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Aliases for FAM220A Gene

Aliases for FAM220A Gene

  • Family With Sequence Similarity 220 Member A 2 3 5
  • STAT3-Interacting Protein As A Repressor 2 3 4
  • Family With Sequence Similarity 220, Member A 2 3
  • C7orf70 3 4
  • SIPAR 3 4
  • Chromosome 7 Open Reading Frame 70 2
  • ACPIN1 3

External Ids for FAM220A Gene

Previous HGNC Symbols for FAM220A Gene

  • C7orf70

Summaries for FAM220A Gene

GeneCards Summary for FAM220A Gene

FAM220A (Family With Sequence Similarity 220 Member A) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FAM220A Gene

  • May negatively regulate STAT3.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM220A Gene

Genomics for FAM220A Gene

Regulatory Elements for FAM220A Gene

Enhancers for FAM220A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM220A on UCSC Golden Path with GeneCards custom track

Promoters for FAM220A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM220A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM220A Gene

6,329,409 bp from pter
6,348,981 bp from pter
19,573 bases
Minus strand

Genomic View for FAM220A Gene

Genes around FAM220A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM220A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM220A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM220A Gene

Proteins for FAM220A Gene

  • Protein details for FAM220A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM220A
    Protein Accession:
    Secondary Accessions:
    • Q75ML2
    • Q8NA52
    • Q9BRR7

    Protein attributes for FAM220A Gene

    259 amino acids
    Molecular mass:
    28021 Da
    Quaternary structure:
    • Interacts with STAT3.
    • Sequence=AAS07509.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAG34819.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

neXtProt entry for FAM220A Gene

Proteomics data for FAM220A Gene at MOPED

Post-translational modifications for FAM220A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM220A Gene

No data available for DME Specific Peptides for FAM220A Gene

Domains & Families for FAM220A Gene

Protein Domains for FAM220A Gene


Suggested Antigen Peptide Sequences for FAM220A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FAM220A: view

No data available for Gene Families and UniProtKB/Swiss-Prot for FAM220A Gene

Function for FAM220A Gene

Molecular function for FAM220A Gene

UniProtKB/Swiss-Prot Function:
May negatively regulate STAT3.

Phenotypes for FAM220A Gene

GenomeRNAi human phenotypes for FAM220A:
genes like me logo Genes that share phenotypes with FAM220A: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM220A Gene

Localization for FAM220A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM220A Gene

Subcellular locations from

Jensen Localization Image for FAM220A Gene COMPARTMENTS Subcellular localization image for FAM220A gene
Compartment Confidence
nucleus 4
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for FAM220A Gene

Pathways & Interactions for FAM220A Gene

SuperPathways for FAM220A Gene

No Data Available

Interacting Proteins for FAM220A Gene

Gene Ontology (GO) - Biological Process for FAM220A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM220A Gene

Drugs & Compounds for FAM220A Gene

No Compound Related Data Available

Transcripts for FAM220A Gene

Unigene Clusters for FAM220A Gene

Family with sequence similarity 220, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM220A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
SP1: -
SP3: - -
SP4: - - -

Relevant External Links for FAM220A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM220A Gene

mRNA expression in normal human tissues for FAM220A Gene

mRNA differential expression in normal tissues according to GTEx for FAM220A Gene

This gene is overexpressed in Testis (x5.6) and Muscle - Skeletal (x4.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM220A Gene

SOURCE GeneReport for Unigene cluster for FAM220A Gene Hs.696146

genes like me logo Genes that share expression patterns with FAM220A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FAM220A Gene

Orthologs for FAM220A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM220A Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia FAM220A 35
  • 73.54 (n)
  • 56.35 (a)
FAM220A 36
  • 53 (a)
(Mus musculus)
Mammalia Fam220a 35
  • 64.33 (n)
  • 45.61 (a)
Fam220a 16
Fam220a 36
  • 42 (a)
(Pan troglodytes)
Mammalia FAM220A 35
  • 98.71 (n)
  • 97.3 (a)
FAM220A 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Fam220a 35
  • 64.55 (n)
  • 46.83 (a)
(Monodelphis domestica)
Mammalia FAM220A 36
  • 39 (a)
(Ornithorhynchus anatinus)
Mammalia FAM220A 36
  • 30 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1877 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.27282 35
(Danio rerio)
Actinopterygii Dr.14199 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3854 35
Species with no ortholog for FAM220A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM220A Gene

Gene Tree for FAM220A (if available)
Gene Tree for FAM220A (if available)

Paralogs for FAM220A Gene

(2) SIMAP similar genes for FAM220A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FAM220A: view

No data available for Paralogs for FAM220A Gene

Variants for FAM220A Gene

Sequence variations from dbSNP and Humsavar for FAM220A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs3750041 - 6,330,944(+) AGCCC(C/T)GCTCG reference, missense
rs3750040 - 6,330,775(+) CTCGC(A/C/T)GCCCC reference, missense
rs3750039 - 6,330,674(+) CGGCA(A/C/G)TTTTT reference, missense
rs6952125 - 6,330,563(+) ATACA(C/T)GTGCA reference, missense
rs2241445 - 6,330,446(+) CAGAC(C/T)ATCTG reference, missense

Variation tolerance for FAM220A Gene

Residual Variation Intolerance Score: 69.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.24; 85.00% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for FAM220A Gene

Disorders for FAM220A Gene

Relevant External Links for FAM220A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM220A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM220A Gene

Publications for FAM220A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Nuclear termination of STAT3 signaling through SIPAR (STAT3-Interacting Protein As a Repressor)-dependent recruitment of T cell tyrosine phosphatase TC-PTP. (PMID: 26026268) Ren F. … Chang Z. (FEBS Lett. 2015) 3
  3. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for FAM220A Gene

Sources for FAM220A Gene