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Aliases for FAM219B Gene

Aliases for FAM219B Gene

  • Family With Sequence Similarity 219 Member B 2 3 5
  • C15orf17 3 4
  • Family With Sequence Similarity 219, Member B 2
  • Chromosome 15 Open Reading Frame 17 2
  • Uncharacterized Protein C15orf17 3
  • Protein FAM219B 3

External Ids for FAM219B Gene

Previous HGNC Symbols for FAM219B Gene

  • C15orf17

Previous GeneCards Identifiers for FAM219B Gene

  • GC15M075193

Summaries for FAM219B Gene

GeneCards Summary for FAM219B Gene

FAM219B (Family With Sequence Similarity 219 Member B) is a Protein Coding gene. An important paralog of this gene is FAM219A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM219B Gene

Genomics for FAM219B Gene

Regulatory Elements for FAM219B Gene

Enhancers for FAM219B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F074775 1.8 FANTOM5 Ensembl ENCODE 10.2 +119.1 119106 26.0 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ULK3 ENSG00000260274 EDC3 C15orf39 CSK RPP25 CPLX3 LMAN1L DNM1P35 CYP1A1
GH15F074953 1.5 FANTOM5 ENCODE 11.1 -49.4 -49350 5.4 PKNOX1 ARNT CREB3L1 SIN3A DMAP1 YY1 ZNF207 FOS ZNF263 SP3 RPP25 LOC105370902 LOC732265 DNM1P49 LOC441728 GOLGA6A EDC3 FAM219B MPI ULK3
GH15F074841 1.4 Ensembl ENCODE 11.1 +63.4 63449 5.0 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143 FOS ENSG00000260274 RPP25 EDC3 MPI ULK3 SCAMP2 DNM1P35 FAM219B ENSG00000203392 NEIL1
GH15F074770 1.3 Ensembl ENCODE 11 +135.7 135661 1.5 HDGF PKNOX1 ARID4B SIN3A GLI4 ZNF48 ZNF2 ZNF121 ZNF143 DEK ULK3 CPLX3 FAM219B SCAMP5 PPCDC PTPN9 CSK CYP1A2
GH15F074856 1.2 Ensembl ENCODE 11.1 +48.8 48832 3.9 HDAC1 ATF1 ZFP64 INSM2 ARID4B KLF17 ZNF2 ZNF121 GLIS2 ZNF366 SCAMP5 MPI CPLX3 FAM219B SCAMP2 ULK3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM219B on UCSC Golden Path with GeneCards custom track

Promoters for FAM219B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000022194 807 1801 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 ZNF263

Genomic Location for FAM219B Gene

Chromosome:
15
Start:
74,899,987 bp from pter
End:
74,907,307 bp from pter
Size:
7,321 bases
Orientation:
Minus strand

Genomic View for FAM219B Gene

Genes around FAM219B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM219B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM219B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM219B Gene

Proteins for FAM219B Gene

  • Protein details for FAM219B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5XKK7-F219B_HUMAN
    Recommended name:
    Protein FAM219B
    Protein Accession:
    Q5XKK7
    Secondary Accessions:
    • A8K4Q5
    • B4DK57
    • Q9NXY0

    Protein attributes for FAM219B Gene

    Size:
    198 amino acids
    Molecular mass:
    21103 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM219B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM219B Gene

Post-translational modifications for FAM219B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM219B Gene

Domains & Families for FAM219B Gene

Protein Domains for FAM219B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM219B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5XKK7

UniProtKB/Swiss-Prot:

F219B_HUMAN :
  • Belongs to the FAM219 family.
Family:
  • Belongs to the FAM219 family.
genes like me logo Genes that share domains with FAM219B: view

No data available for Gene Families for FAM219B Gene

Function for FAM219B Gene

genes like me logo Genes that share phenotypes with FAM219B: view

Animal Model Products

miRNA for FAM219B Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM219B Gene

Localization for FAM219B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM219B gene
Compartment Confidence
nucleus 3
golgi apparatus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM219B Gene

Pathways & Interactions for FAM219B Gene

SuperPathways for FAM219B Gene

No Data Available

Interacting Proteins for FAM219B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000350260%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000350260 Q5XKK7-F219B_HUMAN for FAM219B Gene via STRING IID

Gene Ontology (GO) - Biological Process for FAM219B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM219B Gene

Transcripts for FAM219B Gene

Unigene Clusters for FAM219B Gene

Family with sequence similarity 219, member B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM219B Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h · 7i · 7j · 7k · 7l ^
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: -
SP4: - -
SP5: - - -
SP6: - - -
SP7: - - -
SP8: - - - - - - - - - -
SP9: -
SP10: - - - - -
SP11: - - - - -
SP12: -
SP13: - - -
SP14: - -
SP15: -
SP16: - - - - - -

ExUns: 8a · 8b · 8c ^ 9
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for FAM219B Gene

GeneLoc Exon Structure for
FAM219B
ECgene alternative splicing isoforms for
FAM219B

Expression for FAM219B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM219B Gene

Protein differential expression in normal tissues from HIPED for FAM219B Gene

This gene is overexpressed in Liver (55.9), Monocytes (6.5), and Pancreatic juice (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM219B Gene



Protein tissue co-expression partners for FAM219B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM219B Gene:

FAM219B

SOURCE GeneReport for Unigene cluster for FAM219B Gene:

Hs.367690
genes like me logo Genes that share expression patterns with FAM219B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM219B Gene

Orthologs for FAM219B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM219B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM219B 34 35
  • 92.15 (n)
dog
(Canis familiaris)
Mammalia C30H15orf17 34
  • 89.95 (n)
FAM219B 35
  • 32 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C21H15orf17 34
  • 88.31 (n)
FAM219B 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam219b 34 16 35
  • 86.13 (n)
rat
(Rattus norvegicus)
Mammalia Fam219b 34
  • 81.63 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM219B 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM219B 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM219B 34
  • 77.13 (n)
lizard
(Anolis carolinensis)
Reptilia FAM219B 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam219b 34
  • 66.9 (n)
Str.3563 34
zebrafish
(Danio rerio)
Actinopterygii fam219b 34 35
  • 60.58 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.170 35
  • 42 (a)
OneToMany
Species where no ortholog for FAM219B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM219B Gene

ENSEMBL:
Gene Tree for FAM219B (if available)
TreeFam:
Gene Tree for FAM219B (if available)

Paralogs for FAM219B Gene

Paralogs for FAM219B Gene

(2) SIMAP similar genes for FAM219B Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with FAM219B: view

Variants for FAM219B Gene

Sequence variations from dbSNP and Humsavar for FAM219B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs111690224 -- 74,905,804(+) ATCAG(A/G)GGACA intron-variant
rs112031848 -- 74,908,182(+) AATCC(G/T)AGCTA upstream-variant-2KB
rs112196602 -- 74,898,821(+) GGCGT(A/G)AGCCA downstream-variant-500B, utr-variant-3-prime
rs112372323 -- 74,905,884(+) GTAAA(A/C)GGAGG intron-variant
rs112620497 -- 74,908,020(+) CTGGC(C/G/T)GGGCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM219B Gene

Variant ID Type Subtype PubMed ID
nsv819808 CNV gain 19587683
nsv1121512 CNV deletion 24896259

Variation tolerance for FAM219B Gene

Residual Variation Intolerance Score: 74.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM219B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM219B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM219B Gene

Disorders for FAM219B Gene

Relevant External Links for FAM219B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM219B

No disorders were found for FAM219B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM219B Gene

Publications for FAM219B Gene

  1. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A. … Ohara O. (DNA Res. 2000) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for FAM219B Gene

Sources for FAM219B Gene

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