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Aliases for FAM214A Gene

Aliases for FAM214A Gene

  • Family With Sequence Similarity 214 Member A 2 3 5
  • KIAA1370 2 3 4
  • Family With Sequence Similarity 214, Member A 2
  • Protein FAM214A 3

External Ids for FAM214A Gene

Previous HGNC Symbols for FAM214A Gene

  • KIAA1370

Previous GeneCards Identifiers for FAM214A Gene

  • GC15M052874
  • GC15M052876
  • GC15M053028
  • GC15M053500
  • GC15M054147

Summaries for FAM214A Gene

GeneCards Summary for FAM214A Gene

FAM214A (Family With Sequence Similarity 214 Member A) is a Protein Coding gene. An important paralog of this gene is FAM214B.

Additional gene information for FAM214A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM214A Gene

Genomics for FAM214A Gene

GeneHancer (GH) Regulatory Elements for FAM214A Gene

Promoters and enhancers for FAM214A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I052676 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 567.2 +29.3 29309 8.1 PKNOX1 CLOCK FOXA2 ARID4B SIN3A ZBTB7B YY1 ZNF207 ZNF143 DEK FAM214A LOC105370821 ENSG00000260618 ENSG00000259935 ENSG00000259712 GNB5
GH15I052651 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 561.8 +56.9 56936 3.5 PKNOX1 FOXA2 ARID4B SIN3A YY1 FOS NFYC MXD4 REST MEF2D FAM214A GNB5 MIR1266 ENSG00000259935 LOC105370821
GH15I052708 Enhancer 1 Ensembl ENCODE 550.8 +0.2 184 2 PKNOX1 FOXA2 ARID4B ZNF2 RAD21 YY1 IKZF2 MIXL1 ZNF280D SP3 FAM214A LOC105370821
GH15I052018 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.9 +688.9 688949 5.6 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 MAPK6 ENSG00000259438 ENSG00000259935 ENSG00000259712 ENSG00000260618 BCL2L10 LYSMD2 FAM214A DMXL2 ENSG00000259398
GH15I052010 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.8 +698.3 698343 1.9 PKNOX1 SMAD1 FEZF1 BATF FOS BCLAF1 RUNX3 JUNB CEBPB ZNF592 ENSG00000259935 ENSG00000260618 FAM214A ENSG00000259712 LEO1 GNB5 MYO5C ENSG00000274528 ENSG00000259438 GC15P052002
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM214A on UCSC Golden Path with GeneCards custom track

Genomic Locations for FAM214A Gene

Genomic Locations for FAM214A Gene
chr15:52,581,317-52,709,817
(GRCh38/hg38)
Size:
128,501 bases
Orientation:
Minus strand
chr15:52,873,514-53,002,014
(GRCh37/hg19)

Genomic View for FAM214A Gene

Genes around FAM214A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM214A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM214A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM214A Gene

Proteins for FAM214A Gene

  • Protein details for FAM214A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q32MH5-F214A_HUMAN
    Recommended name:
    Protein FAM214A
    Protein Accession:
    Q32MH5
    Secondary Accessions:
    • A8KA52
    • B4DEP5
    • B4DF40
    • F5H8G0
    • Q32MH6
    • Q4G0R7
    • Q5XJ16
    • Q6PDA3
    • Q9NV24
    • Q9P2H7

    Protein attributes for FAM214A Gene

    Size:
    1076 amino acids
    Molecular mass:
    121670 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91936.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA92608.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG57156.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM214A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM214A Gene

Post-translational modifications for FAM214A Gene

No Post-translational modifications

No data available for DME Specific Peptides for FAM214A Gene

Domains & Families for FAM214A Gene

Gene Families for FAM214A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM214A Gene

Suggested Antigen Peptide Sequences for FAM214A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q32MH5

UniProtKB/Swiss-Prot:

F214A_HUMAN :
  • Belongs to the FAM214 family.
Family:
  • Belongs to the FAM214 family.
genes like me logo Genes that share domains with FAM214A: view

Function for FAM214A Gene

Phenotypes From GWAS Catalog for FAM214A Gene

Gene Ontology (GO) - Molecular Function for FAM214A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM214A: view
genes like me logo Genes that share phenotypes with FAM214A: view

Animal Model Products

miRNA for FAM214A Gene

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM214A Gene

Localization for FAM214A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM214A gene
Compartment Confidence
nucleus 3
cytosol 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM214A Gene

Pathways & Interactions for FAM214A Gene

SuperPathways for FAM214A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM214A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM214A Gene

Drugs & Compounds for FAM214A Gene

No Compound Related Data Available

Transcripts for FAM214A Gene

Unigene Clusters for FAM214A Gene

Family with sequence similarity 214, member A:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM214A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
SP1: - -
SP2: - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - - -
SP7:
SP8: -

Relevant External Links for FAM214A Gene

GeneLoc Exon Structure for
FAM214A
ECgene alternative splicing isoforms for
FAM214A

Expression for FAM214A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM214A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM214A Gene

This gene is overexpressed in Liver (35.5), Plasma (13.9), and Blymphocyte (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM214A Gene



Protein tissue co-expression partners for FAM214A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM214A Gene:

FAM214A

SOURCE GeneReport for Unigene cluster for FAM214A Gene:

Hs.152385

Evidence on tissue expression from TISSUES for FAM214A Gene

  • Blood(5)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with FAM214A: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM214A Gene

Orthologs for FAM214A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM214A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM214A 33 34
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia KIAA1370 33
  • 90.16 (n)
FAM214A 34
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA1370 33
  • 89.9 (n)
FAM214A 34
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam214a 33
  • 78.81 (n)
mouse
(Mus musculus)
Mammalia Fam214a 33 16 34
  • 78.39 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM214A 34
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM214A 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM214A 33 34
  • 72.61 (n)
lizard
(Anolis carolinensis)
Reptilia FAM214A 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2731 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6950 33
zebrafish
(Danio rerio)
Actinopterygii fam214a 34
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9005 34
  • 15 (a)
OneToMany
Species where no ortholog for FAM214A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM214A Gene

ENSEMBL:
Gene Tree for FAM214A (if available)
TreeFam:
Gene Tree for FAM214A (if available)

Paralogs for FAM214A Gene

Paralogs for FAM214A Gene

genes like me logo Genes that share paralogs with FAM214A: view

Variants for FAM214A Gene

Sequence variations from dbSNP and Humsavar for FAM214A Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000092484 -- 52,618,292(-) G/A intron_variant
rs1000099162 -- 52,634,170(-) T/C intron_variant
rs1000139272 -- 52,616,769(-) C/T intron_variant
rs1000143630 -- 52,630,151(-) G/A intron_variant
rs1000231756 -- 52,678,548(-) T/C genic_upstream_transcript_variant, intron_variant, non_coding_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM214A Gene

Variant ID Type Subtype PubMed ID
esv1977718 CNV deletion 18987734
esv2749699 CNV deletion 23290073
esv2749700 CNV deletion 23290073
esv3382591 CNV insertion 20981092
esv3636490 CNV loss 21293372
nsv1047775 CNV gain 25217958
nsv457140 CNV loss 19166990
nsv471245 CNV gain 18288195
nsv833006 CNV gain 17160897

Variation tolerance for FAM214A Gene

Residual Variation Intolerance Score: 53.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.87; 74.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM214A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM214A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM214A Gene

Disorders for FAM214A Gene

Additional Disease Information for FAM214A

No disorders were found for FAM214A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM214A Gene

Publications for FAM214A Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  4. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods NT … Monteiro AN (Science signaling 2012) 3 58
  5. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S … Ideker T (Nature methods 2010) 3 58

Products for FAM214A Gene

Sources for FAM214A Gene

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