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Aliases for FAM217B Gene

Aliases for FAM217B Gene

  • Family With Sequence Similarity 217 Member B 2 3 5
  • C20orf177 3 4
  • Family With Sequence Similarity 217, Member B 2
  • Chromosome 20 Open Reading Frame 177 2
  • Uncharacterized Protein C20orf177 3
  • Protein FAM217B 3
  • DJ551D2.5 3

External Ids for FAM217B Gene

Previous HGNC Symbols for FAM217B Gene

  • C20orf177

Previous GeneCards Identifiers for FAM217B Gene

  • GC20P058509

Summaries for FAM217B Gene

GeneCards Summary for FAM217B Gene

FAM217B (Family With Sequence Similarity 217 Member B) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM217B Gene

Genomics for FAM217B Gene

Regulatory Elements for FAM217B Gene

Enhancers for FAM217B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G060074 1.2 dbSUPER 9.8 +141.9 141858 1.3 CREB3L1 MLX ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF416 ZNF263 FAM217B ENSG00000276093 C20orf197
GH20G060054 1.8 FANTOM5 Ensembl ENCODE dbSUPER 4.5 +123.2 123184 4.9 YBX1 FEZF1 GLIS2 GATA2 ELK1 ZNF143 FOS ZNF263 ZNF518A ZNF592 C20orf197 PPP1R3D FAM217B SYCP2 ENSG00000276093
GH20G059876 0.3 FANTOM5 12.7 -57.2 -57215 0.4 FAM217B SYCP2 PPP1R3D RNU7-141P
GH20G060045 1.6 FANTOM5 Ensembl ENCODE dbSUPER 1.9 +112.8 112797 1.5 HDGF SIX4 CTCF OVOL3 MAX MNT PAX8 ZBTB7B OSR2 ZNF316 C20orf197 PPP1R3D FAM217B PHACTR3 CDH26
GH20G060228 0.8 FANTOM5 dbSUPER 3.6 +294.7 294719 0.2 MAX ELF1 EZH2 C20orf197 PPP1R3D FAM217B PIR59955 MIR646HG
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM217B on UCSC Golden Path with GeneCards custom track

Promoters for FAM217B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000139522 236 1200 HDGF CREB3L1 AGO1 ARID4B SIN3A ZNF48 ZBTB7B GLIS2 ELK1 ZNF143

Genomic Location for FAM217B Gene

Chromosome:
20
Start:
59,933,764 bp from pter
End:
59,948,680 bp from pter
Size:
14,917 bases
Orientation:
Plus strand

Genomic View for FAM217B Gene

Genes around FAM217B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM217B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM217B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM217B Gene

Proteins for FAM217B Gene

  • Protein details for FAM217B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTX9-F217B_HUMAN
    Recommended name:
    Protein FAM217B
    Protein Accession:
    Q9NTX9
    Secondary Accessions:
    • B3KWH1
    • Q9NTA3

    Protein attributes for FAM217B Gene

    Size:
    383 amino acids
    Molecular mass:
    42052 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM217B Gene

Post-translational modifications for FAM217B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM217B Gene

No data available for DME Specific Peptides for FAM217B Gene

Domains & Families for FAM217B Gene

Protein Domains for FAM217B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM217B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NTX9

UniProtKB/Swiss-Prot:

F217B_HUMAN :
  • Belongs to the FAM217 family.
Family:
  • Belongs to the FAM217 family.
genes like me logo Genes that share domains with FAM217B: view

No data available for Gene Families for FAM217B Gene

Function for FAM217B Gene

genes like me logo Genes that share phenotypes with FAM217B: view

Animal Models for FAM217B Gene

MGI Knock Outs for FAM217B:

Animal Model Products

CRISPR Products

miRNA for FAM217B Gene

miRTarBase miRNAs that target FAM217B

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM217B Gene

Localization for FAM217B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM217B gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for FAM217B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with FAM217B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM217B Gene

Pathways & Interactions for FAM217B Gene

SuperPathways for FAM217B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM217B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM217B Gene

Drugs & Compounds for FAM217B Gene

No Compound Related Data Available

Transcripts for FAM217B Gene

Unigene Clusters for FAM217B Gene

Family with sequence similarity 217, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM217B Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6
SP1: - -
SP2: - - - -
SP3: -
SP4:

Relevant External Links for FAM217B Gene

GeneLoc Exon Structure for
FAM217B
ECgene alternative splicing isoforms for
FAM217B

Expression for FAM217B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM217B Gene

mRNA differential expression in normal tissues according to GTEx for FAM217B Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of FAM217B Gene:

FAM217B

SOURCE GeneReport for Unigene cluster for FAM217B Gene:

Hs.54973

Evidence on tissue expression from TISSUES for FAM217B Gene

  • Nervous system(4.3)
  • Kidney(4.1)
genes like me logo Genes that share expression patterns with FAM217B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM217B Gene

Orthologs for FAM217B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM217B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM217B 34 35
  • 99.83 (n)
cow
(Bos Taurus)
Mammalia FAM217B 34 35
  • 74.6 (n)
mouse
(Mus musculus)
Mammalia Fam217b 34 16 35
  • 71.43 (n)
rat
(Rattus norvegicus)
Mammalia Fam217b 34
  • 69.83 (n)
dog
(Canis familiaris)
Mammalia C24H20orf177 34
  • 63.59 (n)
FAM217B 35
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM217B 35
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM217B 35
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves C20H20ORF177 34
  • 59.89 (n)
FAM217B 35
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM217B 35
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fam217b 35
  • 17 (a)
OneToMany
FAM217B (2 of 2) 35
  • 17 (a)
OneToMany
Species where no ortholog for FAM217B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM217B Gene

ENSEMBL:
Gene Tree for FAM217B (if available)
TreeFam:
Gene Tree for FAM217B (if available)

Paralogs for FAM217B Gene

(1) SIMAP similar genes for FAM217B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM217B: view

No data available for Paralogs for FAM217B Gene

Variants for FAM217B Gene

Sequence variations from dbSNP and Humsavar for FAM217B Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_035691 A breast cancer sample
rs1000034704 -- 59,936,647(+) CAACA(A/G)CTCTG intron-variant, downstream-variant-500B
rs1000085208 -- 59,936,479(+) GATCC(A/G)GAAGG intron-variant, downstream-variant-500B
rs1000248144 -- 59,933,179(+) GCGCA(A/G)CCCCA intron-variant, upstream-variant-2KB
rs1000296092 -- 59,933,296(+) CGAGG(C/T)TGGCC intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM217B Gene

Variant ID Type Subtype PubMed ID
dgv4335n100 CNV loss 25217958
dgv4336n100 CNV loss 25217958
nsv1062669 CNV loss 25217958
nsv1065994 CNV loss 25217958

Variation tolerance for FAM217B Gene

Residual Variation Intolerance Score: 39.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 20.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM217B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM217B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM217B Gene

Disorders for FAM217B Gene

Relevant External Links for FAM217B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM217B

No disorders were found for FAM217B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM217B Gene

Publications for FAM217B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64

Products for FAM217B Gene

Sources for FAM217B Gene

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