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Aliases for FAM21A Gene

Aliases for FAM21A Gene

  • Family With Sequence Similarity 21, Member A 2 3
  • Family With Sequence Similarity 21, Member B 2 3
  • WASH Complex Subunit FAM21A 3
  • WASH Complex Subunit FAM21B 3
  • BA56A21.1 3
  • BA98I6.1 3
  • FAM21B 3

External Ids for FAM21A Gene

Previous HGNC Symbols for FAM21A Gene

  • FAM21B

Previous GeneCards Identifiers for FAM21A Gene

  • GC10U900459
  • GC10P051501
  • GC10P051827

Summaries for FAM21A Gene

GeneCards Summary for FAM21A Gene

FAM21A (Family With Sequence Similarity 21, Member A) is a Protein Coding gene. An important paralog of this gene is FAM21C.

UniProtKB/Swiss-Prot for FAM21A Gene

  • Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, SDCCAG3, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1, CCDC93 and C16orf62. Plays a role in fluid-phase endocytosis, a process exploited by vaccinia intracellular mature virus (IMV) to enter cells. As a result, may facilitate the penetration of IMV into cells (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM21A Gene

Genomics for FAM21A Gene

Regulatory Elements for FAM21A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM21A Gene

Start:
50,067,850 bp from pter
End:
50,133,509 bp from pter
Size:
65,660 bases
Orientation:
Plus strand

Genomic View for FAM21A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM21A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM21A Gene

Proteins for FAM21A Gene

  • Protein details for FAM21A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q641Q2-FA21A_HUMAN
    Recommended name:
    WASH complex subunit FAM21A
    Protein Accession:
    Q641Q2
    Secondary Accessions:
    • A2A3S2
    • A2A3U6
    • Q6DHY0

    Protein attributes for FAM21A Gene

    Size:
    1341 amino acids
    Molecular mass:
    147184 Da
    Quaternary structure:
    • Component of the WASH core complex also described as WASH regulatory complex SHRC composed of WASH (WASH1, WASH2P or WASH3P), FAM21 (FAM21A or FAM21C), KIAA1033/ SWIP, KIAA0196/strumpellin and CCDC53; in the complex interacts (via N-terminus) directly with WASH1. The WASH core complex associates with the F-actin-capping protein dimer (formed by CAPZA1, CAPZA2 or CAPZA3 and CAPZB) in a transient or substoichiometric manner which was initially described as WASH complex. Interacts with VPS35; mediates the association with the retromer CSC complex. Interacts with FKBP15. Interacts with CCDC93, CCDC22, C16orf62; indicative for an association of the WASH core complex with the CCC complex (By similarity).
    Miscellaneous:
    • In human, FAM21 has undergone evolutionary duplication, with 4 highly homologous family members existing, including FAM21A, FAM21B, FAM21C, and an N-terminally truncated FAM21D form

    Alternative splice isoforms for FAM21A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM21A Gene

Proteomics data for FAM21A Gene at MOPED

Post-translational modifications for FAM21A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM21A Gene

Domains for FAM21A Gene

Protein Domains for FAM21A Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q641Q2

UniProtKB/Swiss-Prot:

FA21A_HUMAN :
  • Q641Q2
Domain:
  • The LFa (leucine-phenylalanine-acidic) motif bind directly to VPS35 of retromer CSC; adjacent motifs can act cooperatively to bind multiple CSCs, although there is significant variability in the affinities of different motifs for retromer.
Family:
  • Belongs to the FAM21 family.
genes like me logo Genes that share domains with FAM21A: view

No data available for Gene Families for FAM21A Gene

Function for FAM21A Gene

Molecular function for FAM21A Gene

UniProtKB/Swiss-Prot Function:
Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, SDCCAG3, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1, CCDC93 and C16orf62. Plays a role in fluid-phase endocytosis, a process exploited by vaccinia intracellular mature virus (IMV) to enter cells. As a result, may facilitate the penetration of IMV into cells (By similarity).

Gene Ontology (GO) - Molecular Function for FAM21A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with FAM21A: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FAM21A Gene

Localization for FAM21A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM21A Gene

Early endosome membrane. Cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM21A Gene COMPARTMENTS Subcellular localization image for FAM21A gene
Compartment Confidence
endosome 4
nucleus 3

Gene Ontology (GO) - Cellular Components for FAM21A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome ISS --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0031901 early endosome membrane IEA --
GO:0071203 WASH complex ISS --
genes like me logo Genes that share ontologies with FAM21A: view

Pathways for FAM21A Gene

SuperPathways for FAM21A Gene

No Data Available

Interacting Proteins for FAM21A Gene

Gene Ontology (GO) - Biological Process for FAM21A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0042147 retrograde transport, endosome to Golgi ISS --
genes like me logo Genes that share ontologies with FAM21A: view

No data available for Pathways by source for FAM21A Gene

Transcripts for FAM21A Gene

mRNA/cDNA for FAM21A Gene

(12) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM21A Gene

Family with sequence similarity 21, member A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM21A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM21A Gene

No ASD Table

Relevant External Links for FAM21A Gene

GeneLoc Exon Structure for
FAM21A
ECgene alternative splicing isoforms for
FAM21A

Expression for FAM21A Gene

mRNA expression in normal human tissues for FAM21A Gene

Protein differential expression in normal tissues for FAM21A Gene

This gene is overexpressed in Pancreas (35.6), Lung (19.4), Peripheral blood mononuclear cells (7.2), and Heart (6.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM21A Gene

SOURCE GeneReport for Unigene cluster for FAM21A Gene Hs.645272

genes like me logo Genes that share expressions with FAM21A: view

Expression partners for FAM21A Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM21A Gene

Orthologs for FAM21A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM21A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM21A 35
  • 84.03 (n)
  • 79.43 (a)
-- 36
  • 79 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC477751 35
  • 86.4 (n)
  • 82.66 (a)
-- 36
  • 82 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fam21 35
  • 79.91 (n)
  • 74.77 (a)
Fam21 36
  • 74 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC738985 35
  • 98.98 (n)
  • 98.17 (a)
FAM21C 36
  • 98 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Fam21c 35
  • 79.21 (n)
  • 74.22 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 62 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
OneToMany
chicken
(Gallus gallus)
Aves FAM21A 35
  • 62.57 (n)
  • 57.51 (a)
FAM21A 36
  • 47 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fam21a 35
  • 58.35 (n)
  • 52.97 (a)
zebrafish
(Danio rerio)
Actinopterygii fam21c 35
  • 54.59 (n)
  • 46.44 (a)
fam21c 36
  • 40 (a)
OneToMany
Species with no ortholog for FAM21A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM21A Gene

ENSEMBL:
Gene Tree for FAM21A (if available)
TreeFam:
Gene Tree for FAM21A (if available)

Paralogs for FAM21A Gene

Paralogs for FAM21A Gene

Selected SIMAP similar genes for FAM21A Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for FAM21A Gene

genes like me logo Genes that share paralogs with FAM21A: view

Variants for FAM21A Gene

Sequence variations from dbSNP and Humsavar for FAM21A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs2305300 -- 50,078,599(+) GTTAC(C/T)GTGTG intron-variant
rs2338072 -- 50,128,797(+) ATAAA(C/T)ACTGC intron-variant
rs2338444 -- 50,103,595(+) TTAGG(A/G)GAGGA intron-variant
rs2458467 -- 50,112,075(+) AAGAA(A/G)TAGGG intron-variant, upstream-variant-2KB
rs2573458 -- 50,117,695(+) GTGAT(A/G)TGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM21A Gene

Variant ID Type Subtype PubMed ID
dgv273e1 CNV Complex 17122850
nsv428232 CNV Gain+Loss 18775914
nsv895383 CNV Loss 21882294
nsv518071 CNV Gain 19592680
essv19403 CNV CNV 17122850
nsv831868 CNV Loss 17160897
nsv895390 CNV Loss 21882294
nsv471356 CNV Duplication 19718026
dgv138e199 CNV Deletion 23128226
esv23741 CNV Gain 19812545
nsv825377 CNV Loss 20364138

Relevant External Links for FAM21A Gene

HapMap Linkage Disequilibrium report
FAM21A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM21A Gene

Disorders for FAM21A Gene

No disorders were found for FAM21A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FAM21A Gene

Publications for FAM21A Gene

  1. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  2. Generation and analysis of 280,000 human expressed sequence tags. (PMID: 8889549) Hillier L.D. … Marra M. (Genome Res. 1996) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3

Products for FAM21A Gene

Sources for FAM21A Gene

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