FAM219A Gene
protein-coding GIFtS: 39
GCID: GC09M034400
|
|
Family With Sequence Similarity 219, Member A(Previous name: chromosome 9 open reading frame 25)
(Previous symbol: C9orf25)
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Aliases
for FAM219A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
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| Aliases |
|---|
| Family With Sequence Similarity 219, Member A1 2 | | C9orf251 2 3 | | Chromosome 9 Open Reading Frame 251 | | bA573M23.52 | | Protein FAM219A2 | | Uncharacterized Protein C9orf252 |
Export aliases for FAM219A gene to outside databases |
Summaries
for FAM219A gene(According to Entrez Gene,
GeneCards,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
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Entrez Gene summary for FAM219A Gene:
The protein encoded by this gene has homologs that have been identified in mouse, macaque, etc organisms. Multiple
alternatively spliced transcript variants that encode different protein isoforms have been described for this
gene. (provided by RefSeq, Dec 2010)
GeneCards Summary for FAM219A Gene:
FAM219A (family with sequence similarity 219, member A) is a protein-coding gene. An important paralog of this gene is FAM219B.
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Genomic Views
for FAM219A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 75),
Regulatory elements and Epigenetics data according to
QIAGEN, and/or
SwitchGear Genomics)
About This Section
TryGeneCards Plus | RefSeq DNA sequence:- NC_000009.12 NT_008413.19 NC_018920.2
Regulatory elements:
 Search for regulatory transcription factor binding sites for FAM219A
Other transcription factors
Search Chromatin IP Primers for FAM219A
Epigenetics:
| | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM219A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p13.3 Ensembl cytogenetic band: 9p13.3 HGNC cytogenetic band: 9p11.2FAM219A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M034400: view genomic region
(about GC identifiers)
Start:
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34,398,182 bp from pter |
End:
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34,458,568 bp from pter |
Size:
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60,387 bases |
Orientation:
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minus strand |
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Proteins
for FAM219A gene
(According to
1UniProtKB,
HORDE,
2neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Antibodies by
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: F219A_HUMAN, Q8IW50 (See
protein sequence)Recommended Name: Protein FAM219A Size: 185 amino acids; 20400 Da
Sequence caution: Sequence=CAI13147.1; Type=Erroneous initiation; Sequence=CAI13149.1; Type=Erroneous initiation;
Sequence=CAI13151.1; Type=Erroneous initiation; Sequence=CAI13152.1; Type=Erroneous initiation;
Sequence=CAI13153.1; Type=Erroneous initiation; Sequence=CAI15969.1; Type=Erroneous initiation;
Sequence=CAI15970.1; Type=Erroneous initiation; Sequence=CAI15972.1; Type=Erroneous initiation;
Sequence=CAI15973.1; Type=Erroneous initiation; Sequence=CAI15974.1; Type=Erroneous initiation;
Secondary accessions: A2A364 B4DFE1 B4DSR8 Q5T590 Q5T591 Q5T592 Q5T594 Q5T595 Q8TAZ8Alternative splicing: 7 isoforms: Q8IW50-1 Q8IW50-2 Q8IW50-3 Q8IW50-4 Q8IW50-5 Q8IW50-6 Q8IW50-7 Explore the universe of human proteins at neXtProt for FAM219A: NX_Q8IW50
Explore proteomics data for FAM219A at MOPED
Post-translational modifications:  Modification sites at neXtProt Modification sites at PhosphoSitePlus
See FAM219A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB
REFSEQ proteins (6 alternative transcripts):
NP_001171869.1 NP_001171870.1 NP_001171871.1 NP_001171872.1 NP_001171874.1 NP_671735.1
ENSEMBL proteins: ENSP00000368382 ENSP00000368380 ENSP00000368377 ENSP00000368372 ENSP00000368371 ENSP00000297620 ENSP00000409737 ENSP00000368369 ENSP00000392452
FAM219A Human Recombinant
Protein Products:FAM219A Antibody
Products:FAM219A Assay Products: |
Domains /
Families
for FAM219A gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
TryGeneCards Plus | ProtoNet protein and cluster: Q8IW50 UniProtKB/Swiss-Prot: F219A_HUMAN, Q8IW50Similarity: Belongs to the FAM219 family |
Function
for FAM219A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
transcription factor targeting from QIAGEN
and/or HOMER,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
SwitchGear Genomics,
Gene Editing from DNA2.0,
Clones from OriGene,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
ESI BIO,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Phenotypes:
2 GenomeRNAi human phenotypes for FAM219A:
Animal Models:
Inhib. RNA
Products: |  | OriGene RNAi products in human, mouse, rat for FAM219A
| | | Predesigned siRNA for gene silencing in human, mouse, rat FAM219A |
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for FAM219A | |  | Browse ESI BIO Cell Lines and PureStem Progenitors for FAM219A  | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM219A |
Localization
for FAM219A gene
(According to UniProtKB, COMPARTMENTS Subcellular localization database,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Pathways & Interactions
for FAM219A gene
(SuperPaths according to PathCards,
Pathways according to
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
QIAGEN,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene).
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Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM219A
Interactions:
Search GeneGlobe Interaction Network for FAM219A
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
Selected Interacting proteins for FAM219A (Q8IW502, 3 ENSP000002976204) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
|
Drugs & Compounds
for FAM219A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience,
ApexBio,
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB)
About This Section
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 Browse compounds at ApexBio
 Browse Tocris compounds for FAM219A (F219A)
|
Transcripts
for FAM219A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
SwitchGear Genomics,
Tagged/untagged cDNA clones from
OriGene,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene, and/or
QIAGEN
)
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REFSEQ mRNAs for FAM219A gene (7 alternative transcripts): NM_001184944.1 NM_001184940.1 NM_001184941.1 NM_001184942.1 NM_001184943.1 NM_001184945.1 NM_147202.1 Unigene Cluster for FAM219A: Family with sequence similarity 219, member A Hs.493771 [show with all ESTs]Unigene Representative Sequence: NM_0011849409 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000379089 ENST00000379087 ENST00000379084 ENST00000379081 ENST00000379080
ENST00000297620 ENST00000422409 ENST00000379078 ENST00000445726(uc011lok.2 uc003zuj.3 uc011lol.2 uc003zul.3 uc022bgc.1 uc022bgd.1 uc003zuk.3)
Inhib. RNA
Products: | | OriGene RNAi products in human, mouse, rat for FAM219A
| |
| | Predesigned siRNA for gene silencing in human, mouse, rat FAM219A |
Additional mRNA sequence: AF131828.1 AK022819.1 AK026087.1 AK091262.1 AK096350.1 AK123887.1 AK294054.1 AK299882.1 AL833397.1 BC015785.1 BC025348.1 BC041009.2 10 DOTS entries: DT.92441080 DT.456056 DT.100661324 DT.100782388 DT.40315883 DT.95082218 DT.75101050 DT.92441082 DT.86850074 DT.92001729 Selected AceView cDNA sequences (see all 198): AF131828 BE901362 T34426 BC015785 BF195182 BM709936 AI825909 BE890487 AI738439 AA349745 CD366413 AI140363 Z40557 NM_147202 AK026087 AI304836 AI696157 BQ888269 AK096350 BG982512 BQ052935 CD366572 AL833397 AI423243
GeneLoc Exon Structure
Selected Alternative Splicing Database (ASD) splice patterns (SP) for FAM219A (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c |
|---|
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| SP1: | | | - | | | | | | - | | - | | | | | | - | | | | | | | | | | |
| SP2: | | | - | | | | | | - | | - | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FAM219A
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Expression
for FAM219A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MaxQB,
plus additional links to
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
QIAGEN,
Primers from
OriGene, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FAM219A expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGCCGTGTAT
About this image
FAM219A expression in embryonic tissues and stem cells About this table
 Data from LifeMap,
the Embryonic Development and Stem Cells Database
FAM219A Protein expression data from MOPED1, PaxDb2 and
MaxQB3: About this image
SOURCE GeneReport for Unigene cluster: Hs.493771
Custom PCR Arrays for FAM219A
Primer
Products: | | OriGene qPCR primer pairs and template standards for FAM219A
OriGene qSTAR qPCR primer pairs in human, mouse for FAM219A
| | | Search Pre-validated RT2 qPCR
Primer Assays in human, mouse, rat FAM219A | | | QuantiTect SYBR Green Assays in human, mouse, rat FAM219A | | | QuantiFast Probe-based Assays in human, mouse, rat FAM219A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM219A |
Orthologs
for FAM219A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
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This gene was present in the common ancestor of chordates.
Orthologs for FAM219A gene from Selected species (see all 12) About this table
ENSEMBL Gene Tree for FAM219A (if available)
TreeFam Gene Tree for FAM219A (if available) |
Paralogs
for FAM219A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
TryGeneCards Plus | Paralogs for FAM219A gene
- FAM219B2
1 SIMAP similar gene for FAM219A using alignment to 3 protein entries: F219A_HUMAN (see all proteins):FAM219B
FAM219A for paralogs About GeneDecksing
|
Genomic Variants
for FAM219A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD), the Human Cytochrome P450 Allele
Nomenclature Database, and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM219A (34398182 - 34458568 bp)
Structural Variations
Database of Genomic Variants (DGV) variations for FAM219A: --
| | Site Specific Mutation Identification with PCR Assays |
| | SeqTarget long-range PCR primers for resequencing FAM219A |
|
Disorders
/ Diseases
for FAM219A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
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Publications
for FAM219A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for FAM219A gene, integrated from 10 sources (see all 18):
(articles sorted by number of sources associating them with FAM219A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
- Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (Genome Res. 1997)
- A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (Anal. Biochem. 1996)
- Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
- N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
- A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
|
External Searches for FAM219A gene (in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing FAM219A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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|
Other Databases showing FAM219A gene
(According to HUGE)
About This Section
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Specialized Databases showing FAM219A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for FAM219A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
TryGeneCards Plus | Patent Information for FAM219A gene:
Search GeneIP for patents involving FAM219A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM219A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or
ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
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 | |
 |
| | | | |
 |
 |
|  | Block miRNA regulation of human, mouse, rat FAM219A using miScript Target Protectors | | SeqTarget long-range PCR primers for resequencing FAM219A | | | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM219A | | Predesigned siRNA for gene silencing in human, mouse, rat FAM219A | | | QuantiFast Probe-based Assays in human, mouse, rat FAM219A | | QuantiTect SYBR Green Assays in human, mouse, rat FAM219A | | | Custom PCR Arrays for FAM219A | | Search Chromatin IP Primers for FAM219A | | | Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat FAM219A | | Search GeneGlobe Interaction Network for FAM219A | | | Search Regulatory tfbs for FAM219A |
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 |  | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM219A |
| |  |  |  |  | | | ThermoFisher Antibodies for FAM219A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM219A |
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