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Aliases for FAM214B Gene

Aliases for FAM214B Gene

  • Family With Sequence Similarity 214, Member B 2 3
  • KIAA1539 2 3 4
  • Protein FAM214B 3
  • P1.11659_5 3
  • BA182N22.6 3

External Ids for FAM214B Gene

Previous HGNC Symbols for FAM214B Gene

  • KIAA1539

Summaries for FAM214B Gene

GeneCards Summary for FAM214B Gene

FAM214B (Family With Sequence Similarity 214, Member B) is a Protein Coding gene. An important paralog of this gene is FAM214A.

Gene Wiki entry for FAM214B Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM214B Gene

Genomics for FAM214B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM214B Gene

Start:
35,104,112 bp from pter
End:
35,116,341 bp from pter
Size:
12,230 bases
Orientation:
Minus strand

Genomic View for FAM214B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM214B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM214B Gene

No data available for Regulatory Elements for FAM214B Gene

Proteins for FAM214B Gene

  • Protein details for FAM214B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L5A3-F214B_HUMAN
    Recommended name:
    Protein FAM214B
    Protein Accession:
    Q7L5A3
    Secondary Accessions:
    • B1AML4
    • B1AML5
    • D3DRN5
    • O60377
    • Q9BQ60
    • Q9HAI9
    • Q9P1Y9

    Protein attributes for FAM214B Gene

    Size:
    538 amino acids
    Molecular mass:
    56690 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC07982.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA96063.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM214B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM214B Gene

Proteomics data for FAM214B Gene at MOPED

Post-translational modifications for FAM214B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM214B Gene

No data available for DME Specific Peptides for FAM214B Gene

Domains for FAM214B Gene

Protein Domains for FAM214B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q7L5A3

UniProtKB/Swiss-Prot:

F214B_HUMAN :
  • Q7L5A3
Family:
  • Belongs to the FAM214 family.
genes like me logo Genes that share domains with FAM214B: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for FAM214B Gene

Function for FAM214B Gene

Gene Ontology (GO) - Molecular Function for FAM214B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with FAM214B: view

Animal Model Products

CRISPR Products

miRNA for FAM214B Gene

miRTarBase miRNAs that target FAM214B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM214B Gene

Localization for FAM214B Gene

Gene Ontology (GO) - Cellular Components for FAM214B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with FAM214B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for FAM214B Gene

Pathways for FAM214B Gene

SuperPathways for FAM214B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM214B Gene

None

No data available for Pathways by source for FAM214B Gene

Transcripts for FAM214B Gene

Unigene Clusters for FAM214B Gene

Family with sequence similarity 214, member B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM214B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM214B Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a ·
SP1: - - - - - - -
SP2: -
SP3: - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - -
SP7: - - -
SP8: - -
SP9: -
SP10:
SP11:
SP12: - - - - -

ExUns: 14b ^ 15a · 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for FAM214B Gene

GeneLoc Exon Structure for
FAM214B
ECgene alternative splicing isoforms for
FAM214B

Expression for FAM214B Gene

mRNA expression in normal human tissues for FAM214B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM214B Gene

This gene is overexpressed in Whole Blood (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FAM214B Gene

SOURCE GeneReport for Unigene cluster for FAM214B Gene Hs.301696

genes like me logo Genes that share expressions with FAM214B: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FAM214B Gene

Orthologs for FAM214B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM214B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM214B 35
  • 99.32 (n)
  • 99.07 (a)
FAM214B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM214B 35
  • 93 (n)
  • 92.57 (a)
FAM214B 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM214B 36
  • 94 (a)
OneToOne
KIAA1539 35
  • 94.59 (n)
  • 94.03 (a)
mouse
(Mus musculus)
Mammalia Fam214b 35
  • 92.75 (n)
  • 91.08 (a)
Fam214b 16
Fam214b 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM214B 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam214b 35
  • 92.63 (n)
  • 91.82 (a)
chicken
(Gallus gallus)
Aves FAM214B 35
  • 59.78 (n)
  • 55.26 (a)
FAM214B 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM214B 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam214b 35
  • 56.7 (n)
  • 49.33 (a)
zebrafish
(Danio rerio)
Actinopterygii fam214b 36
  • 33 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9005 36
  • 9 (a)
OneToMany
Species with no ortholog for FAM214B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM214B Gene

ENSEMBL:
Gene Tree for FAM214B (if available)
TreeFam:
Gene Tree for FAM214B (if available)

Paralogs for FAM214B Gene

Paralogs for FAM214B Gene

Selected SIMAP similar genes for FAM214B Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for FAM214B Gene

genes like me logo Genes that share paralogs with FAM214B: view

Variants for FAM214B Gene

Sequence variations from dbSNP and Humsavar for FAM214B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs944698 -- 35,109,503(+) ACCAC(G/T)GGTGC intron-variant
rs944699 -- 35,109,575(+) AGCCA(A/G)CTGCC intron-variant
rs944700 -- 35,109,952(+) ATCTG(A/G)GCAGC intron-variant
rs1332605 -- 35,108,575(+) CCCCC(C/G/T)CTTCT intron-variant
rs3808866 -- 35,116,434(-) AGGCT(A/G)GCAGC upstream-variant-2KB

Relevant External Links for FAM214B Gene

HapMap Linkage Disequilibrium report
FAM214B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM214B Gene

Disorders for FAM214B Gene

No disorders were found for FAM214B Gene.

No data available for UniProtKB/Swiss-Prot for FAM214B Gene

Publications for FAM214B Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3

Products for FAM214B Gene

Sources for FAM214B Gene

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