FAM217B Gene
protein-coding GIFtS: 39
GCID: GC20P058509
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|
family with sequence similarity 217, member B(Previous name: chromosome 20 open reading frame 177 )
(Previous symbol: C20orf177)
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Aliases
for FAM217B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 217, Member B1 2 | | C20orf1771 2 3 | | DJ551D2.51 | | Chromosome 20 Open Reading Frame 1771 | | Protein FAM217B2 | | Uncharacterized Protein C20orf1772 |
Export aliases for FAM217B gene to outside databases |
Summaries
for FAM217B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM217B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for FAM217B
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM217B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM217B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.33 Ensembl cytogenetic band: 20q13.33 HGNC cytogenetic band: 20q13.33FAM217B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P058509: view genomic region
(about GC identifiers)
Start:
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58,508,819 bp from pter |
End:
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58,523,735 bp from pter |
Size:
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14,917 bases |
Orientation:
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plus strand |
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Proteins
for FAM217B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F217B_HUMAN, Q9NTX9 (See
protein sequence)Recommended Name: Protein FAM217B Size: 383 amino acids; 42052 Da
Secondary accessions: B3KWH1 Q9NTA3Explore the universe of human proteins at neXtProt for FAM217B: NX_Q9NTX9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NTX9
FAM217B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001177755.1 NP_001177756.1 NP_071389.1
ENSEMBL proteins: ENSP00000351040 ENSP00000354056 ENSP00000414543
Human Recombinant Protein Products:
FAM217B Antibody Products:
Assay Products for FAM217B: |
Protein
Domains /
Families
for FAM217B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9NTX9 UniProtKB/Swiss-Prot: F217B_HUMAN, Q9NTX9Similarity: Belongs to the FAM217 family |
Function
for FAM217B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM217B (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM217B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for FAM217B | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM217B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM217B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM217B |
1 GenomeRNAi human phenotype for FAM217B:
|
Pathways & Interactions
for FAM217B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM217B
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for FAM217B (ENSP000003510404) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FAM217B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM217B
Search CenterWatch for drugs/clinical trials and news about FAM217B / F217B
|
Transcripts
for FAM217B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM217B gene (3 alternative transcripts): NM_001190826.1 NM_001190827.1 NM_022106.2 Unigene Cluster for FAM217B: Family with sequence similarity 217, member B Hs.54973 [show with all ESTs]Unigene Representative Sequence: NM_0011908264 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000358293(uc002yba.3) ENST00000360816(uc002ybc.3 uc010zzx.2)
ENST00000469084 ENST00000421092
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM217B (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM217B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for FAM217B | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM217B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM217B |
Additional cDNA sequence: AK074295.1 AK125073.1 AK304220.1 AL137442.1 BC020771.1 BC054002.1 11 DOTS entries: DT.95162283 DT.95162286 DT.101981416 DT.443807 DT.95088415 DT.95162287 DT.95162288 DT.120818550 DT.95162285 DT.100747416 DT.91906570 24/126 AceView cDNA sequences (see all 126): AA555013 AI280104 AA442210 BE396080 AA211172 CB122565 AA994842 AA442098 BX363280 NM_022106 CB159578 F13169 AA356065 CR612343 BQ645912 AI768939 AA939007 BU508746 BQ212337 AI827921 AI420895 AW088641 BC020771 AA974689
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for FAM217B About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 |
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| SP1: | | | | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | | | | | - | | - | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FAM217B
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Expression
for FAM217B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM217B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTTATTGTA
About this image
See FAM217B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM217B
SOURCE GeneReport for Unigene cluster: Hs.54973
SABiosciences Custom PCR Arrays for FAM217B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM217B
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat FAM217B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM217B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM217B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM217B |
Orthologs
for FAM217B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FAM217B gene from 4/9 species (see all 9) About this table
ENSEMBL Gene Tree for FAM217B (if available)
TreeFam Gene Tree for FAM217B (if available) |
Paralogs
for FAM217B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for FAM217B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM217B (58508819 - 58523735 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM217B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM217B |
|
Disorders
/ Diseases
for FAM217B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for FAM217B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM217B gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM217B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for FAM217B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing FAM217B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM217B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM217B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM217B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM217B gene:
Search GeneIP for patents involving FAM217B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM217B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM217B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM217B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM217B | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM217B | | OriGene 3'-UTR Clone for FAM217B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM217B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM217B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM217B | | OriGene Custom Protein Services for FAM217B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM217B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM217B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM217B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM217B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM217B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM217B |
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 |  |  |  | |
| | | | Search Tocris compounds for FAM217B |
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 | | | FAM217B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM217B |
|  |  |  | | | | ThermoFisher Antibodies for FAM217B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM217B |
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