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Aliases for FAM220A Gene

Aliases for FAM220A Gene

  • Family With Sequence Similarity 220 Member A 2 3 5
  • STAT3-Interacting Protein As A Repressor 2 3 4
  • Acrosomal Protein 1 2 3
  • C7orf70 3 4
  • SIPAR 3 4
  • Family With Sequence Similarity 220, Member A 2
  • Chromosome 7 Open Reading Frame 70 2
  • Protein FAM220A 3
  • ACPIN1 3

External Ids for FAM220A Gene

Previous HGNC Symbols for FAM220A Gene

  • C7orf70

Summaries for FAM220A Gene

GeneCards Summary for FAM220A Gene

FAM220A (Family With Sequence Similarity 220 Member A) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FAM220A Gene

  • May negatively regulate STAT3.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM220A Gene

Genomics for FAM220A Gene

Regulatory Elements for FAM220A Gene

Enhancers for FAM220A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G006381 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.3 -36.4 -36384 7.5 HDGF FOXA2 ATF1 ARID4B SIN3A FEZF1 YY1 SLC30A9 ZNF121 FOS DAGLB FAM220A RAC1 CCZ1 ZDHHC4 USP42 PIR50924
GH07G006317 1.1 Ensembl ENCODE 12.9 +30.9 30948 1.5 ARID4B ZNF48 RARA EGR1 FOS HMG20B SP5 CEBPB NFYC PPARG CYTH3 FAM220A EIF2AK1 RNU6-218P GC07P006327 GC07M006297
GH07G006408 1.1 dbSUPER 12.2 -60.7 -60671 2.7 HDGF FOXA2 PKNOX1 CREB3L1 MLX ARNT AGO1 ZFP64 ARID4B SIN3A DAGLB ENSG00000198580 ENSG00000228010 RAC1 FAM220A CCZ1 ZDHHC4 CCZ1B GC07M006427 PIR50924
GH07G006407 1 dbSUPER 12.2 -58.6 -58569 0.9 ARNT ZFP64 SIN3A ZBTB7B ZNF121 GLIS2 ZNF143 KLF7 FOS KDM4B DAGLB RAC1 FAM220A KDELR2 ZDHHC4 PIR50924 GC07M006427
GH07G006412 0.8 dbSUPER 12.2 -63.8 -63779 1.3 ATF1 ZNF175 BACH1 FOSL1 ZNF316 ZNF766 ZFHX2 ELK1 POLR2A ADNP DAGLB FAM220A GC07M006427 PIR50924
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM220A on UCSC Golden Path with GeneCards custom track

Promoters for FAM220A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000208207 281 1401 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF207

Genomic Location for FAM220A Gene

6,329,409 bp from pter
6,348,981 bp from pter
19,573 bases
Minus strand

Genomic View for FAM220A Gene

Genes around FAM220A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM220A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM220A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM220A Gene

Proteins for FAM220A Gene

  • Protein details for FAM220A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM220A
    Protein Accession:
    Secondary Accessions:
    • Q75ML2
    • Q8NA52
    • Q9BRR7

    Protein attributes for FAM220A Gene

    259 amino acids
    Molecular mass:
    28021 Da
    Quaternary structure:
    • Interacts with STAT3.
    • Sequence=AAS07509.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAG34819.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

neXtProt entry for FAM220A Gene

Post-translational modifications for FAM220A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM220A Gene

No data available for DME Specific Peptides for FAM220A Gene

Domains & Families for FAM220A Gene

Protein Domains for FAM220A Gene


Suggested Antigen Peptide Sequences for FAM220A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FAM220A: view

No data available for Gene Families and UniProtKB/Swiss-Prot for FAM220A Gene

Function for FAM220A Gene

Molecular function for FAM220A Gene

UniProtKB/Swiss-Prot Function:
May negatively regulate STAT3.

Gene Ontology (GO) - Molecular Function for FAM220A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0097677 STAT family protein binding IEA --
genes like me logo Genes that share ontologies with FAM220A: view

Phenotypes for FAM220A Gene

GenomeRNAi human phenotypes for FAM220A:
genes like me logo Genes that share phenotypes with FAM220A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM220A Gene

Localization for FAM220A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM220A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM220A gene
Compartment Confidence
nucleus 4
cytosol 1

Gene Ontology (GO) - Cellular Components for FAM220A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with FAM220A: view

Pathways & Interactions for FAM220A Gene

SuperPathways for FAM220A Gene

No Data Available

Interacting Proteins for FAM220A Gene

Gene Ontology (GO) - Biological Process for FAM220A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006470 protein dephosphorylation IEA --
GO:0032092 positive regulation of protein binding IEA --
genes like me logo Genes that share ontologies with FAM220A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM220A Gene

Drugs & Compounds for FAM220A Gene

No Compound Related Data Available

Transcripts for FAM220A Gene

Unigene Clusters for FAM220A Gene

Family with sequence similarity 220, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM220A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
SP1: -
SP3: - -
SP4: - - -

Relevant External Links for FAM220A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM220A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM220A Gene

mRNA differential expression in normal tissues according to GTEx for FAM220A Gene

This gene is overexpressed in Testis (x5.6) and Muscle - Skeletal (x4.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM220A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM220A Gene:


SOURCE GeneReport for Unigene cluster for FAM220A Gene:


Evidence on tissue expression from TISSUES for FAM220A Gene

  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with FAM220A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM220A Gene

Orthologs for FAM220A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM220A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM220A 34 35
  • 98.71 (n)
(Canis familiaris)
Mammalia FAM220A 34 35
  • 73.54 (n)
(Rattus norvegicus)
Mammalia Fam220a 34
  • 64.55 (n)
(Mus musculus)
Mammalia Fam220a 34 16 35
  • 64.33 (n)
(Monodelphis domestica)
Mammalia FAM220A 35
  • 39 (a)
(Ornithorhynchus anatinus)
Mammalia FAM220A 35
  • 30 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1877 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.27282 34
(Danio rerio)
Actinopterygii Dr.14199 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3854 34
Species where no ortholog for FAM220A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM220A Gene

Gene Tree for FAM220A (if available)
Gene Tree for FAM220A (if available)

Paralogs for FAM220A Gene

(2) SIMAP similar genes for FAM220A Gene using alignment to 3 proteins: Pseudogenes for FAM220A Gene

genes like me logo Genes that share paralogs with FAM220A: view

No data available for Paralogs for FAM220A Gene

Variants for FAM220A Gene

Sequence variations from dbSNP and Humsavar for FAM220A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000065705 -- 6,339,876(+) AGCTC(A/G)GCGTC intron-variant
rs1000137293 -- 6,348,798(+) CCCTC(C/T)CCGCG utr-variant-5-prime
rs1000416847 -- 6,340,009(+) CCTCC(C/T)GAGTA intron-variant
rs1000483518 -- 6,332,952(+) TCAGG(A/G)GTTCG intron-variant
rs1000717823 -- 6,347,527(+) AAAAA(-/AAAG)AGATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM220A Gene

Variant ID Type Subtype PubMed ID
esv1914954 OTHER inversion 16254605
esv2668165 CNV deletion 23128226
esv3541120 CNV deletion 23714750
esv3612023 CNV loss 21293372
nsv1020236 CNV gain 25217958
nsv1020251 CNV loss 25217958
nsv1025381 CNV loss 25217958
nsv436904 CNV insertion 17901297
nsv7392 OTHER inversion 18451855
nsv970442 CNV duplication 23825009

Variation tolerance for FAM220A Gene

Residual Variation Intolerance Score: 69.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.24; 85.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM220A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM220A Gene

Disorders for FAM220A Gene

Relevant External Links for FAM220A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM220A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM220A Gene

Publications for FAM220A Gene

  1. Nuclear termination of STAT3 signaling through SIPAR (STAT3-Interacting Protein As a Repressor)-dependent recruitment of T cell tyrosine phosphatase TC-PTP. (PMID: 26026268) Ren F. … Chang Z. (FEBS Lett. 2015) 2 3 64
  2. SIPAR negatively regulates STAT3 signaling and inhibits progression of melanoma. (PMID: 23917203) Ren F. … Chang Z. (Cell. Signal. 2013) 2 3 64
  3. Unique alternative translation from two open reading frames on Acpin1 mRNA yields an acrosomal protein and a salivary-gland-specific protein. (PMID: 19659802) Ueda T. … Tanaka H. (Int. J. Urol. 2009) 2 3 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64

Products for FAM220A Gene

Sources for FAM220A Gene

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