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Aliases for FAM217A Gene

Aliases for FAM217A Gene

  • Family With Sequence Similarity 217 Member A 2 3 5
  • C6orf146 3 4
  • Family With Sequence Similarity 217, Member A 2
  • Chromosome 6 Open Reading Frame 146 2
  • Uncharacterized Protein C6orf146 3
  • Protein FAM217A 3

External Ids for FAM217A Gene

Previous HGNC Symbols for FAM217A Gene

  • C6orf146

Summaries for FAM217A Gene

GeneCards Summary for FAM217A Gene

FAM217A (Family With Sequence Similarity 217 Member A) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM217A Gene

Genomics for FAM217A Gene

Regulatory Elements for FAM217A Gene

Enhancers for FAM217A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F004188 0.5 FANTOM5 24.4 -101.6 -101641 0.1 SCRT1 CBX3 SCRT2 NRF1 ZBTB33 C6orf201 FAM217A LOC100129052 LOC100507506
GH06F003612 1.2 Ensembl ENCODE 12.4 +474.6 474601 1.5 PKNOX1 FEZF1 ZNF2 KLF7 FOS YY2 TSHZ1 REST ZNF488 ZNF518A PSMG4 LOC107987516 FAM136BP LOC102724096 LOC105374895 ENSG00000228365 FAM217A RIPK1 GC06P003631 GC06M003534
GH06F004055 0.2 ENCODE 12.1 +31.6 31636 1.3 CTCF PKNOX1 RAD21 TEAD3 FOSL1 SLC30A9 FOXK2 SMC3 TRIM24 ZNF600 ENSG00000230648 C6orf201 FAM217A PRPF4B GC06M004041 GC06M004066
GH06F004133 1 ENCODE 12 -47.9 -47887 3.8 HDGF CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 C6orf201 FAM217A ECI2 ENSG00000254821 GC06P004132
GH06F004110 0.6 Ensembl 11.9 -22.8 -22757 0.2 LOC100507506 ECI2 ENSG00000254821 FAM217A C6orf201 GC06P004125 GC06M004088
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FAM217A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM217A Gene

4,049,434 bp from pter
4,087,344 bp from pter
37,911 bases
Minus strand

Genomic View for FAM217A Gene

Genes around FAM217A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM217A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM217A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM217A Gene

Proteins for FAM217A Gene

  • Protein details for FAM217A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM217A
    Protein Accession:
    Secondary Accessions:
    • Q5JYK1

    Protein attributes for FAM217A Gene

    508 amino acids
    Molecular mass:
    57420 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI42122.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for FAM217A Gene

Post-translational modifications for FAM217A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM217A Gene

Domains & Families for FAM217A Gene

Protein Domains for FAM217A Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM217 family.
  • Belongs to the FAM217 family.
genes like me logo Genes that share domains with FAM217A: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for FAM217A Gene

Function for FAM217A Gene

Phenotypes for FAM217A Gene

GenomeRNAi human phenotypes for FAM217A:
genes like me logo Genes that share phenotypes with FAM217A: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM217A Gene

Localization for FAM217A Gene

Subcellular locations from

Jensen Localization Image for FAM217A Gene COMPARTMENTS Subcellular localization image for FAM217A gene
Compartment Confidence
cytosol 2
nucleus 2
golgi apparatus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM217A Gene

Pathways & Interactions for FAM217A Gene

SuperPathways for FAM217A Gene

No Data Available

Interacting Proteins for FAM217A Gene

Selected Interacting proteins: Q8IXS0-F217A_HUMAN for FAM217A Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for FAM217A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM217A Gene

Transcripts for FAM217A Gene

Unigene Clusters for FAM217A Gene

Family with sequence similarity 217, member A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM217A Gene

No ASD Table

Relevant External Links for FAM217A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM217A Gene

mRNA expression in normal human tissues for FAM217A Gene

mRNA differential expression in normal tissues according to GTEx for FAM217A Gene

This gene is overexpressed in Testis (x41.7).

Protein differential expression in normal tissues from HIPED for FAM217A Gene

This gene is overexpressed in Pancreatic juice (43.1) and Plasma (25.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM217A Gene

Protein tissue co-expression partners for FAM217A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM217A Gene:


SOURCE GeneReport for Unigene cluster for FAM217A Gene:

genes like me logo Genes that share expression patterns with FAM217A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FAM217A Gene

Orthologs for FAM217A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM217A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM217A 34
  • 99.15 (n)
(Canis familiaris)
Mammalia C35H6orf146 34
  • 85.19 (n)
FAM217A 35
  • 56 (a)
(Bos Taurus)
Mammalia FAM217A 34 35
  • 76.45 (n)
(Mus musculus)
Mammalia Fam217a 34 16 35
  • 75.23 (n)
(Rattus norvegicus)
Mammalia Fam217a 34
  • 74.52 (n)
(Monodelphis domestica)
Mammalia FAM217A 35
  • 44 (a)
(Anolis carolinensis)
Reptilia FAM217A 35
  • 38 (a)
Species where no ortholog for FAM217A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM217A Gene

Gene Tree for FAM217A (if available)
Gene Tree for FAM217A (if available)

Paralogs for FAM217A Gene Pseudogenes for FAM217A Gene

genes like me logo Genes that share paralogs with FAM217A: view

No data available for Paralogs for FAM217A Gene

Variants for FAM217A Gene

Sequence variations from dbSNP and Humsavar for FAM217A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10080405 -- 4,069,297(+) TCGTT(G/T)GTAGT reference, missense
rs10080424 -- 4,079,347(+) CCGCC(C/G)GGCCT intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs101418 -- 4,083,038(+) AGCCT(C/T)AGCTT intron-variant
rs10485172 -- 4,068,899(-) CTCCA(A/G)TGCCA reference, missense
rs10485173 -- 4,068,365(-) TTGAC(G/T)TATTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM217A Gene

Variant ID Type Subtype PubMed ID
nsv600860 CNV loss 21841781

Variation tolerance for FAM217A Gene

Residual Variation Intolerance Score: 91.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.04; 84.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM217A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM217A Gene

Disorders for FAM217A Gene

Relevant External Links for FAM217A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM217A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM217A Gene

Publications for FAM217A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64

Products for FAM217A Gene

Sources for FAM217A Gene

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