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Aliases for FAM219A Gene

Aliases for FAM219A Gene

  • Family With Sequence Similarity 219 Member A 2 3 5
  • C9orf25 3 4
  • Family With Sequence Similarity 219, Member A 2
  • Chromosome 9 Open Reading Frame 25 2
  • Uncharacterized Protein C9orf25 3
  • Protein FAM219A 3

External Ids for FAM219A Gene

Previous HGNC Symbols for FAM219A Gene

  • C9orf25

Summaries for FAM219A Gene

Entrez Gene Summary for FAM219A Gene

  • The protein encoded by this gene has homologs that have been identified in mouse, macaque, etc organisms. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for FAM219A Gene

FAM219A (Family With Sequence Similarity 219 Member A) is a Protein Coding gene. An important paralog of this gene is FAM219B.

Additional gene information for FAM219A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM219A Gene

Genomics for FAM219A Gene

GeneHancer (GH) Regulatory Elements for FAM219A Gene

Promoters and enhancers for FAM219A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I034456 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 556.5 +0.9 851 2.9 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 ZNF143 SP3 ZHX2 MXD4 FAM219A DNAI1 FANCG NUDT2
GH09I034459 Enhancer 0.6 ENCODE 550.8 -0.7 -671 0 HDAC1 ZSCAN26 BCL11B ZNF335 ZNF366 BCL11A IKZF1 NR2C1 NR2F6 NR2C2 DNAI1 FAM219A RN7SKP24
GH09I034575 Enhancer 0.8 FANTOM5 ENCODE 14.1 -119.6 -119618 5.1 ZFHX2 POLR2A ZNF366 ZNF341 REST EZH2 EGR2 GC09P034579 GC09P034580 GALT RPP25L ENSG00000230074 ENHO FAM219A ENSG00000232983 ARID3C CNTFR
GH09I034500 Enhancer 0.7 ENCODE 15.3 -42.2 -42238 0.2 CTCF ZNF654 ARID4B JUNB TRIM22 REST BATF ZNF2 IRF4 RAD21 FAM219A ENSG00000230729 ENHO DNAI1 ARID3C GALT SIGMAR1 PIR54959 RN7SKP24
GH09I034341 Enhancer 1 Ensembl ENCODE dbSUPER 10.1 +114.8 114784 5 FOXA2 NFIA RXRA ZIC2 YY1 OSR2 JUND ATF3 HNF4A SMAD4 NUDT2 MYORG C9orf24 RNU2-50P FAM219A DNAI1 IMPDH1P1 DCAF12 ENSG00000230729 RPP25L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM219A on UCSC Golden Path with GeneCards custom track

Genomic Locations for FAM219A Gene

Genomic Locations for FAM219A Gene
60,427 bases
Minus strand

Genomic View for FAM219A Gene

Genes around FAM219A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM219A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM219A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM219A Gene

Proteins for FAM219A Gene

  • Protein details for FAM219A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM219A
    Protein Accession:
    Secondary Accessions:
    • A2A364
    • B4DFE1
    • B4DSR8
    • Q5T590
    • Q5T591
    • Q5T592
    • Q5T594
    • Q5T595
    • Q8TAZ8

    Protein attributes for FAM219A Gene

    185 amino acids
    Molecular mass:
    20400 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI13147.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI13149.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI13151.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI13152.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI13153.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15969.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15970.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15972.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15973.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15974.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM219A Gene

neXtProt entry for FAM219A Gene

Post-translational modifications for FAM219A Gene

No Post-translational modifications

No data available for DME Specific Peptides for FAM219A Gene

Domains & Families for FAM219A Gene

Gene Families for FAM219A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM219A Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM219 family.
  • Belongs to the FAM219 family.
genes like me logo Genes that share domains with FAM219A: view

No data available for Suggested Antigen Peptide Sequences for FAM219A Gene

Function for FAM219A Gene

genes like me logo Genes that share phenotypes with FAM219A: view

Animal Model Products

CRISPR Products

miRNA for FAM219A Gene

miRTarBase miRNAs that target FAM219A

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM219A Gene

Localization for FAM219A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM219A gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Nucleoplasm (3)
  • Vesicles (3)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM219A Gene

Pathways & Interactions for FAM219A Gene

SuperPathways for FAM219A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM219A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM219A Gene

Drugs & Compounds for FAM219A Gene

No Compound Related Data Available

Transcripts for FAM219A Gene

Unigene Clusters for FAM219A Gene

Family with sequence similarity 219, member A:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM219A Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: -
SP6: -

Relevant External Links for FAM219A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM219A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM219A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM219A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM219A Gene:


SOURCE GeneReport for Unigene cluster for FAM219A Gene:


Evidence on tissue expression from TISSUES for FAM219A Gene

  • Nervous system(3.9)
genes like me logo Genes that share expression patterns with FAM219A: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM219A Gene

Orthologs for FAM219A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM219A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM219A 33 34
  • 99.46 (n)
(Monodelphis domestica)
Mammalia FAM219A 34
  • 98 (a)
(Bos Taurus)
Mammalia FAM219A 33 34
  • 97.12 (n)
(Canis familiaris)
Mammalia FAM219A 33 34
  • 96.4 (n)
(Mus musculus)
Mammalia Fam219a 33 16 34
  • 93.85 (n)
(Rattus norvegicus)
Mammalia Fam219a 33
  • 92.57 (n)
(Ornithorhynchus anatinus)
Mammalia FAM219A 34
  • 78 (a)
(Gallus gallus)
Aves FAM219A 34
  • 99 (a)
CZH9ORF25 33
  • 84.86 (n)
(Anolis carolinensis)
Reptilia FAM219A 34
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485411 33
  • 84.85 (n)
(Danio rerio)
Actinopterygii fam219ab 34
  • 83 (a)
fam219aa 33 34
  • 77.66 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.170 34
  • 44 (a)
Species where no ortholog for FAM219A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM219A Gene

Gene Tree for FAM219A (if available)
Gene Tree for FAM219A (if available)

Paralogs for FAM219A Gene

Paralogs for FAM219A Gene

(1) SIMAP similar genes for FAM219A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FAM219A: view

Variants for FAM219A Gene

Sequence variations from dbSNP and Humsavar for FAM219A Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs11547035 benign, likely-benign, not specified, Primary ciliary dyskinesia 34,459,027(-) G/C/T upstream_transcript_variant
rs148701985 uncertain-significance, likely-benign, not specified, Primary ciliary dyskinesia 34,459,052(-) A/G upstream_transcript_variant
rs180838420 uncertain-significance, Primary ciliary dyskinesia 34,458,826(-) G/A upstream_transcript_variant
rs200245894 uncertain-significance, Primary ciliary dyskinesia 34,458,965(-) T/C upstream_transcript_variant
rs3802429 likely-benign, Primary ciliary dyskinesia 34,458,828(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM219A Gene

Variant ID Type Subtype PubMed ID
esv3620335 CNV gain 21293372
esv6052 CNV gain 19470904
nsv1015595 CNV gain 25217958
nsv1016251 CNV gain 25217958
nsv1028418 CNV gain 25217958
nsv1115170 CNV deletion 24896259
nsv1125318 OTHER inversion 24896259
nsv831542 CNV gain 17160897
nsv831543 CNV loss 17160897

Variation tolerance for FAM219A Gene

Residual Variation Intolerance Score: 47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM219A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM219A Gene

Disorders for FAM219A Gene

Additional Disease Information for FAM219A

No disorders were found for FAM219A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM219A Gene

Publications for FAM219A Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 2 3 58

Products for FAM219A Gene

Sources for FAM219A Gene

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