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Aliases for FAM217B Gene

Aliases for FAM217B Gene

  • Family With Sequence Similarity 217 Member B 2 3 5
  • Family With Sequence Similarity 217, Member B 2 3
  • C20orf177 3 4
  • Chromosome 20 Open Reading Frame 177 2
  • Uncharacterized Protein C20orf177 3
  • DJ551D2.5 3

External Ids for FAM217B Gene

Previous HGNC Symbols for FAM217B Gene

  • C20orf177

Previous GeneCards Identifiers for FAM217B Gene

  • GC20P058509

Summaries for FAM217B Gene

GeneCards Summary for FAM217B Gene

FAM217B (Family With Sequence Similarity 217 Member B) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM217B Gene

Genomics for FAM217B Gene

Regulatory Elements for FAM217B Gene

Promoters for FAM217B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM217B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM217B Gene

Chromosome:
20
Start:
59,933,764 bp from pter
End:
59,948,680 bp from pter
Size:
14,917 bases
Orientation:
Plus strand

Genomic View for FAM217B Gene

Genes around FAM217B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM217B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM217B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM217B Gene

Proteins for FAM217B Gene

  • Protein details for FAM217B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTX9-F217B_HUMAN
    Recommended name:
    Protein FAM217B
    Protein Accession:
    Q9NTX9
    Secondary Accessions:
    • B3KWH1
    • Q9NTA3

    Protein attributes for FAM217B Gene

    Size:
    383 amino acids
    Molecular mass:
    42052 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM217B Gene

Proteomics data for FAM217B Gene at MOPED

Post-translational modifications for FAM217B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM217B Gene

No data available for DME Specific Peptides for FAM217B Gene

Domains & Families for FAM217B Gene

Protein Domains for FAM217B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM217B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NTX9

UniProtKB/Swiss-Prot:

F217B_HUMAN :
  • Belongs to the FAM217 family.
Family:
  • Belongs to the FAM217 family.
genes like me logo Genes that share domains with FAM217B: view

No data available for Gene Families for FAM217B Gene

Function for FAM217B Gene

genes like me logo Genes that share phenotypes with FAM217B: view

Animal Model Products

miRNA for FAM217B Gene

miRTarBase miRNAs that target FAM217B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM217B Gene

Localization for FAM217B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM217B Gene COMPARTMENTS Subcellular localization image for FAM217B gene
Compartment Confidence
nucleus 4
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM217B Gene

Pathways & Interactions for FAM217B Gene

SuperPathways for FAM217B Gene

No Data Available

Interacting Proteins for FAM217B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000351040%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000351040 for FAM217B Gene via STRING

Symbol External ID(s) Details
ELAVL1

Gene Ontology (GO) - Biological Process for FAM217B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM217B Gene

Drugs & Compounds for FAM217B Gene

No Compound Related Data Available

Transcripts for FAM217B Gene

Unigene Clusters for FAM217B Gene

Family with sequence similarity 217, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM217B Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6
SP1: - -
SP2: - - - -
SP3: -
SP4:

Relevant External Links for FAM217B Gene

GeneLoc Exon Structure for
FAM217B
ECgene alternative splicing isoforms for
FAM217B

Expression for FAM217B Gene

mRNA expression in normal human tissues for FAM217B Gene

mRNA differential expression in normal tissues according to GTEx for FAM217B Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.5).

SOURCE GeneReport for Unigene cluster for FAM217B Gene Hs.54973

genes like me logo Genes that share expression patterns with FAM217B: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FAM217B Gene

Orthologs for FAM217B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM217B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM217B 35
  • 99.83 (n)
  • 100 (a)
FAM217B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM217B 36
  • 69 (a)
OneToOne
FAM217B 35
  • 74.6 (n)
  • 69.58 (a)
dog
(Canis familiaris)
Mammalia C24H20orf177 35
  • 63.59 (n)
  • 56.42 (a)
FAM217B 36
  • 53 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam217b 16
Fam217b 35
  • 71.43 (n)
  • 63.23 (a)
Fam217b 36
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM217B 36
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM217B 36
  • 40 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam217b 35
  • 69.83 (n)
  • 61.74 (a)
chicken
(Gallus gallus)
Aves C20H20ORF177 35
  • 59.89 (n)
  • 49.68 (a)
FAM217B 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM217B 36
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fam217b 36
  • 17 (a)
OneToMany
FAM217B (2 of 2) 36
  • 17 (a)
OneToMany
Species with no ortholog for FAM217B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM217B Gene

ENSEMBL:
Gene Tree for FAM217B (if available)
TreeFam:
Gene Tree for FAM217B (if available)

Paralogs for FAM217B Gene

(1) SIMAP similar genes for FAM217B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM217B: view

No data available for Paralogs for FAM217B Gene

Variants for FAM217B Gene

Sequence variations from dbSNP and Humsavar for FAM217B Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs194973 -- 59,948,049(+) AAAAA(A/G)AAAAA utr-variant-3-prime
rs3928738 -- 59,936,231(-) TATAT(A/G)ACGT intron-variant, utr-variant-5-prime
rs6071039 -- 59,948,313(+) TAAAA(A/G)GAAAA utr-variant-3-prime
rs34470681 -- 59,943,597(+) TTTTT(-/T)CCAAA intron-variant
rs34392887 -- 59,948,275(+) AAGAG(-/G)AATAT utr-variant-3-prime

Variation tolerance for FAM217B Gene

Residual Variation Intolerance Score: 39.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 20.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM217B Gene

HapMap Linkage Disequilibrium report
FAM217B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM217B Gene

Disorders for FAM217B Gene

Relevant External Links for FAM217B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM217B

No disorders were found for FAM217B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM217B Gene

Publications for FAM217B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for FAM217B Gene

Sources for FAM217B Gene

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