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Aliases for FAM216B Gene

Aliases for FAM216B Gene

  • Family With Sequence Similarity 216 Member B 2 3 5
  • C13orf30 3 4
  • Family With Sequence Similarity 216, Member B 2
  • Chromosome 13 Open Reading Frame 30 2
  • Protein FAM216B 3

External Ids for FAM216B Gene

Previous HGNC Symbols for FAM216B Gene

  • C13orf30

Previous GeneCards Identifiers for FAM216B Gene

  • GC13P043356

Summaries for FAM216B Gene

GeneCards Summary for FAM216B Gene

FAM216B (Family With Sequence Similarity 216 Member B) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM216B Gene

Genomics for FAM216B Gene

Regulatory Elements for FAM216B Gene

Enhancers for FAM216B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13G042832 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +51.2 51152 1.2 FOXA2 CEBPB MAX CEBPG RAD21 YY1 CTBP1 JUND ATF3 CEBPA FAM216B LINC01050 EPSTI1 GC13P042855
GH13G042814 1.1 ENCODE dbSUPER 12 +33.4 33430 0.2 INSM2 SIN3A FEZF1 ZNF2 ZEB1 RFX5 ZNF366 ZSCAN5C RCOR1 FOS FAM216B LINC01050 GC13P042855
GH13G042746 1 Ensembl ENCODE 11.6 -34.3 -34257 2.6 MXI1 TAF1 ZNF473 MAX KLF17 RAD21 ZFHX2 SCRT2 HNF4G FOS FAM216B GC13M042780 GC13P042584
GH13G042803 0.9 FANTOM5 dbSUPER 11 +22.5 22505 0.1 GATA2 CEBPB FEZF1 FOS WT1 FAM216B LINC01050
GH13G042804 0.8 Ensembl dbSUPER 11.3 +23.0 22951 0.2 IKZF1 IKZF2 PRDM1 SPI1 FAM216B LINC01050
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM216B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM216B Gene

Chromosome:
13
Start:
42,781,550 bp from pter
End:
42,791,549 bp from pter
Size:
10,000 bases
Orientation:
Plus strand

Genomic View for FAM216B Gene

Genes around FAM216B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM216B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM216B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM216B Gene

Proteins for FAM216B Gene

  • Protein details for FAM216B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7L0-F216B_HUMAN
    Recommended name:
    Protein FAM216B
    Protein Accession:
    Q8N7L0
    Secondary Accessions:
    • B1ALI3

    Protein attributes for FAM216B Gene

    Size:
    139 amino acids
    Molecular mass:
    16362 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM216B Gene

Post-translational modifications for FAM216B Gene

No Post-translational modifications

Other Protein References for FAM216B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM216B Gene

Domains & Families for FAM216B Gene

Protein Domains for FAM216B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8N7L0

UniProtKB/Swiss-Prot:

F216B_HUMAN :
  • Belongs to the FAM216 family.
Family:
  • Belongs to the FAM216 family.
genes like me logo Genes that share domains with FAM216B: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for FAM216B Gene

Function for FAM216B Gene

genes like me logo Genes that share phenotypes with FAM216B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM216B Gene

Localization for FAM216B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM216B gene
Compartment Confidence
mitochondrion 3
peroxisome 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM216B Gene

Pathways & Interactions for FAM216B Gene

SuperPathways for FAM216B Gene

No Data Available

Interacting Proteins for FAM216B Gene

Gene Ontology (GO) - Biological Process for FAM216B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM216B Gene

Drugs & Compounds for FAM216B Gene

No Compound Related Data Available

Transcripts for FAM216B Gene

mRNA/cDNA for FAM216B Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM216B Gene

Family with sequence similarity 216, member B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM216B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2:

Relevant External Links for FAM216B Gene

GeneLoc Exon Structure for
FAM216B
ECgene alternative splicing isoforms for
FAM216B

Expression for FAM216B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM216B Gene

mRNA differential expression in normal tissues according to GTEx for FAM216B Gene

This gene is overexpressed in Heart - Atrial Appendage (x15.8), Cervix - Endocervix (x6.2), Fallopian Tube (x5.6), Brain - Hypothalamus (x5.0), Brain - Caudate (basal ganglia) (x4.7), and Lung (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of FAM216B Gene:

FAM216B

SOURCE GeneReport for Unigene cluster for FAM216B Gene:

Hs.16970
genes like me logo Genes that share expression patterns with FAM216B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM216B Gene

Orthologs for FAM216B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM216B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM216B 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia FAM216B 34 35
  • 82.49 (n)
cow
(Bos Taurus)
Mammalia FAM216B 34 35
  • 80.34 (n)
rat
(Rattus norvegicus)
Mammalia Fam216b 34
  • 74.1 (n)
mouse
(Mus musculus)
Mammalia Fam216b 34 16 35
  • 73.9 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM216B 35
  • 21 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM216B 35
  • 38 (a)
OneToOne
Species where no ortholog for FAM216B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM216B Gene

ENSEMBL:
Gene Tree for FAM216B (if available)
TreeFam:
Gene Tree for FAM216B (if available)

Paralogs for FAM216B Gene

No data available for Paralogs for FAM216B Gene

Variants for FAM216B Gene

Sequence variations from dbSNP and Humsavar for FAM216B Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000265988 -- 42,785,775(+) GGCCA(-/T)TTTTT intron-variant
rs1000439110 -- 42,792,034(+) TGCGT(-/GTGC)GTGTG downstream-variant-500B
rs1000581931 -- 42,779,985(+) GAGAG(A/T)GTCCA upstream-variant-2KB
rs1000608217 -- 42,786,451(+) CAACC(C/T)ACTTT intron-variant
rs1000615988 -- 42,780,653(+) ATTGA(A/C)AATGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM216B Gene

Variant ID Type Subtype PubMed ID
dgv3129n54 CNV gain 21841781
esv3892334 CNV gain 25118596
nsv455869 CNV gain 19166990
nsv561552 CNV gain 21841781
nsv561555 CNV gain 21841781

Variation tolerance for FAM216B Gene

Residual Variation Intolerance Score: 43.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM216B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM216B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM216B Gene

Disorders for FAM216B Gene

Relevant External Links for FAM216B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM216B

No disorders were found for FAM216B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM216B Gene

Publications for FAM216B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  4. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for FAM216B Gene

Sources for FAM216B Gene

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