Aliases for FAM219A Gene
Aliases for FAM219A Gene
External Ids for FAM219A Gene
- HGNC: 19920
- Entrez Gene: 203259
- Ensembl: ENSG00000164970
- UniProtKB: Q8IW50
Previous HGNC Symbols for FAM219A Gene
- C9orf25
Summaries for FAM219A Gene
-
The protein encoded by this gene has homologs that have been identified in mouse, macaque, etc organisms. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Dec 2010]
GeneCards Summary for FAM219A Gene
FAM219A (Family With Sequence Similarity 219 Member A) is a Protein Coding gene. An important paralog of this gene is FAM219B.
Additional gene information for FAM219A Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM219A Gene
Genomics for FAM219A Gene
GeneHancer (GH) Regulatory Elements for FAM219A Gene
Promoters and enhancers for FAM219A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around FAM219A on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for FAM219A Gene
Genomic Locations for FAM219A Gene
- chr9:34,398,184-34,458,610
- (GRCh38/hg38)
- Size:
- 60,427 bases
- Orientation:
- Minus strand
- chr9:34,398,182-34,458,568
- (GRCh37/hg19)
Genomic View for FAM219A Gene
Genes around FAM219A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9p13.3 by Ensembl
- 9p13.3 by Entrez Gene
- 9p13.3 by HGNC
FAM219A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FAM219A Gene
Proteins for FAM219A Gene
-
Protein details for FAM219A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IW50-F219A_HUMAN
- Recommended name:
- Protein FAM219A
- Protein Accession:
- Q8IW50
- A2A364
- B4DFE1
- B4DSR8
- Q5T590
- Q5T591
- Q5T592
- Q5T594
- Q5T595
- Q8TAZ8
Protein attributes for FAM219A Gene
- Size:
- 185 amino acids
- Molecular mass:
- 20400 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=CAI13147.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI13149.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI13151.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI13152.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI13153.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15969.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15970.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15972.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15973.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15974.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for FAM219A Gene
Post-translational modifications for FAM219A Gene
No Post-translational modifications
Other Protein References for FAM219A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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Protein Products
-
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-
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Assay Products
No data available for DME Specific Peptides for FAM219A Gene
Domains & Families for FAM219A Gene
Gene Families for FAM219A Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Graphical View of Domain Structure for InterPro Entry
Q8IW50- Family:
-
- Belongs to the FAM219 family.
No data available for Suggested Antigen Peptide Sequences for FAM219A Gene
Function for FAM219A Gene
Phenotypes for FAM219A Gene
- GenomeRNAi human phenotypes for FAM219A:
Animal Model Products
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-
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CRISPR Products
-
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-
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-
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miRNA for FAM219A Gene
- miRTarBase miRNAs that target FAM219A
miRNA Products
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Inhibitory RNA Products
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Clone Products
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OriGene ORF clones in human for FAM219A
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available C9orf25 gene related products
- orf clones - Search results for available C9orf25 gene related products
- Applied Biological Materials Clones for FAM219A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for FAM219A
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM219A Gene
Localization for FAM219A Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| cytosol | 2 |
| golgi apparatus | 2 |
| extracellular | 1 |
- Golgi apparatus (3)
- Nucleoplasm (3)
- Vesicles (3)
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM219A Gene
Pathways & Interactions for FAM219A Gene
No Data Available
Interacting Proteins for FAM219A Gene
Selected Interacting proteins:
Q8IW50-F219A_HUMAN
ENSP00000392452
for FAM219A Gene via
MINT
STRING
IID
No data available for Pathways by source and SIGNOR curated interactions for FAM219A Gene
Transcripts for FAM219A Gene
mRNA/cDNA for FAM219A Gene
- (11) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (198) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FAM219A Gene
- Family with sequence similarity 219, member A:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for FAM219A
- genomics-online: gRNA clones - Search results for available C9orf25 gene related products
- Applied Biological Materials CRISPR for FAM219A
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM219A
- GenScript: Design CRISPR guide RNA sequences for FAM219A
miRNA Products
- Search ViGene Biosciences for FAM219A
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for FAM219A
- Browse OriGene Inhibitory RNA Products For FAM219A
- genomics-online: shRNA clones - Search results for available C9orf25 gene related products
Clone Products
-
OriGene ORF clones in human for FAM219A
- RG215183
- RC215183L2
- RC215183L1
- RC215183
- RG229602
- RC229602L2
- RC229602L1
- RC229602
- RG229624
- RC229624L2
- RC229624L1
- RC229624
- RG229635
- RC229635L2
- RC229635L1
- RC229635
- RG229643
- RC229643L2
- RC229643L1
- RC229643
- RG229646
- RC229646L2
- RC229646L1
- RC229646
- RC215183L2V
- RC215183L1V
- RC229602L2V
- RC229602L1V
- RC229624L2V
- RC229624L1V
- RC229635L2V
- RC229635L1V
- RC229643L2V
- RC229643L1V
- RC229646L2V
- RC229646L1V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FAM219A
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for FAM219A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FAM219A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available C9orf25 gene related products
- orf clones - Search results for available C9orf25 gene related products
- Applied Biological Materials Clones for FAM219A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||
| SP6: | - |
Expression for FAM219A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Ureteric Bud Cells Ureteric Bud
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM219A Gene
NURSA nuclear receptor signaling pathways regulating expression of FAM219A Gene:
FAM219ASOURCE GeneReport for Unigene cluster for FAM219A Gene:
Hs.493771Evidence on tissue expression from TISSUES for FAM219A Gene
- Nervous system(3.9)
Primer Products
-
OriGene qPCR primer pairs for FAM219A
-
OriGene qPCR primer pairs and template standards for FAM219A
- genomics-online: primer clones - Search results for available C9orf25 gene related products
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM219A Gene
Orthologs for FAM219A Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FAM219A 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FAM219A 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | FAM219A 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | FAM219A 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fam219a 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fam219a 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FAM219A 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FAM219A 34 |
|
OneToOne | |
| CZH9ORF25 33 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | FAM219A 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100485411 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fam219ab 34 |
|
OneToMany | |
| fam219aa 33 34 |
|
||||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.170 34 |
|
OneToMany |
- Species where no ortholog for FAM219A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FAM219A Gene
(1) SIMAP similar genes for FAM219A Gene using alignment to 3 proteins:
Variants for FAM219A Gene
| SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs11547035 | benign, likely-benign, not specified, Primary ciliary dyskinesia | 34,459,027(-) | G/C/T | upstream_transcript_variant | |
| rs148701985 | uncertain-significance, likely-benign, not specified, Primary ciliary dyskinesia | 34,459,052(-) | A/G | upstream_transcript_variant | |
| rs180838420 | uncertain-significance, Primary ciliary dyskinesia | 34,458,826(-) | G/A | upstream_transcript_variant | |
| rs200245894 | uncertain-significance, Primary ciliary dyskinesia | 34,458,965(-) | T/C | upstream_transcript_variant | |
| rs3802429 | likely-benign, Primary ciliary dyskinesia | 34,458,828(-) | G/C | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3620335 | CNV | gain | 21293372 |
| esv6052 | CNV | gain | 19470904 |
| nsv1015595 | CNV | gain | 25217958 |
| nsv1016251 | CNV | gain | 25217958 |
| nsv1028418 | CNV | gain | 25217958 |
| nsv1115170 | CNV | deletion | 24896259 |
| nsv1125318 | OTHER | inversion | 24896259 |
| nsv831542 | CNV | gain | 17160897 |
| nsv831543 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.04;
0.82% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FAM219A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FAM219A
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM219A Gene
Disorders for FAM219A Gene
Additional Disease Information for FAM219A
No disorders were found for FAM219A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM219A Gene
Publications for FAM219A Gene
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 2 3 58
Products for FAM219A Gene
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- Invitrogen Antibodies for FAM219A
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- VectorBuilder custom plasmid, inducible vectors for FAM219A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FAM219A
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 26 available C9orf25 Antibodies ranked by validation data
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- antibodies-online: Search results for available C9orf25 related products ranked by validation data
- antibodies-online: Search results for 3 available C9orf25 Proteins ranked by validation data
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- Quality Products:
- GeneTex FAM219A antibody for FAM219A
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- genomics-online: cdna clones - Search results for available C9orf25 gene related products
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- genomics-online: gRNA clones - Search results for available C9orf25 gene related products
- genomics-online: primer clones - Search results for available C9orf25 gene related products
- genomics-online: shRNA clones - Search results for available C9orf25 gene related products
Sources for FAM219A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
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