000178397 euGenes: HUgn84792
    ECgene: FAM220A H-InvDB: FAM220A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM220A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM220A gene:
    Search GeneIP for patents involving FAM220A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Browse ESI BIO Cell Lines and PureStem Progenitors for FAM220A
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM220A
     Browse SwitchGear 3'UTR luciferase reporter plasmids for FAM220A
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     Search ThermoFisher Antibodies for FAM220A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM220A
     Browse compounds at ApexBio
     Search Addgene for plasmids for FAM220A
      Search eBioscience for proteins for FAM220A
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      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for FAM220A
     antibodies-online antibodies for FAM220A
     antibodies-online kits for FAM220A (3 products)
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     antibodies-online proteins for FAM220A (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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