FAM21A Gene
protein-coding GIFtS: 38
GCID: GC10P051827
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|
family with sequence similarity 21, member A
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Aliases
for FAM21A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 21, Member A1 2 | | BA56A21.11 | | WASH Complex Subunit FAM21A2 |
Export aliases for FAM21A gene to outside databasesPrevious GC identifers: GC10U900459 GC10P051501 |
Summaries
for FAM21A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FA21A_HUMAN, Q641Q2Function: Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates theArp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serveas transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of thecomplex to endosome membranes (By similarity)
|
Genomic Views
for FAM21A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM21A gene promoter:
TBP NF-1/L NF-1 Pax-5 MEF-2 ATF-2 Nkx2-2 GATA-2 MEF-2A Zic3
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM21A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM21A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q11.23 Ensembl cytogenetic band: 10q11.23 HGNC cytogenetic band: 10q11.23FAM21A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P051827: view genomic region
(about GC identifiers)
Start:
|
51,827,648 bp from pter |
End:
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51,893,269 bp from pter |
Size:
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65,622 bases |
Orientation:
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plus strand |
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Proteins
for FAM21A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FA21A_HUMAN, Q641Q2 (See
protein sequence)Recommended Name: WASH complex subunit FAM21A Size: 1341 amino acids; 147184 Da
Subunit: Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3),F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A,FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts (via N-terminus) with WASH1; the interaction is direct (Bysimilarity)
Subcellular location: Early endosome membrane (By similarity)
Miscellaneous: In human, FAM21 has undergone evolutionary duplication, with 4 highly homologous family membersexisting, including FAM21A, FAM21B, FAM21C, and an N-terminally truncated FAM21D form
Secondary accessions: A2A3S2 A2A3U6 Q6DHY0Alternative splicing: 2 isoforms: Q641Q2-1 Q641Q2-2 Explore the universe of human proteins at neXtProt for FAM21A: NX_Q641Q2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q641Q2
FAM21A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001005751.1
ENSEMBL proteins: ENSP00000403781 ENSP00000282633 ENSP00000398095 ENSP00000344037 ENSP00000314417 ENSP00000382277
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
FAM21A for ontologies About GeneDecksing
FAM21A Antibody Products:
Assay Products for FAM21A: |
Protein
Domains /
Families
for FAM21A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q641Q2 UniProtKB/Swiss-Prot: FA21A_HUMAN, Q641Q2Similarity: Belongs to the FAM21 family |
Function
for FAM21A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FA21A_HUMAN, Q641Q2Function: Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates theArp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serveas transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of thecomplex to endosome membranes (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM21A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM21A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for FAM21A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM21A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM21A |
|
Pathways & Interactions
for FAM21A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM21A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)
5/15 Interacting proteins for FAM21A (Q641Q23 ENSP000002826334) via UniProtKB, MINT, STRING, and/or I2D (see all 15)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0042147 | retrograde transport, endosome to Golgi |
ISS | -- |
FAM21A for ontologies About GeneDecksing
|
Drugs & Compounds
for FAM21A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM21A
Search CenterWatch for drugs/clinical trials and news about FAM21A / FA21A
|
Transcripts
for FAM21A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM21A gene: NM_001005751.1 Unigene Cluster for FAM21A: Family with sequence similarity 21, member A Hs.645272 [show with all ESTs]Unigene Representative Sequence: NM_0010057518 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000434114(uc001jja.1) ENST00000282633 ENST00000492914 ENST00000476514
ENST00000454806 ENST00000351071(uc001jjb.3 uc010qhi.2) ENST00000314664(uc010qhj.2)
ENST00000399339(uc009xoq.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM21A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM21A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FAM21A (NM_001005751) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM21A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM21A |
Additional cDNA sequence: AK001686.1 AK295129.1 AK304116.1 AL080183.1 BC064639.1 BC065500.1 BC075815.1 BC082258.1 BC144479.1 23 DOTS entries: DT.102840051 DT.448378 DT.75179780 DT.101982956 DT.102834635 DT.100016532 DT.101979413 DT.100790428 DT.102840029 DT.102844139 DT.121250323 DT.121251158 DT.121288860 DT.121289139 DT.91638363 DT.92442330 DT.95145660 DT.95333118 DT.100735099 DT.100760574 DT.100774984 DT.95333122 DT.97774500
GeneLoc Exon Structure
|
Expression
for FAM21A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM21A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCTCCAAGG
About this image
See FAM21A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM21A
SOURCE GeneReport for Unigene cluster: Hs.645272
SABiosciences Custom PCR Arrays for FAM21A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM21A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM21A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM21A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM21A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM21A |
Orthologs
for FAM21A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FAM21A gene from 4/18 species (see all 18) About this table
ENSEMBL Gene Tree for FAM21A (if available)
TreeFam Gene Tree for FAM21A (if available) |
Paralogs
for FAM21A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM21A gene
- FAM21C1 2 FAM21D2 FAM21B2
4 SIMAP similar genes for FAM21A using alignment to 7 protein entries: FA21A_HUMAN (see all proteins):FAM21D DKFZp434O171 FAM21B FAM21C
FAM21A for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for FAM21A
PGOHUM00000238448 PGOHUM00000238487
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Genomic Variants
for FAM21A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM21A (51827648 - 51893269 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for FAM21A
6 CNVs: 3800 75254 85278 75253 75252 65675 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM21A |
|
Disorders
/ Diseases
for FAM21A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for FAM21A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM21A gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with FAM21A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Rab GTPase-activating proteins in autophagy: regulatio n of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. (PubMed id 22354992)1 Popovic D....Dikic I. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Control of HIV replication in astrocytes by a family o f highly conserved host proteins with a common Rev-interacting domain (Risp). (PubMed id 20827171)1 Vincendeau M....Brack-Werner R. (2010)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Identification of a novel Rev-interacting cellular pro tein. (PubMed id 15847701)1 Kramer-Hammerle S....Brack-Werner R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
|
External Searches for FAM21A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM21A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM21A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM21A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM21A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM21A gene:
Search GeneIP for patents involving FAM21A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM21A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM21A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM21A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM21A | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM21A | | OriGene 3'-UTR Clone for FAM21A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM21A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM21A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM21A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM21A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM21A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM21A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM21A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM21A |
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| | | | Search Tocris compounds for FAM21A |
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 | | | FAM21A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM21A |
|  |  |  | | | | Search ThermoFisher Antibodies for FAM21A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM21A |
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