FAM214B Gene
protein-coding GIFtS: 43
GCID: GC09M035104 (predicted)
|
|
family with sequence similarity 214, member B(Previous name: KIAA1539 )
(Previous symbol: KIAA1539)
| |
Aliases
for FAM214B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 214, Member B1 2 | | P1.11659_52 | | KIAA15391 2 3 | | RP11-182N22.62 | | BA182N22.61 | | Protein FAM214B2 | | FLJ115601 | | |
Export aliases for FAM214B gene to outside databases |
Summaries
for FAM214B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for FAM214B (KIAA1539)
|
Genomic Views
for FAM214B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for FAM214B
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM214B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM214B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p13.3 Ensembl cytogenetic band: 9p13.3 HGNC cytogenetic band: 9p13.2FAM214B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M035104: view genomic region
(about GC identifiers)
Start:
|
35,104,109 bp from pter |
End:
|
35,115,999 bp from pter |
Size:
|
11,891 bases |
Orientation:
|
minus strand |
|
Proteins
for FAM214B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F214B_HUMAN, Q7L5A3 (See
protein sequence)Recommended Name: Protein FAM214B Size: 538 amino acids; 56690 Da
Sequence caution: Sequence=AAC07982.1; Type=Erroneous gene model prediction; Sequence=BAA96063.1; Type=Erroneousinitiation; Note=Translation N-terminally shortened;
Secondary accessions: B1AML4 B1AML5 D3DRN5 O60377 Q9BQ60 Q9HAI9 Q9P1Y9Alternative splicing: 3 isoforms: Q7L5A3-1 Q7L5A3-2 Q7L5A3-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FAM214B: NX_Q7L5A3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7L5A3
FAM214B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079458.2
ENSEMBL proteins: ENSP00000367829 ENSP00000319897 ENSP00000367823 ENSP00000367819 ENSP00000367816
Human Recombinant Protein Products for FAM214B:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IDA | -- |
FAM214B for ontologies About GeneDecksing
FAM214B Antibody Products:
Assay Products for FAM214B: |
Protein
Domains /
Families
for FAM214B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM214B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q7L5A3ProtoNet protein and cluster: Q7L5A3 UniProtKB/Swiss-Prot: F214B_HUMAN, Q7L5A3Similarity: Belongs to the FAM214 family |
Function
for FAM214B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM214B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM214B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for FAM214B | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM214B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM214B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM214B |
|
Pathways & Interactions
for FAM214B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM214B
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
4 Interacting proteins for FAM214B (Q7L5A33 ENSP000003198974) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FAM214B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM214B
Search CenterWatch for drugs/clinical trials and news about FAM214B / F214B
|
Transcripts
for FAM214B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM214B gene: NM_025182.2 Unigene Cluster for FAM214B: Family with sequence similarity 214, member B Hs.301696 [show with all ESTs]Unigene Representative Sequence: NM_0251827 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000378566(uc003zwn.3) ENST00000322813(uc003zwp.1 uc003zwo.3 uc010mkk.1)
ENST00000378561(uc003zwl.3 uc003zwm.3) ENST00000378557 ENST00000378554
ENST00000479357 ENST00000488109
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM214B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM214B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for FAM214B | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM214B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM214B |
Additional cDNA sequence: AK021622.1 AK022837.1 AK307682.1 AL583909.1 BC004406.1 22 DOTS entries: DT.100788141 DT.100788143 DT.97802032 DT.454982 DT.91747748 DT.100788147 DT.102830116 DT.100788146 DT.121171296 DT.91747745 DT.100658845 DT.100788148 DT.215854 DT.97819816 DT.100658843 DT.102830117 DT.102830118 DT.121171290 DT.121171321 DT.121171323 DT.95147846 DT.95078305 24/162 AceView cDNA sequences (see all 162): CA412628 AK022837 AL583909 BM769095 BF807614 BU624331 AB040972 D80382 CR601417 AI934697 BX396308 CD370453 AA330337 BF346704 CD370278 BM833641 D80313 BM854293 BQ448687 NM_025182 AW965488 BU191183 BQ007023 BG223350
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for FAM214B (see all 12) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | · | 8f | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 | ^ | 14a | · |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | - | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 14b | ^ | 15a | · | 15b |
|---|
|
| SP1: | | | | | | | |
| SP2: | | | | | | | |
| SP3: | | | | | | | |
| SP4: | | | | | | | |
| SP5: | | | | | | |
ECgene alternative splicing isoforms for FAM214B
|
Expression
for FAM214B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM214B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGTTCCAAA
About this image
See FAM214B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM214B
SOURCE GeneReport for Unigene cluster: Hs.301696
SABiosciences Custom PCR Arrays for FAM214B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM214B
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat FAM214B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM214B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM214B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM214B |
Orthologs
for FAM214B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FAM214B gene from 4/16 species (see all 16) About this table
ENSEMBL Gene Tree for FAM214B (if available)
TreeFam Gene Tree for FAM214B (if available) |
Paralogs
for FAM214B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM214B gene
- FAM214A2
2 SIMAP similar genes for FAM214B using alignment to 1 protein entry: F214B_HUMAN:KIAA1539 FAM214A
FAM214B for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for FAM214B
PGOHUM00000237730 PGOHUM00000250493
|
Genomic Variants
for FAM214B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM214B (35104109 - 35115999 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM214B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM214B |
|
Disorders
/ Diseases
for FAM214B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for FAM214B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM214B gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with FAM214B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2, 3 Nagase T.... Ohara O. (2000)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for FAM214B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM214B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM214B gene
(According to HUGE)
About This Section
| |
Specialized Databases showing FAM214B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM214B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM214B gene:
Search GeneIP for patents involving FAM214B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM214B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM214B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM214B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM214B | | | OriGene Protein Over-expression Lysate for FAM214B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM214B | | OriGene 3'-UTR Clone for FAM214B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM214B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM214B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM214B | | OriGene Custom Protein Services for FAM214B | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM214B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM214B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM214B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM214B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM214B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM214B |
| |
 |  |  |  | |
| | | | Search Tocris compounds for FAM214B |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM214B |
|  |  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM214B |
| |  | |
|
|
|
