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Aliases for FAM214B Gene

Aliases for FAM214B Gene

  • Family With Sequence Similarity 214 Member B 2 3 5
  • KIAA1539 2 3 4
  • Family With Sequence Similarity 214, Member B 2
  • Protein FAM214B 3

External Ids for FAM214B Gene

Previous HGNC Symbols for FAM214B Gene

  • KIAA1539

Summaries for FAM214B Gene

GeneCards Summary for FAM214B Gene

FAM214B (Family With Sequence Similarity 214 Member B) is a Protein Coding gene. An important paralog of this gene is FAM214A.

Gene Wiki entry for FAM214B Gene

Additional gene information for FAM214B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM214B Gene

Genomics for FAM214B Gene

Regulatory Elements for FAM214B Gene

Enhancers for FAM214B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H035108 1.8 FANTOM5 ENCODE dbSUPER 23.1 +3.3 3321 9 HDGF PKNOX1 ARNT ARID4B SIN3A YY1 ZNF143 FOS SP3 SP5 FAM214B PIGO SPAG8 TMEM8B RUSC2 ARHGEF39 VCP FANCG UNC13B DNAJB5
GH09H035487 1.7 FANTOM5 ENCODE dbSUPER 10.7 -374.1 -374144 5.5 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZNF766 SP3 ZHX2 MXD4 PIGO FANCG TMEM8B FAM214B SPAG8 FAM166B NPR2 HMGB3P24 UNC13B GBA2
GH09H035161 1 ENCODE 10.9 -46.0 -45983 2.6 PKNOX1 ATF1 ARID4B SIN3A DMAP1 GLI4 ZNF2 YY1 ZNF121 GLIS2 NPR2 OR13E1P UNC13B HRCT1 FAM214B TMEM8B GC09M035178
GH09H035481 0.9 Ensembl dbSUPER 10.7 -365.4 -365350 0.2 CTCF ZNF654 NFIA REST RAD21 CC2D1A NFIC ZNF143 SMC3 FAM214B FAM166B UNC13B GBA2 PIR41937 RUSC2
GH09H035477 0.8 ENCODE 11.5 -361.1 -361058 0.2 ELF3 CTCF PKNOX1 SAP130 ARID4B MAX RAD21 RFX5 CC2D1A ZNF316 FAM214B PIR41937 PIR61897
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM214B on UCSC Golden Path with GeneCards custom track

Promoters for FAM214B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000234599 251 2601 HDGF PKNOX1 ATF1 ARNT ARID4B SIN3A YY1 GLIS2 ZNF143 ATF7

Genomic Locations for FAM214B Gene

Genomic Locations for FAM214B Gene
chr9:35,104,112-35,116,351
(GRCh38/hg38)
Size:
12,240 bases
Orientation:
Minus strand
chr9:35,104,109-35,116,338
(GRCh37/hg19)

Genomic View for FAM214B Gene

Genes around FAM214B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM214B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM214B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM214B Gene

Proteins for FAM214B Gene

  • Protein details for FAM214B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L5A3-F214B_HUMAN
    Recommended name:
    Protein FAM214B
    Protein Accession:
    Q7L5A3
    Secondary Accessions:
    • B1AML4
    • B1AML5
    • D3DRN5
    • O60377
    • Q9BQ60
    • Q9HAI9
    • Q9P1Y9

    Protein attributes for FAM214B Gene

    Size:
    538 amino acids
    Molecular mass:
    56690 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC07982.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA96063.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM214B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM214B Gene

Post-translational modifications for FAM214B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM214B Gene

Domains & Families for FAM214B Gene

Gene Families for FAM214B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM214B Gene

Suggested Antigen Peptide Sequences for FAM214B Gene

Graphical View of Domain Structure for InterPro Entry

Q7L5A3

UniProtKB/Swiss-Prot:

F214B_HUMAN :
  • Belongs to the FAM214 family.
Family:
  • Belongs to the FAM214 family.
genes like me logo Genes that share domains with FAM214B: view

Function for FAM214B Gene

Phenotypes From GWAS Catalog for FAM214B Gene

Gene Ontology (GO) - Molecular Function for FAM214B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with FAM214B: view
genes like me logo Genes that share phenotypes with FAM214B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM214B Gene

Localization for FAM214B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM214B gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM214B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with FAM214B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM214B Gene

Pathways & Interactions for FAM214B Gene

SuperPathways for FAM214B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM214B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM214B Gene

Drugs & Compounds for FAM214B Gene

No Compound Related Data Available

Transcripts for FAM214B Gene

Unigene Clusters for FAM214B Gene

Family with sequence similarity 214, member B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM214B Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a ·
SP1: - - - - - - -
SP2: -
SP3: - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - -
SP7: - - -
SP8: - -
SP9: -
SP10:
SP11:
SP12: - - - - -

ExUns: 14b ^ 15a · 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for FAM214B Gene

GeneLoc Exon Structure for
FAM214B
ECgene alternative splicing isoforms for
FAM214B

Expression for FAM214B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM214B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM214B Gene

This gene is overexpressed in Whole Blood (x7.1).

Protein differential expression in normal tissues from HIPED for FAM214B Gene

This gene is overexpressed in Adrenal (17.4), Spinal cord (13.1), Testis (12.1), Frontal cortex (6.9), and Heart (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM214B Gene



NURSA nuclear receptor signaling pathways regulating expression of FAM214B Gene:

FAM214B

SOURCE GeneReport for Unigene cluster for FAM214B Gene:

Hs.301696

Evidence on tissue expression from TISSUES for FAM214B Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with FAM214B: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM214B Gene

Orthologs for FAM214B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM214B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM214B 33 34
  • 99.32 (n)
dog
(Canis familiaris)
Mammalia KIAA1539 33
  • 94.59 (n)
FAM214B 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM214B 33 34
  • 93 (n)
mouse
(Mus musculus)
Mammalia Fam214b 33 16 34
  • 92.75 (n)
rat
(Rattus norvegicus)
Mammalia Fam214b 33
  • 92.63 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM214B 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM214B 33 34
  • 59.78 (n)
lizard
(Anolis carolinensis)
Reptilia FAM214B 34
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam214b 33
  • 56.7 (n)
zebrafish
(Danio rerio)
Actinopterygii fam214b 34
  • 33 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9005 34
  • 9 (a)
OneToMany
Species where no ortholog for FAM214B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM214B Gene

ENSEMBL:
Gene Tree for FAM214B (if available)
TreeFam:
Gene Tree for FAM214B (if available)

Paralogs for FAM214B Gene

Paralogs for FAM214B Gene

(2) SIMAP similar genes for FAM214B Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for FAM214B Gene

genes like me logo Genes that share paralogs with FAM214B: view

Variants for FAM214B Gene

Sequence variations from dbSNP and Humsavar for FAM214B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000055107 -- 35,112,845(+) CCCAG(A/G)GCCCT intron-variant, upstream-variant-2KB
rs1000087148 -- 35,116,744(+) GCGGG(G/T)GTGGG upstream-variant-2KB
rs1000872643 -- 35,114,217(+) AAACC(A/G)CCCCA intron-variant, upstream-variant-2KB
rs1000967150 -- 35,114,835(+) TAAAT(A/G)TGGCT intron-variant
rs1001112008 -- 35,114,387(+) CCCCC(C/T)TCCCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM214B Gene

Variant ID Type Subtype PubMed ID
nsv1125318 OTHER inversion 24896259
nsv1030303 CNV gain 25217958
esv24832 CNV loss 19812545

Variation tolerance for FAM214B Gene

Residual Variation Intolerance Score: 69.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.47; 55.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM214B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM214B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM214B Gene

Disorders for FAM214B Gene

Relevant External Links for FAM214B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM214B

No disorders were found for FAM214B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM214B Gene

Publications for FAM214B Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. An inter-species protein-protein interaction network across vast evolutionary distance. (PMID: 27107014) Zhong Q … Vidal M (Molecular systems biology 2016) 3 60
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H … Vidal M (Nature methods 2011) 3 60

Products for FAM214B Gene

Sources for FAM214B Gene

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