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Aliases for FAM219A Gene

Aliases for FAM219A Gene

  • Family With Sequence Similarity 219 Member A 2 3 5
  • C9orf25 3 4
  • Family With Sequence Similarity 219, Member A 2
  • Chromosome 9 Open Reading Frame 25 2
  • Uncharacterized Protein C9orf25 3
  • Protein FAM219A 3

External Ids for FAM219A Gene

Previous HGNC Symbols for FAM219A Gene

  • C9orf25

Summaries for FAM219A Gene

Entrez Gene Summary for FAM219A Gene

  • The protein encoded by this gene has homologs that have been identified in mouse, macaque, etc organisms. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for FAM219A Gene

FAM219A (Family With Sequence Similarity 219 Member A) is a Protein Coding gene. An important paralog of this gene is FAM219B.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM219A Gene

Genomics for FAM219A Gene

Regulatory Elements for FAM219A Gene

Enhancers for FAM219A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G034575 1 FANTOM5 ENCODE 14.1 -119.6 -119618 5.1 ZNF263 CTCF RNF2 SUZ12 CBX2 RBBP5 REST JUND ZFHX2 POLR2A GALT RPP25L ENSG00000230074 ENHO FAM219A ENSG00000232983 ARID3C CNTFR ENSG00000230729 SIGMAR1
GH09G034341 1.2 Ensembl ENCODE dbSUPER 10.1 +114.8 114784 5.0 NFIA CEBPG ZIC2 NR2F2 YY1 OSR2 JUND ATF3 HNF4A SMAD4 NUDT2 KIAA1161 C9orf24 RNU2-50P DNAI1 FAM219A IMPDH1P1 DCAF12 ENSG00000230729 RPP25L
GH09G034363 1.1 Ensembl ENCODE dbSUPER 10.5 +94.3 94268 2.6 ZSCAN4 FOXP2 RBBP5 HNF4A ZIC2 ZNF48 TRIM28 FAM219A DNAI1 RPP25L ENSG00000230729 ENSG00000228352 UBAP1 KIF24 KIAA1161
GH09G034500 0.7 ENCODE 15.3 -42.2 -42238 0.2 CTCF ZNF654 WRNIP1 ARID4B TRIM22 JUNB REST ZNF2 RAD21 ZNF143 FAM219A ENSG00000230729 ENHO DNAI1 ARID3C SIGMAR1 GALT PIR54959 RN7SKP24
GH09G034501 0.6 ENCODE 17 -43.5 -43547 0.6 CTCF KLF1 NFIA MIER2 RAD21 ZFHX2 SMC3 HNRNPL EGR2 FAM219A ENSG00000232983 CNTFR-AS1 DNAI1 RPP25L ARID3C SIGMAR1 GALT PIR54959 RN7SKP24
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM219A on UCSC Golden Path with GeneCards custom track

Promoters for FAM219A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000234532 410 1601 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 ZNF143 FOS ZNF263 SP3

Genomic Location for FAM219A Gene

Chromosome:
9
Start:
34,398,184 bp from pter
End:
34,458,610 bp from pter
Size:
60,427 bases
Orientation:
Minus strand

Genomic View for FAM219A Gene

Genes around FAM219A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM219A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM219A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM219A Gene

Proteins for FAM219A Gene

  • Protein details for FAM219A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IW50-F219A_HUMAN
    Recommended name:
    Protein FAM219A
    Protein Accession:
    Q8IW50
    Secondary Accessions:
    • A2A364
    • B4DFE1
    • B4DSR8
    • Q5T590
    • Q5T591
    • Q5T592
    • Q5T594
    • Q5T595
    • Q8TAZ8

    Protein attributes for FAM219A Gene

    Size:
    185 amino acids
    Molecular mass:
    20400 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI13147.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI13149.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI13151.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI13152.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI13153.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15969.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15970.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15972.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15973.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15974.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM219A Gene

neXtProt entry for FAM219A Gene

Post-translational modifications for FAM219A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM219A Gene

Domains & Families for FAM219A Gene

Protein Domains for FAM219A Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8IW50

UniProtKB/Swiss-Prot:

F219A_HUMAN :
  • Belongs to the FAM219 family.
Family:
  • Belongs to the FAM219 family.
genes like me logo Genes that share domains with FAM219A: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for FAM219A Gene

Function for FAM219A Gene

genes like me logo Genes that share phenotypes with FAM219A: view

Animal Model Products

CRISPR Products

miRNA for FAM219A Gene

miRTarBase miRNAs that target FAM219A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM219A Gene

Localization for FAM219A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM219A gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM219A Gene

Pathways & Interactions for FAM219A Gene

SuperPathways for FAM219A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM219A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM219A Gene

Drugs & Compounds for FAM219A Gene

No Compound Related Data Available

Transcripts for FAM219A Gene

Unigene Clusters for FAM219A Gene

Family with sequence similarity 219, member A:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM219A Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: -
SP6: -

Relevant External Links for FAM219A Gene

GeneLoc Exon Structure for
FAM219A
ECgene alternative splicing isoforms for
FAM219A

Expression for FAM219A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM219A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM219A Gene



NURSA nuclear receptor signaling pathways regulating expression of FAM219A Gene:

FAM219A

SOURCE GeneReport for Unigene cluster for FAM219A Gene:

Hs.493771

Evidence on tissue expression from TISSUES for FAM219A Gene

  • Nervous system(3.9)
genes like me logo Genes that share expression patterns with FAM219A: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM219A Gene

Orthologs for FAM219A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM219A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM219A 34 35
  • 99.46 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM219A 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM219A 34 35
  • 97.12 (n)
dog
(Canis familiaris)
Mammalia FAM219A 34 35
  • 96.4 (n)
mouse
(Mus musculus)
Mammalia Fam219a 34 16 35
  • 93.85 (n)
rat
(Rattus norvegicus)
Mammalia Fam219a 34
  • 92.57 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM219A 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM219A 35
  • 99 (a)
OneToOne
CZH9ORF25 34
  • 84.86 (n)
lizard
(Anolis carolinensis)
Reptilia FAM219A 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485411 34
  • 84.85 (n)
zebrafish
(Danio rerio)
Actinopterygii fam219ab 35
  • 83 (a)
OneToMany
fam219aa 34 35
  • 77.66 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.170 35
  • 44 (a)
OneToMany
Species where no ortholog for FAM219A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM219A Gene

ENSEMBL:
Gene Tree for FAM219A (if available)
TreeFam:
Gene Tree for FAM219A (if available)

Paralogs for FAM219A Gene

Paralogs for FAM219A Gene

(1) SIMAP similar genes for FAM219A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FAM219A: view

Variants for FAM219A Gene

Sequence variations from dbSNP and Humsavar for FAM219A Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs397515363 Pathogenic 34,459,055(+) CAGGT(-/T)AACGT upstream-variant-2KB, splice-donor-variant
rs11547035 Likely benign 34,459,027(+) CGAAG(C/G/T)CTCCC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs3802429 Likely benign 34,458,828(-) CAACT(C/G)CCTGA nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs148701985 Uncertain significance 34,459,052(+) TAAGC(A/G)GGTAA nc-transcript-variant, upstream-variant-2KB, reference, missense
rs180838420 Uncertain significance 34,458,826(+) CGTCA(A/G)GGAGT nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM219A Gene

Variant ID Type Subtype PubMed ID
esv3620335 CNV gain 21293372
esv6052 CNV gain 19470904
nsv1015595 CNV gain 25217958
nsv1016251 CNV gain 25217958
nsv1028418 CNV gain 25217958
nsv1115170 CNV deletion 24896259
nsv1125318 OTHER inversion 24896259
nsv831542 CNV gain 17160897
nsv831543 CNV loss 17160897

Variation tolerance for FAM219A Gene

Residual Variation Intolerance Score: 47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM219A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM219A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM219A Gene

Disorders for FAM219A Gene

Relevant External Links for FAM219A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM219A

No disorders were found for FAM219A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM219A Gene

Publications for FAM219A Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3 64

Products for FAM219A Gene

Sources for FAM219A Gene

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