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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FAM216B Gene

protein-coding GIFtS: 35
GCID: GC13P043356

family with sequence similarity 216, member B

(Previous name: chromosome 13 open reading frame 30 )
(Previous symbol: C13orf30)

Search for FAM216B
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Family With Sequence Similarity 216, Member B¹ ²
C13orf30¹ ² ³
FLJ40919¹
Chromosome 13 Open Reading Frame 30¹
Protein FAM216B²
Uncharacterized Protein C13orf30²

External Ids:	HGNC: 26883¹	Entrez Gene: 144809²	Ensembl: ENSG00000179813⁷	UniProtKB: Q8N7L0³

Export aliases for FAM216B gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000013.10 NC_018924.1 NT_024524.14

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for FAM216B
Other transcription factors

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM216B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.11 Ensembl cytogenetic band: 13q14.11 HGNC cytogenetic band: 13q14.11

FAM216B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM216B gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P043356: view genomic region (about GC identifiers)

Start:	43,355,686 bp from pter	End:	43,365,685 bp from pter
Size:	10,000 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: F216B_HUMAN, Q8N7L0 (See protein sequence)

Recommended Name: Protein FAM216B

Size: 139 amino acids; 16362 Da

Secondary accessions: B1ALI3

Explore the universe of human proteins at neXtProt for FAM216B: NX_Q8N7L0

FAM216B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_872314.1

ENSEMBL proteins:

ENSP00000319336 ENSP00000445786

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q8N7L0

UniProtKB/Swiss-Prot: F216B_HUMAN, Q8N7L0

Similarity: Belongs to the FAM216 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Phenotypes:
1 GenomeRNAi human phenotype for FAM216B:

Decreased viability of wild-ty

Animal Models:

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FAM216B

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAM216B
Search CenterWatch for drugs/clinical trials and news about FAM216B / F216B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FAM216B gene:

NM_182508.2

Unigene Cluster for FAM216B:

Family with sequence similarity 216, member B

Hs.16970 [show with all ESTs]

Unigene Representative Sequence: NM_182508

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000313851 ENST00000537894(uc010tfk.2 uc010tfl.2)

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Additional cDNA sequence:

AK098238.1 AK310859.1 BC093659.1 BC112237.1

1 DOTS entry:

DT.403900

15 AceView cDNA sequences:

CB240730 BX118523 BM979385 AI694299 AK098238 AI821360 NM_182508 AI820513

BU676113 CD692309 CD703496 T93585 T92146 T92157 T93573

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for FAM216B About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b
SP1:
SP2:

ECgene alternative splicing isoforms for FAM216B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM216B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

FAM216B expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Dorsal forebrain-like neurons (Generation of midbra...)

Brain

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FAM216B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM216B

SOURCE GeneReport for Unigene cluster: Hs.16970

SABiosciences Custom PCR Arrays for FAM216B

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for FAM216B gene from 1/5 species (see all 5) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Fam216b^{1 , 5}	expressed sequence AU021034⁵ family with sequence similarity 216, member B¹	73.9(n)¹ 68.87(a)¹		14 (41.15 cM)⁵ 219170¹ NM_177629.4¹ NP_808297.1¹ 78081021⁵

ENSEMBL Gene Tree for FAM216B (if available)
TreeFam Gene Tree for FAM216B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs180893885^1,2		--	43353700(+)	`TCTTAA/GGCAGT`	1	--	us2k¹		0	--	--	--	--
rs74058522^1,2	C	--	43353765(+)	`AATAGC/TTGACA`	1	--	us2k¹		1		WA	2
rs4941441^1,2	C,F,A,H	--	43353776(+)	`TTGTAT/CTCCCT`	1	--	us2k¹		16		NA NS EA WA CSA	894
rs7321304^1,2	C,F,A,H	--	43353837(+)	`TAAATC/TCTTTT`	1	--	us2k¹ tfbs³		17		NA NS EA WA	932
rs35474941^1,2	C	--	43353855(+)	`TTAAAC/GTAGTC`	1	--	us2k¹		2		NA	122
rs142793052^1,2		--	43353916(+)	`TTCTTA/GTATTT`	1	--	us2k¹		0	--	--	--	--
rs185969138^1,2		--	43354038(+)	`CATTGA/TCTGTA`	1	--	us2k¹		0	--	--	--	--
rs1323611^1,2	C,F,A,H	--	43354059(-)	`GGAGGC/ATGAAG`	1	--	us2k¹		18		NS EA NA WA CSA	792
rs151011236^1,2		--	43354135(+)	`TCTGTC/TGGCCT`	1	--	us2k¹		0	--	--	--	--
rs140862841^1,2		--	43354267(+)	`GGAAGA/GAGCCA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FAM216B (43355686 - 43365685 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM216B: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FAM216B gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM216B)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)² Dunham A.... Ross M.T. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 144809	HGNC: 26883	AceView: FLJ40919	Ensembl:ENSG00000179813	euGenes: HUgn144809
ECgene: FAM216B	H-InvDB: FAM216B

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FAM216B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FAM216B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FAM216B gene:
Search GeneIP for patents involving FAM216B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes FAM216B gene at Home site.

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FAM216B Gene

family with sequence similarity 216, member B

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for FAM216B gene

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for FAM216B gene

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for FAM216B gene

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Families
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Function
for FAM216B gene

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Transcripts
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Expression
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FAM216B Gene

family with sequence similarity 216, member B

Aliasesfor FAM216B gene

Summariesfor FAM216B gene

Genomic Viewsfor FAM216B gene

Proteinsfor FAM216B gene

Protein Domains /Familiesfor FAM216B gene

Functionfor FAM216B gene

Pathways & Interactionsfor FAM216B gene

Drugs & Compoundsfor FAM216B gene

Transcriptsfor FAM216B gene

Expression for FAM216B gene

Orthologsfor FAM216B gene

Paralogsfor FAM216B gene

Genomic Variantsfor FAM216B gene

Disorders / Diseasesfor FAM216B gene

Publicationsfor FAM216B gene

External Searches for FAM216B gene

Genome Databases showing FAM216B gene

Other Databases showing FAM216B gene

Specialized Databases showing FAM216B gene

Intellectual Propertyfor FAM216B gene

Productsfor FAM216B gene

View Random Gene

Aliases
for FAM216B gene

Summaries
for FAM216B gene

Genomic Views
for FAM216B gene

Proteins
for FAM216B gene

Protein Domains /
Families
for FAM216B gene

Function
for FAM216B gene

Pathways & Interactions
for FAM216B gene

Drugs & Compounds
for FAM216B gene

Transcripts
for FAM216B gene

Expression
for FAM216B gene

Orthologs
for FAM216B gene

Paralogs
for FAM216B gene

Genomic Variants
for FAM216B gene

Disorders / Diseases
for FAM216B gene

Publications
for FAM216B gene

Intellectual Property
for FAM216B gene

Products
for FAM216B gene