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Aliases for FAM216B Gene

Aliases for FAM216B Gene

  • Family With Sequence Similarity 216 Member B 2 3 5
  • Family With Sequence Similarity 216, Member B 2 3
  • C13orf30 3 4
  • Chromosome 13 Open Reading Frame 30 2

External Ids for FAM216B Gene

Previous HGNC Symbols for FAM216B Gene

  • C13orf30

Previous GeneCards Identifiers for FAM216B Gene

  • GC13P043356

Summaries for FAM216B Gene

GeneCards Summary for FAM216B Gene

FAM216B (Family With Sequence Similarity 216 Member B) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM216B Gene

Genomics for FAM216B Gene

Genomic Location for FAM216B Gene

42,781,550 bp from pter
42,791,549 bp from pter
10,000 bases
Plus strand

Genomic View for FAM216B Gene

Genes around FAM216B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM216B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM216B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM216B Gene

No data available for Regulatory Elements for FAM216B Gene

Proteins for FAM216B Gene

  • Protein details for FAM216B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM216B
    Protein Accession:
    Secondary Accessions:
    • B1ALI3

    Protein attributes for FAM216B Gene

    139 amino acids
    Molecular mass:
    16362 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM216B Gene

Proteomics data for FAM216B Gene at MOPED

Post-translational modifications for FAM216B Gene

No Post-translational modifications

Other Protein References for FAM216B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM216B Gene

Domains & Families for FAM216B Gene

Protein Domains for FAM216B Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM216 family.
  • Belongs to the FAM216 family.
genes like me logo Genes that share domains with FAM216B: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for FAM216B Gene

Function for FAM216B Gene

genes like me logo Genes that share phenotypes with FAM216B: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM216B Gene

Localization for FAM216B Gene

Subcellular locations from

Jensen Localization Image for FAM216B Gene COMPARTMENTS Subcellular localization image for FAM216B gene
Compartment Confidence
mitochondrion 3
cytosol 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM216B Gene

Pathways & Interactions for FAM216B Gene

SuperPathways for FAM216B Gene

No Data Available

Interacting Proteins for FAM216B Gene

Gene Ontology (GO) - Biological Process for FAM216B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM216B Gene

Drugs & Compounds for FAM216B Gene

No Compound Related Data Available

Transcripts for FAM216B Gene

mRNA/cDNA for FAM216B Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM216B Gene

Family with sequence similarity 216, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM216B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b

Relevant External Links for FAM216B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM216B Gene

mRNA expression in normal human tissues for FAM216B Gene

mRNA differential expression in normal tissues according to GTEx for FAM216B Gene

This gene is overexpressed in Heart - Atrial Appendage (x15.8), Cervix - Endocervix (x6.2), Fallopian Tube (x5.6), Brain - Hypothalamus (x5.0), Brain - Caudate (basal ganglia) (x4.7), and Lung (x4.5).

SOURCE GeneReport for Unigene cluster for FAM216B Gene Hs.16970

genes like me logo Genes that share expression patterns with FAM216B: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FAM216B Gene

Orthologs for FAM216B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM216B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM216B 35
  • 80.34 (n)
  • 68.35 (a)
FAM216B 36
  • 65 (a)
(Canis familiaris)
Mammalia FAM216B 35
  • 82.49 (n)
  • 74.1 (a)
FAM216B 36
  • 75 (a)
(Mus musculus)
Mammalia Fam216b 35
  • 73.9 (n)
  • 68.87 (a)
Fam216b 16
Fam216b 36
  • 54 (a)
(Pan troglodytes)
Mammalia FAM216B 35
  • 100 (n)
  • 100 (a)
FAM216B 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fam216b 35
  • 74.1 (n)
  • 63.64 (a)
(Ornithorhynchus anatinus)
Mammalia FAM216B 36
  • 21 (a)
(Anolis carolinensis)
Reptilia FAM216B 36
  • 38 (a)
Species with no ortholog for FAM216B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM216B Gene

Gene Tree for FAM216B (if available)
Gene Tree for FAM216B (if available)

Paralogs for FAM216B Gene

No data available for Paralogs for FAM216B Gene

Variants for FAM216B Gene

Sequence variations from dbSNP and Humsavar for FAM216B Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs35889214 - 42,788,770(+) AAAGG(C/T)GCCAA reference, missense
rs1323611 -- 42,779,923(-) GGAGG(A/C)TGAAG upstream-variant-2KB
rs1324422 -- 42,784,040(+) GCTTT(A/G)TTGTT intron-variant
rs1324427 -- 42,787,864(+) CACCT(C/G/T)TATGT intron-variant
rs1535689 -- 42,785,230(-) TACTT(C/T)ATAAT intron-variant

Variation tolerance for FAM216B Gene

Residual Variation Intolerance Score: 43.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM216B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM216B Gene

Disorders for FAM216B Gene

Relevant External Links for FAM216B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM216B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM216B Gene

Publications for FAM216B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for FAM216B Gene

Sources for FAM216B Gene

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