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Aliases for FAM220A Gene

Aliases for FAM220A Gene

  • Family With Sequence Similarity 220, Member A 2 3
  • STAT3-Interacting Protein As A Repressor 2 3 4
  • C7orf70 3 4
  • SIPAR 3 4
  • Chromosome 7 Open Reading Frame 70 2
  • Protein FAM220A 3

External Ids for FAM220A Gene

Previous Symbols for FAM220A Gene

  • C7orf70

Summaries for FAM220A Gene

GeneCards Summary for FAM220A Gene

FAM220A (Family With Sequence Similarity 220, Member A) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FAM220A Gene

  • May negatively regulate STAT3.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM220A Gene

Genomics for FAM220A Gene

Genomic Location for FAM220A Gene

Start:
6,329,409 bp from pter
End:
6,348,981 bp from pter
Size:
19,573 bases
Orientation:
Minus strand

Genomic View for FAM220A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM220A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM220A Gene

No data available for Regulatory Elements for FAM220A Gene

Proteins for FAM220A Gene

  • Protein details for FAM220A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4H9-F220A_HUMAN
    Recommended name:
    Protein FAM220A
    Protein Accession:
    Q7Z4H9
    Secondary Accessions:
    • Q75ML2
    • Q8NA52
    • Q9BRR7

    Protein attributes for FAM220A Gene

    Size:
    259 amino acids
    Molecular mass:
    28021 Da
    Quaternary structure:
    • Interacts with STAT3.
    SequenceCaution:
    • Sequence=AAS07509.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAG34819.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

neXtProt entry for FAM220A Gene

Proteomics data for FAM220A Gene at MOPED

Post-translational modifications for FAM220A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM220A Gene

No data available for DME Specific Peptides for FAM220A Gene

Domains for FAM220A Gene

Protein Domains for FAM220A Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with FAM220A: view

No data available for Gene Families and UniProtKB/Swiss-Prot for FAM220A Gene

Function for FAM220A Gene

Molecular function for FAM220A Gene

UniProtKB/Swiss-Prot Function: May negatively regulate STAT3.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FAM220A Gene

Localization for FAM220A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM220A Gene

Gene Ontology (GO) - Cellular Components for FAM220A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with FAM220A: view

Pathways for FAM220A Gene

SuperPathways for FAM220A Gene

No Data Available

Interacting Proteins for FAM220A Gene

Gene Ontology (GO) - Biological Process for FAM220A Gene

None

No data available for Pathways by source for FAM220A Gene

Transcripts for FAM220A Gene

Unigene Clusters for FAM220A Gene

Family with sequence similarity 220, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM220A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
SP1: -
SP2:
SP3: - -
SP4: - - -

Relevant External Links for FAM220A Gene

GeneLoc Exon Structure for
FAM220A
ECgene alternative splicing isoforms for
FAM220A

Expression for FAM220A Gene

mRNA expression in normal human tissues for FAM220A Gene

mRNA differential expression in normal tissues according to GTEx for FAM220A Gene

This gene is overexpressed in Testis (5.6) and Muscle - Skeletal (4.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FAM220A Gene

SOURCE GeneReport for Unigene cluster for FAM220A Gene Hs.696146

genes like me logo Genes that share expressions with FAM220A: view

Orthologs for FAM220A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM220A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM220A 36
  • 98.71 (n)
  • 97.3 (a)
FAM220A 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM220A 36
  • 73.54 (n)
  • 56.35 (a)
FAM220A 37
  • 53 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam220a 36
  • 64.33 (n)
  • 45.61 (a)
Fam220a 16
Fam220a 37
  • 42 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM220A 37
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM220A 37
  • 30 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam220a 36
  • 64.55 (n)
  • 46.83 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.27282 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1877 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3854 36
zebrafish
(Danio rerio)
Actinopterygii Dr.14199 36
Species with no ortholog for FAM220A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM220A Gene

ENSEMBL:
Gene Tree for FAM220A (if available)
TreeFam:
Gene Tree for FAM220A (if available)

Paralogs for FAM220A Gene

Selected SIMAP similar genes for FAM220A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FAM220A: view

No data available for Paralogs for FAM220A Gene

Variants for FAM220A Gene

Sequence variations from dbSNP and Humsavar for FAM220A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs735414 -- 6,346,528(+) CTGCC(C/T)Ggcca intron-variant
rs747457 -- 6,337,139(+) CAATC(C/T)CAGCT intron-variant
rs755629 -- 6,347,199(-) ATTCC(A/C)GTTGC intron-variant
rs1043965 -- 6,330,513(-) CTTGA(C/T)CGTTT reference, synonymous-codon
rs1127536 -- 6,330,534(-) GAGGA(A/G)ACAAA synonymous-codon, reference

Relevant External Links for FAM220A Gene

HapMap Linkage Disequilibrium report
FAM220A

No data available for Structural Variations from Database of Genomic Variants (DGV) for FAM220A Gene

Disorders for FAM220A Gene

No disorders were found for FAM220A Gene.

No data available for UniProtKB/Swiss-Prot for FAM220A Gene

Publications for FAM220A Gene

  1. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for FAM220A Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate FAM220A
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for FAM220A
    • Block miRNA regulation of FAM220A using miScript Target Protectors

    Sources for FAM220A Gene

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