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FAM21C Gene

protein-coding   GIFtS: 48
GCID: GC10P046222

Family With Sequence Similarity 21, Member C

  See FAM21C-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 21, Member C1 2
VPEF2 3 5
Vaccinia Virus Penetration Factor2 3
KIAA05923 5
FAM21A2
WASH Complex Subunit FAM21C2

External Ids:    HGNC: 234141   Entrez Gene: 2537252   Ensembl: ENSG000001726617   OMIM: 6136315   UniProtKB: Q9Y4E13   

Export aliases for FAM21C gene to outside databases

Previous GC identifers: GC10U900458 GC10P045540 GC10P042755


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM21C Gene:
FAM21C (family with sequence similarity 21, member C) is a protein-coding gene. Diseases associated with FAM21C include vaccinia. An important paralog of this gene is FAM21A.

UniProtKB/Swiss-Prot: FA21C_HUMAN, Q9Y4E1
Function: Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates
the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules
that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the
recruitment of the complex to endosome membranes. Plays a role in fluid-phase endocytosis, a process exploited by
vaccinia intracellular mature virus (IMV) to enter cells. As a result, may facilitate the penetration of IMV into
cells

Gene Wiki entry for FAM21C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM21C gene promoter:
         NF-1   NF-1/L   Pax-5   MEF-2   Nkx2-2   GATA-2   MEF-2A   aMEF-2   Zic3   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM21C promoter sequence
   Search Chromatin IP Primers for FAM21C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM21C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.1   Ensembl cytogenetic band:  10q11.22   HGNC cytogenetic band: 10q11.22

FAM21C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM21C gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P046222:  view genomic region     (about GC identifiers)

Start:
46,222,648 bp from pter      End:
46,288,412 bp from pter
Size:
65,765 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FA21C_HUMAN, Q9Y4E1 (See protein sequence)
Recommended Name: WASH complex subunit FAM21C  
Size: 1318 amino acids; 144668 Da
Subunit: Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or
CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P),
FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts (via N-terminus) with WASH1; the
interaction is direct
Miscellaneous: In human, FAM21 has undergone evolutionary duplication, with 4 highly homologous family members
existing, including FAM21A, FAM21B, FAM21C, and an N-terminally truncated FAM21D form
Sequence caution: Sequence=AAH06456.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA25518.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B4DZQ6 B9EK53 F5H0J6 F5H871 Q5SQU4 Q5SQU5 Q7L521 Q9UG79
Alternative splicing: 6 isoforms:  Q9Y4E1-1   Q9Y4E1-2   Q9Y4E1-3   Q9Y4E1-4   Q9Y4E1-5   Q9Y4E1-6   (Gene prediction confirmed by EST data)

Explore the universe of human proteins at neXtProt for FAM21C: NX_Q9Y4E1

Explore proteomics data for FAM21C at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM21C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001162577.1  NP_001162578.1  NP_056077.2  

    ENSEMBL proteins: 
     ENSP00000363482   ENSP00000416630   ENSP00000337541   ENSP00000439811   ENSP00000442128  
     ENSP00000352922  

    FAM21C Human Recombinant Protein Products:

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    Novus Biologicals FAM21C Protein
    Novus Biologicals FAM21C Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FAM21C

     
    Search eBioscience for Proteins for FAM21C 

     
    antibodies-online proteins for FAM21C (2 products) 

     
    Search antibodies-online for peptides for FAM21C

    FAM21C Antibody Products:

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    antibodies-online antibodies for FAM21C (13 products) 

    FAM21C Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FAM21C
    Cloud-Clone Corp. CLIAs for FAM21C
    Search eBioscience for ELISAs for FAM21C 
    antibodies-online kits for FAM21C (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR027308 FAM21

    Graphical View of Domain Structure for InterPro Entry Q9Y4E1

    ProtoNet protein and cluster: Q9Y4E1

    UniProtKB/Swiss-Prot: FA21C_HUMAN, Q9Y4E1
    Similarity: Belongs to the FAM21 family


    Find genes that share domains with FAM21C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FA21C_HUMAN, Q9Y4E1
    Function: Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates
    the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules
    that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the
    recruitment of the complex to endosome membranes. Plays a role in fluid-phase endocytosis, a process exploited by
    vaccinia intracellular mature virus (IMV) to enter cells. As a result, may facilitate the penetration of IMV into
    cells

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19922874
         
    Find genes that share ontologies with FAM21C           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM21C
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM21C
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM21C

    miRNA
    Products:
        
    miRTarBase miRNAs that target FAM21C:
    hsa-mir-149-5p (MIRT045583), hsa-mir-598-3p (MIRT040482), hsa-mir-27a-3p (MIRT050034)

    Block miRNA regulation of human, mouse, rat FAM21C using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate FAM21C:
    hsa-miR-152 hsa-miR-3140-3p hsa-miR-148b hsa-miR-10b hsa-miR-148a hsa-miR-10a
    SwitchGear 3'UTR luciferase reporter plasmidFAM21C 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FAM21C
    Predesigned siRNA for gene silencing in human, mouse, rat FAM21C

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for FAM21C

    Clone
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    OriGene clones in human, mouse for FAM21C (see all 15)
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    GenScript: all cDNA clones in your preferred vector (see all 3): FAM21C (NM_015262)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM21C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM21C

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM21C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FA21C_HUMAN, Q9Y4E1: Early endosome membrane. Cell membrane. Note=Partially colocalizes with RAB11A, a recycling
    endosome marker. Associates with lipid raft microdomains on the plasma membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    plasma membrane5
    nucleus3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome IDA--
    GO:0005769early endosome IDA19922874
    GO:0005886plasma membrane IEA--
    GO:0031901early endosome membrane IEA--
    GO:0071203WASH complex IDA19922875

    Find genes that share ontologies with FAM21C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM21C
    Interactions:

        Search GeneGlobe Interaction Network for FAM21C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for FAM21C (Q9Y4E12, 3 ENSP000003375414) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542532, 3, ENSP000002447694MINT-2879283 I2D: score=2 STRING: ENSP00000244769
    CCDC53ENSP000002400794STRING: ENSP00000240079
    CAPZA1ENSP000002631684STRING: ENSP00000263168
    FAM21AENSP000002826334STRING: ENSP00000282633
    FAM21BENSP000003512594STRING: ENSP00000351259
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042147retrograde transport, endosome to Golgi IMP19922874

    Find genes that share ontologies with FAM21C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM21C (FA21C)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM21C gene (3 alternative transcripts): 
    NM_001169106.1  NM_001169107.1  NM_015262.2  

    Unigene Cluster for FAM21C:

    Family with sequence similarity 21, member C
    Hs.365286  [show with all ESTs]
    Unigene Representative Sequence: NM_015262
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374362(uc010qfj.2) ENST00000420848 ENST00000485850 ENST00000374359
    ENST00000471102(uc001jcw.3) ENST00000336378(uc001jcu.3) ENST00000540872(uc001jcs.2 uc010qfk.2)
    ENST00000537517(uc010qfi.2) ENST00000359860
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FAM21C using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate FAM21C:
    hsa-miR-152 hsa-miR-3140-3p hsa-miR-148b hsa-miR-10b hsa-miR-148a hsa-miR-10a
    SwitchGear 3'UTR luciferase reporter plasmidFAM21C 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FAM21C
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): FAM21C (NM_015262)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM21C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM21C
    Primer
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    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat FAM21C
      QuantiTect SYBR Green Assays in human, mouse, rat FAM21C
      QuantiFast Probe-based Assays in human, mouse, rat FAM21C

    Additional mRNA sequence: 

    AB011164.1 AK001545.1 AK126291.1 AK291430.1 AK293929.1 AK298385.1 AK303048.1 AL050279.1 
    BC006456.1 BC039561.1 BC053887.1 BC150611.1 

    Selected DOTS entries (see all 29):

    DT.95145660  DT.100760574  DT.97774500  DT.99959336  DT.121289139  DT.102840029  DT.102844138  DT.102834635 
    DT.100774984  DT.102840051  DT.100790427  DT.121281881  DT.121289116  DT.121281526  DT.75179780  DT.100790422 
    DT.101967902  DT.121289145  DT.121281510  DT.121288860  DT.85104246  DT.100735099  DT.121288843  DT.121289127 

    Selected AceView cDNA sequences (see all 227):

    BQ643086 BM683766 BQ477336 CB152199 AI023041 AI697152 CN483274 AI174597 
    BQ925312 W88944 BQ059202 AA385102 BU956896 BM930297 BU687724 BQ057553 
    CA945210 BM825136 AA323441 BQ675387 AI289417 AA059448 AI021909 AA604437 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM21C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FAM21C Expression
    About this image


    FAM21C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Cerebral Cortex
             Septum   
    FAM21C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM21C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.365286
        Custom PCR Arrays for FAM21C
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat FAM21C
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM21C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FAM21C gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam211 , 5 DNA segment, Chr 6, Wayne State University 116, expressed5
    family with sequence similarity 211
    79.71(n)1
    74.83(a)1
      6 (53.76 cM)5
    280061  NM_026585.31  NP_080861.21 
     1162080335 
    chicken
    (Gallus gallus)
    Aves FAM21A1 family with sequence similarity 21, member A 62.77(n)
    58.04(a)
      423772  NM_001012593.2  NP_001012611.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    50(a)
    1 → many
    GL343297.1(359191-399942)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fam21a1 family with sequence similarity 21, member A 58.85(n)
    53.89(a)
      100170418  XM_002935971.2  XP_002936017.2 
    zebrafish
    (Danio rerio)
    Actinopterygii fam21c1 family with sequence similarity 21, member C 54.48(n)
    46.45(a)
      567272  XM_005156707.1  XP_005156764.1 


    ENSEMBL Gene Tree for FAM21C (if available)
    TreeFam Gene Tree for FAM21C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM21C gene
    FAM21A1 2  FAM21D2  FAM21B2  
    4 SIMAP similar genes for FAM21C using alignment to 2 protein entries:     FA21C_HUMAN (see all proteins):
    DKFZp434O171    FAM21D    FAM21A    FAM21B

    Find genes that share paralogs with FAM21C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM21C (see all 778)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs618567111,2
    C,F--45848621(+) TTCCAG/ATGTCA 1 -- int13Minor allele frequency- A:0.33NA 6
    rs26104801,2
    C--45848659(-) CCGGCC/TGGAAT 1 -- int11Minor allele frequency- T:0.50NA 2
    rs1869798841,2
    --45848664(+) GGCCGC/GGCACA 1 -- int10--------
    rs1906907831,2
    --45848921(+) GAGTGA/CAACTC 1 -- int10--------
    rs2014744431,2
    C,F--45849035(+) GATACT/CACTGT 1 -- int11Minor allele frequency- C:0.00EU 593
    rs597972971,2
    C--45849037(+) TACTAC/TTGTAT 1 -- int10--------
    rs171579711,2
    C,F,H--45849132(+) GTGGAC/TGGACT 2 D syn1 ese39Minor allele frequency- T:0.05NA NS WA EU 953
    rs2001621171,2
    C--45849134(+) GGACGA/GACTAA 2 E G mis10--------
    rs28051161,2
    C,O--45849141(+) CTAATC/TCGGGA 3 I M syn1 mis1 ese31Minor allele frequency- T:0.50NA 2
    rs1837026271,2
    --45849354(+) TTTTTA/CTCTGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for FAM21C (46222648 - 46288412 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FAM21C (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv33964CNV Loss17666407
    esv2750898CNV Loss17911159
    esv34875CNV Gain17911159
    dgv651n71CNV Gain21882294
    nsv895114CNV Gain21882294
    esv2750899CNV Gain17911159
    esv23760CNV Gain+Loss19812545
    nsv516485CNV Gain+Loss19592680
    essv18092CNV CNV17122850
    dgv253e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM21C
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613631    OMIM disorders: --

    1 disease for FAM21C:    
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    vaccinia


    Find genes that share disorders with FAM21C           About GenesLikeMe


    Export disorders for FAM21C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM21C gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with FAM21C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex. (PubMed id 19922875)1, 2 Derivery E.... Gautreau A. (Dev. Cell 2009)
    2. A FAM21-containing WASH complex regulates retromer-dependent sorting. (PubMed id 19922874)1, 2 Gomez T.S. and Billadeau D.D. (Dev. Cell 2009)
    3. A novel cellular protein, VPEF, facilitates vaccinia virus penetration into HeLa cells through fluid phase endocytosis. (PubMed id 18550675)1, 2 Huang C.Y.... Chang W. (J. Virol. 2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    7. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2 Nagase T....Ohara O. (DNA Res. 1998)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer. (PubMed id 22513087)1 Jia D....Rosen M.K. (Mol. Biol. Cell 2012)
    10. Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35. (PubMed id 22070227)1 Harbour M.E....Seaman M.N. (Biochem. J. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 253725 HGNC: 23414 AceView: KIAA0592 Ensembl:ENSG00000172661 euGenes: HUgn253725
    ECgene: FAM21C H-InvDB: FAM21C

    (According to HUGE)
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    HUGE: KIAA0592

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM21C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM21C gene:
    Search GeneIP for patents involving FAM21C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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