|
|
family with sequence similarity 215, member A (non-protein...(Previous name: chromosome 17 open reading frame 88 )
(Previous symbol: C17orf88)
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Aliases
for FAM215A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Subcategory (RNA class): lncRNA
Quality score for this RNA gene is 3
| Aliases |
|---|
| Family With Sequence Similarity 215, Member A (Non-Protein Coding)1 2 | | Chromosome 17 Open Reading Frame 881 | | APR-21 2 3 | | APR23 | | C17orf881 2 3 | | Putative Apoptosis-Related Protein 23 | | LINC005301 2 | | |
| External Ids: | HGNC: 175051 | Entrez Gene: 235912 | Ensembl: ENSG000002674967 | UniProtKB: Q9Y5M13 | | ORGUL members: | |
|---|
| NONCODE:n407303 | |
Export aliases for FAM215A gene to outside databases
|---|
Summaries
for FAM215A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM215A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for FAM215A
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM215A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM215A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.31 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21.31FAM215A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P041995: view genomic region
(about GC identifiers)
Start:
|
41,994,576 bp from pter |
End:
|
41,995,355 bp from pter |
Size:
|
780 bases |
Orientation:
|
plus strand |
|
Proteins
for FAM215A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F215A_HUMAN, Q9Y5M1 (See
protein sequence)Recommended Name: Putative protein FAM215A Size: 114 amino acids; 11973 Da
Caution: Defined as a non-coding RNA by HGNC. However, proteomics data suggest the existence of the protein
Secondary accessions: Q6NTD6Explore the universe of human proteins at neXtProt for FAM215A: NX_Q9Y5M1
FAM215A Protein expression data from MOPED and PaxDb: --
ENSEMBL proteins: ENSP00000464743
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
FAM215A for ontologies About GeneDecksing
FAM215A Antibody Products:
Assay Products for FAM215A: |
Protein
Domains /
Families
for FAM215A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9Y5M1 |
Function
for FAM215A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
FAM215A for ontologies About GeneDecksing
|
Pathways & Interactions
for FAM215A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM215A
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006915 | apoptotic process |
IEA | -- | | GO:0008150 | biological_process |
ND | -- |
FAM215A for ontologies About GeneDecksing
|
Drugs & Compounds
for FAM215A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
FAM215A for compounds About GeneDecksing
 Browse Tocris compounds for FAM215A
3 Novoseek chemical compound relationships for FAM215A gene About this table
Search CenterWatch for drugs/clinical trials and news about FAM215A 
|
Transcripts
for FAM215A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
Unigene Cluster for FAM215A: Family with sequence similarity 215, member A (non-protein coding) Hs.721804 Unigene Representative Sequence: AF1432361 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000588043
Additional cDNA sequence: AF143236.1 BC069097.1 NR_026770.1 1 DOTS entry: DT.91745071 2 AceView cDNA sequences: BC069097 AF143236
GeneLoc Exon Structure
|
Expression
for FAM215A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for FAM215A:none
See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
Genevestigator expression for FAM215A
SOURCE GeneReport for Unigene cluster: Hs.721804
SABiosciences Custom PCR Arrays for FAM215A
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM215A
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat FAM215A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM215A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM215A |
Orthologs
for FAM215A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for FAM215A (if available)
TreeFam Gene Tree for FAM215A (if available) |
Paralogs
for FAM215A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for FAM215A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM215A (41994576 - 41995355 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM215A: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for FAM215A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAM215A for disorders About GeneDecksing
20/50  diseases for FAM215A (see all 50): About MalaCardslarge granular lymphocyte leukemia non-hodgkin lymphoma familial adenomatous polyposis cervical intraepithelial neoplasia
polycythemia vera gastrointestinal stromal tumor primary biliary cirrhosis squamous cell carcinoma
lichen planus oral squamous cell carcinoma conjunctivochalasis esophageal squamous cell carcinoma
lymphocytic leukemia hodgkin's lymphoma down syndrome chronic lymphocytic leukemia
polycythemia ulcerative colitis polyposis alzheimer's disease
10/15 Novoseek disease relationships for FAM215A gene (see all 15) About this table
Export disorders for FAM215A gene to outside databases
|
Publications
for FAM215A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM215A gene, integrated from 9 sources (see all 82):
(articles sorted by number of sources associating them with FAM215A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Improved PCR-based subtractive hybridization strategy for cloning differentially expressed genes. (PubMed id 10948432)1, 2, 3 Zhu F....Wang C.J. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- [Expression of hypoxia inducible factor-1alpha and relationship thereof to apoptosis related protein in non-small cell lung cancer] (PubMed id 17650407)9 Chen Y.F....Li X.J. (2007)
- Differential expression of apoptosis related proteins and nitric oxide synthases in Epstein Barr associated gastric carcinomas. (PubMed id 16937490)9 Begnami M.D....Soares F.A. (2006)
- Diffuse and intestinal type gastric carcinomas differ in their expression of apoptosis related proteins. (PubMed id 12944556)9 van der Woude C.J....Moshage H. (2003)
- Expression of apoptosis related proteins: RAIDD, ZIP kinase, Bim/BOD, p21, Bax, Bcl-2 and NF-kappaB in brains of patients with Down syndrome. (PubMed id 11771742)9 Engidawork E....Lubec G. (2001)
- Cathepsin D and apoptosis related proteins are elevat ed in the brain of autistic subjects. (PubMed id 19854241)9 Sheikh A.M....Malik M. (2010)
|
External Searches for FAM215A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM215A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM215A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM215A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM215A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM215A gene:
Search GeneIP for patents involving FAM215A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM215A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 |
| | | | |
 |
 |
|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM215A | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM215A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM215A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM215A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM215A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM215A |
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 |  |  |  | |
| | | | Search Tocris compounds for FAM215A |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for FAM215A |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM215A |
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GeneCards Homepage -
Last full update: 18 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013
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