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FAM216A Gene

protein-coding   GIFtS: 34
GCID: GC12P110907

Family With Sequence Similarity 216, Member A

(Previous name: chromosome 12 open reading frame 24)
(Previous symbol: C12orf24)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Family With Sequence Similarity 216, Member A1 2     Protein FAM216A2
C12orf241 2 3     Protein Predicted By Clone 237332
Chromosome 12 Open Reading Frame 241     Uncharacterized Protein C12orf242
HSU792742     

External Ids:    HGNC: 301801   Entrez Gene: 299022   Ensembl: ENSG000002048567   UniProtKB: Q8WUB23   
ORGUL members:         

Export aliases for FAM216A gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM216A Gene:
FAM216A (family with sequence similarity 216, member A) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for FAM216A
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FAM216A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM216A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.11   Ensembl cytogenetic band:  12q24.11   HGNC cytogenetic band: 12q24.11

FAM216A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM216A gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P110907:  view genomic region     (about GC identifiers)

Start:
110,906,169 bp from pter      End:
110,928,192 bp from pter
Size:
22,024 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: F216A_HUMAN, Q8WUB2 (See protein sequence)
Recommended Name: Protein FAM216A  
Size: 273 amino acids; 30792 Da
Caution: It is uncertain whether Met-1 or Met-18 is the initiator
Secondary accessions: A6NH30 Q99776

Explore the universe of human proteins at neXtProt for FAM216A: NX_Q8WUB2

Explore proteomics data for FAM216A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM216A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037432.2  
    ENSEMBL proteins: 
     ENSP00000366901   ENSP00000448777  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q8WUB2

    UniProtKB/Swiss-Prot: F216A_HUMAN, Q8WUB2
    Similarity: Belongs to the FAM216 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 MGI phenotypic allele for Fam216a (no phenotypes)

    Find genes that share phenotypes with FAM216A           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FAM216A

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    hsa-mir-877-3p (MIRT037065), hsa-mir-149-5p (MIRT045639)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM216A
    Interactions:

        Search GeneGlobe Interaction Network for FAM216A

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for FAM216A (F216A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM216A gene: 
    NM_013300.2  

    Unigene Cluster for FAM216A:

    Family with sequence similarity 216, member A
    Hs.436618  [show with all ESTs]
    Unigene Representative Sequence: AK296280
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377673(uc001tqu.4) ENST00000538285(uc009zvo.2) ENST00000548869(uc010sxz.1)
    ENST00000548449 ENST00000546396 ENST00000547539
    miRNA
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    Additional mRNA sequence: 

    AK225731.1 AK296280.1 AK297684.1 AK308802.1 AK309603.1 BC020967.1 CR457001.1 U79274.1 

    13 DOTS entries:

    DT.100791738  DT.113540  DT.100791739  DT.100799611  DT.95330984  DT.121216234  DT.91683593  DT.95248079 
    DT.121216085  DT.40314176  DT.435149  DT.75199270  DT.95254462 

    Selected AceView cDNA sequences (see all 133):

    CR622941 NM_013300 BU154781 AA451900 CB121970 AV709924 U79274 CR622888 
    AI288620 BC020967 CR609045 CR595487 AA523887 AA764751 CR623722 CR623239 
    BQ943229 CR602160 AA649004 BX116128 AA287898 BQ440884 BM714167 BX395071 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM216A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAACATATAC
    FAM216A Expression
    About this image

    FAM216A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM216A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436618
        Custom PCR Arrays for FAM216A
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for FAM216A gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam216a1 , 5 RIKEN cDNA 1500011H22 gene5
    family with sequence similarity 216, member A1
    79.97(n)1
    73.56(a)1
      5 (62.33 cM)5
    689481  NM_026883.31  NP_081159.11 
     1223645805 


    ENSEMBL Gene Tree for FAM216A (if available)
    TreeFam Gene Tree for FAM216A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM216A (see all 374)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs756737751,2
    C,F--110908623(+) AAAACT/CACAAT 1 -- int11Minor allele frequency- C:0.03EA 120
    rs96520601,2
    C,F,H--110908817(+) ATTCCA/GGTCAT 1 -- int118Minor allele frequency- G:0.09NS NA WA CSA EA 1600
    rs1905893481,2
    --110908986(+) CCTCCA/GCCTCC 1 -- int10--------
    rs604390111,2
    C,F--110909179(+) GGAGCT/CACCGT 1 -- int14Minor allele frequency- C:0.21WA CSA NA 242
    rs1832083631,2
    --110909345(+) CTTCAA/GAACTC 1 -- int10--------
    rs1466263491,2
    C--110909368(+) TAAAGC/TCAACC 1 -- int10--------
    rs1388013911,2
    --110909457(+) TTGCTA/TGTTGG 1 -- int10--------
    rs1493613981,2
    --110909567(+) AGTTCA/CTAACA 1 -- int10--------
    rs1865578741,2
    --110909663(+) TTTAGA/GAAAGA 1 -- int10--------
    rs2013795301,2
    --110909708(+) CCAAC-/TTATTAGT 1 -- int10--------

    HapMap Linkage Disequilibrium report for FAM216A (110906169 - 110928192 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FAM216A: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM216A
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM216A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM216A gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM216A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 2 Yu W.... Gibbs R.A. (Genome Res. 1997)
    2. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    4. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1 Andersson B.... Gibbs R.A. (Anal. Biochem. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29902 HGNC: 30180 AceView: HSU79274 Ensembl:ENSG00000204856 euGenes: HUgn29902
    ECgene: FAM216A H-InvDB: FAM216A

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM216A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM216A gene:
    Search GeneIP for patents involving FAM216A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     Browse SwitchGear Promoter luciferase reporter plasmids for FAM216A
     Search ThermoFisher Antibodies for FAM216A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM216A
     Browse compounds at ApexBio
     Search Addgene for plasmids for FAM216A
      Search eBioscience for proteins for FAM216A
      Search eBioscience for elisas for FAM216A
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for FAM216A
     antibodies-online antibodies for FAM216A (18 products)
     antibodies-online kits for FAM216A (2 products)
     antibodies-online peptides for FAM216A
     antibodies-online proteins for FAM216A (5 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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