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Aliases for FAM218A Gene

Aliases for FAM218A Gene

  • Family With Sequence Similarity 218 Member A 2 3 5
  • C4orf39 3 4
  • Family With Sequence Similarity 218, Member A 2
  • Chromosome 4 Open Reading Frame 39 2
  • Uncharacterized Protein C4orf39 3
  • Protein FAM218A 3

External Ids for FAM218A Gene

Previous HGNC Symbols for FAM218A Gene

  • C4orf39

Previous GeneCards Identifiers for FAM218A Gene

  • GC04P165879

Summaries for FAM218A Gene

GeneCards Summary for FAM218A Gene

FAM218A (Family With Sequence Similarity 218 Member A) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM218A Gene

Genomics for FAM218A Gene

Regulatory Elements for FAM218A Gene

Enhancers for FAM218A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G164760 0.6 ENCODE 14.8 -195.8 -195777 2.2 ZFP64 ZNF426 ZNF394 ZNF781 ZNF518A ZNF697 ZNF555 ZNF34 PRDM12 LINC01207 FAM218A NACA3P RNU6-668P GC04P164788
GH04G165439 1.5 FANTOM5 Ensembl ENCODE 2.8 +483.4 483435 1.6 PKNOX1 NFIB ZSCAN4 INSM2 ZNF76 KLF17 FEZF1 ZNF2 ZEB1 RFX5 MIR578 HADHAP1 CPE FAM218A GC04M165414 GC04P165491
GH04G164961 0.3 FANTOM5 7.4 +4.4 4364 0.3 FAM218A CPE ENSG00000248632
GH04G164956 1.2 Ensembl ENCODE 0.7 +1.6 1612 4.1 FOXA2 ATF1 CREB3L1 SIN3A ZNF76 ZBTB40 GLIS2 ZNF366 ZNF143 KLF7 TRIM60P14 ENSG00000248632 LOC391713 FAM218A
GH04G165410 0.3 FANTOM5 1.4 +453.4 453398 0.2 MSMO1 CPE FAM218A HADHAP1 GC04M165414
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM218A on UCSC Golden Path with GeneCards custom track

Promoters for FAM218A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000175725 153 1399 FOXA2 CREB3L1 SIN3A ZNF76 ZBTB40 GLIS2 ZNF366 ZNF143 KLF7 CREM

Genomic Location for FAM218A Gene

Chromosome:
4
Start:
164,956,948 bp from pter
End:
164,959,122 bp from pter
Size:
2,175 bases
Orientation:
Plus strand

Genomic View for FAM218A Gene

Genes around FAM218A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM218A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM218A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM218A Gene

Proteins for FAM218A Gene

  • Protein details for FAM218A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MZ4-F218A_HUMAN
    Recommended name:
    Protein FAM218A
    Protein Accession:
    Q96MZ4

    Protein attributes for FAM218A Gene

    Size:
    157 amino acids
    Molecular mass:
    17021 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM218A Gene

Post-translational modifications for FAM218A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM218A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM218A Gene

Domains & Families for FAM218A Gene

Protein Domains for FAM218A Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FAM218A: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for FAM218A Gene

Function for FAM218A Gene

Gene Ontology (GO) - Molecular Function for FAM218A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM218A: view

Phenotypes for FAM218A Gene

GenomeRNAi human phenotypes for FAM218A:
genes like me logo Genes that share phenotypes with FAM218A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM218A Gene

Localization for FAM218A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM218A gene
Compartment Confidence
nucleus 2
extracellular 1
mitochondrion 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM218A Gene

Pathways & Interactions for FAM218A Gene

SuperPathways for FAM218A Gene

No Data Available

Interacting Proteins for FAM218A Gene

Selected Interacting proteins: Q96MZ4-F218A_HUMAN for FAM218A Gene via IID UniProtKB

Symbol External ID(s) Details
PSMA3

Gene Ontology (GO) - Biological Process for FAM218A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM218A Gene

Drugs & Compounds for FAM218A Gene

No Compound Related Data Available

Transcripts for FAM218A Gene

mRNA/cDNA for FAM218A Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM218A Gene

Family with sequence similarity 218, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM218A Gene

No ASD Table

Relevant External Links for FAM218A Gene

GeneLoc Exon Structure for
FAM218A
ECgene alternative splicing isoforms for
FAM218A

Expression for FAM218A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM218A Gene

Protein differential expression in normal tissues from HIPED for FAM218A Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM218A Gene



Protein tissue co-expression partners for FAM218A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM218A Gene:

FAM218A

SOURCE GeneReport for Unigene cluster for FAM218A Gene:

Hs.178648
genes like me logo Genes that share expression patterns with FAM218A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM218A Gene

Orthologs for FAM218A Gene

Evolution for FAM218A Gene

ENSEMBL:
Gene Tree for FAM218A (if available)
TreeFam:
Gene Tree for FAM218A (if available)

No data available for Orthologs for FAM218A Gene

Paralogs for FAM218A Gene

Pseudogenes.org Pseudogenes for FAM218A Gene

genes like me logo Genes that share paralogs with FAM218A: view

No data available for Paralogs for FAM218A Gene

Variants for FAM218A Gene

Sequence variations from dbSNP and Humsavar for FAM218A Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000132797 -- 164,955,558(+) AGAGA(C/G)ATTCA intron-variant, upstream-variant-2KB
rs10001548 -- 164,958,229(+) AGCTA(C/T)AGAAA intron-variant, utr-variant-3-prime
rs1000256225 -- 164,955,829(+) TTAAA(C/T)TAATT intron-variant, upstream-variant-2KB
rs1000776480 -- 164,955,223(+) TGTAT(A/G)ACAAT intron-variant, upstream-variant-2KB
rs1002176141 -- 164,958,214(+) CATGC(G/T)TTAGT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM218A Gene

Variant ID Type Subtype PubMed ID
esv21636 CNV gain 19812545
esv2421831 CNV duplication 20811451
esv2759299 CNV gain 17122850
esv2760876 CNV gain 21179565
esv3603011 CNV gain 21293372
nsv1019150 CNV gain 25217958
nsv10607 CNV gain 18304495
nsv517554 CNV loss 19592680
nsv528686 CNV gain 19592680
nsv830140 CNV loss 17160897

Variation tolerance for FAM218A Gene

Residual Variation Intolerance Score: 74.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.84; 67.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM218A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM218A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM218A Gene

Disorders for FAM218A Gene

Relevant External Links for FAM218A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM218A

No disorders were found for FAM218A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM218A Gene

Publications for FAM218A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3 64
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64

Products for FAM218A Gene

Sources for FAM218A Gene

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