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Aliases for FAM219B Gene

Aliases for FAM219B Gene

  • Family With Sequence Similarity 219 Member B 2 3 5
  • Family With Sequence Similarity 219, Member B 2 3
  • C15orf17 3 4
  • Chromosome 15 Open Reading Frame 17 2
  • Uncharacterized Protein C15orf17 3

External Ids for FAM219B Gene

Previous HGNC Symbols for FAM219B Gene

  • C15orf17

Previous GeneCards Identifiers for FAM219B Gene

  • GC15M075193

Summaries for FAM219B Gene

GeneCards Summary for FAM219B Gene

FAM219B (Family With Sequence Similarity 219 Member B) is a Protein Coding gene. An important paralog of this gene is FAM219A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM219B Gene

Genomics for FAM219B Gene

Regulatory Elements for FAM219B Gene

Promoters for FAM219B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM219B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM219B Gene

74,899,987 bp from pter
74,907,307 bp from pter
7,321 bases
Minus strand

Genomic View for FAM219B Gene

Genes around FAM219B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM219B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM219B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM219B Gene

Proteins for FAM219B Gene

  • Protein details for FAM219B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM219B
    Protein Accession:
    Secondary Accessions:
    • A8K4Q5
    • B4DK57
    • Q9NXY0

    Protein attributes for FAM219B Gene

    198 amino acids
    Molecular mass:
    21103 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM219B Gene


neXtProt entry for FAM219B Gene

Proteomics data for FAM219B Gene at MOPED

Post-translational modifications for FAM219B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM219B Gene

Domains & Families for FAM219B Gene

Protein Domains for FAM219B Gene


Suggested Antigen Peptide Sequences for FAM219B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM219 family.
  • Belongs to the FAM219 family.
genes like me logo Genes that share domains with FAM219B: view

No data available for Gene Families for FAM219B Gene

Function for FAM219B Gene

Phenotypes for FAM219B Gene

genes like me logo Genes that share phenotypes with FAM219B: view

Animal Model Products

CRISPR Products

miRNA for FAM219B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM219B Gene

Localization for FAM219B Gene

Subcellular locations from

Jensen Localization Image for FAM219B Gene COMPARTMENTS Subcellular localization image for FAM219B gene
Compartment Confidence
nucleus 3
golgi apparatus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM219B Gene

Pathways & Interactions for FAM219B Gene

SuperPathways for FAM219B Gene

No Data Available

Interacting Proteins for FAM219B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q5XKK7-F219B_HUMAN ENSP00000350260 for FAM219B Gene via I2D STRING

Gene Ontology (GO) - Biological Process for FAM219B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM219B Gene

Drugs & Compounds for FAM219B Gene

No Compound Related Data Available

Transcripts for FAM219B Gene

Unigene Clusters for FAM219B Gene

Family with sequence similarity 219, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM219B Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h · 7i · 7j · 7k · 7l ^
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: -
SP4: - -
SP5: - - -
SP6: - - -
SP7: - - -
SP8: - - - - - - - - - -
SP9: -
SP10: - - - - -
SP11: - - - - -
SP12: -
SP13: - - -
SP14: - -
SP15: -
SP16: - - - - - -

ExUns: 8a · 8b · 8c ^ 9
SP1: - -

Relevant External Links for FAM219B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM219B Gene

mRNA expression in normal human tissues for FAM219B Gene

Protein differential expression in normal tissues from HIPED for FAM219B Gene

This gene is overexpressed in Liver (55.9), Monocytes (6.5), and Pancreatic juice (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM219B Gene

SOURCE GeneReport for Unigene cluster for FAM219B Gene Hs.367690

genes like me logo Genes that share expression patterns with FAM219B: view

Protein tissue co-expression partners for FAM219B Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM219B Gene

Orthologs for FAM219B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM219B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C21H15orf17 35
  • 88.31 (n)
  • 86.91 (a)
FAM219B 36
  • 87 (a)
(Canis familiaris)
Mammalia C30H15orf17 35
  • 89.95 (n)
  • 91.1 (a)
FAM219B 36
  • 32 (a)
(Mus musculus)
Mammalia Fam219b 35
  • 86.13 (n)
  • 83.76 (a)
Fam219b 16
Fam219b 36
  • 80 (a)
(Pan troglodytes)
Mammalia FAM219B 35
  • 92.15 (n)
  • 88.48 (a)
FAM219B 36
  • 86 (a)
(Rattus norvegicus)
Mammalia Fam219b 35
  • 81.63 (n)
  • 75.59 (a)
(Monodelphis domestica)
Mammalia FAM219B 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia FAM219B 36
  • 65 (a)
(Gallus gallus)
Aves FAM219B 35
  • 77.13 (n)
  • 75.21 (a)
(Anolis carolinensis)
Reptilia FAM219B 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam219b 35
  • 66.9 (n)
  • 70.83 (a)
Str.3563 35
(Danio rerio)
Actinopterygii fam219b 35
  • 60.58 (n)
  • 53.28 (a)
fam219b 36
  • 47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.170 36
  • 42 (a)
Species with no ortholog for FAM219B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM219B Gene

Gene Tree for FAM219B (if available)
Gene Tree for FAM219B (if available)

Paralogs for FAM219B Gene

Paralogs for FAM219B Gene

(2) SIMAP similar genes for FAM219B Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with FAM219B: view

Variants for FAM219B Gene

Sequence variations from dbSNP and Humsavar for FAM219B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1127796 -- 74,900,663(-) AGAAC(A/G)TCTCC intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1127797 -- 74,900,636(-) CCATC(G/T)GCAGA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1128350 -- 74,901,788(-) AGCCT(G/T)CAGTT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs3935818 -- 74,902,087(+) ACTCA(C/T)TTTAT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs4886635 -- 74,903,811(+) CCAGC(A/C)CTTCA intron-variant

Variation tolerance for FAM219B Gene

Residual Variation Intolerance Score: 74.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM219B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM219B Gene

Disorders for FAM219B Gene

Relevant External Links for FAM219B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM219B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM219B Gene

Publications for FAM219B Gene

  1. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for FAM219B Gene

Sources for FAM219B Gene

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