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FAM21A Gene

protein-coding   GIFtS: 39
GCID: GC10P051827

Family With Sequence Similarity 21, Member A

  Search for FAM21A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 21, Member A1 2
bA56A21.12
WASH Complex Subunit FAM21A2

External Ids:    HGNC: 234161   Entrez Gene: 3876802   Ensembl: ENSG000000992907   UniProtKB: Q641Q23   

Export aliases for FAM21A gene to outside databases

Previous GC identifers: GC10U900459 GC10P051501


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM21A Gene:
FAM21A (family with sequence similarity 21, member A) is a protein-coding gene. An important paralog of this gene is FAM21C.

UniProtKB/Swiss-Prot: FA21A_HUMAN, Q641Q2
Function: Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates
the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules
that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the
recruitment of the complex to endosome membranes (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM21A gene promoter:
         TBP   NF-1/L   NF-1   Pax-5   MEF-2   ATF-2   Nkx2-2   GATA-2   MEF-2A   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM21A promoter sequence
   Search Chromatin IP Primers for FAM21A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM21A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.23   Ensembl cytogenetic band:  10q11.23   HGNC cytogenetic band: 10q11.23

FAM21A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM21A gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P051827:  view genomic region     (about GC identifiers)

Start:
51,827,648 bp from pter      End:
51,893,269 bp from pter
Size:
65,622 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FA21A_HUMAN, Q641Q2 (See protein sequence)
Recommended Name: WASH complex subunit FAM21A  
Size: 1341 amino acids; 147184 Da
Subunit: Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or
CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P),
FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts (via N-terminus) with WASH1; the
interaction is direct (By similarity)
Miscellaneous: In human, FAM21 has undergone evolutionary duplication, with 4 highly homologous family members
existing, including FAM21A, FAM21B, FAM21C, and an N-terminally truncated FAM21D form
Secondary accessions: A2A3S2 A2A3U6 Q6DHY0
Alternative splicing: 2 isoforms:  Q641Q2-1   Q641Q2-2   

Explore the universe of human proteins at neXtProt for FAM21A: NX_Q641Q2

Explore proteomics data for FAM21A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM21A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001005751.1  
    ENSEMBL proteins: 
     ENSP00000403781   ENSP00000282633   ENSP00000398095   ENSP00000344037   ENSP00000314417  
     ENSP00000382277  

    FAM21A Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for FAM21A

     
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    FAM21A Assay Products:

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    Search eBioscience for ELISAs for FAM21A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR027308 FAM21

    Graphical View of Domain Structure for InterPro Entry Q641Q2

    ProtoNet protein and cluster: Q641Q2

    UniProtKB/Swiss-Prot: FA21A_HUMAN, Q641Q2
    Similarity: Belongs to the FAM21 family


    Find genes that share domains with FAM21A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FA21A_HUMAN, Q641Q2
    Function: Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates
    the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules
    that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the
    recruitment of the complex to endosome membranes (By similarity)

    Animal Models:

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM21A
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM21A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM21A

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    hsa-miR-152 hsa-miR-3140-3p hsa-miR-148b hsa-miR-298 hsa-miR-10b hsa-miR-148a hsa-miR-10a
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM21A

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FA21A_HUMAN, Q641Q2: Early endosome membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome4
    nucleus3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005769early endosome ISS--
    GO:0031901early endosome membrane IEA--
    GO:0071203WASH complex ISS--

    Find genes that share ontologies with FAM21A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM21A
    Interactions:

        Search GeneGlobe Interaction Network for FAM21A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for FAM21A (Q641Q23 ENSP000002826334) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPS6KA3P518123I2D: score=1 
    CAPZA1ENSP000002631684STRING: ENSP00000263168
    CCDC53ENSP000002400794STRING: ENSP00000240079
    FAM21BENSP000003512594STRING: ENSP00000351259
    FAM21CENSP000003375414STRING: ENSP00000337541
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042147retrograde transport, endosome to Golgi ISS--

    Find genes that share ontologies with FAM21A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM21A (FA21A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM21A gene: 
    NM_001005751.1  

    Unigene Cluster for FAM21A:

    Family with sequence similarity 21, member A
    Hs.645272  [show with all ESTs]
    Unigene Representative Sequence: NM_001005751
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000434114(uc001jja.1) ENST00000282633 ENST00000492914 ENST00000476514
    ENST00000454806 ENST00000351071(uc001jjb.3 uc010qhi.2) ENST00000314664(uc010qhj.2)
    ENST00000399339(uc009xoq.3)
    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate FAM21A:
    hsa-miR-152 hsa-miR-3140-3p hsa-miR-148b hsa-miR-298 hsa-miR-10b hsa-miR-148a hsa-miR-10a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: FAM21A (NM_001005751)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat FAM21A
      QuantiFast Probe-based Assays in human, mouse, rat FAM21A

    Additional mRNA sequence: 

    AK001686.1 AK295129.1 AK304116.1 AL080183.1 BC064639.1 BC065500.1 BC075815.1 BC082258.1 
    BC144479.1 

    23 DOTS entries:

    DT.102840051  DT.448378  DT.75179780  DT.101982956  DT.102834635  DT.100016532  DT.101979413  DT.100790428 
    DT.102840029  DT.102844139  DT.121250323  DT.121251158  DT.121288860  DT.121289139  DT.91638363  DT.92442330 
    DT.95145660  DT.95333118  DT.100735099  DT.100760574  DT.100774984  DT.95333122  DT.97774500 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM21A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTCCAAGG
    FAM21A Expression
    About this image

    FAM21A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM21A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.645272
        Custom PCR Arrays for FAM21A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM21A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FAM21A gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam211 family with sequence similarity 21 79.91(n)
    74.77(a)
      28006  NM_026585.3  NP_080861.2 
    chicken
    (Gallus gallus)
    Aves FAM21A1 family with sequence similarity 21, member A 62.57(n)
    57.51(a)
      423772  NM_001012593.2  NP_001012611.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    51(a)
    1 → many
    GL343297.1(359191-399942)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fam21a1 family with sequence similarity 21, member A 58.35(n)
    52.97(a)
      100170418  XM_002935971.2  XP_002936017.2 
    zebrafish
    (Danio rerio)
    Actinopterygii fam21c1 family with sequence similarity 21, member C 54.59(n)
    46.44(a)
      567272  XM_005156707.1  XP_005156764.1 


    ENSEMBL Gene Tree for FAM21A (if available)
    TreeFam Gene Tree for FAM21A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM21A gene
    FAM21C1 2  FAM21D2  FAM21B2  
    4 SIMAP similar genes for FAM21A using alignment to 7 protein entries:     FA21A_HUMAN (see all proteins):
    FAM21D    DKFZp434O171    FAM21C    FAM21B

    Find genes that share paralogs with FAM21A           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for FAM21A
    PGOHUM00000238448 PGOHUM00000238487


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM21A (see all 253)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1381828501,2
    --51829691(+) TATACC/TTCGGT 1 -- int10--------
    rs1873970311,2
    C--51829713(+) TTGTCA/GTTTTG 1 -- int10--------
    rs1491636301,2
    --51829774(+) TGTGGC/TGTGAT 1 -- int10--------
    rs1906971911,2
    --51829823(+) CACCAC/GCATAT 1 -- int10--------
    rs715080401,2
    C,F--51829836(+) TTTCAG/CTTGTT 1 -- int11Minor allele frequency- C:0.50NA 2
    rs1836287121,2
    --51829975(+) TAAATC/TTATGT 1 -- int10--------
    rs1881187931,2
    --51830045(+) AGAGCC/TTCTCC 1 -- int10--------
    rs1482410651,2
    --51830262(+) ATAAAA/GTTTTC 1 -- int10--------
    rs1404006581,2
    C--51831312(+) CGCCCA/GCCTCG 1 -- int10--------
    rs1928721111,2
    --51832082(+) GGTTGC/TCGCTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for FAM21A (51827648 - 51893269 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FAM21A (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv138e199CNV Deletion23128226
    nsv471356CNV Duplication19718026
    nsv831868CNV Loss17160897
    nsv895383CNV Loss21882294
    nsv895390CNV Loss21882294
    nsv825377CNV Loss20364138
    esv23741CNV Gain19812545
    nsv518071CNV Gain19592680
    nsv428232CNV Gain+Loss18775914
    essv19403CNV CNV17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM21A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM21A gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with FAM21A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    2. Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. (PubMed id 22354992)1 Popovic D....Dikic I. (Mol. Cell. Biol. 2012)
    3. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    6. Control of HIV replication in astrocytes by a family of highly conserved host proteins with a common Rev-interacting domain (Risp). (PubMed id 20827171)1 Vincendeau M....Brack-Werner R. (AIDS 2010)
    7. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)
    8. Identification of a novel Rev-interacting cellular protein. (PubMed id 15847701)1 Kramer-HAommerle S....Brack-Werner R. (BMC Cell Biol. 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 387680 HGNC: 23416 Ensembl:ENSG00000099290 euGenes: HUgn387680 ECgene: FAM21A
    H-InvDB: FAM21A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM21A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM21A gene:
    Search GeneIP for patents involving FAM21A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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     Search Addgene for plasmids for FAM21A
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      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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