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Aliases for FAM214B Gene

Aliases for FAM214B Gene

  • Family With Sequence Similarity 214 Member B 2 3 5
  • KIAA1539 2 3 4
  • Family With Sequence Similarity 214, Member B 2 3

External Ids for FAM214B Gene

Previous HGNC Symbols for FAM214B Gene

  • KIAA1539

Summaries for FAM214B Gene

GeneCards Summary for FAM214B Gene

FAM214B (Family With Sequence Similarity 214 Member B) is a Protein Coding gene. An important paralog of this gene is FAM214A.

Gene Wiki entry for FAM214B Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM214B Gene

Genomics for FAM214B Gene

Regulatory Elements for FAM214B Gene

Enhancers for FAM214B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM214B on UCSC Golden Path with GeneCards custom track

Promoters for FAM214B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM214B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM214B Gene

35,104,112 bp from pter
35,116,351 bp from pter
12,240 bases
Minus strand

Genomic View for FAM214B Gene

Genes around FAM214B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM214B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM214B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM214B Gene

Proteins for FAM214B Gene

  • Protein details for FAM214B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM214B
    Protein Accession:
    Secondary Accessions:
    • B1AML4
    • B1AML5
    • D3DRN5
    • O60377
    • Q9BQ60
    • Q9HAI9
    • Q9P1Y9

    Protein attributes for FAM214B Gene

    538 amino acids
    Molecular mass:
    56690 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC07982.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA96063.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM214B Gene


neXtProt entry for FAM214B Gene

Proteomics data for FAM214B Gene at MOPED

Post-translational modifications for FAM214B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM214B Gene

No data available for DME Specific Peptides for FAM214B Gene

Domains & Families for FAM214B Gene

Protein Domains for FAM214B Gene


Suggested Antigen Peptide Sequences for FAM214B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM214 family.
  • Belongs to the FAM214 family.
genes like me logo Genes that share domains with FAM214B: view

No data available for Gene Families for FAM214B Gene

Function for FAM214B Gene

genes like me logo Genes that share phenotypes with FAM214B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM214B Gene

Localization for FAM214B Gene

Subcellular locations from

Jensen Localization Image for FAM214B Gene COMPARTMENTS Subcellular localization image for FAM214B gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM214B Gene

Pathways & Interactions for FAM214B Gene

SuperPathways for FAM214B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM214B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM214B Gene

Drugs & Compounds for FAM214B Gene

No Compound Related Data Available

Transcripts for FAM214B Gene

Unigene Clusters for FAM214B Gene

Family with sequence similarity 214, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM214B Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a ·
SP1: - - - - - - -
SP2: -
SP3: - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - -
SP7: - - -
SP8: - -
SP9: -
SP12: - - - - -

ExUns: 14b ^ 15a · 15b

Relevant External Links for FAM214B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM214B Gene

mRNA expression in normal human tissues for FAM214B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM214B Gene

This gene is overexpressed in Whole Blood (x7.1).

Protein differential expression in normal tissues from HIPED for FAM214B Gene

This gene is overexpressed in Adrenal (17.4), Spinal cord (13.1), Testis (12.1), Frontal cortex (6.9), and Heart (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM214B Gene

SOURCE GeneReport for Unigene cluster for FAM214B Gene Hs.301696

genes like me logo Genes that share expression patterns with FAM214B: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FAM214B Gene

Orthologs for FAM214B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM214B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM214B 35
  • 93 (n)
  • 92.57 (a)
FAM214B 36
  • 93 (a)
(Canis familiaris)
Mammalia KIAA1539 35
  • 94.59 (n)
  • 94.03 (a)
FAM214B 36
  • 94 (a)
(Mus musculus)
Mammalia Fam214b 35
  • 92.75 (n)
  • 91.08 (a)
Fam214b 16
Fam214b 36
  • 91 (a)
(Pan troglodytes)
Mammalia FAM214B 35
  • 99.32 (n)
  • 99.07 (a)
FAM214B 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fam214b 35
  • 92.63 (n)
  • 91.82 (a)
(Monodelphis domestica)
Mammalia FAM214B 36
  • 76 (a)
(Gallus gallus)
Aves FAM214B 35
  • 59.78 (n)
  • 55.26 (a)
FAM214B 36
  • 43 (a)
(Anolis carolinensis)
Reptilia FAM214B 36
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam214b 35
  • 56.7 (n)
  • 49.33 (a)
(Danio rerio)
Actinopterygii fam214b 36
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9005 36
  • 9 (a)
Species with no ortholog for FAM214B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM214B Gene

Gene Tree for FAM214B (if available)
Gene Tree for FAM214B (if available)

Paralogs for FAM214B Gene

Paralogs for FAM214B Gene

(2) SIMAP similar genes for FAM214B Gene using alignment to 1 proteins: Pseudogenes for FAM214B Gene

genes like me logo Genes that share paralogs with FAM214B: view

Variants for FAM214B Gene

Sequence variations from dbSNP and Humsavar for FAM214B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs944698 -- 35,109,503(+) ACCAC(G/T)GGTGC intron-variant
rs944699 -- 35,109,575(+) AGCCA(A/G)CTGCC intron-variant
rs944700 -- 35,109,952(+) ATCTG(A/G)GCAGC intron-variant, utr-variant-5-prime
rs1332605 -- 35,108,575(+) CCCCC(C/G/T)CTTCT intron-variant
rs7852201 -- 35,117,720(+) TTGAG(A/T)ATTTA upstream-variant-2KB

Variation tolerance for FAM214B Gene

Residual Variation Intolerance Score: 69.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.47; 55.02% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for FAM214B Gene

Disorders for FAM214B Gene

Relevant External Links for FAM214B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM214B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM214B Gene

Publications for FAM214B Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3

Products for FAM214B Gene

Sources for FAM214B Gene