FAM219B Gene
protein-coding GIFtS: 39
GCID: GC15M075193
|
|
family with sequence similarity 219, member B(Previous name: chromosome 15 open reading frame 17 )
(Previous symbol: C15orf17)
| |
Aliases
for FAM219B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 219, Member B1 2 | | C15orf171 2 3 | | FLJ000051 | | Chromosome 15 Open Reading Frame 171 | | Protein FAM219B2 | | Uncharacterized Protein C15orf172 |
Export aliases for FAM219B gene to outside databases |
Summaries
for FAM219B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM219B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for FAM219B
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM219B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM219B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q24.1 Ensembl cytogenetic band: 15q24.1 HGNC cytogenetic band: 15q23FAM219B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M075193: view genomic region
(about GC identifiers)
Start:
|
75,192,328 bp from pter |
End:
|
75,199,462 bp from pter |
Size:
|
7,135 bases |
Orientation:
|
minus strand |
|
Proteins
for FAM219B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F219B_HUMAN, Q5XKK7 (See
protein sequence)Recommended Name: Protein FAM219B Size: 198 amino acids; 21103 Da
Secondary accessions: A8K4Q5 B4DK57 Q9NXY0Alternative splicing: 3 isoforms: Q5XKK7-1 Q5XKK7-2 Q5XKK7-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FAM219B: NX_Q5XKK7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5XKK7
FAM219B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065180.1
ENSEMBL proteins: ENSP00000350260 ENSP00000457778 ENSP00000456404 ENSP00000454719 ENSP00000457861 ENSP00000457594 ENSP00000457328 ENSP00000455248 ENSP00000457998 ENSP00000456406 ENSP00000454553 ENSP00000454600 ENSP00000454832 ENSP00000454277 ENSP00000456744 ENSP00000392823
Human Recombinant Protein Products for FAM219B:
FAM219B Antibody Products:
Assay Products for FAM219B: |
Protein
Domains /
Families
for FAM219B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q5XKK7 UniProtKB/Swiss-Prot: F219B_HUMAN, Q5XKK7Similarity: Belongs to the FAM219 family |
Function
for FAM219B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
1 GenomeRNAi human phenotype for FAM219B:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM219B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM219B (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for FAM219B | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM219B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM219B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM219B |
|
Pathways & Interactions
for FAM219B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM219B
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for FAM219B (Q5XKK73 ENSP000003502604) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FAM219B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM219B
Search CenterWatch for drugs/clinical trials and news about FAM219B / F219B
|
Transcripts
for FAM219B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM219B gene: NM_020447.3 Unigene Cluster for FAM219B: Family with sequence similarity 219, member B Hs.367690 [show with all ESTs]Unigene Representative Sequence: NM_02044718/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20): ENST00000357635(uc010bkh.3 uc002azh.4 uc002azf.3 uc002azg.2)
ENST00000566132 ENST00000563671 ENST00000563119 ENST00000569524 ENST00000564723
ENST00000566894 ENST00000563069 ENST00000563413 ENST00000565772 ENST00000570143
ENST00000563877 ENST00000566194 ENST00000564857 ENST00000567388 ENST00000569761
ENST00000563706 ENST00000562698
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM219B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM219B (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for FAM219B | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM219B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM219B |
Additional cDNA sequence: AB593185.1 AK001572.1 AK025373.1 AK291020.1 AK296403.1 AK308954.1 BC006348.2 BC015637.2 BC064575.1 15 DOTS entries: DT.75179674 DT.91759315 DT.99943158 DT.91759322 DT.100735319 DT.100788847 DT.91759312 DT.91759313 DT.100029583 DT.100788845 DT.91759310 DT.91759311 DT.91838317 DT.101955282 DT.75190971 24/271 AceView cDNA sequences (see all 271): CA411666 BM829256 BU948110 BU677394 AI079857 BM805202 CA392580 CN480848 AI609362 BU622016 BC015637 AI700090 BQ631115 NM_020447 BM976157 AK000005 AI383615 CB122209 CA425962 AK001572 BQ581497 BG259001 AA156746 AA878194
GeneLoc Exon Structure
5/16 Alternative Splicing Database (ASD) splice patterns (SP) for FAM219B (see all 16) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | · | 7f | · | 7g | · | 7h | · | 7i | · | 7j | · | 7k | · | 7l | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | |
| SP3: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 8a | · | 8b | · | 8c | ^ | 9 |
|---|
|
| SP1: | | | - | | - | | | | |
| SP2: | | | | | | | | | |
| SP3: | | | | | | | | | |
| SP4: | | | | | | | | | |
| SP5: | | | | | | | | |
ECgene alternative splicing isoforms for FAM219B
|
Expression
for FAM219B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM219B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGGAGGGTG
About this image
See FAM219B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM219B
SOURCE GeneReport for Unigene cluster: Hs.367690
SABiosciences Custom PCR Arrays for FAM219B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM219B
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat FAM219B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM219B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM219B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM219B |
Orthologs
for FAM219B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FAM219B gene from 5/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Fam219b1 , 5 |
RIKEN cDNA 2310046O06 gene5
family with sequence similarity 219, member B1 |
86.13(n)1
83.76(a)1 |
|
9 (31.05 cM)5
783231 NM_001166364.11 NP_001159836.11
575375285 |
chicken
(Gallus gallus) |
Aves |
C15orf176 |
Uncharacterized protein |
50(a) |
1 ↔ 1 |
10(1779796-1781517) |
lizard
(Anolis carolinensis) |
Reptilia |
C15orf176 |
-- |
75(a) |
1 ↔ 1 |
GL343492.1(565632-569333) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.35632 |
Transcribed sequences |
76.33(n) |
|
AL848898.2 |
zebrafish
(Danio rerio) |
Actinopterygii |
BM342425.12 |
-- |
74.44(n) |
|
BM342425.1 |
ENSEMBL Gene Tree for FAM219B (if available)
TreeFam Gene Tree for FAM219B (if available) |
Paralogs
for FAM219B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM219B gene
- FAM219A2
2 SIMAP similar genes for FAM219B using alignment to 8 protein entries: F219B_HUMAN (see all proteins):C15orf17 FAM219A
FAM219B for paralogs About GeneDecksing
|
Genomic Variants
for FAM219B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM219B (75192328 - 75199462 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM219B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM219B |
|
Disorders
/ Diseases
for FAM219B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for FAM219B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM219B gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM219B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of long cDNA clones from human adult spleen. (PubMed id 11214971)1, 2, 3 Hattori A.... Ohara O. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for FAM219B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM219B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM219B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM219B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM219B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM219B gene:
Search GeneIP for patents involving FAM219B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM219B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM219B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM219B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM219B | | | OriGene Protein Over-expression Lysate for FAM219B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM219B | | OriGene 3'-UTR Clone for FAM219B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM219B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM219B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FAM219B | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM219B | | OriGene Custom Protein Services for FAM219B | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM219B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM219B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM219B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM219B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM219B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM219B |
| |
 |  |  |  | |
| | | | Search Tocris compounds for FAM219B |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | FAM219B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM219B |
|  |  |  |  | | | | ThermoFisher Antibodies for FAM219B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM219B |
| |  | |
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